PubMed:1380242
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-27 | DNA | denotes | SRC-related proto-oncogenes |
| T2 | 32-53 | protein | denotes | transcription factors |
| T3 | 65-78 | cell_type | denotes | human T cells |
| T4 | 133-146 | cell_type | denotes | T lymphocytes |
| T5 | 172-177 | DNA | denotes | genes |
| T6 | 191-202 | protein | denotes | lymphokines |
| T7 | 204-229 | DNA | denotes | Interleukin-2 (IL-2) gene |
| T8 | 313-337 | protein | denotes | trans-activating factors |
| T9 | 355-368 | DNA | denotes | IL-2 enhancer |
| T10 | 426-430 | protein | denotes | IL-2 |
| T11 | 434-447 | cell_type | denotes | T lymphocytes |
| T12 | 500-515 | DNA | denotes | src gene family |
| T13 | 521-564 | protein | denotes | lymphocyte-specific protein tyrosine kinase |
| T14 | 566-572 | protein | denotes | p56lck |
| T15 | 597-601 | protein | denotes | IL-2 |
| T16 | 643-646 | protein | denotes | lck |
| T17 | 688-696 | DNA | denotes | lck gene |
| T18 | 804-809 | DNA | denotes | NF-AT |
| T19 | 814-824 | DNA | denotes | AP-1 sites |
| T20 | 832-845 | DNA | denotes | IL-2 enhancer |
| T21 | 870-875 | protein | denotes | NF-AT |
| T22 | 880-884 | protein | denotes | AP-1 |
| T23 | 931-935 | protein | denotes | IL-2 |
| T24 | 1055-1079 | protein | denotes | trans-activating factors |
semrep-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| E1-ti-1 | 0-3 | cui:C0080059 | denotes | SRC |
| E2-ti-1 | 4-11 | cui:C1522149 | denotes | related |
| E3-ti-1 | 12-27 | cui:C0033713 | denotes | proto-oncogenes |
| E4-ti-1 | 32-53 | cui:C0040648 | denotes | transcription factors |
| E5-ti-1 | 65-70 | cui:C0020114 | denotes | human |
| E6-ti-1 | 71-78 | cui:C0039194 | denotes | T cells |
| E7-ti-1 | 94-107 | cui:C0010592 | denotes | cyclosporin A |
| E8-ti-1 | 112-117 | cui:C0729218 | denotes | FK506 |
| T1 | 65-78 | PART_OF | denotes | human T cells |
| T2 | 54-56 | LOCATION_OF | denotes | in |
| T3 | 54-56 | LOCATION_OF | denotes | in |
| E1-ab-1 | 133-146 | cui:C0039194 | denotes | T lymphocytes |
| E2-ab-1 | 155-168 | cui:C0040649 | denotes | transcription |
| E3-ab-1 | 172-177 | cui:C0017337 | denotes | genes |
| E4-ab-1 | 191-202 | cui:C0024297 | denotes | lymphokines |
| E1-ab-2 | 204-229 | cui:C0879590 | denotes | Interleukin-2 (IL-2) gene |
| E2-ab-2 | 230-240 | cui:C0185117 | denotes | expression |
| E3-ab-2 | 280-291 | cui:C0679729 | denotes | cooperative |
| E4-ab-2 | 292-300 | cui:C0439167 | denotes | activity |
| E5-ab-2 | 330-337 | cui:C1521761 | denotes | factors |
| E6-ab-2 | 355-359 | cui:C0021756 | denotes | IL-2 |
| E7-ab-2 | 360-368 | cui:C0086222 | denotes | enhancer |
| T4 | 343-347 | INTERACTS_WITH | denotes | bind |
| E1-ab-3 | 370-383 | cui:C0010592 | denotes | Cyclosporin A |
| E2-ab-3 | 394-399 | cui:C0729218 | denotes | FK506 |
| E3-ab-3 | 412-422 | cui:C0033268 | denotes | production |
| E4-ab-3 | 426-430 | cui:C0021756 | denotes | IL-2 |
| E5-ab-3 | 434-447 | cui:C0039194 | denotes | T lymphocytes |
| E6-ab-3 | 464-482 | cui:C0040649 | denotes | gene transcription |
| T5 | 400-407 | INHIBITS | denotes | inhibit |
| T6 | 400-407 | INHIBITS | denotes | inhibit |
| T7 | 431-433 | LOCATION_OF | denotes | in |
| E1-ab-4 | 486-492 | cui:C0680022 | denotes | member |
| E2-ab-4 | 500-503 | cui:C0080059 | denotes | src |
| E3-ab-4 | 504-515 | cui:C1517488 | denotes | gene family |
| E4-ab-4 | 521-564 | cui:C0065344 | denotes | lymphocyte-specific protein tyrosine kinase |
| E5-ab-4 | 566-572 | entrez:3932 | denotes | p56lck |
| E6-ab-4 | 597-601 | cui:C0021756 | denotes | IL-2 |
| E7-ab-4 | 602-612 | cui:C0033268 | denotes | production |
| T8 | 583-593 | INTERACTS_WITH | denotes | implicated |
| E1-ab-5 | 614-617 | cui:C0010592 | denotes | CsA |
| E2-ab-5 | 628-631 | cui:C1518422 | denotes | not |
| E3-ab-5 | 643-646 | cui:C0065344 | denotes | lck |
| E4-ab-5 | 647-662 | cui:C0017262 | denotes | gene expression |
| E5-ab-5 | 672-680 | cui:C0439167 | denotes | activity |
| E6-ab-5 | 688-691 | cui:C0065344 | denotes | lck |
| E7-ab-5 | 692-704 | cui:C0033684 | denotes | gene product |
| T9 | 688-704 | ISA | denotes | lck gene product |
| T10 | 635-642 | INHIBITS | denotes | inhibit |
| E1-ab-6 | 715-718 | cui:C0010592 | denotes | CsA |
| E2-ab-6 | 723-728 | cui:C0729218 | denotes | FK506 |
| E3-ab-6 | 741-751 | cui:C0700364 | denotes | appearance |
| E4-ab-6 | 755-766 | cui:C1148673 | denotes | DNA binding |
| E5-ab-6 | 767-775 | cui:C0439167 | denotes | activity |
| E6-ab-6 | 779-786 | cui:C1521761 | denotes | factors |
| E7-ab-6 | 814-818 | cui:C0002059 | denotes | AP-1 |
| E8-ab-6 | 819-824 | cui:C0205145 | denotes | sites |
| E9-ab-6 | 832-836 | cui:C0021756 | denotes | IL-2 |
| E10-ab-6 | 837-845 | cui:C0086222 | denotes | enhancer |
| E1-ab-7 | 857-866 | cui:C0857127 | denotes | induction |
| E2-ab-7 | 880-884 | cui:C0002059 | denotes | AP-1 |
| E3-ab-7 | 903-907 | cui:C0445247 | denotes | same |
| E4-ab-7 | 908-915 | cui:C0234402 | denotes | stimuli |
| E5-ab-7 | 931-935 | cui:C0021756 | denotes | IL-2 |
| E6-ab-7 | 936-946 | cui:C0033268 | denotes | production |
| E7-ab-7 | 954-961 | cui:C1274040 | denotes | results |
| E8-ab-7 | 980-997 | cui:C0021081 | denotes | immunosuppressant |
| E9-ab-7 | 1008-1011 | cui:C0010592 | denotes | CsA |
| E10-ab-7 | 1016-1021 | cui:C0729218 | denotes | FK506 |
| E11-ab-7 | 1072-1079 | cui:C1521761 | denotes | factors |
| T11 | 921-930 | STIMULATES | denotes | stimulate |
| R1 | E6-ti-1 | T1 | subjectOf | T cells,human T cells |
| R2 | E5-ti-1 | T1 | objectOf | human,human T cells |
| R3 | E6-ti-1 | T2 | subjectOf | T cells,in |
| R4 | E4-ti-1 | T2 | objectOf | transcription factors,in |
| R5 | E6-ti-1 | T3 | subjectOf | T cells,in |
| R6 | E3-ti-1 | T3 | objectOf | proto-oncogenes,in |
| R7 | E1-ab-2 | T4 | subjectOf | Interleukin-2 (IL-2) gene,bind |
| R8 | E7-ab-2 | T4 | objectOf | enhancer,bind |
| R9 | E2-ab-3 | T5 | subjectOf | FK506,inhibit |
| R10 | E4-ab-3 | T5 | objectOf | IL-2,inhibit |
| R11 | E1-ab-3 | T6 | subjectOf | Cyclosporin A,inhibit |
| R12 | E4-ab-3 | T6 | objectOf | IL-2,inhibit |
| R13 | E5-ab-3 | T7 | subjectOf | T lymphocytes,in |
| R14 | E4-ab-3 | T7 | objectOf | IL-2,in |
| R15 | E5-ab-4 | T8 | subjectOf | p56lck,implicated |
| R16 | E6-ab-4 | T8 | objectOf | IL-2,implicated |
| R17 | E6-ab-5 | T9 | subjectOf | lck,lck gene product |
| R18 | E7-ab-5 | T9 | objectOf | gene product,lck gene product |
| R19 | E1-ab-5 | T10 | subjectOf | CsA,inhibit |
| R20 | E3-ab-5 | T10 | objectOf | lck,inhibit |
| R21 | E2-ab-7 | T11 | subjectOf | AP-1,stimulate |
| R22 | E5-ab-7 | T11 | objectOf | IL-2,stimulate |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-118 | Sentence | denotes | SRC-related proto-oncogenes and transcription factors in primary human T cells: modulation by cyclosporin A and FK506. |
| S2 | 119-203 | Sentence | denotes | Activation of T lymphocytes induces transcription of genes encoding for lymphokines. |
| S3 | 204-369 | Sentence | denotes | Interleukin-2 (IL-2) gene expression is controlled transcriptionally by the cooperative activity of specific trans-activating factors that bind to the IL-2 enhancer. |
| S4 | 370-483 | Sentence | denotes | Cyclosporin A (CsA) and FK506 inhibit the production of IL-2 in T lymphocytes at the level of gene transcription. |
| S5 | 484-613 | Sentence | denotes | A member of the src gene family, the lymphocyte-specific protein tyrosine kinase, p56lck, has been implicated in IL-2 production. |
| S6 | 614-705 | Sentence | denotes | CsA was found not to inhibit lck gene expression, nor the activity of the lck gene product. |
| S7 | 706-846 | Sentence | denotes | However, CsA and FK506 inhibit the appearance of DNA binding activity of factors that bind to the NF-AT and AP-1 sites in the IL-2 enhancer. |
| S8 | 847-1080 | Sentence | denotes | Since the induction of NF-AT and AP-1 is induced by the same stimuli that stimulate IL-2 production, these results indicate that the immunosuppressant action of CsA and FK506 is exerted at the level of these trans-activating factors. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 32-53 | NP | denotes | transcription factors |
| C2 | 57-78 | NP | denotes | primary human T cells |
| C3 | 94-107 | NP | denotes | cyclosporin A |
| C4 | 112-117 | NP | denotes | FK506 |
| C5 | 133-146 | NP | denotes | T lymphocytes |
| C6 | 204-224 | NP | denotes | Interleukin-2 (IL-2) |
| C7 | 304-337 | NP | denotes | specific trans-activating factors |
| C8 | 338-342 | NP | denotes | that |
| C9 | 351-368 | NP | denotes | the IL-2 enhancer |
| C10 | 370-389 | NP | denotes | Cyclosporin A (CsA) |
| C11 | 394-399 | NP | denotes | FK506 |
| C12 | 426-430 | NP | denotes | IL-2 |
| C13 | 434-447 | NP | denotes | T lymphocytes |
| C14 | 484-515 | NP | denotes | A member of the src gene family |
| C15 | 517-564 | NP | denotes | the lymphocyte-specific protein tyrosine kinase |
| C16 | 566-572 | NP | denotes | p56lck |
| C17 | 597-612 | NP | denotes | IL-2 production |
| C18 | 614-617 | NP | denotes | CsA |
| C19 | 715-718 | NP | denotes | CsA |
| C20 | 723-728 | NP | denotes | FK506 |
| C21 | 779-786 | NP | denotes | factors |
| C22 | 787-791 | NP | denotes | that |
| C23 | 828-845 | NP | denotes | the IL-2 enhancer |
| C24 | 899-915 | NP | denotes | the same stimuli |
| C25 | 916-920 | NP | denotes | that |
| C26 | 931-946 | NP | denotes | IL-2 production |
| C27 | 1008-1011 | NP | denotes | CsA |
| C28 | 1016-1021 | NP | denotes | FK506 |
| C29 | 1049-1079 | NP | denotes | these trans-activating factors |
| R1 | C5 | C2 | coref-other | T lymphocytes,primary human T cells |
| R2 | C7 | C1 | coref-other | specific trans-activating factors,transcription factors |
| R3 | C8 | C7 | coref-relat | that,specific trans-activating factors |
| R4 | C10 | C3 | coref-ident | Cyclosporin A (CsA),cyclosporin A |
| R5 | C11 | C4 | coref-ident | FK506,FK506 |
| R6 | C12 | C6 | coref-ident | IL-2,Interleukin-2 (IL-2) |
| R7 | C13 | C5 | coref-ident | T lymphocytes,T lymphocytes |
| R8 | C15 | C14 | coref-appos | the lymphocyte-specific protein tyrosine kinase,A member of the src gene family |
| R9 | C16 | C15 | coref-appos | p56lck,the lymphocyte-specific protein tyrosine kinase |
| R10 | C18 | C10 | coref-ident | CsA,Cyclosporin A (CsA) |
| R11 | C19 | C18 | coref-ident | CsA,CsA |
| R12 | C20 | C11 | coref-ident | FK506,FK506 |
| R13 | C21 | C7 | coref-other | factors,specific trans-activating factors |
| R14 | C22 | C21 | coref-relat | that,factors |
| R15 | C23 | C9 | coref-ident | the IL-2 enhancer,the IL-2 enhancer |
| R16 | C25 | C24 | coref-relat | that,the same stimuli |
| R17 | C26 | C17 | coref-ident | IL-2 production,IL-2 production |
| R18 | C27 | C19 | coref-ident | CsA,CsA |
| R19 | C28 | C20 | coref-ident | FK506,FK506 |
| R20 | C29 | C21 | coref-other | these trans-activating factors,factors |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-27 | DNA_family_or_group | denotes | SRC-related proto-oncogenes |
| T2 | 32-53 | protein_family_or_group | denotes | transcription factors |
| T3 | 65-78 | cell_type | denotes | human T cells |
| T4 | 94-107 | other_organic_compound | denotes | cyclosporin A |
| T5 | 112-117 | other_organic_compound | denotes | FK506 |
| T6 | 133-146 | cell_type | denotes | T lymphocytes |
| T7 | 172-177 | DNA_family_or_group | denotes | genes |
| T8 | 191-202 | protein_domain_or_region | denotes | lymphokines |
| T9 | 204-217 | protein_molecule | denotes | Interleukin-2 |
| T10 | 219-223 | protein_molecule | denotes | IL-2 |
| T11 | 313-337 | protein_family_or_group | denotes | trans-activating factors |
| T12 | 355-359 | protein_molecule | denotes | IL-2 |
| T13 | 370-383 | other_organic_compound | denotes | Cyclosporin A |
| T14 | 385-388 | other_organic_compound | denotes | CsA |
| T15 | 394-399 | other_organic_compound | denotes | FK506 |
| T16 | 426-430 | protein_molecule | denotes | IL-2 |
| T17 | 434-447 | cell_type | denotes | T lymphocytes |
| T18 | 464-482 | other_name | denotes | gene transcription |
| T19 | 500-515 | DNA_family_or_group | denotes | src gene family |
| T20 | 521-564 | protein_molecule | denotes | lymphocyte-specific protein tyrosine kinase |
| T21 | 566-572 | protein_molecule | denotes | p56lck |
| T22 | 597-601 | protein_molecule | denotes | IL-2 |
| T23 | 614-617 | other_organic_compound | denotes | CsA |
| T24 | 643-646 | protein_molecule | denotes | lck |
| T25 | 688-696 | DNA_domain_or_region | denotes | lck gene |
| T26 | 715-718 | other_organic_compound | denotes | CsA |
| T27 | 723-728 | other_organic_compound | denotes | FK506 |
| T28 | 755-775 | other_name | denotes | DNA binding activity |
| T29 | 804-809 | DNA_domain_or_region | denotes | NF-AT |
| T30 | 814-824 | DNA_domain_or_region | denotes | AP-1 sites |
| T31 | 832-836 | protein_molecule | denotes | IL-2 |
| T32 | 870-875 | protein_family_or_group | denotes | NF-AT |
| T33 | 880-884 | protein_molecule | denotes | AP-1 |
| T34 | 931-935 | protein_molecule | denotes | IL-2 |
| T35 | 980-1004 | other_name | denotes | immunosuppressant action |
| T36 | 1008-1011 | other_organic_compound | denotes | CsA |
| T37 | 1016-1021 | other_organic_compound | denotes | FK506 |
| T38 | 1055-1079 | protein_family_or_group | denotes | trans-activating factors |
metamap-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 66-71 | C0086418 | denotes | uman |
| T2 | 13-28 | C0033713 | denotes | roto-oncogenes |
| T3 | 1009-1012 | C0010592 | denotes | sA |
| T4 | 716-719 | C0010592 | denotes | sA |
| T5 | 615-618 | C0010592 | denotes | sA |
| T6 | 371-384 | C0010592 | denotes | yclosporin A |
| T7 | 95-108 | C0010592 | denotes | yclosporin A |
| T8 | 1017-1022 | C0729218 | denotes | K506 |
| T9 | 724-729 | C0729218 | denotes | K506 |
| T10 | 395-400 | C0729218 | denotes | K506 |
| T11 | 113-118 | C0729218 | denotes | K506. |
| T12 | 465-483 | C0040649 | denotes | ene transcription. |
| T13 | 33-46 | C0040649 | denotes | ranscription |
| T14 | 81-91 | C0443264 | denotes | odulation |
| T15 | 5-12 | C0439849 | denotes | elated |
| T16 | 74-79 | C0007634 | denotes | ells: |
| T17 | 58-65 | C0205225 | denotes | rimary |
| T18 | 730-737 | C0018790 | denotes | nhibit |
| T19 | 636-643 | C0018790 | denotes | nhibit |
| T20 | 401-408 | C0018790 | denotes | nhibit |
| T21 | 501-516 | C0038085 | denotes | rc gene family, |
| T22 | 522-565 | C0919477 | denotes | ymphocyte-specific protein tyrosine kinase, |
| T23 | 881-885 | C0085828 | denotes | P-1 |
| T24 | 192-203 | C0024297 | denotes | ymphokines. |
| T25 | 981-998 | C0021081 | denotes | mmunosuppressant |
| T26 | 932-947 | C1819447 | denotes | L-2 production, |
| T27 | 598-613 | C1819447 | denotes | L-2 production. |
| T28 | 889-896 | C0205263 | denotes | nduced |
| T29 | 858-867 | C0205263 | denotes | nduction |
| T30 | 148-155 | C0205263 | denotes | nduces |
| T31 | 1073-1080 | C1521761 | denotes | actors. |
| T32 | 780-787 | C1521761 | denotes | actors |
| T33 | 331-338 | C1521761 | denotes | actors |
| T34 | 648-663 | C0017262 | denotes | ene expression, |
| T35 | 756-759 | C0012854 | denotes | NA |
| T36 | 1041-1046 | C0441889 | denotes | evel |
| T37 | 456-461 | C0441889 | denotes | evel |
| T38 | 356-360 | C0879590 | denotes | L-2 |
| T39 | 653-663 | C0185117 | denotes | xpression, |
| T40 | 231-241 | C0185117 | denotes | xpression |
| T41 | 793-797 | C1167622 | denotes | ind |
| T42 | 344-348 | C1167622 | denotes | ind |
| T43 | 673-681 | C1561536 | denotes | ctivity |
| T44 | 293-301 | C1561536 | denotes | ctivity |
| T45 | 1062-1072 | C1879547 | denotes | ctivating |
| T46 | 320-330 | C1879547 | denotes | ctivating |
| T47 | 1056-1061 | C2826298 | denotes | rans- |
| T48 | 314-319 | C2826298 | denotes | rans- |
| T49 | 838-846 | C0086222 | denotes | nhancer. |
| T50 | 361-369 | C0086222 | denotes | nhancer. |
| T51 | 693-705 | C0033684 | denotes | ene product. |
| T52 | 245-255 | C2587213 | denotes | ontrolled |
| T53 | 623-628 | C0150312 | denotes | ound |
| T54 | 955-962 | C2825142 | denotes | esults |
| T55 | 629-632 | C1518422 | denotes | ot |
| T56 | 179-187 | C2700640 | denotes | ncoding |
| T57 | 904-907 | C0445247 | denotes | ame |
| T58 | 909-916 | C0234402 | denotes | timuli |
| T59 | 999-1005 | C0441472 | denotes | ction |
| T60 | 487-493 | C0680022 | denotes | ember |
| T61 | 742-751 | C0233426 | denotes | ppearance |
| T62 | 820-825 | C0205145 | denotes | ites |
| T63 | 1026-1033 | C0015264 | denotes | xerted |
| T64 | 305-313 | C0205369 | denotes | pecific |
| T65 | 281-292 | C0679729 | denotes | ooperative |
| T66 | 760-776 | C2266866 | denotes | inding activity |
| T67 | 698-705 | C1514468 | denotes | roduct. |