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PubMed:1372941 JSONTXT

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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 120-312 BACKGROUND denotes The presence of multiple, low-molecular-weight, insulinlike growth factor (IGF)-binding proteins in lung tumor cell-conditioned medium and lung cancer patient serum has been recently reported.
T2 322-748 OBJECTIVE denotes To begin to elucidate the genetic basis for these observations, the present study examines the expression by lung tumor cell lines of three IGF-binding protein genes, namely, IGFBP-1, IGFBP-2, and IGFBP-3. Since IGF-binding proteins are thought to modulate the biologic action of the IGFs, the relationship between the expression of IGF-binding protein genes and the genes encoding IGF-I and IGF-II also has been investigated.
T3 758-982 METHODS denotes Gene expression was studied in four small-cell lung cancer (SCLC) and three non-small-cell lung cancer (NSCLC) cell lines using Northern blot analysis and reverse transcriptase polymerase chain reaction (RT-PCR) for IGFBP-1.
T4 992-1728 RESULTS denotes IGFBP-1 gene expression was detected by Northern blot analysis in one NSCLC cell line only. However, RT-PCR revealed that the IGFBP-1 gene was expressed in all four SCLC cell lines and in two of the three NSCLC lines. Northern blot analysis of IGFBP-2 gene expression demonstrated that all lung tumor cell lines expressed this gene. A low level of IGFBP-3 gene expression was detected in one SCLC cell line and in all three NSCLC cell lines. All lung tumor cell lines expressed the IGF-II gene as determined by Northern blot analysis. In marked contrast, none of the lines showed evidence of IGF-I gene expression using this method. However, RT-PCR revealed a low level of IGF-I gene expression in one SCLC and one NSCLC cell line only.
T5 1742-2136 CONCLUSIONS denotes These observations indicate 1) that IGF-binding proteins secreted by lung tumors are encoded by at least three different genes; 2) that there may be a close association between IGF-II and IGFBP-2 gene expression, such that, where there is production of IGF-II, IGFBP-2 is the principal BP; and 3) that the IGF-II gene is more widely expressed than the IGF-I gene in human lung tumor cell lines.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
1372941-11#40#45#gene3479 1665-1670 gene3479 denotes IGF-I
1372941-11#69#73#diseaseC0149925 1694-1698 diseaseC0149925 denotes SCLC
1372941-11#82#87#diseaseC0007131 1707-1712 diseaseC0007131 denotes NSCLC
1372941-12#177#183#gene3481 1919-1925 gene3481 denotes IGF-II
1372941-12#188#195#gene3485 1930-1937 gene3485 denotes IGFBP-2
1372941-12#253#259#gene3481 1995-2001 gene3481 denotes IGF-II
1372941-12#261#268#gene3485 2003-2010 gene3485 denotes IGFBP-2
1372941-12#306#312#gene3481 2048-2054 gene3481 denotes IGF-II
1372941-12#352#357#gene3479 2094-2099 gene3479 denotes IGF-I
1372941-12#69#80#diseaseC0024121 1811-1822 diseaseC0024121 denotes lung tumors
1372941-12#372#382#diseaseC0024121 2114-2124 diseaseC0024121 denotes lung tumor
1372941-12#69#80#diseaseC0024121 1811-1822 diseaseC0024121 denotes lung tumors
1372941-12#372#382#diseaseC0024121 2114-2124 diseaseC0024121 denotes lung tumor
1372941-12#69#80#diseaseC0024121 1811-1822 diseaseC0024121 denotes lung tumors
1372941-12#372#382#diseaseC0024121 2114-2124 diseaseC0024121 denotes lung tumor
1372941-12#69#80#diseaseC0024121 1811-1822 diseaseC0024121 denotes lung tumors
1372941-12#372#382#diseaseC0024121 2114-2124 diseaseC0024121 denotes lung tumor
1372941-12#69#80#diseaseC0024121 1811-1822 diseaseC0024121 denotes lung tumors
1372941-12#372#382#diseaseC0024121 2114-2124 diseaseC0024121 denotes lung tumor
1372941-6#34#41#gene3484 1118-1125 gene3484 denotes IGFBP-1
1372941-6#73#77#diseaseC0149925 1157-1161 diseaseC0149925 denotes SCLC
1372941-6#113#118#diseaseC0007131 1197-1202 diseaseC0007131 denotes NSCLC
1372941-8#15#22#gene3486 1340-1347 gene3486 denotes IGFBP-3
1372941-8#59#63#diseaseC0149925 1384-1388 diseaseC0149925 denotes SCLC
1372941-8#91#96#diseaseC0007131 1416-1421 diseaseC0007131 denotes NSCLC
40#45#gene347969#73#diseaseC0149925 1372941-11#40#45#gene3479 1372941-11#69#73#diseaseC0149925 associated_with IGF-I,SCLC
40#45#gene347982#87#diseaseC0007131 1372941-11#40#45#gene3479 1372941-11#82#87#diseaseC0007131 associated_with IGF-I,NSCLC
177#183#gene348169#80#diseaseC0024121 1372941-12#177#183#gene3481 1372941-12#69#80#diseaseC0024121 associated_with IGF-II,lung tumors
177#183#gene3481372#382#diseaseC0024121 1372941-12#177#183#gene3481 1372941-12#372#382#diseaseC0024121 associated_with IGF-II,lung tumor
177#183#gene348169#80#diseaseC0024121 1372941-12#177#183#gene3481 1372941-12#69#80#diseaseC0024121 associated_with IGF-II,lung tumors
177#183#gene3481372#382#diseaseC0024121 1372941-12#177#183#gene3481 1372941-12#372#382#diseaseC0024121 associated_with IGF-II,lung tumor
177#183#gene348169#80#diseaseC0024121 1372941-12#177#183#gene3481 1372941-12#69#80#diseaseC0024121 associated_with IGF-II,lung tumors
177#183#gene3481372#382#diseaseC0024121 1372941-12#177#183#gene3481 1372941-12#372#382#diseaseC0024121 associated_with IGF-II,lung tumor
177#183#gene348169#80#diseaseC0024121 1372941-12#177#183#gene3481 1372941-12#69#80#diseaseC0024121 associated_with IGF-II,lung tumors
177#183#gene3481372#382#diseaseC0024121 1372941-12#177#183#gene3481 1372941-12#372#382#diseaseC0024121 associated_with IGF-II,lung tumor
177#183#gene348169#80#diseaseC0024121 1372941-12#177#183#gene3481 1372941-12#69#80#diseaseC0024121 associated_with IGF-II,lung tumors
177#183#gene3481372#382#diseaseC0024121 1372941-12#177#183#gene3481 1372941-12#372#382#diseaseC0024121 associated_with IGF-II,lung tumor
188#195#gene348569#80#diseaseC0024121 1372941-12#188#195#gene3485 1372941-12#69#80#diseaseC0024121 associated_with IGFBP-2,lung tumors
188#195#gene3485372#382#diseaseC0024121 1372941-12#188#195#gene3485 1372941-12#372#382#diseaseC0024121 associated_with IGFBP-2,lung tumor
188#195#gene348569#80#diseaseC0024121 1372941-12#188#195#gene3485 1372941-12#69#80#diseaseC0024121 associated_with IGFBP-2,lung tumors
188#195#gene3485372#382#diseaseC0024121 1372941-12#188#195#gene3485 1372941-12#372#382#diseaseC0024121 associated_with IGFBP-2,lung tumor
188#195#gene348569#80#diseaseC0024121 1372941-12#188#195#gene3485 1372941-12#69#80#diseaseC0024121 associated_with IGFBP-2,lung tumors
188#195#gene3485372#382#diseaseC0024121 1372941-12#188#195#gene3485 1372941-12#372#382#diseaseC0024121 associated_with IGFBP-2,lung tumor
188#195#gene348569#80#diseaseC0024121 1372941-12#188#195#gene3485 1372941-12#69#80#diseaseC0024121 associated_with IGFBP-2,lung tumors
188#195#gene3485372#382#diseaseC0024121 1372941-12#188#195#gene3485 1372941-12#372#382#diseaseC0024121 associated_with IGFBP-2,lung tumor
188#195#gene348569#80#diseaseC0024121 1372941-12#188#195#gene3485 1372941-12#69#80#diseaseC0024121 associated_with IGFBP-2,lung tumors
188#195#gene3485372#382#diseaseC0024121 1372941-12#188#195#gene3485 1372941-12#372#382#diseaseC0024121 associated_with IGFBP-2,lung tumor
253#259#gene348169#80#diseaseC0024121 1372941-12#253#259#gene3481 1372941-12#69#80#diseaseC0024121 associated_with IGF-II,lung tumors
253#259#gene3481372#382#diseaseC0024121 1372941-12#253#259#gene3481 1372941-12#372#382#diseaseC0024121 associated_with IGF-II,lung tumor
253#259#gene348169#80#diseaseC0024121 1372941-12#253#259#gene3481 1372941-12#69#80#diseaseC0024121 associated_with IGF-II,lung tumors
253#259#gene3481372#382#diseaseC0024121 1372941-12#253#259#gene3481 1372941-12#372#382#diseaseC0024121 associated_with IGF-II,lung tumor
253#259#gene348169#80#diseaseC0024121 1372941-12#253#259#gene3481 1372941-12#69#80#diseaseC0024121 associated_with IGF-II,lung tumors
253#259#gene3481372#382#diseaseC0024121 1372941-12#253#259#gene3481 1372941-12#372#382#diseaseC0024121 associated_with IGF-II,lung tumor
253#259#gene348169#80#diseaseC0024121 1372941-12#253#259#gene3481 1372941-12#69#80#diseaseC0024121 associated_with IGF-II,lung tumors
253#259#gene3481372#382#diseaseC0024121 1372941-12#253#259#gene3481 1372941-12#372#382#diseaseC0024121 associated_with IGF-II,lung tumor
253#259#gene348169#80#diseaseC0024121 1372941-12#253#259#gene3481 1372941-12#69#80#diseaseC0024121 associated_with IGF-II,lung tumors
253#259#gene3481372#382#diseaseC0024121 1372941-12#253#259#gene3481 1372941-12#372#382#diseaseC0024121 associated_with IGF-II,lung tumor
261#268#gene348569#80#diseaseC0024121 1372941-12#261#268#gene3485 1372941-12#69#80#diseaseC0024121 associated_with IGFBP-2,lung tumors
261#268#gene3485372#382#diseaseC0024121 1372941-12#261#268#gene3485 1372941-12#372#382#diseaseC0024121 associated_with IGFBP-2,lung tumor
261#268#gene348569#80#diseaseC0024121 1372941-12#261#268#gene3485 1372941-12#69#80#diseaseC0024121 associated_with IGFBP-2,lung tumors
261#268#gene3485372#382#diseaseC0024121 1372941-12#261#268#gene3485 1372941-12#372#382#diseaseC0024121 associated_with IGFBP-2,lung tumor
261#268#gene348569#80#diseaseC0024121 1372941-12#261#268#gene3485 1372941-12#69#80#diseaseC0024121 associated_with IGFBP-2,lung tumors
261#268#gene3485372#382#diseaseC0024121 1372941-12#261#268#gene3485 1372941-12#372#382#diseaseC0024121 associated_with IGFBP-2,lung tumor
261#268#gene348569#80#diseaseC0024121 1372941-12#261#268#gene3485 1372941-12#69#80#diseaseC0024121 associated_with IGFBP-2,lung tumors
261#268#gene3485372#382#diseaseC0024121 1372941-12#261#268#gene3485 1372941-12#372#382#diseaseC0024121 associated_with IGFBP-2,lung tumor
261#268#gene348569#80#diseaseC0024121 1372941-12#261#268#gene3485 1372941-12#69#80#diseaseC0024121 associated_with IGFBP-2,lung tumors
261#268#gene3485372#382#diseaseC0024121 1372941-12#261#268#gene3485 1372941-12#372#382#diseaseC0024121 associated_with IGFBP-2,lung tumor
306#312#gene348169#80#diseaseC0024121 1372941-12#306#312#gene3481 1372941-12#69#80#diseaseC0024121 associated_with IGF-II,lung tumors
306#312#gene3481372#382#diseaseC0024121 1372941-12#306#312#gene3481 1372941-12#372#382#diseaseC0024121 associated_with IGF-II,lung tumor
306#312#gene348169#80#diseaseC0024121 1372941-12#306#312#gene3481 1372941-12#69#80#diseaseC0024121 associated_with IGF-II,lung tumors
306#312#gene3481372#382#diseaseC0024121 1372941-12#306#312#gene3481 1372941-12#372#382#diseaseC0024121 associated_with IGF-II,lung tumor
306#312#gene348169#80#diseaseC0024121 1372941-12#306#312#gene3481 1372941-12#69#80#diseaseC0024121 associated_with IGF-II,lung tumors
306#312#gene3481372#382#diseaseC0024121 1372941-12#306#312#gene3481 1372941-12#372#382#diseaseC0024121 associated_with IGF-II,lung tumor
306#312#gene348169#80#diseaseC0024121 1372941-12#306#312#gene3481 1372941-12#69#80#diseaseC0024121 associated_with IGF-II,lung tumors
306#312#gene3481372#382#diseaseC0024121 1372941-12#306#312#gene3481 1372941-12#372#382#diseaseC0024121 associated_with IGF-II,lung tumor
306#312#gene348169#80#diseaseC0024121 1372941-12#306#312#gene3481 1372941-12#69#80#diseaseC0024121 associated_with IGF-II,lung tumors
306#312#gene3481372#382#diseaseC0024121 1372941-12#306#312#gene3481 1372941-12#372#382#diseaseC0024121 associated_with IGF-II,lung tumor
352#357#gene347969#80#diseaseC0024121 1372941-12#352#357#gene3479 1372941-12#69#80#diseaseC0024121 associated_with IGF-I,lung tumors
352#357#gene3479372#382#diseaseC0024121 1372941-12#352#357#gene3479 1372941-12#372#382#diseaseC0024121 associated_with IGF-I,lung tumor
352#357#gene347969#80#diseaseC0024121 1372941-12#352#357#gene3479 1372941-12#69#80#diseaseC0024121 associated_with IGF-I,lung tumors
352#357#gene3479372#382#diseaseC0024121 1372941-12#352#357#gene3479 1372941-12#372#382#diseaseC0024121 associated_with IGF-I,lung tumor
352#357#gene347969#80#diseaseC0024121 1372941-12#352#357#gene3479 1372941-12#69#80#diseaseC0024121 associated_with IGF-I,lung tumors
352#357#gene3479372#382#diseaseC0024121 1372941-12#352#357#gene3479 1372941-12#372#382#diseaseC0024121 associated_with IGF-I,lung tumor
352#357#gene347969#80#diseaseC0024121 1372941-12#352#357#gene3479 1372941-12#69#80#diseaseC0024121 associated_with IGF-I,lung tumors
352#357#gene3479372#382#diseaseC0024121 1372941-12#352#357#gene3479 1372941-12#372#382#diseaseC0024121 associated_with IGF-I,lung tumor
352#357#gene347969#80#diseaseC0024121 1372941-12#352#357#gene3479 1372941-12#69#80#diseaseC0024121 associated_with IGF-I,lung tumors
352#357#gene3479372#382#diseaseC0024121 1372941-12#352#357#gene3479 1372941-12#372#382#diseaseC0024121 associated_with IGF-I,lung tumor
34#41#gene348473#77#diseaseC0149925 1372941-6#34#41#gene3484 1372941-6#73#77#diseaseC0149925 associated_with IGFBP-1,SCLC
34#41#gene3484113#118#diseaseC0007131 1372941-6#34#41#gene3484 1372941-6#113#118#diseaseC0007131 associated_with IGFBP-1,NSCLC
15#22#gene348659#63#diseaseC0149925 1372941-8#15#22#gene3486 1372941-8#59#63#diseaseC0149925 associated_with IGFBP-3,SCLC
15#22#gene348691#96#diseaseC0007131 1372941-8#15#22#gene3486 1372941-8#91#96#diseaseC0007131 associated_with IGFBP-3,NSCLC

DisGeNET

Id Subject Object Predicate Lexical cue
T0 606-709 gene:3481 denotes IGFs, the relationship between the expression of IGF-binding protein genes and the genes encoding IGF-I
T1 146-230 disease:C0024121 denotes low-molecular-weight, insulinlike growth factor (IGF)-binding proteins in lung tumor
R1 T0 T1 associated_with "IGFs, the relationship between the expression of IGF-binding protein genes and the genes encoding IGF-I","low-molecular-weight, insulinlike growth factor (IGF)-binding proteins in lung tumor"