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PubMed:1371788 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 22-43 protein denotes tumor necrosis factor
T2 58-73 cell_type denotes human monocytes
T3 80-106 cell_type denotes normal and malignant cells
T4 298-301 protein denotes TNF
T5 305-320 cell_type denotes blood monocytes
T6 332-362 cell_line denotes monocytic cell line Mono Mac 6
T7 480-483 protein denotes TNF
T8 505-509 cell_type denotes PBMC
T9 525-541 cell_line denotes Mono Mac 6 cells
T10 704-707 protein denotes TNF
T11 722-726 cell_type denotes PBMC
T12 735-745 cell_line denotes Mono Mac 6
T13 926-941 RNA denotes TNF transcripts
T14 983-1005 protein denotes nuclear factor kappa B
T15 1169-1176 protein denotes CD14 Ag
T16 1180-1197 protein denotes receptor molecule
T17 1202-1235 protein denotes LPS-LPS binding protein complexes
T18 1314-1340 protein denotes platelet activating factor
T19 1391-1394 protein denotes TNF
T20 1409-1425 cell_line denotes Mono Mac 6 cells
T21 1615-1618 protein denotes TNF
T22 1638-1647 cell_type denotes monocytes

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-74 Sentence denotes Gangliosides suppress tumor necrosis factor production in human monocytes.
S2 75-233 Sentence denotes Both normal and malignant cells contain gangliosides as important cell membrane constituents that, after being shed, may influence cells of the immune system.
S3 234-363 Sentence denotes We have studied the impact of gangliosides on the expression of TNF in blood monocytes and in the monocytic cell line Mono Mac 6.
S4 364-602 Sentence denotes Although under standard culture conditions, bovine brain gangliosides (100 micrograms/ml) suppressed LPS-stimulated TNF production 5-fold in PBMC and 10-fold in Mono Mac 6 cells, suppression was more efficient under serum-free conditions.
S5 603-765 Sentence denotes Looking at highly purified gangliosides, GD3, GD1a, GM3, GM2, and GM1 were all effective in reducing TNF production in PBMC, and in Mono Mac 6 by factor 10 to 50.
S6 766-859 Sentence denotes The suppressive activity was lost in molecules, lacking the sugar moiety or the lipid moiety.
S7 860-1018 Sentence denotes Gangliosides appear to act at an early step of activation in that TNF transcripts were reduced and the mobilization of the nuclear factor kappa B was blocked.
S8 1019-1137 Sentence denotes Furthermore, in time kinetics, gangliosides were effective for up to 30 min after addition of LPS, but not thereafter.
S9 1138-1268 Sentence denotes However, the expression of the CD14 Ag, a receptor molecule for LPS-LPS binding protein complexes, was unaffected by gangliosides.
S10 1269-1453 Sentence denotes Finally, when using Staphylococcus aureus or platelet activating factor as a stimulus, gangliosides were able to suppress TNF production in Mono Mac 6 cells by factor 5 to 10, as well.
S11 1454-1572 Sentence denotes On the other hand, phorbol ester-induced production of O2- was similar in cells treated with and without gangliosides.
S12 1573-1757 Sentence denotes Taken together, our data demonstrate that TNF gene expression in monocytes induced by different types of stimuli can be blocked by gangliosides at an early step of signal transduction.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-12 NP denotes Gangliosides
C2 22-54 NP denotes tumor necrosis factor production
C3 115-127 NP denotes gangliosides
C4 264-276 NP denotes gangliosides
C5 280-301 NP denotes the expression of TNF
C6 328-362 NP denotes the monocytic cell line Mono Mac 6
C7 408-433 NP denotes bovine brain gangliosides
C8 480-494 NP denotes TNF production
C9 505-509 NP denotes PBMC
C10 525-541 NP denotes Mono Mac 6 cells
C11 614-642 NP denotes highly purified gangliosides
C12 644-672 NP denotes GD3, GD1a, GM3, GM2, and GM1
C13 704-718 NP denotes TNF production
C14 722-726 NP denotes PBMC
C15 735-745 NP denotes Mono Mac 6
C16 860-872 NP denotes Gangliosides
C17 1050-1062 NP denotes gangliosides
C18 1165-1176 NP denotes the CD14 Ag
C19 1178-1235 NP denotes a receptor molecule for LPS-LPS binding protein complexes
C20 1255-1267 NP denotes gangliosides
C21 1356-1368 NP denotes gangliosides
C22 1391-1405 NP denotes TNF production
C23 1409-1425 NP denotes Mono Mac 6 cells
C24 1559-1571 NP denotes gangliosides
C25 1615-1634 NP denotes TNF gene expression
C26 1704-1716 NP denotes gangliosides
R1 C3 C1 coref-ident gangliosides,Gangliosides
R2 C4 C3 coref-ident gangliosides,gangliosides
R3 C7 C4 coref-other bovine brain gangliosides,gangliosides
R4 C8 C2 coref-ident TNF production,tumor necrosis factor production
R5 C10 C6 coref-ident Mono Mac 6 cells,the monocytic cell line Mono Mac 6
R6 C11 C12 coref-appos highly purified gangliosides,"GD3, GD1a, GM3, GM2, and GM1"
R7 C13 C8 coref-ident TNF production,TNF production
R8 C14 C9 coref-ident PBMC,PBMC
R9 C15 C10 coref-ident Mono Mac 6,Mono Mac 6 cells
R10 C16 C4 coref-ident Gangliosides,gangliosides
R11 C17 C16 coref-ident gangliosides,Gangliosides
R12 C19 C18 coref-appos a receptor molecule for LPS-LPS binding protein complexes,the CD14 Ag
R13 C20 C17 coref-ident gangliosides,gangliosides
R14 C21 C20 coref-ident gangliosides,gangliosides
R15 C22 C13 coref-ident TNF production,TNF production
R16 C23 C15 coref-ident Mono Mac 6 cells,Mono Mac 6
R17 C24 C21 coref-ident gangliosides,gangliosides
R18 C25 C5 coref-ident TNF gene expression,the expression of TNF
R19 C26 C24 coref-ident gangliosides,gangliosides

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-12 other_organic_compound denotes Gangliosides
T2 22-43 protein_molecule denotes tumor necrosis factor
T3 58-63 cell_type denotes human
T4 64-73 cell_type denotes monocytes
T5 115-127 other_organic_compound denotes gangliosides
T6 141-154 cell_component denotes cell membrane
T7 219-232 body_part denotes immune system
T8 264-276 other_organic_compound denotes gangliosides
T9 298-301 protein_molecule denotes TNF
T10 305-320 cell_type denotes blood monocytes
T11 332-362 cell_line denotes monocytic cell line Mono Mac 6
T12 421-433 other_organic_compound denotes gangliosides
T13 465-479 other_name denotes LPS-stimulated
T14 480-483 protein_molecule denotes TNF
T15 505-509 cell_type denotes PBMC
T16 525-541 cell_line denotes Mono Mac 6 cells
T17 630-642 other_organic_compound denotes gangliosides
T18 644-647 other_organic_compound denotes GD3
T19 649-653 other_organic_compound denotes GD1a
T20 655-658 other_organic_compound denotes GM3
T21 660-663 other_organic_compound denotes GM2
T22 669-672 other_organic_compound denotes GM1
T23 704-707 protein_molecule denotes TNF
T24 722-726 cell_type denotes PBMC
T25 735-745 cell_line denotes Mono Mac 6
T26 826-838 carbohydrate denotes sugar moiety
T27 846-858 lipid denotes lipid moiety
T28 860-872 other_organic_compound denotes Gangliosides
T29 926-929 protein_molecule denotes TNF
T30 983-1005 protein_molecule denotes nuclear factor kappa B
T31 1050-1062 other_organic_compound denotes gangliosides
T32 1113-1116 lipid denotes LPS
T33 1169-1176 protein_molecule denotes CD14 Ag
T34 1180-1197 protein_family_or_group denotes receptor molecule
T35 1202-1235 protein_complex denotes LPS-LPS binding protein complexes
T36 1255-1267 other_organic_compound denotes gangliosides
T37 1289-1310 mono_cell denotes Staphylococcus aureus
T38 1314-1340 protein_molecule denotes platelet activating factor
T39 1356-1368 other_organic_compound denotes gangliosides
T40 1391-1394 protein_molecule denotes TNF
T41 1409-1419 cell_line denotes Mono Mac 6
T42 1473-1486 other_organic_compound denotes phorbol ester
T43 1559-1571 other_organic_compound denotes gangliosides
T44 1615-1618 protein_molecule denotes TNF
T45 1638-1647 cell_type denotes monocytes
T46 1704-1716 other_organic_compound denotes gangliosides
T47 1737-1756 other_name denotes signal transduction