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PubMed:13679858 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-118 Sentence denotes Loss of expression of tropomyosin-1, a novel class II tumor suppressor that induces anoikis, in primary breast tumors.
TextSentencer_T2 119-265 Sentence denotes Suppression of tropomyosins (TMs), a family of actin-binding, microfilament-associated proteins, is a prominent feature of many transformed cells.
TextSentencer_T3 266-336 Sentence denotes Yet it is unclear whether downregulation of TMs occur in human tumors.
TextSentencer_T4 337-478 Sentence denotes We have investigated the expression of tropomyosin-1 (TM1) in human breast carcinoma tissues by in situ hybridization and immunofluorescence.
TextSentencer_T5 479-548 Sentence denotes TM1 mRNA and protein are readily detectable in normal mammary tissue.
TextSentencer_T6 549-625 Sentence denotes In contrast, TM1 expression is abolished in the primary human breast tumors.
TextSentencer_T7 626-697 Sentence denotes Expression of other TM isoforms, however, is variable among the tumors.
TextSentencer_T8 698-823 Sentence denotes The consistent and profound downregulation of TM1 suggests that TM1 may be a novel and useful biomarker of mammary neoplasms.
TextSentencer_T9 824-994 Sentence denotes These data also support the hypothesis that suppression of TM1 expression during the malignant conversion of mammary epithelium as a contributing factor of breast cancer.
TextSentencer_T10 995-1141 Sentence denotes In support of this hypothesis, we show that the ability to suppress malignant growth properties of breast cancer cells is specific to TM1 isoform.
TextSentencer_T11 1142-1296 Sentence denotes Investigations into the mechanisms of TM1-induced tumor suppression reveal that TM1 induces anoikis (detachment induced apoptosis) in breast cancer cells.
TextSentencer_T12 1297-1525 Sentence denotes Downregulation of TM1 in breast tumors may destabilize microfilament architecture and confer resistance to anoikis, which facilitates survival of neoplastic cells outside the normal microenvironment and promote malignant growth.
T1 0-118 Sentence denotes Loss of expression of tropomyosin-1, a novel class II tumor suppressor that induces anoikis, in primary breast tumors.
T2 119-265 Sentence denotes Suppression of tropomyosins (TMs), a family of actin-binding, microfilament-associated proteins, is a prominent feature of many transformed cells.
T3 266-336 Sentence denotes Yet it is unclear whether downregulation of TMs occur in human tumors.
T4 337-478 Sentence denotes We have investigated the expression of tropomyosin-1 (TM1) in human breast carcinoma tissues by in situ hybridization and immunofluorescence.
T5 479-548 Sentence denotes TM1 mRNA and protein are readily detectable in normal mammary tissue.
T6 549-625 Sentence denotes In contrast, TM1 expression is abolished in the primary human breast tumors.
T7 626-697 Sentence denotes Expression of other TM isoforms, however, is variable among the tumors.
T8 698-823 Sentence denotes The consistent and profound downregulation of TM1 suggests that TM1 may be a novel and useful biomarker of mammary neoplasms.
T9 824-994 Sentence denotes These data also support the hypothesis that suppression of TM1 expression during the malignant conversion of mammary epithelium as a contributing factor of breast cancer.
T10 995-1141 Sentence denotes In support of this hypothesis, we show that the ability to suppress malignant growth properties of breast cancer cells is specific to TM1 isoform.
T11 1142-1296 Sentence denotes Investigations into the mechanisms of TM1-induced tumor suppression reveal that TM1 induces anoikis (detachment induced apoptosis) in breast cancer cells.
T12 1297-1525 Sentence denotes Downregulation of TM1 in breast tumors may destabilize microfilament architecture and confer resistance to anoikis, which facilitates survival of neoplastic cells outside the normal microenvironment and promote malignant growth.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
13679858-0#22#35#gene7168 22-35 gene7168 denotes tropomyosin-1
13679858-0#104#117#diseaseC1458155 104-117 diseaseC1458155 denotes breast tumors
13679858-10#38#41#gene7168 1180-1183 gene7168 denotes TM1
13679858-10#80#83#gene7168 1222-1225 gene7168 denotes TM1
13679858-10#134#147#diseaseC0006142 1276-1289 diseaseC0006142 denotes breast cancer
13679858-10#134#147#diseaseC0678222 1276-1289 diseaseC0678222 denotes breast cancer
13679858-10#134#147#diseaseC0006142 1276-1289 diseaseC0006142 denotes breast cancer
13679858-10#134#147#diseaseC0678222 1276-1289 diseaseC0678222 denotes breast cancer
22#35#gene7168104#117#diseaseC1458155 13679858-0#22#35#gene7168 13679858-0#104#117#diseaseC1458155 associated_with tropomyosin-1,breast tumors
38#41#gene7168134#147#diseaseC0006142 13679858-10#38#41#gene7168 13679858-10#134#147#diseaseC0006142 associated_with TM1,breast cancer
38#41#gene7168134#147#diseaseC0678222 13679858-10#38#41#gene7168 13679858-10#134#147#diseaseC0678222 associated_with TM1,breast cancer
38#41#gene7168134#147#diseaseC0006142 13679858-10#38#41#gene7168 13679858-10#134#147#diseaseC0006142 associated_with TM1,breast cancer
38#41#gene7168134#147#diseaseC0678222 13679858-10#38#41#gene7168 13679858-10#134#147#diseaseC0678222 associated_with TM1,breast cancer
80#83#gene7168134#147#diseaseC0006142 13679858-10#80#83#gene7168 13679858-10#134#147#diseaseC0006142 associated_with TM1,breast cancer
80#83#gene7168134#147#diseaseC0678222 13679858-10#80#83#gene7168 13679858-10#134#147#diseaseC0678222 associated_with TM1,breast cancer
80#83#gene7168134#147#diseaseC0006142 13679858-10#80#83#gene7168 13679858-10#134#147#diseaseC0006142 associated_with TM1,breast cancer
80#83#gene7168134#147#diseaseC0678222 13679858-10#80#83#gene7168 13679858-10#134#147#diseaseC0678222 associated_with TM1,breast cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2077 1180-1183 gene:7168 denotes TM1
T2078 1276-1289 disease:C0006142 denotes breast cancer
T2079 1222-1225 gene:7168 denotes TM1
R1 T2077 T2078 associated_with TM1,breast cancer
R2 T2077 T2078 associated_with TM1,breast cancer
R3 T2079 T2078 associated_with TM1,breast cancer
R4 T2079 T2078 associated_with TM1,breast cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 104-110 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 405-411 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 611-617 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 980-986 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 1094-1100 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 1276-1282 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T7 1322-1328 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T8 422-429 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T9 541-547 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T10 941-951 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 422-429 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T2 541-547 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T3 104-110 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 405-411 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 611-617 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 980-986 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T7 1094-1100 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T8 1276-1282 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T9 1322-1328 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T10 941-951 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium

DisGeNET

Id Subject Object Predicate Lexical cue
T0 562-565 gene:7168 denotes TM1
T1 611-624 disease:C1458155 denotes breast tumors
R1 T0 T1 associated_with TM1,breast tumors