PubMed:1355091 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/1355091","sourcedb":"PubMed","sourceid":"1355091","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/1355091","text":"Orthostatic hypotension occurs following alpha 2-adrenoceptor blockade in chronic prazosin-pretreated conscious spontaneously hypertensive rats.\n1. Studies were performed to evaluate whether chronic prazosin treatment alters the alpha 2-adrenoceptor function for orthostatic control of arterial blood pressure in conscious spontaneously hypertensive rats (SHR). 2. Conscious SHR (male 300-350 g) were subjected to 90 degrees head-up tilts for 60 s following acute administration of prazosin (0.1 mg kg-1 i.p.) or rauwolscine (3 mg kg-1 i.v.). Orthostatic hypotension was determined by the average decrease (%) in mean arterial pressure (MAP femoral) over the 60-s tilt period. The basal MAP of conscious SHR was reduced to a similar extent by prazosin (-23%(-)-26% MAP) and rauwolscine (-16%(-)-33% MAP). However, the head-up tilt induced orthostatic hypotension in the SHR treated with prazosin (-16% MAP, n = 6), but not in the SHR treated with rauwolscine (less than +2% MAP, n = 6). 3. Conscious SHR were treated for 4 days with prazosin at 2 mg kg-1 day-1 i.p. for chronic alpha 1-adrenoceptor blockade. MAP in conscious SHR after chronic prazosin treatment was 14% lower than in the untreated SHR (n = 8). Head-up tilts in these rats did not produce orthostatic hypotension when performed either prior to or after acute dosing of prazosin (0.1 mg kg-1 i.p.). Conversely, administration of rauwolscine (3 mg kg-1 i.v.) in chronic prazosin treated SHR decreased the basal MAP by 12-31% (n = 4), and subsequent tilts induced further drops of MAP by 19-23% in these rats. 4. The pressor responses and bradycardia to the alpha 1-agonist cirazoline (0.6 and 2 micrograms kg-1 i.v.), the alpha 2-agonist Abbott-53693 (1 and 3 micrograms kg-1 i.v.), and noradrenaline (0.1 and 1.0 micrograms kg-1 i.v.) were determined in conscious SHR with and without chronic prazosin pretreatment. Both the pressor and bradycardia effects of cirazoline were abolished in chronic prazosin treated SHR (n = 4) as compared to the untreated SHR (n = 4). On the other hand, the pressor effects of Abbott-53693 were similar in both groups of SHR, but the accompanying bradycardia was greater in SHR with chronic prazosin treatment than without such treatment. Furthermore, the bradycardia that accompanied the noradrenaline-induced pressor effect in SHR was similar with and without chronic prazosin treatment despite a 47-71% reduction of the pressor effect in chronic alpha 1-receptor blocked SHR.(ABSTRACT TRUNCATED AT 400 WORDS)","tracks":[{"project":"bc5cdr-valid-experiment","denotations":[{"id":"T1","span":{"begin":0,"end":23},"obj":"Disease"},{"id":"T2","span":{"begin":82,"end":90},"obj":"Chemical"},{"id":"T3","span":{"begin":126,"end":138},"obj":"Disease"},{"id":"T4","span":{"begin":199,"end":207},"obj":"Chemical"},{"id":"T5","span":{"begin":337,"end":349},"obj":"Disease"},{"id":"T6","span":{"begin":482,"end":490},"obj":"Chemical"},{"id":"T7","span":{"begin":513,"end":524},"obj":"Chemical"},{"id":"T8","span":{"begin":543,"end":566},"obj":"Disease"},{"id":"T9","span":{"begin":743,"end":751},"obj":"Chemical"},{"id":"T10","span":{"begin":774,"end":785},"obj":"Chemical"},{"id":"T11","span":{"begin":839,"end":862},"obj":"Disease"},{"id":"T12","span":{"begin":887,"end":895},"obj":"Chemical"},{"id":"T13","span":{"begin":947,"end":958},"obj":"Chemical"},{"id":"T14","span":{"begin":1033,"end":1041},"obj":"Chemical"},{"id":"T15","span":{"begin":1144,"end":1152},"obj":"Chemical"},{"id":"T16","span":{"begin":1256,"end":1279},"obj":"Disease"},{"id":"T17","span":{"begin":1336,"end":1344},"obj":"Chemical"},{"id":"T18","span":{"begin":1395,"end":1406},"obj":"Chemical"},{"id":"T19","span":{"begin":1435,"end":1443},"obj":"Chemical"},{"id":"T20","span":{"begin":1603,"end":1614},"obj":"Disease"},{"id":"T21","span":{"begin":1638,"end":1648},"obj":"Chemical"},{"id":"T22","span":{"begin":1703,"end":1715},"obj":"Chemical"},{"id":"T23","span":{"begin":1752,"end":1765},"obj":"Chemical"},{"id":"T24","span":{"begin":1859,"end":1867},"obj":"Chemical"},{"id":"T25","span":{"begin":1903,"end":1914},"obj":"Disease"},{"id":"T26","span":{"begin":1926,"end":1936},"obj":"Chemical"},{"id":"T27","span":{"begin":1963,"end":1971},"obj":"Chemical"},{"id":"T28","span":{"begin":2076,"end":2088},"obj":"Chemical"},{"id":"T29","span":{"begin":2146,"end":2157},"obj":"Disease"},{"id":"T30","span":{"begin":2190,"end":2198},"obj":"Chemical"},{"id":"T31","span":{"begin":2255,"end":2266},"obj":"Disease"},{"id":"T32","span":{"begin":2288,"end":2301},"obj":"Chemical"},{"id":"T33","span":{"begin":2369,"end":2377},"obj":"Chemical"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T16","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T17","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T18","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T19","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T20","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T21","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T22","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T23","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T24","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T25","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T26","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T27","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T28","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T29","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T30","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T31","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T32","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T33","pred":"source","obj":"bc5cdr-valid-experiment"}]},{"project":"bc5cdr-valid-deepseek-nr-ng-experiment","denotations":[{"id":"T1","span":{"begin":0,"end":23},"obj":"Disease"},{"id":"T2","span":{"begin":82,"end":90},"obj":"Chemical"},{"id":"T3","span":{"begin":199,"end":207},"obj":"Chemical"},{"id":"T4","span":{"begin":482,"end":490},"obj":"Chemical"},{"id":"T5","span":{"begin":513,"end":524},"obj":"Chemical"},{"id":"T6","span":{"begin":743,"end":751},"obj":"Chemical"},{"id":"T7","span":{"begin":774,"end":785},"obj":"Chemical"},{"id":"T8","span":{"begin":887,"end":895},"obj":"Chemical"},{"id":"T9","span":{"begin":1144,"end":1152},"obj":"Chemical"},{"id":"T10","span":{"begin":1336,"end":1344},"obj":"Chemical"},{"id":"T11","span":{"begin":1435,"end":1443},"obj":"Chemical"},{"id":"T12","span":{"begin":1638,"end":1648},"obj":"Chemical"},{"id":"T13","span":{"begin":1703,"end":1715},"obj":"Chemical"},{"id":"T14","span":{"begin":1752,"end":1765},"obj":"Chemical"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng-experiment"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng-experiment"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng-experiment"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng-experiment"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng-experiment"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng-experiment"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng-experiment"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng-experiment"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng-experiment"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng-experiment"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng-experiment"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng-experiment"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng-experiment"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-deepseek-nr-ng-experiment"}]},{"project":"bc5cdr-valid-deepseek-nr-g-experiment","denotations":[{"id":"T1","span":{"begin":0,"end":23},"obj":"Disease"},{"id":"T2","span":{"begin":82,"end":90},"obj":"Chemical"},{"id":"T3","span":{"begin":126,"end":143},"obj":"Disease"},{"id":"T4","span":{"begin":199,"end":207},"obj":"Chemical"},{"id":"T5","span":{"begin":482,"end":490},"obj":"Chemical"},{"id":"T6","span":{"begin":513,"end":524},"obj":"Chemical"},{"id":"T7","span":{"begin":543,"end":566},"obj":"Disease"},{"id":"T8","span":{"begin":743,"end":751},"obj":"Chemical"},{"id":"T9","span":{"begin":774,"end":785},"obj":"Chemical"},{"id":"T10","span":{"begin":887,"end":895},"obj":"Chemical"},{"id":"T11","span":{"begin":1033,"end":1041},"obj":"Chemical"},{"id":"T12","span":{"begin":1144,"end":1152},"obj":"Chemical"},{"id":"T13","span":{"begin":1638,"end":1648},"obj":"Chemical"},{"id":"T14","span":{"begin":1703,"end":1715},"obj":"Chemical"},{"id":"T15","span":{"begin":1752,"end":1765},"obj":"Chemical"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g-experiment"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g-experiment"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g-experiment"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g-experiment"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g-experiment"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g-experiment"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g-experiment"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g-experiment"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g-experiment"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g-experiment"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g-experiment"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g-experiment"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g-experiment"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g-experiment"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-deepseek-nr-g-experiment"}]},{"project":"bc5cdr-valid-gpt-r-ng-experiment","denotations":[{"id":"T1","span":{"begin":0,"end":23},"obj":"Disease"},{"id":"T2","span":{"begin":82,"end":90},"obj":"Chemical"},{"id":"T3","span":{"begin":126,"end":138},"obj":"Disease"},{"id":"T4","span":{"begin":199,"end":207},"obj":"Chemical"},{"id":"T5","span":{"begin":337,"end":349},"obj":"Disease"},{"id":"T6","span":{"begin":482,"end":490},"obj":"Chemical"},{"id":"T7","span":{"begin":513,"end":524},"obj":"Chemical"},{"id":"T8","span":{"begin":543,"end":566},"obj":"Disease"},{"id":"T9","span":{"begin":743,"end":751},"obj":"Chemical"},{"id":"T10","span":{"begin":774,"end":785},"obj":"Chemical"},{"id":"T11","span":{"begin":839,"end":862},"obj":"Disease"},{"id":"T12","span":{"begin":887,"end":895},"obj":"Chemical"},{"id":"T13","span":{"begin":947,"end":958},"obj":"Chemical"},{"id":"T14","span":{"begin":1033,"end":1041},"obj":"Chemical"},{"id":"T15","span":{"begin":1144,"end":1152},"obj":"Chemical"},{"id":"T16","span":{"begin":1256,"end":1279},"obj":"Disease"},{"id":"T17","span":{"begin":1336,"end":1344},"obj":"Chemical"},{"id":"T18","span":{"begin":1395,"end":1406},"obj":"Chemical"},{"id":"T19","span":{"begin":1435,"end":1443},"obj":"Chemical"},{"id":"T20","span":{"begin":1603,"end":1614},"obj":"Disease"},{"id":"T21","span":{"begin":1638,"end":1648},"obj":"Chemical"},{"id":"T22","span":{"begin":1703,"end":1715},"obj":"Chemical"},{"id":"T23","span":{"begin":1752,"end":1765},"obj":"Chemical"},{"id":"T24","span":{"begin":1859,"end":1867},"obj":"Chemical"},{"id":"T25","span":{"begin":1903,"end":1914},"obj":"Disease"},{"id":"T26","span":{"begin":1926,"end":1936},"obj":"Chemical"},{"id":"T27","span":{"begin":1963,"end":1971},"obj":"Chemical"},{"id":"T28","span":{"begin":2076,"end":2088},"obj":"Chemical"},{"id":"T29","span":{"begin":2146,"end":2157},"obj":"Disease"},{"id":"T30","span":{"begin":2190,"end":2198},"obj":"Chemical"},{"id":"T31","span":{"begin":2255,"end":2266},"obj":"Disease"},{"id":"T32","span":{"begin":2288,"end":2301},"obj":"Chemical"},{"id":"T33","span":{"begin":2369,"end":2377},"obj":"Chemical"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T16","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T17","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T18","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T19","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T20","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T21","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T22","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T23","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T24","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T25","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T26","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T27","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T28","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T29","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T30","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T31","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T32","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"},{"subj":"T33","pred":"source","obj":"bc5cdr-valid-gpt-r-ng-experiment"}]},{"project":"bc5cdr-valid-gpt-r-g-experiment","denotations":[{"id":"T1","span":{"begin":0,"end":23},"obj":"Disease"},{"id":"T2","span":{"begin":82,"end":90},"obj":"Chemical"},{"id":"T3","span":{"begin":126,"end":138},"obj":"Disease"},{"id":"T4","span":{"begin":199,"end":207},"obj":"Chemical"},{"id":"T5","span":{"begin":337,"end":349},"obj":"Disease"},{"id":"T6","span":{"begin":482,"end":490},"obj":"Chemical"},{"id":"T7","span":{"begin":513,"end":524},"obj":"Chemical"},{"id":"T8","span":{"begin":543,"end":566},"obj":"Disease"},{"id":"T9","span":{"begin":743,"end":751},"obj":"Chemical"},{"id":"T10","span":{"begin":774,"end":785},"obj":"Chemical"},{"id":"T11","span":{"begin":839,"end":862},"obj":"Disease"},{"id":"T12","span":{"begin":887,"end":895},"obj":"Chemical"},{"id":"T13","span":{"begin":947,"end":958},"obj":"Chemical"},{"id":"T14","span":{"begin":1033,"end":1041},"obj":"Chemical"},{"id":"T15","span":{"begin":1144,"end":1152},"obj":"Chemical"},{"id":"T16","span":{"begin":1256,"end":1279},"obj":"Disease"},{"id":"T17","span":{"begin":1336,"end":1344},"obj":"Chemical"},{"id":"T18","span":{"begin":1395,"end":1406},"obj":"Chemical"},{"id":"T19","span":{"begin":1435,"end":1443},"obj":"Chemical"},{"id":"T20","span":{"begin":1603,"end":1614},"obj":"Disease"},{"id":"T21","span":{"begin":1638,"end":1648},"obj":"Chemical"},{"id":"T22","span":{"begin":1703,"end":1715},"obj":"Chemical"},{"id":"T23","span":{"begin":1752,"end":1765},"obj":"Chemical"},{"id":"T24","span":{"begin":1859,"end":1867},"obj":"Chemical"},{"id":"T25","span":{"begin":1903,"end":1914},"obj":"Disease"},{"id":"T26","span":{"begin":1926,"end":1936},"obj":"Chemical"},{"id":"T27","span":{"begin":1963,"end":1971},"obj":"Chemical"},{"id":"T28","span":{"begin":2076,"end":2088},"obj":"Chemical"},{"id":"T29","span":{"begin":2146,"end":2157},"obj":"Disease"},{"id":"T30","span":{"begin":2190,"end":2198},"obj":"Chemical"},{"id":"T31","span":{"begin":2255,"end":2266},"obj":"Disease"},{"id":"T32","span":{"begin":2288,"end":2301},"obj":"Chemical"},{"id":"T33","span":{"begin":2369,"end":2377},"obj":"Chemical"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T16","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T17","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T18","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T19","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T20","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T21","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T22","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T23","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T24","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T25","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T26","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T27","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T28","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T29","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T30","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T31","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T32","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"},{"subj":"T33","pred":"source","obj":"bc5cdr-valid-gpt-r-g-experiment"}]},{"project":"bc5cdr-valid-gpt-r-m30","denotations":[{"id":"T1","span":{"begin":0,"end":23},"obj":"Disease"},{"id":"T2","span":{"begin":82,"end":90},"obj":"Chemical"},{"id":"T3","span":{"begin":126,"end":138},"obj":"Disease"},{"id":"T4","span":{"begin":199,"end":207},"obj":"Chemical"},{"id":"T5","span":{"begin":337,"end":349},"obj":"Disease"},{"id":"T6","span":{"begin":482,"end":490},"obj":"Chemical"},{"id":"T7","span":{"begin":513,"end":524},"obj":"Chemical"},{"id":"T8","span":{"begin":543,"end":566},"obj":"Disease"},{"id":"T9","span":{"begin":743,"end":751},"obj":"Chemical"},{"id":"T10","span":{"begin":774,"end":785},"obj":"Chemical"},{"id":"T11","span":{"begin":839,"end":862},"obj":"Disease"},{"id":"T12","span":{"begin":887,"end":895},"obj":"Chemical"},{"id":"T13","span":{"begin":947,"end":958},"obj":"Chemical"},{"id":"T14","span":{"begin":1033,"end":1041},"obj":"Chemical"},{"id":"T15","span":{"begin":1144,"end":1152},"obj":"Chemical"},{"id":"T16","span":{"begin":1256,"end":1279},"obj":"Disease"},{"id":"T17","span":{"begin":1336,"end":1344},"obj":"Chemical"},{"id":"T18","span":{"begin":1395,"end":1406},"obj":"Chemical"},{"id":"T19","span":{"begin":1435,"end":1443},"obj":"Chemical"},{"id":"T20","span":{"begin":1603,"end":1614},"obj":"Disease"},{"id":"T21","span":{"begin":1638,"end":1648},"obj":"Chemical"},{"id":"T22","span":{"begin":1703,"end":1715},"obj":"Chemical"},{"id":"T23","span":{"begin":1752,"end":1765},"obj":"Chemical"},{"id":"T24","span":{"begin":1859,"end":1867},"obj":"Chemical"},{"id":"T25","span":{"begin":1903,"end":1914},"obj":"Disease"},{"id":"T26","span":{"begin":1926,"end":1936},"obj":"Chemical"},{"id":"T27","span":{"begin":1963,"end":1971},"obj":"Chemical"},{"id":"T28","span":{"begin":2076,"end":2088},"obj":"Chemical"},{"id":"T29","span":{"begin":2146,"end":2157},"obj":"Disease"},{"id":"T30","span":{"begin":2190,"end":2198},"obj":"Chemical"},{"id":"T31","span":{"begin":2255,"end":2266},"obj":"Disease"},{"id":"T32","span":{"begin":2288,"end":2301},"obj":"Chemical"},{"id":"T33","span":{"begin":2369,"end":2377},"obj":"Chemical"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T16","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T17","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T18","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T19","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T20","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T21","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T22","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T23","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T24","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T25","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T26","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T27","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T28","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T29","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T30","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T31","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T32","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"},{"subj":"T33","pred":"source","obj":"bc5cdr-valid-gpt-r-m30"}]},{"project":"bc5cdr-valid-gpt-r-m20","denotations":[{"id":"T1","span":{"begin":0,"end":23},"obj":"Disease"},{"id":"T2","span":{"begin":82,"end":90},"obj":"Chemical"},{"id":"T3","span":{"begin":126,"end":138},"obj":"Disease"},{"id":"T4","span":{"begin":199,"end":207},"obj":"Chemical"},{"id":"T5","span":{"begin":337,"end":349},"obj":"Disease"},{"id":"T6","span":{"begin":482,"end":490},"obj":"Chemical"},{"id":"T7","span":{"begin":513,"end":524},"obj":"Chemical"},{"id":"T8","span":{"begin":543,"end":566},"obj":"Disease"},{"id":"T9","span":{"begin":743,"end":751},"obj":"Chemical"},{"id":"T10","span":{"begin":774,"end":785},"obj":"Chemical"},{"id":"T11","span":{"begin":839,"end":862},"obj":"Disease"},{"id":"T12","span":{"begin":887,"end":895},"obj":"Chemical"},{"id":"T13","span":{"begin":947,"end":958},"obj":"Chemical"},{"id":"T14","span":{"begin":1033,"end":1041},"obj":"Chemical"},{"id":"T15","span":{"begin":1144,"end":1152},"obj":"Chemical"},{"id":"T16","span":{"begin":1256,"end":1279},"obj":"Disease"},{"id":"T17","span":{"begin":1336,"end":1344},"obj":"Chemical"},{"id":"T18","span":{"begin":1395,"end":1406},"obj":"Chemical"},{"id":"T19","span":{"begin":1435,"end":1443},"obj":"Chemical"},{"id":"T20","span":{"begin":1603,"end":1614},"obj":"Disease"},{"id":"T21","span":{"begin":1638,"end":1648},"obj":"Chemical"},{"id":"T22","span":{"begin":1703,"end":1715},"obj":"Chemical"},{"id":"T23","span":{"begin":1752,"end":1765},"obj":"Chemical"},{"id":"T24","span":{"begin":1859,"end":1867},"obj":"Chemical"},{"id":"T25","span":{"begin":1903,"end":1914},"obj":"Disease"},{"id":"T26","span":{"begin":1926,"end":1936},"obj":"Chemical"},{"id":"T27","span":{"begin":1963,"end":1971},"obj":"Chemical"},{"id":"T28","span":{"begin":2076,"end":2088},"obj":"Chemical"},{"id":"T29","span":{"begin":2146,"end":2157},"obj":"Disease"},{"id":"T30","span":{"begin":2190,"end":2198},"obj":"Chemical"},{"id":"T31","span":{"begin":2255,"end":2266},"obj":"Disease"},{"id":"T32","span":{"begin":2288,"end":2301},"obj":"Chemical"},{"id":"T33","span":{"begin":2369,"end":2377},"obj":"Chemical"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T16","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T17","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T18","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T19","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T20","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T21","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T22","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T23","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T24","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T25","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T26","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T27","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T28","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T29","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T30","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T31","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T32","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"},{"subj":"T33","pred":"source","obj":"bc5cdr-valid-gpt-r-m20"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"bc5cdr-valid-experiment","color":"#ec93dc","default":true},{"id":"bc5cdr-valid-deepseek-nr-ng-experiment","color":"#93ece2"},{"id":"bc5cdr-valid-deepseek-nr-g-experiment","color":"#ecc893"},{"id":"bc5cdr-valid-gpt-r-ng-experiment","color":"#ae93ec"},{"id":"bc5cdr-valid-gpt-r-g-experiment","color":"#93ec94"},{"id":"bc5cdr-valid-gpt-r-m30","color":"#ec93ab"},{"id":"bc5cdr-valid-gpt-r-m20","color":"#93c5ec"}]}]}}