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PubMed:1351090 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 45-89 cell_line denotes ethyl-methanesulfonate-treated CEM subclones
T2 126-142 protein denotes protein kinase C
T3 216-229 cell_line denotes CEM subclones
T4 243-256 protein denotes CD4 receptors
T5 274-279 protein denotes gp120
T6 410-426 protein denotes protein kinase C
T7 428-431 protein denotes PKC
T8 470-500 protein denotes CD3 and CD25 (IL-2R) receptors
T9 535-575 cell_line denotes ethyl-methanesulfonate-derived subclones
T10 624-627 protein denotes PKC
T11 668-671 protein denotes PKC
T12 746-749 protein denotes CD4
T13 812-824 protein denotes c-raf kinase
T14 843-869 DNA denotes HIV-1 long terminal repeat
T15 894-939 DNA denotes nuclear factor kB (NF-kB) regulatory elements
T16 981-986 protein denotes NF-kB
T17 1025-1059 protein denotes Chloramphenicol acetyl transferase
T18 1061-1064 protein denotes CAT
T19 1083-1129 DNA denotes HIV-1 (-139)long terminal repeat-CAT construct
T20 1157-1160 protein denotes CAT
T21 1267-1288 protein denotes phosphatases 1 and 2A
T22 1401-1406 protein denotes NF-kB
T23 1439-1456 cell_type denotes PMA-treated cells
T24 1500-1530 protein denotes nuclear NF-kB binding proteins
T25 1568-1581 protein denotes wild type CEM
T26 1696-1718 protein denotes NF-kB binding proteins
T27 1773-1776 protein denotes PKC
T28 1793-1798 protein denotes NF-kB

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-161 Sentence denotes Reduced susceptibility to HIV-1 infection of ethyl-methanesulfonate-treated CEM subclones correlates with a blockade in their protein kinase C signaling pathway.
S2 162-348 Sentence denotes We have described the isolation of chemically induced CEM subclones that express CD4 receptors and bind soluble gp120, yet show a markedly reduced susceptibility to infection with HIV-1.
S3 349-447 Sentence denotes Two subclones were found to have an abnormal response to the protein kinase C (PKC) activator PMA.
S4 448-606 Sentence denotes PMA treatment induced CD3 and CD25 (IL-2R) receptors on the parental line and on other ethyl-methanesulfonate-derived subclones, but not on these two mutants.
S5 607-652 Sentence denotes Direct assays of PKC activity were conducted.
S6 653-733 Sentence denotes Total cellular PKC enzymatic activity was found to be normal in these subclones.
S7 734-784 Sentence denotes PMA-induced CD4 down-modulation occurred normally.
S8 785-836 Sentence denotes In addition, activation of c-raf kinase was normal.
S9 837-1024 Sentence denotes Since HIV-1 long terminal repeat contains two functional nuclear factor kB (NF-kB) regulatory elements, we studied the ability of PMA to induce NF-kB binding activity by different assays.
S10 1025-1236 Sentence denotes Chloramphenicol acetyl transferase (CAT) assays using the HIV-1 (-139)long terminal repeat-CAT construct showed no PMA induction of CAT activity in these subclones (unlike the parental line and other subclones).
S11 1237-1337 Sentence denotes Okadaic acid, an inhibitor of phosphatases 1 and 2A, did not overcome the defect in these subclones.
S12 1338-1605 Sentence denotes Gel retardation assays, using a 32P-probe containing the HIV-1 NF-kB probe and nuclear extracts from PMA-treated cells, showed significantly reduced induction of nuclear NF-kB binding proteins in these two subclones compared with wild type CEM and a control subclone.
S13 1606-1748 Sentence denotes Deoxycholate treatment of cytoplasmic extracts from these subclones released much reduced NF-kB binding proteins from their cytoplasmic pools.
S14 1749-1959 Sentence denotes Thus, reduced levels of PKC-induced nuclear NF-kB activity in two T cell subclones did not affect their normal cell growth, but correlated with a pronounced reduction in their susceptibility to HIV-1 infection.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-41 NP denotes Reduced susceptibility to HIV-1 infection
C2 45-89 NP denotes ethyl-methanesulfonate-treated CEM subclones
C3 120-125 NP denotes their
C4 197-229 NP denotes chemically induced CEM subclones
C5 230-234 NP denotes that
C6 290-347 NP denotes a markedly reduced susceptibility to infection with HIV-1
C7 349-362 NP denotes Two subclones
C8 406-446 NP denotes the protein kinase C (PKC) activator PMA
C9 448-451 NP denotes PMA
C10 504-521 NP denotes the parental line
C11 529-575 NP denotes other ethyl-methanesulfonate-derived subclones
C12 588-605 NP denotes these two mutants
C13 717-732 NP denotes these subclones
C14 967-970 NP denotes PMA
C15 1025-1065 NP denotes Chloramphenicol acetyl transferase (CAT)
C16 1140-1143 NP denotes PMA
C17 1157-1160 NP denotes CAT
C18 1173-1188 NP denotes these subclones
C19 1197-1214 NP denotes the parental line
C20 1219-1234 NP denotes other subclones
C21 1237-1249 NP denotes Okadaic acid
C22 1251-1288 NP denotes an inhibitor of phosphatases 1 and 2A
C23 1321-1336 NP denotes these subclones
C24 1500-1530 NP denotes nuclear NF-kB binding proteins
C25 1534-1553 NP denotes these two subclones
C26 1658-1673 NP denotes these subclones
C27 1683-1718 NP denotes much reduced NF-kB binding proteins
C28 1724-1729 NP denotes their
C29 1811-1831 NP denotes two T cell subclones
C30 1847-1852 NP denotes their
C32 1919-1924 NP denotes their
C31 1919-1958 NP denotes their susceptibility to HIV-1 infection
R1 C3 C2 coref-pron their,ethyl-methanesulfonate-treated CEM subclones
R2 C5 C4 coref-relat that,chemically induced CEM subclones
R3 C6 C1 coref-ident a markedly reduced susceptibility to infection with HIV-1,Reduced susceptibility to HIV-1 infection
R4 C7 C4 coref-other Two subclones,chemically induced CEM subclones
R5 C9 C8 coref-ident PMA,the protein kinase C (PKC) activator PMA
R6 C12 C7 coref-ident these two mutants,Two subclones
R7 C13 C12 coref-ident these subclones,these two mutants
R8 C14 C9 coref-ident PMA,PMA
R9 C16 C14 coref-ident PMA,PMA
R10 C17 C15 coref-ident CAT,Chloramphenicol acetyl transferase (CAT)
R11 C18 C13 coref-ident these subclones,these subclones
R12 C19 C10 coref-ident the parental line,the parental line
R13 C20 C11 coref-ident other subclones,other ethyl-methanesulfonate-derived subclones
R14 C22 C21 coref-appos an inhibitor of phosphatases 1 and 2A,Okadaic acid
R15 C23 C18 coref-ident these subclones,these subclones
R16 C25 C23 coref-ident these two subclones,these subclones
R17 C26 C25 coref-ident these subclones,these two subclones
R18 C27 C24 coref-other much reduced NF-kB binding proteins,nuclear NF-kB binding proteins
R19 C28 C26 coref-pron their,these subclones
R20 C29 C26 coref-other two T cell subclones,these subclones
R21 C30 C29 coref-pron their,two T cell subclones
R22 C32 C29 coref-pron their,two T cell subclones
R23 C31 C6 coref-other their susceptibility to HIV-1 infection,a markedly reduced susceptibility to infection with HIV-1

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 26-31 virus denotes HIV-1
T2 45-89 cell_line denotes ethyl-methanesulfonate-treated CEM subclones
T3 126-142 protein_molecule denotes protein kinase C
T4 216-229 cell_line denotes CEM subclones
T5 243-256 protein_family_or_group denotes CD4 receptors
T6 274-279 protein_molecule denotes gp120
T7 342-347 virus denotes HIV-1
T8 410-426 protein_molecule denotes protein kinase C
T9 428-431 protein_molecule denotes PKC
T10 443-446 other_organic_compound denotes PMA
T11 448-461 other_name denotes PMA treatment
T12 535-575 cell_line denotes ethyl-methanesulfonate-derived subclones
T13 624-627 protein_molecule denotes PKC
T14 668-671 protein_molecule denotes PKC
T15 734-737 other_organic_compound denotes PMA
T16 746-749 protein_molecule denotes CD4
T17 812-824 protein_molecule denotes c-raf kinase
T18 843-869 DNA_domain_or_region denotes HIV-1 long terminal repeat
T19 894-913 DNA_domain_or_region denotes nuclear factor kB (
T20 913-918 protein_molecule denotes NF-kB
T21 967-970 other_organic_compound denotes PMA
T22 981-986 protein_molecule denotes NF-kB
T23 1025-1059 protein_molecule denotes Chloramphenicol acetyl transferase
T24 1061-1064 protein_molecule denotes CAT
T25 1083-1088 virus denotes HIV-1
T26 1140-1143 other_organic_compound denotes PMA
T27 1157-1160 protein_molecule denotes CAT
T28 1237-1249 other_organic_compound denotes Okadaic acid
T29 1338-1360 other_name denotes Gel retardation assays
T30 1370-1379 other_organic_compound denotes 32P-probe
T31 1395-1400 virus denotes HIV-1
T32 1401-1406 protein_molecule denotes NF-kB
T33 1417-1433 cell_component denotes nuclear extracts
T34 1439-1442 other_organic_compound denotes PMA
T35 1500-1507 protein_family_or_group denotes nuclear
T36 1508-1513 protein_molecule denotes NF-kB
T37 1568-1577 protein_molecule denotes wild type
T38 1578-1581 protein_molecule denotes CEM
T39 1606-1618 other_organic_compound denotes Deoxycholate
T40 1632-1652 cell_component denotes cytoplasmic extracts
T41 1696-1701 protein_molecule denotes NF-kB
T42 1773-1776 protein_molecule denotes PKC
T43 1793-1798 protein_molecule denotes NF-kB
T44 1943-1948 virus denotes HIV-1