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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-123 Sentence denotes Interleukin-6 antagonizes tumor necrosis factor-mediated mycobacteriostatic and mycobactericidal activities in macrophages.
T2 124-267 Sentence denotes Interleukin-6 (IL-6) is a cytokine produced by a number of cells, including macrophages, and is directly involved in the inflammatory response.
T3 268-367 Sentence denotes The production of IL-6 can be stimulated by monokines such as IL-1 and tumor necrosis factor (TNF).
T4 368-466 Sentence denotes Mycobacterium avium complex organisms frequently cause disseminated disease in patients with AIDS.
T5 467-543 Sentence denotes M. avium is an intracellular bacterium that that mainly infects macrophages.
T6 544-836 Sentence denotes Treatment of M. avium-infected macrophage monolayers with recombinant IL-6 decreased the ability of TNF to activate cultured macrophages to inhibit growth of or kill intracellular M. avium (68% +/- 14% decrease in intracellular killing compared with that in monolayers not treated with IL-6).
T7 837-1076 Sentence denotes To further evaluate whether this effect was dependent on the down regulation of membrane receptors to TNF, we examined 125I-TNF binding to macrophages previously exposed to IL-6: the expression of TNF receptors was decreased by 78% +/- 9%.
T8 1077-1155 Sentence denotes The effect of IL-6 on TNF receptors was observed after 4 h and was reversible.
T9 1156-1389 Sentence denotes Infection of macrophages with different M. avium serovars was associated with release of IL-6, and IL-6 production peaked at 48 h after infection in concentrations ranging from 328 +/- 87 ng/10(5) cells to 907 +/- 224 ng/10(5) cells.
T10 1390-1508 Sentence denotes IL-6 did not have any influence on the rate of growth of the tested strains of M. avium within or outside macrophages.
T11 1509-1657 Sentence denotes These results suggest that release of IL-6 by M. avium-infected macrophages may influence the host's immune response and the outcome of the disease.
T1 0-123 Sentence denotes Interleukin-6 antagonizes tumor necrosis factor-mediated mycobacteriostatic and mycobactericidal activities in macrophages.
T2 124-267 Sentence denotes Interleukin-6 (IL-6) is a cytokine produced by a number of cells, including macrophages, and is directly involved in the inflammatory response.
T3 268-367 Sentence denotes The production of IL-6 can be stimulated by monokines such as IL-1 and tumor necrosis factor (TNF).
T4 368-466 Sentence denotes Mycobacterium avium complex organisms frequently cause disseminated disease in patients with AIDS.
T5 467-543 Sentence denotes M. avium is an intracellular bacterium that that mainly infects macrophages.
T6 544-836 Sentence denotes Treatment of M. avium-infected macrophage monolayers with recombinant IL-6 decreased the ability of TNF to activate cultured macrophages to inhibit growth of or kill intracellular M. avium (68% +/- 14% decrease in intracellular killing compared with that in monolayers not treated with IL-6).
T7 837-1076 Sentence denotes To further evaluate whether this effect was dependent on the down regulation of membrane receptors to TNF, we examined 125I-TNF binding to macrophages previously exposed to IL-6: the expression of TNF receptors was decreased by 78% +/- 9%.
T8 1077-1155 Sentence denotes The effect of IL-6 on TNF receptors was observed after 4 h and was reversible.
T9 1156-1389 Sentence denotes Infection of macrophages with different M. avium serovars was associated with release of IL-6, and IL-6 production peaked at 48 h after infection in concentrations ranging from 328 +/- 87 ng/10(5) cells to 907 +/- 224 ng/10(5) cells.
T10 1390-1508 Sentence denotes IL-6 did not have any influence on the rate of growth of the tested strains of M. avium within or outside macrophages.
T11 1509-1657 Sentence denotes These results suggest that release of IL-6 by M. avium-infected macrophages may influence the host's immune response and the outcome of the disease.