| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-103 |
Sentence |
denotes |
Role of kinins in pain and hyperalgesia: psychophysical studies in a patient with kininogen deficiency. |
| T2 |
104-106 |
Sentence |
denotes |
1. |
| T3 |
107-225 |
Sentence |
denotes |
Bradykinin is considered to be an important mediator of pain and hyperalgesia associated with injury and inflammation. |
| T4 |
226-413 |
Sentence |
denotes |
Psychophysical studies were conducted in a patient with complete kininogen deficiency to determine whether the absence of bradykinin was associated with abnormalities in pain sensibility. |
| T5 |
414-573 |
Sentence |
denotes |
Pain evoked by heat stimuli to the thenar eminence was tested before and after a localized burn, which has been shown to cause hyperalgesia in normal subjects. |
| T6 |
574-753 |
Sentence |
denotes |
In addition, pain evoked by intradermal administration of bradykinin (0.1-10 micrograms) to the forearm and the effects of bradykinin on pain induced by heat stimuli were studied. |
| T7 |
754-881 |
Sentence |
denotes |
The patient rated the intensity of pain evoked by all heat stimuli relative to the pain induced by a 3 s 45 degrees C stimulus. |
| T8 |
882-884 |
Sentence |
denotes |
2. |
| T9 |
885-1075 |
Sentence |
denotes |
The patient's heat pain threshold (45 degrees C) in the glabrous skin was similar to that of age-matched control subjects (n = 5) and to that previously observed in younger control subjects. |
| T10 |
1076-1078 |
Sentence |
denotes |
3. |
| T11 |
1079-1187 |
Sentence |
denotes |
The burn resulted in a decrease in pain threshold and an increase in pain induced by suprathreshold stimuli. |
| T12 |
1188-1316 |
Sentence |
denotes |
The magnitude of hyperalgesia was within the range observed in the age-matched control subjects and in younger control subjects. |
| T13 |
1317-1402 |
Sentence |
denotes |
Thus, kinins are not essential for the development of hyperalgesia after heat injury. |
| T14 |
1403-1405 |
Sentence |
denotes |
4. |
| T15 |
1406-1511 |
Sentence |
denotes |
In control subjects, intradermal injections of bradykinin produced pain and hyperalgesia to heat stimuli. |
| T16 |
1512-1619 |
Sentence |
denotes |
In the patient, intradermal bradykinin injections induced minimal pain and no hyperalgesia to heat stimuli. |
| T17 |
1620-1719 |
Sentence |
denotes |
Thus, congenital absence of kininogens may be associated with a deficiency in bradykinin receptors. |
| T1 |
0-103 |
Sentence |
denotes |
Role of kinins in pain and hyperalgesia: psychophysical studies in a patient with kininogen deficiency. |
| T2 |
104-106 |
Sentence |
denotes |
1. |
| T3 |
107-225 |
Sentence |
denotes |
Bradykinin is considered to be an important mediator of pain and hyperalgesia associated with injury and inflammation. |
| T4 |
226-413 |
Sentence |
denotes |
Psychophysical studies were conducted in a patient with complete kininogen deficiency to determine whether the absence of bradykinin was associated with abnormalities in pain sensibility. |
| T5 |
414-573 |
Sentence |
denotes |
Pain evoked by heat stimuli to the thenar eminence was tested before and after a localized burn, which has been shown to cause hyperalgesia in normal subjects. |
| T6 |
574-753 |
Sentence |
denotes |
In addition, pain evoked by intradermal administration of bradykinin (0.1-10 micrograms) to the forearm and the effects of bradykinin on pain induced by heat stimuli were studied. |
| T7 |
754-881 |
Sentence |
denotes |
The patient rated the intensity of pain evoked by all heat stimuli relative to the pain induced by a 3 s 45 degrees C stimulus. |
| T8 |
882-884 |
Sentence |
denotes |
2. |
| T9 |
885-1075 |
Sentence |
denotes |
The patient's heat pain threshold (45 degrees C) in the glabrous skin was similar to that of age-matched control subjects (n = 5) and to that previously observed in younger control subjects. |
| T10 |
1076-1078 |
Sentence |
denotes |
3. |
| T11 |
1079-1187 |
Sentence |
denotes |
The burn resulted in a decrease in pain threshold and an increase in pain induced by suprathreshold stimuli. |
| T12 |
1188-1316 |
Sentence |
denotes |
The magnitude of hyperalgesia was within the range observed in the age-matched control subjects and in younger control subjects. |
| T13 |
1317-1402 |
Sentence |
denotes |
Thus, kinins are not essential for the development of hyperalgesia after heat injury. |
| T14 |
1403-1405 |
Sentence |
denotes |
4. |
| T15 |
1406-1511 |
Sentence |
denotes |
In control subjects, intradermal injections of bradykinin produced pain and hyperalgesia to heat stimuli. |
| T16 |
1512-1619 |
Sentence |
denotes |
In the patient, intradermal bradykinin injections induced minimal pain and no hyperalgesia to heat stimuli. |
| T17 |
1620-1719 |
Sentence |
denotes |
Thus, congenital absence of kininogens may be associated with a deficiency in bradykinin receptors. |