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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-104 Sentence denotes Ibuprofen intervention in canine septic shock: reduction of pathophysiology without decreased cytokines.
T2 105-278 Sentence denotes This study was undertaken to evaluate the effect of a cyclooxygenase inhibitor, ibuprofen, at various time intervals in a live Escherichia coli model of canine septic shock.
T3 279-402 Sentence denotes Group I (control) animals (n = 5) received a LD100 dose of 10(9) live E. coli per kilogram were given no further treatment.
T4 403-502 Sentence denotes Group II animals (n = 5) received a 10 mg/kg bolus of ibuprofen 10 min prior to bacterial infusion.
T5 503-584 Sentence denotes Group III animals (n = 5) received ibuprofen 15 min after the bacterial infusion.
T6 585-629 Sentence denotes Statistical analysis revealed the following:
T7 630-878 Sentence denotes Group II animals had significantly higher MABP and significantly lower levels of serum fluorescent products (superoxide radical activity), plasma thromboxane B2, prostaglandin E2, and endotoxin levels compared to Group I animals (P less than 0.05).
T8 879-1125 Sentence denotes Plasma levels of tumor necrosis factor (TNF) and interleukin-6 (IL-6) were significantly elevated (P less than 0.05) from baseline in all animals (Groups I, II, and III), but ibuprofen treatment failed to either increase or decrease these levels.
T9 1126-1354 Sentence denotes This study demonstrates that ibuprofen treatment can significantly reverse the deleterious hemodynamic and metabolic effects commonly seen in live E. coli septic shock without depressing the endogenous production of TNF or IL-6.
T10 1355-1619 Sentence denotes These data support the hypothesis that sepsis initiates a cascade of mediators with the cytokines TNF and IL-6 being proximal events which in turn stimulate the next level, with ibuprofen probably exerting its inhibitory effect distal to this point in the cascade.
T1 0-104 Sentence denotes Ibuprofen intervention in canine septic shock: reduction of pathophysiology without decreased cytokines.
T2 105-278 Sentence denotes This study was undertaken to evaluate the effect of a cyclooxygenase inhibitor, ibuprofen, at various time intervals in a live Escherichia coli model of canine septic shock.
T3 279-402 Sentence denotes Group I (control) animals (n = 5) received a LD100 dose of 10(9) live E. coli per kilogram were given no further treatment.
T4 403-502 Sentence denotes Group II animals (n = 5) received a 10 mg/kg bolus of ibuprofen 10 min prior to bacterial infusion.
T5 503-584 Sentence denotes Group III animals (n = 5) received ibuprofen 15 min after the bacterial infusion.
T6 585-629 Sentence denotes Statistical analysis revealed the following:
T7 630-878 Sentence denotes Group II animals had significantly higher MABP and significantly lower levels of serum fluorescent products (superoxide radical activity), plasma thromboxane B2, prostaglandin E2, and endotoxin levels compared to Group I animals (P less than 0.05).
T8 879-1125 Sentence denotes Plasma levels of tumor necrosis factor (TNF) and interleukin-6 (IL-6) were significantly elevated (P less than 0.05) from baseline in all animals (Groups I, II, and III), but ibuprofen treatment failed to either increase or decrease these levels.
T9 1126-1354 Sentence denotes This study demonstrates that ibuprofen treatment can significantly reverse the deleterious hemodynamic and metabolic effects commonly seen in live E. coli septic shock without depressing the endogenous production of TNF or IL-6.
T10 1355-1619 Sentence denotes These data support the hypothesis that sepsis initiates a cascade of mediators with the cytokines TNF and IL-6 being proximal events which in turn stimulate the next level, with ibuprofen probably exerting its inhibitory effect distal to this point in the cascade.