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PubMed:1325437 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-101 Sentence denotes Analysis of the oligomerization of myogenin and E2A products in vivo using a two-hybrid assay system.
T2 102-221 Sentence denotes Members of the helix-loop-helix (HLH) family of proteins bind DNA and activate transcription as homo- and heterodimers.
T3 222-391 Sentence denotes Myogenin is a muscle-specific HLH protein that binds DNA in vitro as a heterodimer with several widely expressed HLH proteins, such as the E2A gene products E12 and E47.
T4 392-698 Sentence denotes We describe a method for detection of protein-protein interactions among HLH proteins in vivo in which dimerization through the HLH motif reconstructs a hybrid transcription factor containing the DNA-binding domain of yeast GAL4 linked to one HLH motif and the activation domain of VP-16 linked to another.
T5 699-924 Sentence denotes We have used this assay to investiagate whether myogenin forms homomeric or heteromeric complexes in vivo and to determine whether growth factors and oncogenes that inhibit myogenesis influence myogenin's ability to dimerize.
T6 925-1050 Sentence denotes The results show that myogenin heterodimerizes with E12 and E47 in vivo, but it does not homodimerize to a measurable extent.
T7 1051-1247 Sentence denotes Peptide growth factors, as well as the immediate early gene products c-Jun, v-Fos, and c-Myc, inhibit the activity of myogenin through a mechanism independent of its association with E2A products.
T1 0-101 Sentence denotes Analysis of the oligomerization of myogenin and E2A products in vivo using a two-hybrid assay system.
T2 102-221 Sentence denotes Members of the helix-loop-helix (HLH) family of proteins bind DNA and activate transcription as homo- and heterodimers.
T3 222-391 Sentence denotes Myogenin is a muscle-specific HLH protein that binds DNA in vitro as a heterodimer with several widely expressed HLH proteins, such as the E2A gene products E12 and E47.
T4 392-698 Sentence denotes We describe a method for detection of protein-protein interactions among HLH proteins in vivo in which dimerization through the HLH motif reconstructs a hybrid transcription factor containing the DNA-binding domain of yeast GAL4 linked to one HLH motif and the activation domain of VP-16 linked to another.
T5 699-924 Sentence denotes We have used this assay to investiagate whether myogenin forms homomeric or heteromeric complexes in vivo and to determine whether growth factors and oncogenes that inhibit myogenesis influence myogenin's ability to dimerize.
T6 925-1050 Sentence denotes The results show that myogenin heterodimerizes with E12 and E47 in vivo, but it does not homodimerize to a measurable extent.
T7 1051-1247 Sentence denotes Peptide growth factors, as well as the immediate early gene products c-Jun, v-Fos, and c-Myc, inhibit the activity of myogenin through a mechanism independent of its association with E2A products.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 236-242 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 35-43 protein denotes myogenin
T2 48-51 protein denotes E2A
T3 222-230 protein denotes Myogenin
T4 361-364 protein denotes E2A
T5 379-382 protein denotes E12
T6 387-390 protein denotes E47
T7 552-572 protein denotes transcription factor
T8 616-620 protein denotes GAL4
T9 674-679 protein denotes VP-16
T10 747-755 protein denotes myogenin
T11 830-844 protein denotes growth factors
T12 893-901 protein denotes myogenin
T13 947-955 protein denotes myogenin
T14 977-980 protein denotes E12
T15 985-988 protein denotes E47
T16 1059-1073 protein denotes growth factors
T17 1120-1125 protein denotes c-Jun
T18 1127-1132 protein denotes v-Fos
T19 1138-1143 protein denotes c-Myc
T20 1169-1177 protein denotes myogenin
T21 1234-1237 protein denotes E2A

AIMed

Id Subject Object Predicate Lexical cue
T1 35-43 protein denotes myogenin
T2 48-51 protein denotes E2A
T3 222-230 protein denotes Myogenin
T4 361-364 protein denotes E2A
T5 379-382 protein denotes E12
T6 387-390 protein denotes E47
T7 674-679 protein denotes VP-16
T8 947-955 protein denotes myogenin
T9 977-980 protein denotes E12
T10 985-988 protein denotes E47
T11 1120-1125 protein denotes c-Jun
T12 1127-1132 protein denotes v-Fos
T13 1138-1143 protein denotes c-Myc
T14 1234-1237 protein denotes E2A

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 135-138 Disease denotes HLH http://purl.obolibrary.org/obo/MONDO_0015540
T2 252-255 Disease denotes HLH http://purl.obolibrary.org/obo/MONDO_0015540
T3 335-338 Disease denotes HLH http://purl.obolibrary.org/obo/MONDO_0015540
T4 465-468 Disease denotes HLH http://purl.obolibrary.org/obo/MONDO_0015540
T5 520-523 Disease denotes HLH http://purl.obolibrary.org/obo/MONDO_0015540
T6 635-638 Disease denotes HLH http://purl.obolibrary.org/obo/MONDO_0015540

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 236-242 Body_part denotes muscle http://purl.obolibrary.org/obo/MAT_0000025

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 198-202 OrganismTaxon denotes homo 9605

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 117-122 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T2 128-133 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T3 135-138 Body_part denotes HLH http://purl.obolibrary.org/obo/UBERON_0002488
T4 236-242 Body_part denotes muscle http://purl.obolibrary.org/obo/UBERON_0001630|http://purl.obolibrary.org/obo/UBERON_0005090
T6 252-255 Body_part denotes HLH http://purl.obolibrary.org/obo/UBERON_0002488
T7 335-338 Body_part denotes HLH http://purl.obolibrary.org/obo/UBERON_0002488
T8 465-468 Body_part denotes HLH http://purl.obolibrary.org/obo/UBERON_0002488
T9 520-523 Body_part denotes HLH http://purl.obolibrary.org/obo/UBERON_0002488
T10 635-638 Body_part denotes HLH http://purl.obolibrary.org/obo/UBERON_0002488