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PubMed:1319995 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 654-663 Glycan_Motif denotes T antigen https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 654-663 http://www.glycoepitope.jp/epitopes/EP0020 denotes T antigen

sentences

Id Subject Object Predicate Lexical cue
T1 0-143 Sentence denotes Identification of an N-terminal domain of eukaryotic DNA topoisomerase I dispensable for catalytic activity but essential for in vivo function.
T2 144-471 Sentence denotes We have found that deletion of a 70-amino acid domain, spanning from position 141 to 210 in the N-terminal part of human topoisomerase I, has no effect on the catalytic activity of the enzyme in vitro but suppresses the lethal consequence of overexpressing human topoisomerase I in a rad52 top1 Saccharomyces cerevisiae strain.
T3 472-581 Sentence denotes By immunostaining, the 70-amino acid domain is shown to be necessary for nuclear location of topoisomerase I.
T4 582-820 Sentence denotes We demonstrate that the nuclear localization signal from the SV40 large T antigen can substitute for the 70-amino acid domain, restoring both the lethal effect of overexpression and the correct subcellular localization of topoisomerase I.
T5 821-1020 Sentence denotes Thus, we have identified a domain in the N-terminal part of human topoisomerase I, nonessential for catalytic activity in vitro but serving an in vivo function by directing the enzyme to the nucleus.
T6 1021-1188 Sentence denotes Based on sequence comparisons, we suggest that this domain is a conserved element in the apparently non-homologous N-terminal parts of yeast and human topoisomerase I.
T1 0-143 Sentence denotes Identification of an N-terminal domain of eukaryotic DNA topoisomerase I dispensable for catalytic activity but essential for in vivo function.
T2 144-471 Sentence denotes We have found that deletion of a 70-amino acid domain, spanning from position 141 to 210 in the N-terminal part of human topoisomerase I, has no effect on the catalytic activity of the enzyme in vitro but suppresses the lethal consequence of overexpressing human topoisomerase I in a rad52 top1 Saccharomyces cerevisiae strain.
T3 472-581 Sentence denotes By immunostaining, the 70-amino acid domain is shown to be necessary for nuclear location of topoisomerase I.
T4 582-820 Sentence denotes We demonstrate that the nuclear localization signal from the SV40 large T antigen can substitute for the 70-amino acid domain, restoring both the lethal effect of overexpression and the correct subcellular localization of topoisomerase I.
T5 821-1020 Sentence denotes Thus, we have identified a domain in the N-terminal part of human topoisomerase I, nonessential for catalytic activity in vitro but serving an in vivo function by directing the enzyme to the nucleus.
T6 1021-1188 Sentence denotes Based on sequence comparisons, we suggest that this domain is a conserved element in the apparently non-homologous N-terminal parts of yeast and human topoisomerase I.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 654-663 https://glytoucan.org/Structures/Glycans/G00031MO denotes T antigen

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 654-663 Glycan denotes T antigen https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 606-633 Disease denotes nuclear localization signal http://purl.obolibrary.org/obo/MONDO_0000179

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 654-663 Glycan denotes T antigen https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 654-663 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T antigen http://www.glycoepitope.jp/epitopes/EP0020

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 606-633 Disease denotes nuclear localization signal MONDO:0000179

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 259-264 Organism denotes human 9606
T2 401-406 Organism denotes human 9606
T3 439-463 Organism denotes Saccharomyces cerevisiae 4932
T4 881-886 Organism denotes human 9606
T5 1166-1171 Organism denotes human 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-143 Sentence denotes Identification of an N-terminal domain of eukaryotic DNA topoisomerase I dispensable for catalytic activity but essential for in vivo function.
T2 144-471 Sentence denotes We have found that deletion of a 70-amino acid domain, spanning from position 141 to 210 in the N-terminal part of human topoisomerase I, has no effect on the catalytic activity of the enzyme in vitro but suppresses the lethal consequence of overexpressing human topoisomerase I in a rad52 top1 Saccharomyces cerevisiae strain.
T3 472-1020 Sentence denotes By immunostaining, the 70-amino acid domain is shown to be necessary for nuclear location of topoisomerase I. We demonstrate that the nuclear localization signal from the SV40 large T antigen can substitute for the 70-amino acid domain, restoring both the lethal effect of overexpression and the correct subcellular localization of topoisomerase I. Thus, we have identified a domain in the N-terminal part of human topoisomerase I, nonessential for catalytic activity in vitro but serving an in vivo function by directing the enzyme to the nucleus.
T4 1021-1188 Sentence denotes Based on sequence comparisons, we suggest that this domain is a conserved element in the apparently non-homologous N-terminal parts of yeast and human topoisomerase I.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 654-663 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T antigen http://www.glycoepitope.jp/epitopes/EP0020

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1012-1019 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 259-264 OrganismTaxon denotes human 9606
T2 401-406 OrganismTaxon denotes human 9606
T3 439-463 OrganismTaxon denotes Saccharomyces cerevisiae 4932
T4 881-886 OrganismTaxon denotes human 9606
T5 1166-1171 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1012-1019 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125