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PubMed:1310680 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-75 Sentence denotes Structure function analysis of vitamin D analogs with C-ring modifications.
T2 76-183 Sentence denotes Analogs of 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25-(OH)2D3) with substitutions on C-11 were synthesized.
T3 184-532 Sentence denotes Small apolar substitutions (11 alpha-methyl, 11 alpha-fluoromethyl) did not markedly decrease the affinity for the vitamin D receptor, but larger (11 alpha-chloromethyl or 11 alpha- or 11 beta-phenyl) or more polar substitutions (11 alpha-hydroxymethyl, 11 alpha-(2-hydroxyethyl] decreased the affinity to less than 5% of that of 1 alpha,25-OH)2D3.
T4 533-615 Sentence denotes Their affinity for the vitamin D-binding protein, however, increased up to 4-fold.
T5 616-902 Sentence denotes The biological activity of 11 alpha-methyl-1 alpha,25-(OH)2D3 closely resembled that of the natural hormone on normal and leukemic cell proliferation and bone resorption, whereas its in vivo effect on calcium metabolism of the rachitic chick was about 50% of that of 1 alpha,25-(OH)2D3.
T6 903-971 Sentence denotes The 11 beta-methyl analog had a greater than 10-fold lower activity.
T7 972-1192 Sentence denotes The differentiating effects of the other C-11 analogs on human promyeloid leukemia cells (HL-60) agreed well with their bone-resorbing activity and receptor affinity, but they demonstrated lower calcemic effects in vivo.
T8 1193-1357 Sentence denotes Large or polar substitutions on C-11 of 1 alpha,25-(OH)2D3 thus impair the binding of the vitamin D receptor but increase the affinity to vitamin D-binding protein.
T9 1358-1498 Sentence denotes The effects of many C-11-substituted 1 alpha,25-(OH)2D3 analogs on HL-60 cell differentiation exceeded their activity on calcium metabolism.
T1 0-75 Sentence denotes Structure function analysis of vitamin D analogs with C-ring modifications.
T2 76-183 Sentence denotes Analogs of 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25-(OH)2D3) with substitutions on C-11 were synthesized.
T3 184-532 Sentence denotes Small apolar substitutions (11 alpha-methyl, 11 alpha-fluoromethyl) did not markedly decrease the affinity for the vitamin D receptor, but larger (11 alpha-chloromethyl or 11 alpha- or 11 beta-phenyl) or more polar substitutions (11 alpha-hydroxymethyl, 11 alpha-(2-hydroxyethyl] decreased the affinity to less than 5% of that of 1 alpha,25-OH)2D3.
T4 533-615 Sentence denotes Their affinity for the vitamin D-binding protein, however, increased up to 4-fold.
T5 616-902 Sentence denotes The biological activity of 11 alpha-methyl-1 alpha,25-(OH)2D3 closely resembled that of the natural hormone on normal and leukemic cell proliferation and bone resorption, whereas its in vivo effect on calcium metabolism of the rachitic chick was about 50% of that of 1 alpha,25-(OH)2D3.
T6 903-971 Sentence denotes The 11 beta-methyl analog had a greater than 10-fold lower activity.
T7 972-1192 Sentence denotes The differentiating effects of the other C-11 analogs on human promyeloid leukemia cells (HL-60) agreed well with their bone-resorbing activity and receptor affinity, but they demonstrated lower calcemic effects in vivo.
T8 1193-1357 Sentence denotes Large or polar substitutions on C-11 of 1 alpha,25-(OH)2D3 thus impair the binding of the vitamin D receptor but increase the affinity to vitamin D-binding protein.
T9 1358-1498 Sentence denotes The effects of many C-11-substituted 1 alpha,25-(OH)2D3 analogs on HL-60 cell differentiation exceeded their activity on calcium metabolism.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 770-774 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T2 1092-1096 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 299-317 protein denotes vitamin D receptor
T2 556-581 protein denotes vitamin D-binding protein
T3 738-751 cell_type denotes leukemic cell
T4 1029-1060 cell_line denotes human promyeloid leukemia cells
T5 1062-1067 cell_line denotes HL-60
T6 1283-1301 protein denotes vitamin D receptor
T7 1331-1356 protein denotes vitamin D-binding protein
T8 1425-1430 cell_line denotes HL-60

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-75 Sentence denotes Structure function analysis of vitamin D analogs with C-ring modifications.
S2 76-183 Sentence denotes Analogs of 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25-(OH)2D3) with substitutions on C-11 were synthesized.
S3 184-532 Sentence denotes Small apolar substitutions (11 alpha-methyl, 11 alpha-fluoromethyl) did not markedly decrease the affinity for the vitamin D receptor, but larger (11 alpha-chloromethyl or 11 alpha- or 11 beta-phenyl) or more polar substitutions (11 alpha-hydroxymethyl, 11 alpha-(2-hydroxyethyl] decreased the affinity to less than 5% of that of 1 alpha,25-OH)2D3.
S4 533-615 Sentence denotes Their affinity for the vitamin D-binding protein, however, increased up to 4-fold.
S5 616-902 Sentence denotes The biological activity of 11 alpha-methyl-1 alpha,25-(OH)2D3 closely resembled that of the natural hormone on normal and leukemic cell proliferation and bone resorption, whereas its in vivo effect on calcium metabolism of the rachitic chick was about 50% of that of 1 alpha,25-(OH)2D3.
S6 903-971 Sentence denotes The 11 beta-methyl analog had a greater than 10-fold lower activity.
S7 972-1192 Sentence denotes The differentiating effects of the other C-11 analogs on human promyeloid leukemia cells (HL-60) agreed well with their bone-resorbing activity and receptor affinity, but they demonstrated lower calcemic effects in vivo.
S8 1193-1357 Sentence denotes Large or polar substitutions on C-11 of 1 alpha,25-(OH)2D3 thus impair the binding of the vitamin D receptor but increase the affinity to vitamin D-binding protein.
S9 1358-1498 Sentence denotes The effects of many C-11-substituted 1 alpha,25-(OH)2D3 analogs on HL-60 cell differentiation exceeded their activity on calcium metabolism.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 31-48 NP denotes vitamin D analogs
C3 87-138 NP denotes 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25-(OH)2D3)
C2 76-138 NP denotes Analogs of 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25-(OH)2D3)
C4 161-165 NP denotes C-11
C5 184-251 NP denotes Small apolar substitutions (11 alpha-methyl, 11 alpha-fluoromethyl)
C7 295-317 NP denotes the vitamin D receptor
C6 278-317 NP denotes the affinity for the vitamin D receptor
C8 474-486 NP denotes the affinity
C9 506-510 NP denotes that
C10 514-531 NP denotes 1 alpha,25-OH)2D3
C11 533-538 NP denotes Their
C12 552-581 NP denotes the vitamin D-binding protein
C13 616-639 NP denotes The biological activity
C14 643-677 NP denotes 11 alpha-methyl-1 alpha,25-(OH)2D3
C15 696-700 NP denotes that
C16 795-798 NP denotes its
C17 807-813 NP denotes effect
C18 817-835 NP denotes calcium metabolism
C19 875-879 NP denotes that
C20 883-901 NP denotes 1 alpha,25-(OH)2D3
C22 1013-1017 NP denotes C-11
C21 1003-1025 NP denotes the other C-11 analogs
C23 1086-1091 NP denotes their
C24 1143-1147 NP denotes they
C25 1225-1229 NP denotes C-11
C26 1233-1251 NP denotes 1 alpha,25-(OH)2D3
C27 1279-1301 NP denotes the vitamin D receptor
C28 1331-1356 NP denotes vitamin D-binding protein
C30 1395-1413 NP denotes 1 alpha,25-(OH)2D3
C29 1378-1421 NP denotes C-11-substituted 1 alpha,25-(OH)2D3 analogs
C31 1461-1466 NP denotes their
C32 1479-1497 NP denotes calcium metabolism
R1 C2 C1 coref-ident "Analogs of 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25-(OH)2D3)",vitamin D analogs
R2 C8 C6 coref-ident the affinity,the affinity for the vitamin D receptor
R3 C9 C8 coref-pron that,the affinity
R4 C10 C3 coref-ident "1 alpha,25-OH)2D3","1 alpha,25-dihydroxyvitamin D3 (1 alpha,25-(OH)2D3)"
R5 C11 C5 coref-pron Their,"Small apolar substitutions (11 alpha-methyl, 11 alpha-fluoromethyl)"
R6 C15 C13 coref-pron that,The biological activity
R7 C16 C14 coref-pron its,"11 alpha-methyl-1 alpha,25-(OH)2D3"
R8 C19 C17 coref-pron that,effect
R9 C20 C10 coref-ident "1 alpha,25-(OH)2D3","1 alpha,25-OH)2D3"
R10 C22 C4 coref-ident C-11,C-11
R11 C23 C21 coref-pron their,the other C-11 analogs
R12 C24 C21 coref-pron they,the other C-11 analogs
R13 C25 C22 coref-ident C-11,C-11
R14 C26 C20 coref-ident "1 alpha,25-(OH)2D3","1 alpha,25-(OH)2D3"
R15 C27 C7 coref-ident the vitamin D receptor,the vitamin D receptor
R16 C28 C12 coref-ident vitamin D-binding protein,the vitamin D-binding protein
R17 C30 C26 coref-ident "1 alpha,25-(OH)2D3","1 alpha,25-(OH)2D3"
R18 C29 C2 coref-other "C-11-substituted 1 alpha,25-(OH)2D3 analogs","Analogs of 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25-(OH)2D3)"
R19 C31 C29 coref-pron their,"C-11-substituted 1 alpha,25-(OH)2D3 analogs"
R20 C32 C18 coref-ident calcium metabolism,calcium metabolism

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 31-40 lipid denotes vitamin D
T2 54-74 other_name denotes C-ring modifications
T3 87-117 lipid denotes 1 alpha,25-dihydroxyvitamin D3
T4 119-137 lipid denotes 1 alpha,25-(OH)2D3
T5 161-165 other_name denotes C-11
T6 184-210 other_name denotes Small apolar substitutions
T7 212-250 lipid denotes 11 alpha-methyl, 11 alpha-fluoromethyl
T8 299-308 lipid denotes vitamin D
T9 331-383 lipid denotes 11 alpha-chloromethyl or 11 alpha- or 11 beta-phenyl
T10 414-462 lipid denotes 11 alpha-hydroxymethyl, 11 alpha-(2-hydroxyethyl
T11 514-531 lipid denotes 1 alpha,25-OH)2D3
T12 556-565 lipid denotes vitamin D
T13 643-677 lipid denotes 11 alpha-methyl-1 alpha,25-(OH)2D3
T14 738-751 cell_type denotes leukemic cell
T15 817-824 atom denotes calcium
T16 883-901 lipid denotes 1 alpha,25-(OH)2D3
T17 907-928 lipid denotes 11 beta-methyl analog
T18 1013-1025 lipid denotes C-11 analogs
T19 1029-1060 cell_line denotes human promyeloid leukemia cells
T20 1062-1067 cell_line denotes HL-60
T21 1202-1221 other_name denotes polar substitutions
T22 1225-1229 lipid denotes C-11
T23 1233-1251 lipid denotes 1 alpha,25-(OH)2D3
T24 1283-1292 lipid denotes vitamin D
T25 1331-1356 protein_family_or_group denotes vitamin D-binding protein
T26 1378-1394 lipid denotes C-11-substituted
T27 1395-1413 lipid denotes 1 alpha,25-(OH)2D3
T28 1425-1430 cell_line denotes HL-60
T29 1479-1486 atom denotes calcium

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 770-774 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T2 1092-1096 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1046-1054 Phenotype denotes leukemia HP:0001909

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1046-1054 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1029-1034 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 770-774 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T3 1092-1096 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481