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PubMed:1309587 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 4-21 DNA denotes cellular oncogene
T2 22-27 DNA denotes c-myb
T3 66-105 protein denotes Epstein-Barr virus BZLF1 transactivator
T4 109-123 cell_type denotes lymphoid cells
T5 168-199 DNA denotes Epstein-Barr virus (EBV) genome
T6 236-272 protein denotes virally encoded transcription factor
T7 274-275 protein denotes Z
T8 277-282 protein denotes BZLF1
T9 308-322 protein denotes Z gene product
T10 339-349 DNA denotes AP-1 sites
T11 396-401 DNA denotes c-Fos
T12 432-450 DNA denotes EBV early promoter
T13 452-457 DNA denotes BMRF1
T14 488-498 cell_line denotes HeLa cells
T15 522-534 cell_line denotes Jurkat cells
T16 566-594 protein denotes c-myb proto-oncogene product
T17 614-633 protein denotes DNA-binding protein
T18 638-668 protein denotes transcriptional transactivator
T19 704-705 protein denotes Z
T20 724-738 DNA denotes BMRF1 promoter
T21 742-754 cell_line denotes Jurkat cells
T22 758-769 cell_line denotes T-cell line
T23 774-784 cell_line denotes Raji cells
T24 789-808 cell_line denotes EBV-positive B-cell
T25 823-841 protein denotes c-myb gene product
T26 875-905 DNA denotes simian virus 40 early promoter
T27 947-966 protein denotes Z/c-myb combination
T28 1003-1017 DNA denotes BMRF1 promoter
T29 1025-1044 protein denotes Z/c-myb combination
T30 1086-1095 protein denotes Z protein
T31 1108-1121 protein denotes c-myb protein
T32 1125-1139 DNA denotes 30-bp sequence
T33 1147-1161 DNA denotes BMRF1 promoter
T34 1179-1193 DNA denotes Z binding site
T35 1197-1216 DNA denotes consensus AP-1 site
T36 1295-1314 protein denotes Z/c-myb combination
T37 1320-1341 DNA denotes heterologous promoter
T38 1352-1374 protein denotes c-myb oncogene product
T39 1412-1430 protein denotes EBV-encoded member
T40 1438-1467 protein denotes leucine zipper protein family
T41 1477-1482 DNA denotes c-myb
T42 1532-1572 protein denotes cellularly encoded transcription factors

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-124 Sentence denotes The cellular oncogene c-myb can interact synergistically with the Epstein-Barr virus BZLF1 transactivator in lymphoid cells.
S2 125-284 Sentence denotes Regulation of replicative functions in the Epstein-Barr virus (EBV) genome is mediated through activation of a virally encoded transcription factor, Z (BZLF1).
S3 285-536 Sentence denotes We have shown that the Z gene product, which binds to AP-1 sites as a homodimer and has sequence similarity to c-Fos, can efficiently activate the EBV early promoter, BMRF1, in certain cell types (i.e., HeLa cells) but not others (i.e., Jurkat cells).
S4 537-870 Sentence denotes Here we demonstrate that the c-myb proto-oncogene product, which is itself a DNA-binding protein and transcriptional transactivator, can interact synergistically with Z in activating the BMRF1 promoter in Jurkat cells (a T-cell line) or Raji cells (an EBV-positive B-cell), whereas the c-myb gene product by itself has little effect.
S5 871-967 Sentence denotes The simian virus 40 early promoter is also synergistically activated by the Z/c-myb combination.
S6 968-1122 Sentence denotes Synergistic transactivation of the BMRF1 promoter by the Z/c-myb combination appears to involve direct binding by the Z protein but not the c-myb protein.
S7 1123-1342 Sentence denotes A 30-bp sequence in the BMRF1 promoter which contains a Z binding site (a consensus AP-1 site) is sufficient to transfer high-level lymphoid-specific responsiveness to the Z/c-myb combination to a heterologous promoter.
S8 1343-1573 Sentence denotes That the c-myb oncogene product can interact synergistically with an EBV-encoded member of the leucine zipper protein family suggests c-myb is likely to engage in similar interactions with cellularly encoded transcription factors.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-27 NP denotes The cellular oncogene c-myb
C3 62-84 NP denotes the Epstein-Barr virus
C2 62-105 NP denotes the Epstein-Barr virus BZLF1 transactivator
C4 164-199 NP denotes the Epstein-Barr virus (EBV) genome
C5 234-272 NP denotes a virally encoded transcription factor
C6 274-283 NP denotes Z (BZLF1)
C8 308-309 NP denotes Z
C7 304-322 NP denotes the Z gene product
C9 324-329 NP denotes which
C10 428-450 NP denotes the EBV early promoter
C11 452-457 NP denotes BMRF1
C12 522-534 NP denotes Jurkat cells
C14 566-571 NP denotes c-myb
C13 562-594 NP denotes the c-myb proto-oncogene product
C15 596-601 NP denotes which
C16 605-611 NP denotes itself
C17 704-705 NP denotes Z
C18 720-738 NP denotes the BMRF1 promoter
C19 742-754 NP denotes Jurkat cells
C21 823-828 NP denotes c-myb
C20 819-841 NP denotes the c-myb gene product
C22 845-851 NP denotes itself
C24 947-948 NP denotes Z
C25 949-954 NP denotes c-myb
C23 943-966 NP denotes the Z/c-myb combination
C26 999-1017 NP denotes the BMRF1 promoter
C28 1025-1026 NP denotes Z
C29 1027-1032 NP denotes c-myb
C27 1021-1044 NP denotes the Z/c-myb combination
C30 1143-1161 NP denotes the BMRF1 promoter
C31 1162-1167 NP denotes which
C33 1295-1296 NP denotes Z
C34 1297-1302 NP denotes c-myb
C32 1291-1314 NP denotes the Z/c-myb combination
C36 1352-1357 NP denotes c-myb
C35 1348-1374 NP denotes the c-myb oncogene product
C37 1477-1482 NP denotes c-myb
R1 C4 C3 coref-ident the Epstein-Barr virus (EBV) genome,the Epstein-Barr virus
R2 C5 C6 coref-appos a virally encoded transcription factor,Z (BZLF1)
R3 C6 C2 coref-ident Z (BZLF1),the Epstein-Barr virus BZLF1 transactivator
R4 C8 C6 coref-ident Z,Z (BZLF1)
R5 C9 C7 coref-relat which,the Z gene product
R6 C10 C11 coref-appos the EBV early promoter,BMRF1
R7 C14 C1 coref-ident c-myb,The cellular oncogene c-myb
R8 C15 C19 coref-relat which,Jurkat cells
R9 C16 C13 coref-pron itself,the c-myb proto-oncogene product
R10 C17 C8 coref-ident Z,Z
R11 C18 C11 coref-ident the BMRF1 promoter,BMRF1
R12 C19 C12 coref-ident Jurkat cells,Jurkat cells
R13 C21 C14 coref-ident c-myb,c-myb
R14 C20 C13 coref-ident the c-myb gene product,the c-myb proto-oncogene product
R15 C22 C20 coref-pron itself,the c-myb gene product
R16 C24 C17 coref-ident Z,Z
R17 C25 C21 coref-ident c-myb,c-myb
R18 C26 C18 coref-ident the BMRF1 promoter,the BMRF1 promoter
R19 C28 C24 coref-ident Z,Z
R20 C29 C25 coref-ident c-myb,c-myb
R21 C27 C23 coref-ident the Z/c-myb combination,the Z/c-myb combination
R22 C30 C26 coref-ident the BMRF1 promoter,the BMRF1 promoter
R23 C31 C30 coref-relat which,the BMRF1 promoter
R24 C33 C28 coref-ident Z,Z
R25 C34 C29 coref-ident c-myb,c-myb
R26 C32 C27 coref-ident the Z/c-myb combination,the Z/c-myb combination
R27 C36 C34 coref-ident c-myb,c-myb
R28 C35 C20 coref-ident the c-myb oncogene product,the c-myb gene product
R29 C37 C36 coref-ident c-myb,c-myb

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 4-21 DNA_family_or_group denotes cellular oncogene
T2 22-27 DNA_domain_or_region denotes c-myb
T3 66-105 protein_molecule denotes Epstein-Barr virus BZLF1 transactivator
T4 109-123 cell_type denotes lymphoid cells
T5 168-186 virus denotes Epstein-Barr virus
T6 188-191 virus denotes EBV
T7 236-272 protein_family_or_group denotes virally encoded transcription factor
T8 274-275 protein_molecule denotes Z
T9 277-282 protein_molecule denotes BZLF1
T10 308-322 protein_molecule denotes Z gene product
T11 339-349 DNA_domain_or_region denotes AP-1 sites
T12 396-401 DNA_domain_or_region denotes c-Fos
T13 432-435 virus denotes EBV
T14 452-457 DNA_domain_or_region denotes BMRF1
T15 488-498 cell_line denotes HeLa cells
T16 522-534 cell_line denotes Jurkat cells
T17 566-571 DNA_domain_or_region denotes c-myb
T18 614-633 protein_family_or_group denotes DNA-binding protein
T19 638-668 protein_family_or_group denotes transcriptional transactivator
T20 704-705 protein_molecule denotes Z
T21 724-738 DNA_domain_or_region denotes BMRF1 promoter
T22 742-754 cell_line denotes Jurkat cells
T23 758-769 cell_line denotes T-cell line
T24 774-784 cell_line denotes Raji cells
T25 789-792 virus denotes EBV
T26 823-841 protein_molecule denotes c-myb gene product
T27 875-890 virus denotes simian virus 40
T28 947-966 protein_complex denotes Z/c-myb combination
T29 1003-1017 DNA_domain_or_region denotes BMRF1 promoter
T30 1025-1044 protein_complex denotes Z/c-myb combination
T31 1086-1095 protein_molecule denotes Z protein
T32 1108-1113 DNA_domain_or_region denotes c-myb
T33 1125-1139 DNA_domain_or_region denotes 30-bp sequence
T34 1147-1161 DNA_domain_or_region denotes BMRF1 promoter
T35 1179-1193 DNA_domain_or_region denotes Z binding site
T36 1197-1216 DNA_domain_or_region denotes consensus AP-1 site
T37 1244-1254 other_name denotes high-level
T38 1255-1287 other_name denotes lymphoid-specific responsiveness
T39 1295-1314 protein_complex denotes Z/c-myb combination
T40 1320-1341 DNA_domain_or_region denotes heterologous promoter
T41 1352-1357 DNA_domain_or_region denotes c-myb
T42 1412-1415 virus denotes EBV
T43 1438-1452 protein_substructure denotes leucine zipper
T44 1477-1482 DNA_domain_or_region denotes c-myb
T45 1532-1550 protein_family_or_group denotes cellularly encoded
T46 1551-1572 protein_family_or_group denotes transcription factors