PubMed:1299224 JSONTXT

{"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":90,"end":100},"obj":"protein"},{"id":"T2","span":{"begin":126,"end":171},"obj":"DNA"},{"id":"T3","span":{"begin":213,"end":245},"obj":"DNA"},{"id":"T4","span":{"begin":270,"end":280},"obj":"protein"},{"id":"T5","span":{"begin":360,"end":403},"obj":"cell_line"},{"id":"T6","span":{"begin":418,"end":458},"obj":"cell_line"},{"id":"T7","span":{"begin":497,"end":500},"obj":"protein"},{"id":"T8","span":{"begin":578,"end":588},"obj":"protein"},{"id":"T9","span":{"begin":668,"end":678},"obj":"protein"}],"text":"Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappa B.\nMice transgenic for the human T cell leukemia virus (HTLV-I) Tax gene develop fibroblastic tumors that express NF-kappa B-inducible early genes. In vitro inhibition of NF-kappa B expression by antisense oligodeoxynucleotides (ODNs) inhibited growth of these culture-adapted Tax-transformed fibroblasts as well as an HTLV-I-transformed human lymphocyte line. In contrast, antisense inhibition of Tax itself had no apparent effect on cell growth. Mice treated with antisense to NF-kappa B ODNs showed rapid regression of transplanted fibrosarcomas. This suggests that NF-kappa B expression may be necessary for the maintenance of the malignant phenotype and provides a therapeutic approach for HTLV-I-associated disease."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"1299224-1#61#64#gene6900","span":{"begin":163,"end":166},"obj":"gene6900"},{"id":"1299224-1#24#45#diseaseC0023493","span":{"begin":126,"end":147},"obj":"diseaseC0023493"}],"relations":[{"id":"61#64#gene690024#45#diseaseC0023493","pred":"associated_with","subj":"1299224-1#61#64#gene6900","obj":"1299224-1#24#45#diseaseC0023493"}],"text":"Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappa B.\nMice transgenic for the human T cell leukemia virus (HTLV-I) Tax gene develop fibroblastic tumors that express NF-kappa B-inducible early genes. In vitro inhibition of NF-kappa B expression by antisense oligodeoxynucleotides (ODNs) inhibited growth of these culture-adapted Tax-transformed fibroblasts as well as an HTLV-I-transformed human lymphocyte line. In contrast, antisense inhibition of Tax itself had no apparent effect on cell growth. Mice treated with antisense to NF-kappa B ODNs showed rapid regression of transplanted fibrosarcomas. This suggests that NF-kappa B expression may be necessary for the maintenance of the malignant phenotype and provides a therapeutic approach for HTLV-I-associated disease."}

{"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":101},"obj":"Sentence"},{"id":"S2","span":{"begin":102,"end":246},"obj":"Sentence"},{"id":"S3","span":{"begin":247,"end":459},"obj":"Sentence"},{"id":"S4","span":{"begin":460,"end":546},"obj":"Sentence"},{"id":"S5","span":{"begin":547,"end":648},"obj":"Sentence"},{"id":"S6","span":{"begin":649,"end":820},"obj":"Sentence"}],"text":"Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappa B.\nMice transgenic for the human T cell leukemia virus (HTLV-I) Tax gene develop fibroblastic tumors that express NF-kappa B-inducible early genes. In vitro inhibition of NF-kappa B expression by antisense oligodeoxynucleotides (ODNs) inhibited growth of these culture-adapted Tax-transformed fibroblasts as well as an HTLV-I-transformed human lymphocyte line. In contrast, antisense inhibition of Tax itself had no apparent effect on cell growth. Mice treated with antisense to NF-kappa B ODNs showed rapid regression of transplanted fibrosarcomas. This suggests that NF-kappa B expression may be necessary for the maintenance of the malignant phenotype and provides a therapeutic approach for HTLV-I-associated disease."}

{"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":58,"end":62},"obj":"NP"},{"id":"C3","span":{"begin":90,"end":100},"obj":"NP"},{"id":"C2","span":{"begin":66,"end":100},"obj":"NP"},{"id":"C5","span":{"begin":122,"end":171},"obj":"NP"},{"id":"C4","span":{"begin":102,"end":171},"obj":"NP"},{"id":"C6","span":{"begin":180,"end":199},"obj":"NP"},{"id":"C7","span":{"begin":200,"end":204},"obj":"NP"},{"id":"C10","span":{"begin":270,"end":280},"obj":"NP"},{"id":"C9","span":{"begin":270,"end":291},"obj":"NP"},{"id":"C11","span":{"begin":305,"end":333},"obj":"NP"},{"id":"C8","span":{"begin":247,"end":333},"obj":"NP"},{"id":"C12","span":{"begin":497,"end":500},"obj":"NP"},{"id":"C13","span":{"begin":501,"end":507},"obj":"NP"},{"id":"C15","span":{"begin":578,"end":588},"obj":"NP"},{"id":"C16","span":{"begin":589,"end":593},"obj":"NP"},{"id":"C14","span":{"begin":547,"end":593},"obj":"NP"},{"id":"C18","span":{"begin":668,"end":678},"obj":"NP"},{"id":"C17","span":{"begin":668,"end":689},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-other","subj":"C4","obj":"C1"},{"id":"R2","pred":"coref-relat","subj":"C7","obj":"C6"},{"id":"R3","pred":"coref-ident","subj":"C10","obj":"C3"},{"id":"R4","pred":"coref-other","subj":"C8","obj":"C2"},{"id":"R5","pred":"coref-other","subj":"C12","obj":"C5"},{"id":"R6","pred":"coref-pron","subj":"C13","obj":"C12"},{"id":"R7","pred":"coref-ident","subj":"C15","obj":"C10"},{"id":"R8","pred":"coref-ident","subj":"C16","obj":"C11"},{"id":"R9","pred":"coref-other","subj":"C14","obj":"C4"},{"id":"R10","pred":"coref-ident","subj":"C18","obj":"C15"},{"id":"R11","pred":"coref-ident","subj":"C17","obj":"C9"}],"text":"Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappa B.\nMice transgenic for the human T cell leukemia virus (HTLV-I) Tax gene develop fibroblastic tumors that express NF-kappa B-inducible early genes. In vitro inhibition of NF-kappa B expression by antisense oligodeoxynucleotides (ODNs) inhibited growth of these culture-adapted Tax-transformed fibroblasts as well as an HTLV-I-transformed human lymphocyte line. In contrast, antisense inhibition of Tax itself had no apparent effect on cell growth. Mice treated with antisense to NF-kappa B ODNs showed rapid regression of transplanted fibrosarcomas. This suggests that NF-kappa B expression may be necessary for the maintenance of the malignant phenotype and provides a therapeutic approach for HTLV-I-associated disease."}

{"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":25,"end":54},"obj":"tissue"},{"id":"T2","span":{"begin":58,"end":62},"obj":"multi_cell"},{"id":"T3","span":{"begin":66,"end":86},"obj":"other_name"},{"id":"T4","span":{"begin":90,"end":100},"obj":"protein_molecule"},{"id":"T5","span":{"begin":103,"end":106},"obj":"multi_cell"},{"id":"T6","span":{"begin":126,"end":153},"obj":"virus"},{"id":"T7","span":{"begin":155,"end":161},"obj":"virus"},{"id":"T8","span":{"begin":163,"end":166},"obj":"protein_molecule"},{"id":"T9","span":{"begin":180,"end":199},"obj":"tissue"},{"id":"T10","span":{"begin":213,"end":245},"obj":"DNA_family_or_group"},{"id":"T11","span":{"begin":270,"end":280},"obj":"protein_molecule"},{"id":"T12","span":{"begin":295,"end":326},"obj":"polynucleotide"},{"id":"T13","span":{"begin":328,"end":332},"obj":"polynucleotide"},{"id":"T14","span":{"begin":360,"end":403},"obj":"cell_line"},{"id":"T15","span":{"begin":418,"end":424},"obj":"virus"},{"id":"T16","span":{"begin":473,"end":493},"obj":"other_name"},{"id":"T17","span":{"begin":497,"end":500},"obj":"protein_molecule"},{"id":"T18","span":{"begin":547,"end":551},"obj":"multi_cell"},{"id":"T19","span":{"begin":578,"end":588},"obj":"protein_molecule"},{"id":"T20","span":{"begin":589,"end":593},"obj":"polynucleotide"},{"id":"T21","span":{"begin":634,"end":647},"obj":"tissue"},{"id":"T22","span":{"begin":668,"end":678},"obj":"protein_molecule"},{"id":"T23","span":{"begin":734,"end":753},"obj":"other_name"},{"id":"T24","span":{"begin":794,"end":800},"obj":"virus"}],"text":"Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappa B.\nMice transgenic for the human T cell leukemia virus (HTLV-I) Tax gene develop fibroblastic tumors that express NF-kappa B-inducible early genes. In vitro inhibition of NF-kappa B expression by antisense oligodeoxynucleotides (ODNs) inhibited growth of these culture-adapted Tax-transformed fibroblasts as well as an HTLV-I-transformed human lymphocyte line. In contrast, antisense inhibition of Tax itself had no apparent effect on cell growth. Mice treated with antisense to NF-kappa B ODNs showed rapid regression of transplanted fibrosarcomas. This suggests that NF-kappa B expression may be necessary for the maintenance of the malignant phenotype and provides a therapeutic approach for HTLV-I-associated disease."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":163,"end":166},"obj":"gene:6900"},{"id":"T1","span":{"begin":126,"end":147},"obj":"disease:C0023493"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappa B.\nMice transgenic for the human T cell leukemia virus (HTLV-I) Tax gene develop fibroblastic tumors that express NF-kappa B-inducible early genes. In vitro inhibition of NF-kappa B expression by antisense oligodeoxynucleotides (ODNs) inhibited growth of these culture-adapted Tax-transformed fibroblasts as well as an HTLV-I-transformed human lymphocyte line. In contrast, antisense inhibition of Tax itself had no apparent effect on cell growth. Mice treated with antisense to NF-kappa B ODNs showed rapid regression of transplanted fibrosarcomas. This suggests that NF-kappa B expression may be necessary for the maintenance of the malignant phenotype and provides a therapeutic approach for HTLV-I-associated disease."}