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PubMed:12975616 JSONTXT

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GlyCosmos15-Species

Id Subject Object Predicate Lexical cue db_id
2 0-4 Species denotes Mice 10090
35 678-682 Species denotes mice 10090
38 712-716 Species denotes mice 10090
40 874-878 Species denotes mice 10090
44 1111-1115 Species denotes mice 10090

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 18-33 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T2 114-129 http://www.glycoepitope.jp/epitopes/EP0086 denotes Heparan sulfate
T3 202-217 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate
T4 443-458 http://www.glycoepitope.jp/epitopes/EP0086 denotes heparan sulfate

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 948-979 HP_0001511 denotes intrauterine growth retardation
T2 961-979 HP_0001510 denotes growth retardation
T3 1020-1032 HP_0003256 denotes coagulopathy

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-113 Sentence denotes Mice deficient in heparan sulfate 3-O-sulfotransferase-1: normal hemostasis with unexpected perinatal phenotypes.
TextSentencer_T2 114-330 Sentence denotes Heparan sulfate that contains antithrombin binding sites is designated as anticoagulant heparan sulfate (HS(act)) since, in vitro, it dramatically enhances the neutralization of coagulation proteases by antithrombin.
TextSentencer_T3 331-491 Sentence denotes Endothelial cell production of HS(act) is controlled by the Hs3st1 gene, which encodes the rate limiting enzyme-heparan sulfate 3-O-sulfotransferase-1 (Hs3st1).
TextSentencer_T4 492-590 Sentence denotes It has long been proposed that levels of endothelial HS(act) may tightly regulate hemostatic tone.
TextSentencer_T5 591-683 Sentence denotes This potential in vivo role of HS(act) was assessed by generating Hs3st1(-/-) knockout mice.
TextSentencer_T6 684-804 Sentence denotes Hs3st1(-/-) and Hs3st1(+/+) mice were evaluated with a variety of methods, capable of detecting altered hemostatic tone.
TextSentencer_T7 805-852 Sentence denotes However, both genotypes were indistinguishable.
TextSentencer_T8 853-980 Sentence denotes Instead, Hs3st1(-/-) mice exhibited lethality on a specific genetic background and also showed intrauterine growth retardation.
TextSentencer_T9 981-1033 Sentence denotes Neither phenotypes result from a gross coagulopathy.
TextSentencer_T10 1034-1162 Sentence denotes So although this enzyme produces the majority of tissue HS(act), Hs3st1(-/-) mice do not show an obvious procoagulant phenotype.
TextSentencer_T11 1163-1326 Sentence denotes These results suggest that the bulk of HS(act) is not essential for normal hemostasis and that hemostatic tone is not tightly regulated by total levels of HS(act).
TextSentencer_T12 1327-1477 Sentence denotes Moreover, the unanticipated non-thrombotic phenotypes suggest structure(s) derived from this enzyme might serve additional/alternative biologic roles.
T1 0-113 Sentence denotes Mice deficient in heparan sulfate 3-O-sulfotransferase-1: normal hemostasis with unexpected perinatal phenotypes.
T2 114-330 Sentence denotes Heparan sulfate that contains antithrombin binding sites is designated as anticoagulant heparan sulfate (HS(act)) since, in vitro, it dramatically enhances the neutralization of coagulation proteases by antithrombin.
T3 331-491 Sentence denotes Endothelial cell production of HS(act) is controlled by the Hs3st1 gene, which encodes the rate limiting enzyme-heparan sulfate 3-O-sulfotransferase-1 (Hs3st1).
T4 492-590 Sentence denotes It has long been proposed that levels of endothelial HS(act) may tightly regulate hemostatic tone.
T5 591-683 Sentence denotes This potential in vivo role of HS(act) was assessed by generating Hs3st1(-/-) knockout mice.
T6 684-804 Sentence denotes Hs3st1(-/-) and Hs3st1(+/+) mice were evaluated with a variety of methods, capable of detecting altered hemostatic tone.
T7 805-852 Sentence denotes However, both genotypes were indistinguishable.
T8 853-980 Sentence denotes Instead, Hs3st1(-/-) mice exhibited lethality on a specific genetic background and also showed intrauterine growth retardation.
T9 981-1033 Sentence denotes Neither phenotypes result from a gross coagulopathy.
T10 1034-1162 Sentence denotes So although this enzyme produces the majority of tissue HS(act), Hs3st1(-/-) mice do not show an obvious procoagulant phenotype.
T11 1163-1326 Sentence denotes These results suggest that the bulk of HS(act) is not essential for normal hemostasis and that hemostatic tone is not tightly regulated by total levels of HS(act).
T12 1327-1477 Sentence denotes Moreover, the unanticipated non-thrombotic phenotypes suggest structure(s) derived from this enzyme might serve additional/alternative biologic roles.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 948-979 Disease denotes intrauterine growth retardation http://purl.obolibrary.org/obo/MONDO_0005030
T2 1020-1032 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 948-979 Phenotype denotes intrauterine growth retardation HP:0001511
T2 1020-1032 Phenotype denotes coagulopathy HP:0003256

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 948-979 Phenotype denotes intrauterine growth retardation HP:0001511
T2 1020-1032 Phenotype denotes coagulopathy HP:0003256

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-113 Sentence denotes Mice deficient in heparan sulfate 3-O-sulfotransferase-1: normal hemostasis with unexpected perinatal phenotypes.
T2 114-330 Sentence denotes Heparan sulfate that contains antithrombin binding sites is designated as anticoagulant heparan sulfate (HS(act)) since, in vitro, it dramatically enhances the neutralization of coagulation proteases by antithrombin.
T3 331-491 Sentence denotes Endothelial cell production of HS(act) is controlled by the Hs3st1 gene, which encodes the rate limiting enzyme-heparan sulfate 3-O-sulfotransferase-1 (Hs3st1).
T4 492-590 Sentence denotes It has long been proposed that levels of endothelial HS(act) may tightly regulate hemostatic tone.
T5 591-683 Sentence denotes This potential in vivo role of HS(act) was assessed by generating Hs3st1(-/-) knockout mice.
T6 684-804 Sentence denotes Hs3st1(-/-) and Hs3st1(+/+) mice were evaluated with a variety of methods, capable of detecting altered hemostatic tone.
T7 805-852 Sentence denotes However, both genotypes were indistinguishable.
T8 853-980 Sentence denotes Instead, Hs3st1(-/-) mice exhibited lethality on a specific genetic background and also showed intrauterine growth retardation.
T9 981-1033 Sentence denotes Neither phenotypes result from a gross coagulopathy.
T10 1034-1162 Sentence denotes So although this enzyme produces the majority of tissue HS(act), Hs3st1(-/-) mice do not show an obvious procoagulant phenotype.
T11 1163-1326 Sentence denotes These results suggest that the bulk of HS(act) is not essential for normal hemostasis and that hemostatic tone is not tightly regulated by total levels of HS(act).
T12 1327-1477 Sentence denotes Moreover, the unanticipated non-thrombotic phenotypes suggest structure(s) derived from this enzyme might serve additional/alternative biologic roles.

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 948-979 Disease denotes intrauterine growth retardation MONDO:0005030
T2 1020-1032 Disease denotes coagulopathy MONDO:0001531

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 18-33 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T2 114-129 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T3 202-217 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T4 443-458 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 0-4 OrganismTaxon denotes Mice 10088
T2 678-682 OrganismTaxon denotes mice 10088
T3 712-716 OrganismTaxon denotes mice 10088
T4 874-878 OrganismTaxon denotes mice 10088
T5 1111-1115 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 331-347 Body_part denotes Endothelial cell http://purl.obolibrary.org/obo/CL_0000115
T2 1083-1089 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 331-347 Cell denotes Endothelial cell http://purl.obolibrary.org/obo/CL:0000115