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PubMed:12975615 JSONTXT

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Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 0-15 http://www.glycoepitope.jp/epitopes/EP0086 denotes Heparan sulfate

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 747-754 http://purl.obolibrary.org/obo/MAT_0000226 denotes embryos
T2 862-868 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T3 915-922 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidneys

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-67 Sentence denotes Heparan sulfate 2-O-sulfotransferase (Hs2st) and mouse development.
TextSentencer_T2 68-372 Sentence denotes Heparan sulphate 2-O-sulphotransferase (Hs2st) acts at an intermediate stage in the pathway of biosynthesis of heparan sulphate (HS), catalysing the transfer of sulphate from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to the C2-position of selected hexuronic acid residues within the maturing HS chain.
TextSentencer_T3 373-556 Sentence denotes It is well established that 2-O-sulphation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions.
TextSentencer_T4 557-695 Sentence denotes HS plays a central role in embryonic development and cellular function, modulating the activities of an extensive range of growth factors.
TextSentencer_T5 696-879 Sentence denotes Interestingly, in contrast to the early failure of embryos entirely lacking HS, Hs2st(-/-) mice survive until birth, but die perinatally due to a complete failure of kidney formation.
TextSentencer_T6 880-1023 Sentence denotes The phenotype of Hs2st(-/-) mutant kidneys suggests that signalling between two tissues, ureteric bud and metanephric mesenchyme, is disrupted.
TextSentencer_T7 1024-1100 Sentence denotes We discuss candidate signalling molecules that may mediate this interaction.
TextSentencer_T8 1101-1274 Sentence denotes The HS generated by these mice lacks 2-O-sulphate groups but is extensively modified above wild type levels by O-sulphation at C-6 of glucosamine-N-sulfate (GlcNS) residues.
TextSentencer_T9 1275-1368 Sentence denotes We will discuss the potentially altered role of this atypical HS in growth factor signalling.
T1 0-67 Sentence denotes Heparan sulfate 2-O-sulfotransferase (Hs2st) and mouse development.
T2 68-372 Sentence denotes Heparan sulphate 2-O-sulphotransferase (Hs2st) acts at an intermediate stage in the pathway of biosynthesis of heparan sulphate (HS), catalysing the transfer of sulphate from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to the C2-position of selected hexuronic acid residues within the maturing HS chain.
T3 373-556 Sentence denotes It is well established that 2-O-sulphation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions.
T4 557-695 Sentence denotes HS plays a central role in embryonic development and cellular function, modulating the activities of an extensive range of growth factors.
T5 696-879 Sentence denotes Interestingly, in contrast to the early failure of embryos entirely lacking HS, Hs2st(-/-) mice survive until birth, but die perinatally due to a complete failure of kidney formation.
T6 880-1023 Sentence denotes The phenotype of Hs2st(-/-) mutant kidneys suggests that signalling between two tissues, ureteric bud and metanephric mesenchyme, is disrupted.
T7 1024-1100 Sentence denotes We discuss candidate signalling molecules that may mediate this interaction.
T8 1101-1274 Sentence denotes The HS generated by these mice lacks 2-O-sulphate groups but is extensively modified above wild type levels by O-sulphation at C-6 of glucosamine-N-sulfate (GlcNS) residues.
T9 1275-1368 Sentence denotes We will discuss the potentially altered role of this atypical HS in growth factor signalling.

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 747-754 Body_part denotes embryos http://purl.obolibrary.org/obo/MAT_0000226
T2 862-868 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119
T3 915-922 Body_part denotes kidneys http://purl.obolibrary.org/obo/MAT_0000119

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-67 Sentence denotes Heparan sulfate 2-O-sulfotransferase (Hs2st) and mouse development.
T2 68-372 Sentence denotes Heparan sulphate 2-O-sulphotransferase (Hs2st) acts at an intermediate stage in the pathway of biosynthesis of heparan sulphate (HS), catalysing the transfer of sulphate from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to the C2-position of selected hexuronic acid residues within the maturing HS chain.
T3 373-556 Sentence denotes It is well established that 2-O-sulphation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions.
T4 557-695 Sentence denotes HS plays a central role in embryonic development and cellular function, modulating the activities of an extensive range of growth factors.
T5 696-879 Sentence denotes Interestingly, in contrast to the early failure of embryos entirely lacking HS, Hs2st(-/-) mice survive until birth, but die perinatally due to a complete failure of kidney formation.
T6 880-1023 Sentence denotes The phenotype of Hs2st(-/-) mutant kidneys suggests that signalling between two tissues, ureteric bud and metanephric mesenchyme, is disrupted.
T7 1024-1100 Sentence denotes We discuss candidate signalling molecules that may mediate this interaction.
T8 1101-1274 Sentence denotes The HS generated by these mice lacks 2-O-sulphate groups but is extensively modified above wild type levels by O-sulphation at C-6 of glucosamine-N-sulfate (GlcNS) residues.
T9 1275-1368 Sentence denotes We will discuss the potentially altered role of this atypical HS in growth factor signalling.

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 49-54 Organism denotes mouse 10088|10090
T3 787-791 Organism denotes mice 10088
T4 1127-1131 Organism denotes mice 10088

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 0-15 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 862-868 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T2 969-981 Body_part denotes ureteric bud http://purl.obolibrary.org/obo/UBERON_0000084
T3 986-1008 Body_part denotes metanephric mesenchyme http://purl.obolibrary.org/obo/UBERON_0003220

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 747-754 Body_part denotes embryos FMA:296970
T2 862-868 Body_part denotes kidney FMA:7203
T3 915-922 Body_part denotes kidneys FMA:7203
T4 960-967 Body_part denotes tissues FMA:9637
T5 969-981 Body_part denotes ureteric bud FMA:0326180

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 747-754 Body_part denotes embryos http://purl.obolibrary.org/obo/MAT_0000226
T2 862-868 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119
T3 915-922 Body_part denotes kidneys http://purl.obolibrary.org/obo/MAT_0000119

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 49-54 OrganismTaxon denotes mouse 10088|10090
T3 787-791 OrganismTaxon denotes mice 10088
T4 1127-1131 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 862-868 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T2 969-981 Body_part denotes ureteric bud http://purl.obolibrary.org/obo/UBERON_0000084
T3 986-1008 Body_part denotes metanephric mesenchyme http://purl.obolibrary.org/obo/UBERON_0003220