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PubMed:12964942 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 311-339 gene:63897 denotes amplified in breast cancer 1
T1 393-406 disease:C0006142 denotes breast cancer
T2 311-339 gene:63897 denotes amplified in breast cancer 1
T3 393-406 disease:C0678222 denotes breast cancer
R1 T0 T1 associated_with amplified in breast cancer 1,breast cancer
R2 T2 T3 associated_with amplified in breast cancer 1,breast cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
12964942-0#95#99#gene116833 95-99 gene116833 denotes AIB1
12964942-0#95#99#gene8202 95-99 gene8202 denotes AIB1
12964942-0#26#39#diseaseC0006142 26-39 diseaseC0006142 denotes breast cancer
12964942-0#26#39#diseaseC0678222 26-39 diseaseC0678222 denotes breast cancer
12964942-0#26#39#diseaseC0006142 26-39 diseaseC0006142 denotes breast cancer
12964942-0#26#39#diseaseC0678222 26-39 diseaseC0678222 denotes breast cancer
12964942-2#4#8#gene2956 270-274 gene2956 denotes p160
12964942-2#4#8#gene10514 270-274 gene10514 denotes p160
12964942-2#4#8#gene27043 270-274 gene27043 denotes p160
12964942-2#45#73#gene63897 311-339 gene63897 denotes amplified in breast cancer 1
12964942-2#127#140#diseaseC0006142 393-406 diseaseC0006142 denotes breast cancer
12964942-2#127#140#diseaseC0678222 393-406 diseaseC0678222 denotes breast cancer
12964942-2#127#140#diseaseC0006142 393-406 diseaseC0006142 denotes breast cancer
12964942-2#127#140#diseaseC0678222 393-406 diseaseC0678222 denotes breast cancer
12964942-2#127#140#diseaseC0006142 393-406 diseaseC0006142 denotes breast cancer
12964942-2#127#140#diseaseC0678222 393-406 diseaseC0678222 denotes breast cancer
12964942-2#127#140#diseaseC0006142 393-406 diseaseC0006142 denotes breast cancer
12964942-2#127#140#diseaseC0678222 393-406 diseaseC0678222 denotes breast cancer
12964942-3#172#189#gene2099 654-671 gene2099 denotes estrogen-receptor
12964942-3#191#193#gene2099 673-675 gene2099 denotes ER
12964942-3#204#217#diseaseC0006142 686-699 diseaseC0006142 denotes breast cancer
12964942-3#204#217#diseaseC0678222 686-699 diseaseC0678222 denotes breast cancer
12964942-3#204#217#diseaseC0006142 686-699 diseaseC0006142 denotes breast cancer
12964942-3#204#217#diseaseC0678222 686-699 diseaseC0678222 denotes breast cancer
95#99#gene11683326#39#diseaseC0006142 12964942-0#95#99#gene116833 12964942-0#26#39#diseaseC0006142 associated_with AIB1,breast cancer
95#99#gene11683326#39#diseaseC0678222 12964942-0#95#99#gene116833 12964942-0#26#39#diseaseC0678222 associated_with AIB1,breast cancer
95#99#gene11683326#39#diseaseC0006142 12964942-0#95#99#gene116833 12964942-0#26#39#diseaseC0006142 associated_with AIB1,breast cancer
95#99#gene11683326#39#diseaseC0678222 12964942-0#95#99#gene116833 12964942-0#26#39#diseaseC0678222 associated_with AIB1,breast cancer
95#99#gene820226#39#diseaseC0006142 12964942-0#95#99#gene8202 12964942-0#26#39#diseaseC0006142 associated_with AIB1,breast cancer
95#99#gene820226#39#diseaseC0678222 12964942-0#95#99#gene8202 12964942-0#26#39#diseaseC0678222 associated_with AIB1,breast cancer
95#99#gene820226#39#diseaseC0006142 12964942-0#95#99#gene8202 12964942-0#26#39#diseaseC0006142 associated_with AIB1,breast cancer
95#99#gene820226#39#diseaseC0678222 12964942-0#95#99#gene8202 12964942-0#26#39#diseaseC0678222 associated_with AIB1,breast cancer
4#8#gene2956127#140#diseaseC0006142 12964942-2#4#8#gene2956 12964942-2#127#140#diseaseC0006142 associated_with p160,breast cancer
4#8#gene2956127#140#diseaseC0678222 12964942-2#4#8#gene2956 12964942-2#127#140#diseaseC0678222 associated_with p160,breast cancer
4#8#gene2956127#140#diseaseC0006142 12964942-2#4#8#gene2956 12964942-2#127#140#diseaseC0006142 associated_with p160,breast cancer
4#8#gene2956127#140#diseaseC0678222 12964942-2#4#8#gene2956 12964942-2#127#140#diseaseC0678222 associated_with p160,breast cancer
4#8#gene2956127#140#diseaseC0006142 12964942-2#4#8#gene2956 12964942-2#127#140#diseaseC0006142 associated_with p160,breast cancer
4#8#gene2956127#140#diseaseC0678222 12964942-2#4#8#gene2956 12964942-2#127#140#diseaseC0678222 associated_with p160,breast cancer
4#8#gene2956127#140#diseaseC0006142 12964942-2#4#8#gene2956 12964942-2#127#140#diseaseC0006142 associated_with p160,breast cancer
4#8#gene2956127#140#diseaseC0678222 12964942-2#4#8#gene2956 12964942-2#127#140#diseaseC0678222 associated_with p160,breast cancer
4#8#gene10514127#140#diseaseC0006142 12964942-2#4#8#gene10514 12964942-2#127#140#diseaseC0006142 associated_with p160,breast cancer
4#8#gene10514127#140#diseaseC0678222 12964942-2#4#8#gene10514 12964942-2#127#140#diseaseC0678222 associated_with p160,breast cancer
4#8#gene10514127#140#diseaseC0006142 12964942-2#4#8#gene10514 12964942-2#127#140#diseaseC0006142 associated_with p160,breast cancer
4#8#gene10514127#140#diseaseC0678222 12964942-2#4#8#gene10514 12964942-2#127#140#diseaseC0678222 associated_with p160,breast cancer
4#8#gene10514127#140#diseaseC0006142 12964942-2#4#8#gene10514 12964942-2#127#140#diseaseC0006142 associated_with p160,breast cancer
4#8#gene10514127#140#diseaseC0678222 12964942-2#4#8#gene10514 12964942-2#127#140#diseaseC0678222 associated_with p160,breast cancer
4#8#gene10514127#140#diseaseC0006142 12964942-2#4#8#gene10514 12964942-2#127#140#diseaseC0006142 associated_with p160,breast cancer
4#8#gene10514127#140#diseaseC0678222 12964942-2#4#8#gene10514 12964942-2#127#140#diseaseC0678222 associated_with p160,breast cancer
4#8#gene27043127#140#diseaseC0006142 12964942-2#4#8#gene27043 12964942-2#127#140#diseaseC0006142 associated_with p160,breast cancer
4#8#gene27043127#140#diseaseC0678222 12964942-2#4#8#gene27043 12964942-2#127#140#diseaseC0678222 associated_with p160,breast cancer
4#8#gene27043127#140#diseaseC0006142 12964942-2#4#8#gene27043 12964942-2#127#140#diseaseC0006142 associated_with p160,breast cancer
4#8#gene27043127#140#diseaseC0678222 12964942-2#4#8#gene27043 12964942-2#127#140#diseaseC0678222 associated_with p160,breast cancer
4#8#gene27043127#140#diseaseC0006142 12964942-2#4#8#gene27043 12964942-2#127#140#diseaseC0006142 associated_with p160,breast cancer
4#8#gene27043127#140#diseaseC0678222 12964942-2#4#8#gene27043 12964942-2#127#140#diseaseC0678222 associated_with p160,breast cancer
4#8#gene27043127#140#diseaseC0006142 12964942-2#4#8#gene27043 12964942-2#127#140#diseaseC0006142 associated_with p160,breast cancer
4#8#gene27043127#140#diseaseC0678222 12964942-2#4#8#gene27043 12964942-2#127#140#diseaseC0678222 associated_with p160,breast cancer
45#73#gene63897127#140#diseaseC0006142 12964942-2#45#73#gene63897 12964942-2#127#140#diseaseC0006142 associated_with amplified in breast cancer 1,breast cancer
45#73#gene63897127#140#diseaseC0678222 12964942-2#45#73#gene63897 12964942-2#127#140#diseaseC0678222 associated_with amplified in breast cancer 1,breast cancer
45#73#gene63897127#140#diseaseC0006142 12964942-2#45#73#gene63897 12964942-2#127#140#diseaseC0006142 associated_with amplified in breast cancer 1,breast cancer
45#73#gene63897127#140#diseaseC0678222 12964942-2#45#73#gene63897 12964942-2#127#140#diseaseC0678222 associated_with amplified in breast cancer 1,breast cancer
45#73#gene63897127#140#diseaseC0006142 12964942-2#45#73#gene63897 12964942-2#127#140#diseaseC0006142 associated_with amplified in breast cancer 1,breast cancer
45#73#gene63897127#140#diseaseC0678222 12964942-2#45#73#gene63897 12964942-2#127#140#diseaseC0678222 associated_with amplified in breast cancer 1,breast cancer
45#73#gene63897127#140#diseaseC0006142 12964942-2#45#73#gene63897 12964942-2#127#140#diseaseC0006142 associated_with amplified in breast cancer 1,breast cancer
45#73#gene63897127#140#diseaseC0678222 12964942-2#45#73#gene63897 12964942-2#127#140#diseaseC0678222 associated_with amplified in breast cancer 1,breast cancer
172#189#gene2099204#217#diseaseC0006142 12964942-3#172#189#gene2099 12964942-3#204#217#diseaseC0006142 associated_with estrogen-receptor,breast cancer
172#189#gene2099204#217#diseaseC0678222 12964942-3#172#189#gene2099 12964942-3#204#217#diseaseC0678222 associated_with estrogen-receptor,breast cancer
172#189#gene2099204#217#diseaseC0006142 12964942-3#172#189#gene2099 12964942-3#204#217#diseaseC0006142 associated_with estrogen-receptor,breast cancer
172#189#gene2099204#217#diseaseC0678222 12964942-3#172#189#gene2099 12964942-3#204#217#diseaseC0678222 associated_with estrogen-receptor,breast cancer
191#193#gene2099204#217#diseaseC0006142 12964942-3#191#193#gene2099 12964942-3#204#217#diseaseC0006142 associated_with ER,breast cancer
191#193#gene2099204#217#diseaseC0678222 12964942-3#191#193#gene2099 12964942-3#204#217#diseaseC0678222 associated_with ER,breast cancer
191#193#gene2099204#217#diseaseC0006142 12964942-3#191#193#gene2099 12964942-3#204#217#diseaseC0006142 associated_with ER,breast cancer
191#193#gene2099204#217#diseaseC0678222 12964942-3#191#193#gene2099 12964942-3#204#217#diseaseC0678222 associated_with ER,breast cancer

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 113-472 BACKGROUND denotes Estrogen signaling plays a critical role in a number of normal physiological processes and has important implications in the treatment of breast cancer. The p160 nuclear receptor coactivator, AIB1 (amplified in breast cancer 1), is frequently amplified and overexpressed in human breast cancer and has been shown to enhance estrogen-dependent transactivation.
T2 482-873 METHODS denotes To better understand the molecular and physiological consequences of AIB1 overexpression in breast cancer cells, an AIB1 cDNA was transfected into the low AIB1 expressing, estrogen-receptor (ER) negative breast cancer cell line, MDA-MB-436. The features of a derivative cell line, designated 436.1, which expresses high levels of AIB1, are described and compared with the parental cell line.
T3 883-1467 RESULTS denotes A significant increase in the levels of CREB binding protein (CBP) was observed in 436.1 cells and immunofluorescent staining revealed altered AIB1 and CBP staining patterns compared to the parental cells. Further, transient transfection assays demonstrated that the overall estrogen-dependent transactivation in 436.1 cells is approximately 20-fold higher than the parental cells and the estrogen dose-response curve is repositioned to the right. Finally, cDNA microarray analysis of approximately 7,100 cDNAs identified a number of differentially expressed genes in the 436.1 cells.
T4 1480-1575 CONCLUSIONS denotes These observations lend insight into downstream signaling pathways that are influenced by AIB1.