PubMed:12933821
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-98 | Sentence | denotes | Transcriptional regulation of CHI3L1, a marker gene for late stages of macrophage differentiation. |
| T2 | 99-275 | Sentence | denotes | The protein product of the CHI3L1 gene, human cartilage 39-kDa glycoprotein (HC-gp39), is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18. |
| T3 | 276-445 | Sentence | denotes | In contrast to many other monocyte/macrophage markers, its expression is absent in monocytes and strongly induced during late stages of human macrophage differentiation. |
| T4 | 446-645 | Sentence | denotes | To gain insights into the molecular mechanisms underlying its cell type-restricted and maturation-associated expression in macrophages, we initiated a detailed study of the proximal HC-gp39 promoter. |
| T5 | 646-880 | Sentence | denotes | Deletion analysis of reporter constructs in macrophage-like THP-1 cells localized a region directing high levels of macrophage-specific reporter gene expression to approximately 300 bp adjacent to the major transcriptional start site. |
| T6 | 881-1078 | Sentence | denotes | The promoter sequence contained consensus binding sites for several known factors, and specific binding of nuclear PU.1, Sp1, Sp3, USF, AML-1, and C/EBP proteins was detectable in gel shift assays. |
| T7 | 1079-1240 | Sentence | denotes | In vivo footprinting assays with dimethyl sulfate demonstrate that the protection of corresponding sequences was enhanced in macrophages compared with monocytes. |
| T8 | 1241-1398 | Sentence | denotes | Mutational analysis of transcription factor binding sites indicated a predominant role for a single Sp1 binding site in regulating HC-gp39 promoter activity. |
| T9 | 1399-1593 | Sentence | denotes | In addition, gel shift assays using nuclear extracts of monocytes and macrophages demonstrated that the binding of nuclear Sp1, but not Sp3, markedly increases during macrophage differentiation. |
| T10 | 1594-1680 | Sentence | denotes | Our results further highlight the important role of Sp1 in macrophage gene regulation. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 145-154 | http://purl.obolibrary.org/obo/MAT_0000189 | denotes | cartilage |
| T2 | 619-627 | http://purl.obolibrary.org/obo/MAT_0000491 | denotes | proximal |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1017-1020 | Disease | denotes | AML | http://purl.obolibrary.org/obo/MONDO_0018874 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 145-154 | Body_part | denotes | cartilage | http://purl.obolibrary.org/obo/MAT_0000189 |
| T2 | 619-627 | Body_part | denotes | proximal | http://purl.obolibrary.org/obo/MAT_0000491 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 1017-1020 | Phenotype | denotes | AML | HP:0004808 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 210-216 | Glycan | denotes | chitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1017-1020 | Disease | denotes | AML | http://purl.obolibrary.org/obo/MONDO_0018874 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 139-144 | OrganismTaxon | denotes | human | 9606 |
| T2 | 412-417 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 71-81 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T3 | 302-310 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T5 | 311-321 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T7 | 359-368 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T9 | 418-428 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T11 | 569-580 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T13 | 690-700 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T15 | 762-772 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T17 | 1204-1215 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T19 | 1230-1239 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T21 | 1455-1464 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T23 | 1469-1480 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T25 | 1566-1576 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T27 | 1653-1663 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 71-81 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T2 | 145-154 | Body_part | denotes | cartilage | http://purl.obolibrary.org/obo/UBERON_0002418|http://purl.obolibrary.org/obo/UBERON_0007844 |
| T4 | 191-197 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T5 | 302-310 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T7 | 311-321 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T8 | 359-368 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T10 | 418-428 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T11 | 569-580 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T12 | 690-700 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T13 | 762-772 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T14 | 1204-1215 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T15 | 1230-1239 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T17 | 1455-1464 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T19 | 1469-1480 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T20 | 1566-1576 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T21 | 1653-1663 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 145-154 | Body_part | denotes | cartilage | http://purl.obolibrary.org/obo/MAT_0000189 |
| T2 | 619-627 | Body_part | denotes | proximal | http://purl.obolibrary.org/obo/MAT_0000491 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-98 | Sentence | denotes | Transcriptional regulation of CHI3L1, a marker gene for late stages of macrophage differentiation. |
| T2 | 99-275 | Sentence | denotes | The protein product of the CHI3L1 gene, human cartilage 39-kDa glycoprotein (HC-gp39), is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18. |
| T3 | 276-445 | Sentence | denotes | In contrast to many other monocyte/macrophage markers, its expression is absent in monocytes and strongly induced during late stages of human macrophage differentiation. |
| T4 | 446-645 | Sentence | denotes | To gain insights into the molecular mechanisms underlying its cell type-restricted and maturation-associated expression in macrophages, we initiated a detailed study of the proximal HC-gp39 promoter. |
| T5 | 646-880 | Sentence | denotes | Deletion analysis of reporter constructs in macrophage-like THP-1 cells localized a region directing high levels of macrophage-specific reporter gene expression to approximately 300 bp adjacent to the major transcriptional start site. |
| T6 | 881-1078 | Sentence | denotes | The promoter sequence contained consensus binding sites for several known factors, and specific binding of nuclear PU.1, Sp1, Sp3, USF, AML-1, and C/EBP proteins was detectable in gel shift assays. |
| T7 | 1079-1240 | Sentence | denotes | In vivo footprinting assays with dimethyl sulfate demonstrate that the protection of corresponding sequences was enhanced in macrophages compared with monocytes. |
| T8 | 1241-1398 | Sentence | denotes | Mutational analysis of transcription factor binding sites indicated a predominant role for a single Sp1 binding site in regulating HC-gp39 promoter activity. |
| T9 | 1399-1593 | Sentence | denotes | In addition, gel shift assays using nuclear extracts of monocytes and macrophages demonstrated that the binding of nuclear Sp1, but not Sp3, markedly increases during macrophage differentiation. |
| T10 | 1594-1680 | Sentence | denotes | Our results further highlight the important role of Sp1 in macrophage gene regulation. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-98 | Sentence | denotes | Transcriptional regulation of CHI3L1, a marker gene for late stages of macrophage differentiation. |
| T2 | 99-275 | Sentence | denotes | The protein product of the CHI3L1 gene, human cartilage 39-kDa glycoprotein (HC-gp39), is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18. |
| T3 | 276-445 | Sentence | denotes | In contrast to many other monocyte/macrophage markers, its expression is absent in monocytes and strongly induced during late stages of human macrophage differentiation. |
| T4 | 446-645 | Sentence | denotes | To gain insights into the molecular mechanisms underlying its cell type-restricted and maturation-associated expression in macrophages, we initiated a detailed study of the proximal HC-gp39 promoter. |
| T5 | 646-880 | Sentence | denotes | Deletion analysis of reporter constructs in macrophage-like THP-1 cells localized a region directing high levels of macrophage-specific reporter gene expression to approximately 300 bp adjacent to the major transcriptional start site. |
| T6 | 881-1078 | Sentence | denotes | The promoter sequence contained consensus binding sites for several known factors, and specific binding of nuclear PU.1, Sp1, Sp3, USF, AML-1, and C/EBP proteins was detectable in gel shift assays. |
| T7 | 1079-1240 | Sentence | denotes | In vivo footprinting assays with dimethyl sulfate demonstrate that the protection of corresponding sequences was enhanced in macrophages compared with monocytes. |
| T8 | 1241-1398 | Sentence | denotes | Mutational analysis of transcription factor binding sites indicated a predominant role for a single Sp1 binding site in regulating HC-gp39 promoter activity. |
| T9 | 1399-1593 | Sentence | denotes | In addition, gel shift assays using nuclear extracts of monocytes and macrophages demonstrated that the binding of nuclear Sp1, but not Sp3, markedly increases during macrophage differentiation. |
| T10 | 1594-1680 | Sentence | denotes | Our results further highlight the important role of Sp1 in macrophage gene regulation. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 210-216 | Glycan | denotes | chitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 139-144 | OrganismTaxon | denotes | human | 9606 |
| T2 | 412-417 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 71-81 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T2 | 145-154 | Body_part | denotes | cartilage | http://purl.obolibrary.org/obo/UBERON_0002418|http://purl.obolibrary.org/obo/UBERON_0007844 |
| T4 | 191-197 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T5 | 302-310 | Body_part | denotes | monocyte | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T7 | 311-321 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T8 | 359-368 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T10 | 418-428 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T11 | 569-580 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T12 | 690-700 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T13 | 762-772 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T14 | 1204-1215 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T15 | 1230-1239 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T17 | 1455-1464 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
| T19 | 1469-1480 | Body_part | denotes | macrophages | http://purl.obolibrary.org/obo/CL_0000235 |
| T20 | 1566-1576 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
| T21 | 1653-1663 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 71-81 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T3 | 302-310 | Cell | denotes | monocyte | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T5 | 311-321 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T7 | 359-368 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T9 | 418-428 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T11 | 569-580 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T13 | 690-700 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T15 | 762-772 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T17 | 1204-1215 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T19 | 1230-1239 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T21 | 1455-1464 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T23 | 1469-1480 | Cell | denotes | macrophages | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T25 | 1566-1576 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |
| T27 | 1653-1663 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |