PubMed:12888555
Annnotations
GlyCosmos600-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 515-519 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-84 | Sentence | denotes | The metalloproteolytic activity of the anthrax lethal factor is substrate-inhibited. |
TextSentencer_T2 | 85-245 | Sentence | denotes | The anthrax lethal factor (LF) is a Zn2+ endopeptidase specific for mitogen-activated protein kinase kinases (MAPKKs), which are cleaved within their N termini. |
TextSentencer_T3 | 246-432 | Sentence | denotes | Here, the proteolytic activity of LF has been investigated using novel chromogenic MAPKK-derived peptide substrates, which allowed us to determine the kinetic parameters of the reaction. |
TextSentencer_T4 | 433-557 | Sentence | denotes | LF displayed maximal proteolytic activity at the pH and temperature values of the cell cytosol, which is its site of action. |
TextSentencer_T5 | 558-677 | Sentence | denotes | LF undergoes substrate inhibition, in keeping with the non-productive binding geometry of the MAPPK-2 N terminus to LF. |
T1 | 0-84 | Sentence | denotes | The metalloproteolytic activity of the anthrax lethal factor is substrate-inhibited. |
T2 | 85-245 | Sentence | denotes | The anthrax lethal factor (LF) is a Zn2+ endopeptidase specific for mitogen-activated protein kinase kinases (MAPKKs), which are cleaved within their N termini. |
T3 | 246-432 | Sentence | denotes | Here, the proteolytic activity of LF has been investigated using novel chromogenic MAPKK-derived peptide substrates, which allowed us to determine the kinetic parameters of the reaction. |
T4 | 433-557 | Sentence | denotes | LF displayed maximal proteolytic activity at the pH and temperature values of the cell cytosol, which is its site of action. |
T5 | 558-677 | Sentence | denotes | LF undergoes substrate inhibition, in keeping with the non-productive binding geometry of the MAPPK-2 N terminus to LF. |
GlyCosmos600-GlycoProteins
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-GlycoProteins-B_T1 | 195-201 | http://purl.uniprot.org/uniprot/Q23977 | denotes | MAPKKs |
PD-GlycoProteins-B_T2 | 329-334 | http://purl.uniprot.org/uniprot/Q23977 | denotes | MAPKK |
pubmed-enju-pas
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
EnjuParser_T0 | 0-3 | DT | denotes | The |
EnjuParser_T1 | 4-22 | JJ | denotes | metalloproteolytic |
EnjuParser_T2 | 23-31 | NN | denotes | activity |
EnjuParser_T3 | 32-34 | IN | denotes | of |
EnjuParser_T4 | 35-38 | DT | denotes | the |
EnjuParser_T5 | 39-46 | NN | denotes | anthrax |
EnjuParser_T6 | 47-53 | JJ | denotes | lethal |
EnjuParser_T7 | 54-60 | NN | denotes | factor |
EnjuParser_T8 | 61-63 | VBZ | denotes | is |
EnjuParser_T9 | 64-83 | JJ | denotes | substrate-inhibited |
EnjuParser_T10 | 85-88 | DT | denotes | The |
EnjuParser_T11 | 89-96 | NN | denotes | anthrax |
EnjuParser_T12 | 97-103 | JJ | denotes | lethal |
EnjuParser_T13 | 104-110 | NN | denotes | factor |
EnjuParser_T14 | 111-112 | -LRB- | denotes | ( |
EnjuParser_T15 | 112-114 | NN | denotes | LF |
EnjuParser_T16 | 114-115 | -RRB- | denotes | ) |
EnjuParser_T17 | 116-118 | VBZ | denotes | is |
EnjuParser_T18 | 119-120 | DT | denotes | a |
EnjuParser_T19 | 121-125 | NN | denotes | Zn2+ |
EnjuParser_T20 | 126-139 | NN | denotes | endopeptidase |
EnjuParser_T21 | 140-148 | JJ | denotes | specific |
EnjuParser_T22 | 149-152 | IN | denotes | for |
EnjuParser_T23 | 153-170 | JJ | denotes | mitogen-activated |
EnjuParser_T24 | 171-178 | NN | denotes | protein |
EnjuParser_T25 | 179-185 | NN | denotes | kinase |
EnjuParser_T26 | 186-193 | NNS | denotes | kinases |
EnjuParser_T27 | 194-195 | -LRB- | denotes | ( |
EnjuParser_T28 | 195-201 | NNS | denotes | MAPKKs |
EnjuParser_T29 | 201-202 | -RRB- | denotes | ) |
EnjuParser_T30 | 202-203 | -COMMA- | denotes | , |
EnjuParser_T31 | 204-209 | WDT | denotes | which |
EnjuParser_T32 | 210-213 | VBP | denotes | are |
EnjuParser_T33 | 214-221 | VBN | denotes | cleaved |
EnjuParser_T34 | 222-228 | IN | denotes | within |
EnjuParser_T35 | 229-234 | PRP-DOLLAR- | denotes | their |
EnjuParser_T36 | 235-236 | NN | denotes | N |
EnjuParser_T37 | 237-244 | NNS | denotes | termini |
EnjuParser_T38 | 246-250 | RB | denotes | Here |
EnjuParser_T39 | 250-251 | -COMMA- | denotes | , |
EnjuParser_T40 | 252-255 | DT | denotes | the |
EnjuParser_T41 | 256-267 | JJ | denotes | proteolytic |
EnjuParser_T42 | 268-276 | NN | denotes | activity |
EnjuParser_T43 | 277-279 | IN | denotes | of |
EnjuParser_T44 | 280-282 | NN | denotes | LF |
EnjuParser_T45 | 283-286 | VBZ | denotes | has |
EnjuParser_T46 | 287-291 | VBN | denotes | been |
EnjuParser_T47 | 292-304 | VBN | denotes | investigated |
EnjuParser_T48 | 305-310 | VBG | denotes | using |
EnjuParser_T49 | 311-316 | JJ | denotes | novel |
EnjuParser_T50 | 317-328 | JJ | denotes | chromogenic |
EnjuParser_T51 | 329-342 | JJ | denotes | MAPKK-derived |
EnjuParser_T52 | 343-350 | NN | denotes | peptide |
EnjuParser_T53 | 351-361 | NNS | denotes | substrates |
EnjuParser_T54 | 361-362 | -COMMA- | denotes | , |
EnjuParser_T55 | 363-368 | WDT | denotes | which |
EnjuParser_T56 | 369-376 | VBD | denotes | allowed |
EnjuParser_T57 | 377-379 | PRP | denotes | us |
EnjuParser_T58 | 380-382 | TO | denotes | to |
EnjuParser_T59 | 383-392 | VB | denotes | determine |
EnjuParser_T60 | 393-396 | DT | denotes | the |
EnjuParser_T61 | 397-404 | JJ | denotes | kinetic |
EnjuParser_T62 | 405-415 | NNS | denotes | parameters |
EnjuParser_T63 | 416-418 | IN | denotes | of |
EnjuParser_T64 | 419-422 | DT | denotes | the |
EnjuParser_T65 | 423-431 | NN | denotes | reaction |
EnjuParser_T66 | 433-435 | NN | denotes | LF |
EnjuParser_T67 | 436-445 | VBD | denotes | displayed |
EnjuParser_T68 | 446-453 | JJ | denotes | maximal |
EnjuParser_T69 | 454-465 | JJ | denotes | proteolytic |
EnjuParser_T70 | 466-474 | NN | denotes | activity |
EnjuParser_T71 | 475-477 | IN | denotes | at |
EnjuParser_T72 | 478-481 | DT | denotes | the |
EnjuParser_T73 | 482-484 | NN | denotes | pH |
EnjuParser_T74 | 485-488 | CC | denotes | and |
EnjuParser_T75 | 489-500 | NN | denotes | temperature |
EnjuParser_T76 | 501-507 | NNS | denotes | values |
EnjuParser_T77 | 508-510 | IN | denotes | of |
EnjuParser_T78 | 511-514 | DT | denotes | the |
EnjuParser_T79 | 515-519 | NN | denotes | cell |
EnjuParser_T80 | 520-527 | NN | denotes | cytosol |
EnjuParser_T81 | 527-528 | -COMMA- | denotes | , |
EnjuParser_T82 | 529-534 | WDT | denotes | which |
EnjuParser_T83 | 535-537 | VBZ | denotes | is |
EnjuParser_T84 | 538-541 | PRP-DOLLAR- | denotes | its |
EnjuParser_T85 | 542-546 | NN | denotes | site |
EnjuParser_T86 | 547-549 | IN | denotes | of |
EnjuParser_T87 | 550-556 | NN | denotes | action |
EnjuParser_T88 | 558-560 | NN | denotes | LF |
EnjuParser_T89 | 561-570 | VBZ | denotes | undergoes |
EnjuParser_T90 | 571-580 | NN | denotes | substrate |
EnjuParser_T91 | 581-591 | NN | denotes | inhibition |
EnjuParser_T92 | 591-592 | -COMMA- | denotes | , |
EnjuParser_T93 | 593-595 | IN | denotes | in |
EnjuParser_T94 | 596-603 | VBG | denotes | keeping |
EnjuParser_T95 | 604-608 | IN | denotes | with |
EnjuParser_T96 | 609-612 | DT | denotes | the |
EnjuParser_T97 | 613-627 | JJ | denotes | non-productive |
EnjuParser_T98 | 628-635 | NN | denotes | binding |
EnjuParser_T99 | 636-644 | NN | denotes | geometry |
EnjuParser_T100 | 645-647 | IN | denotes | of |
EnjuParser_T101 | 648-651 | DT | denotes | the |
EnjuParser_T102 | 652-659 | NN | denotes | MAPPK-2 |
EnjuParser_T103 | 660-661 | NN | denotes | N |
EnjuParser_T104 | 662-670 | NN | denotes | terminus |
EnjuParser_T105 | 671-673 | TO | denotes | to |
EnjuParser_T106 | 674-676 | NN | denotes | LF |
EnjuParser_R0 | EnjuParser_T2 | EnjuParser_T0 | arg1Of | activity,The |
EnjuParser_R1 | EnjuParser_T2 | EnjuParser_T1 | arg1Of | activity,metalloproteolytic |
EnjuParser_R2 | EnjuParser_T2 | EnjuParser_T3 | arg1Of | activity,of |
EnjuParser_R3 | EnjuParser_T7 | EnjuParser_T3 | arg2Of | factor,of |
EnjuParser_R4 | EnjuParser_T7 | EnjuParser_T4 | arg1Of | factor,the |
EnjuParser_R5 | EnjuParser_T7 | EnjuParser_T5 | arg1Of | factor,anthrax |
EnjuParser_R6 | EnjuParser_T7 | EnjuParser_T6 | arg1Of | factor,lethal |
EnjuParser_R7 | EnjuParser_T2 | EnjuParser_T8 | arg1Of | activity,is |
EnjuParser_R8 | EnjuParser_T9 | EnjuParser_T8 | arg2Of | substrate-inhibited,is |
EnjuParser_R9 | EnjuParser_T2 | EnjuParser_T9 | arg1Of | activity,substrate-inhibited |
EnjuParser_R10 | EnjuParser_T13 | EnjuParser_T10 | arg1Of | factor,The |
EnjuParser_R11 | EnjuParser_T13 | EnjuParser_T11 | arg1Of | factor,anthrax |
EnjuParser_R12 | EnjuParser_T13 | EnjuParser_T12 | arg1Of | factor,lethal |
EnjuParser_R13 | EnjuParser_T13 | EnjuParser_T14 | arg1Of | factor,( |
EnjuParser_R14 | EnjuParser_T15 | EnjuParser_T14 | arg2Of | LF,( |
EnjuParser_R15 | EnjuParser_T16 | EnjuParser_T14 | arg3Of | ),( |
EnjuParser_R16 | EnjuParser_T13 | EnjuParser_T17 | arg1Of | factor,is |
EnjuParser_R17 | EnjuParser_T20 | EnjuParser_T17 | arg2Of | endopeptidase,is |
EnjuParser_R18 | EnjuParser_T20 | EnjuParser_T18 | arg1Of | endopeptidase,a |
EnjuParser_R19 | EnjuParser_T20 | EnjuParser_T19 | arg1Of | endopeptidase,Zn2+ |
EnjuParser_R20 | EnjuParser_T20 | EnjuParser_T21 | arg1Of | endopeptidase,specific |
EnjuParser_R21 | EnjuParser_T21 | EnjuParser_T22 | arg1Of | specific,for |
EnjuParser_R22 | EnjuParser_T26 | EnjuParser_T22 | arg2Of | kinases,for |
EnjuParser_R23 | EnjuParser_T26 | EnjuParser_T23 | arg1Of | kinases,mitogen-activated |
EnjuParser_R24 | EnjuParser_T26 | EnjuParser_T24 | arg1Of | kinases,protein |
EnjuParser_R25 | EnjuParser_T26 | EnjuParser_T25 | arg1Of | kinases,kinase |
EnjuParser_R26 | EnjuParser_T26 | EnjuParser_T27 | arg1Of | kinases,( |
EnjuParser_R27 | EnjuParser_T28 | EnjuParser_T27 | arg2Of | MAPKKs,( |
EnjuParser_R28 | EnjuParser_T29 | EnjuParser_T27 | arg3Of | ),( |
EnjuParser_R29 | EnjuParser_T26 | EnjuParser_T30 | arg1Of | kinases,"," |
EnjuParser_R30 | EnjuParser_T26 | EnjuParser_T31 | arg1Of | kinases,which |
EnjuParser_R31 | EnjuParser_T26 | EnjuParser_T32 | arg1Of | kinases,are |
EnjuParser_R32 | EnjuParser_T33 | EnjuParser_T32 | arg2Of | cleaved,are |
EnjuParser_R33 | EnjuParser_T26 | EnjuParser_T33 | arg2Of | kinases,cleaved |
EnjuParser_R34 | EnjuParser_T33 | EnjuParser_T34 | arg1Of | cleaved,within |
EnjuParser_R35 | EnjuParser_T37 | EnjuParser_T34 | arg2Of | termini,within |
EnjuParser_R36 | EnjuParser_T37 | EnjuParser_T35 | arg1Of | termini,their |
EnjuParser_R37 | EnjuParser_T37 | EnjuParser_T36 | arg1Of | termini,N |
EnjuParser_R38 | EnjuParser_T47 | EnjuParser_T38 | arg1Of | investigated,Here |
EnjuParser_R39 | EnjuParser_T47 | EnjuParser_T39 | arg1Of | investigated,"," |
EnjuParser_R40 | EnjuParser_T42 | EnjuParser_T40 | arg1Of | activity,the |
EnjuParser_R41 | EnjuParser_T42 | EnjuParser_T41 | arg1Of | activity,proteolytic |
EnjuParser_R42 | EnjuParser_T42 | EnjuParser_T43 | arg1Of | activity,of |
EnjuParser_R43 | EnjuParser_T44 | EnjuParser_T43 | arg2Of | LF,of |
EnjuParser_R44 | EnjuParser_T42 | EnjuParser_T45 | arg1Of | activity,has |
EnjuParser_R45 | EnjuParser_T47 | EnjuParser_T45 | arg2Of | investigated,has |
EnjuParser_R46 | EnjuParser_T42 | EnjuParser_T46 | arg1Of | activity,been |
EnjuParser_R47 | EnjuParser_T47 | EnjuParser_T46 | arg2Of | investigated,been |
EnjuParser_R48 | EnjuParser_T42 | EnjuParser_T47 | arg2Of | activity,investigated |
EnjuParser_R49 | EnjuParser_T53 | EnjuParser_T48 | arg2Of | substrates,using |
EnjuParser_R50 | EnjuParser_T47 | EnjuParser_T48 | modOf | investigated,using |
EnjuParser_R51 | EnjuParser_T53 | EnjuParser_T49 | arg1Of | substrates,novel |
EnjuParser_R52 | EnjuParser_T53 | EnjuParser_T50 | arg1Of | substrates,chromogenic |
EnjuParser_R53 | EnjuParser_T53 | EnjuParser_T51 | arg1Of | substrates,MAPKK-derived |
EnjuParser_R54 | EnjuParser_T53 | EnjuParser_T52 | arg1Of | substrates,peptide |
EnjuParser_R55 | EnjuParser_T53 | EnjuParser_T54 | arg1Of | substrates,"," |
EnjuParser_R56 | EnjuParser_T53 | EnjuParser_T55 | arg1Of | substrates,which |
EnjuParser_R57 | EnjuParser_T53 | EnjuParser_T56 | arg1Of | substrates,allowed |
EnjuParser_R58 | EnjuParser_T57 | EnjuParser_T56 | arg2Of | us,allowed |
EnjuParser_R59 | EnjuParser_T59 | EnjuParser_T56 | arg3Of | determine,allowed |
EnjuParser_R60 | EnjuParser_T59 | EnjuParser_T58 | arg1Of | determine,to |
EnjuParser_R61 | EnjuParser_T57 | EnjuParser_T59 | arg1Of | us,determine |
EnjuParser_R62 | EnjuParser_T62 | EnjuParser_T59 | arg2Of | parameters,determine |
EnjuParser_R63 | EnjuParser_T62 | EnjuParser_T60 | arg1Of | parameters,the |
EnjuParser_R64 | EnjuParser_T62 | EnjuParser_T61 | arg1Of | parameters,kinetic |
EnjuParser_R65 | EnjuParser_T62 | EnjuParser_T63 | arg1Of | parameters,of |
EnjuParser_R66 | EnjuParser_T65 | EnjuParser_T63 | arg2Of | reaction,of |
EnjuParser_R67 | EnjuParser_T65 | EnjuParser_T64 | arg1Of | reaction,the |
EnjuParser_R68 | EnjuParser_T66 | EnjuParser_T67 | arg1Of | LF,displayed |
EnjuParser_R69 | EnjuParser_T70 | EnjuParser_T67 | arg2Of | activity,displayed |
EnjuParser_R70 | EnjuParser_T70 | EnjuParser_T68 | arg1Of | activity,maximal |
EnjuParser_R71 | EnjuParser_T70 | EnjuParser_T69 | arg1Of | activity,proteolytic |
EnjuParser_R72 | EnjuParser_T67 | EnjuParser_T71 | arg1Of | displayed,at |
EnjuParser_R73 | EnjuParser_T76 | EnjuParser_T71 | arg2Of | values,at |
EnjuParser_R74 | EnjuParser_T76 | EnjuParser_T72 | arg1Of | values,the |
EnjuParser_R75 | EnjuParser_T76 | EnjuParser_T73 | arg1Of | values,pH |
EnjuParser_R76 | EnjuParser_T73 | EnjuParser_T74 | arg1Of | pH,and |
EnjuParser_R77 | EnjuParser_T75 | EnjuParser_T74 | arg2Of | temperature,and |
EnjuParser_R78 | EnjuParser_T76 | EnjuParser_T75 | arg1Of | values,temperature |
EnjuParser_R79 | EnjuParser_T76 | EnjuParser_T77 | arg1Of | values,of |
EnjuParser_R80 | EnjuParser_T80 | EnjuParser_T77 | arg2Of | cytosol,of |
EnjuParser_R81 | EnjuParser_T80 | EnjuParser_T78 | arg1Of | cytosol,the |
EnjuParser_R82 | EnjuParser_T80 | EnjuParser_T79 | arg1Of | cytosol,cell |
EnjuParser_R83 | EnjuParser_T80 | EnjuParser_T81 | arg1Of | cytosol,"," |
EnjuParser_R84 | EnjuParser_T80 | EnjuParser_T82 | arg1Of | cytosol,which |
EnjuParser_R85 | EnjuParser_T80 | EnjuParser_T83 | arg1Of | cytosol,is |
EnjuParser_R86 | EnjuParser_T85 | EnjuParser_T83 | arg2Of | site,is |
EnjuParser_R87 | EnjuParser_T85 | EnjuParser_T84 | arg1Of | site,its |
EnjuParser_R88 | EnjuParser_T85 | EnjuParser_T86 | arg1Of | site,of |
EnjuParser_R89 | EnjuParser_T87 | EnjuParser_T86 | arg2Of | action,of |
EnjuParser_R90 | EnjuParser_T88 | EnjuParser_T89 | arg1Of | LF,undergoes |
EnjuParser_R91 | EnjuParser_T91 | EnjuParser_T89 | arg2Of | inhibition,undergoes |
EnjuParser_R92 | EnjuParser_T91 | EnjuParser_T90 | arg1Of | inhibition,substrate |
EnjuParser_R93 | EnjuParser_T89 | EnjuParser_T92 | arg1Of | undergoes,"," |
EnjuParser_R94 | EnjuParser_T89 | EnjuParser_T93 | arg1Of | undergoes,in |
EnjuParser_R95 | EnjuParser_T94 | EnjuParser_T93 | arg2Of | keeping,in |
EnjuParser_R96 | EnjuParser_T94 | EnjuParser_T95 | arg1Of | keeping,with |
EnjuParser_R97 | EnjuParser_T99 | EnjuParser_T95 | arg2Of | geometry,with |
EnjuParser_R98 | EnjuParser_T99 | EnjuParser_T96 | arg1Of | geometry,the |
EnjuParser_R99 | EnjuParser_T99 | EnjuParser_T97 | arg1Of | geometry,non-productive |
EnjuParser_R100 | EnjuParser_T99 | EnjuParser_T98 | arg1Of | geometry,binding |
EnjuParser_R101 | EnjuParser_T99 | EnjuParser_T100 | arg1Of | geometry,of |
EnjuParser_R102 | EnjuParser_T104 | EnjuParser_T100 | arg2Of | terminus,of |
EnjuParser_R103 | EnjuParser_T104 | EnjuParser_T101 | arg1Of | terminus,the |
EnjuParser_R104 | EnjuParser_T104 | EnjuParser_T102 | arg1Of | terminus,MAPPK-2 |
EnjuParser_R105 | EnjuParser_T104 | EnjuParser_T103 | arg1Of | terminus,N |
EnjuParser_R106 | EnjuParser_T99 | EnjuParser_T105 | arg1Of | geometry,to |
EnjuParser_R107 | EnjuParser_T106 | EnjuParser_T105 | arg2Of | LF,to |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 39-46 | Disease | denotes | anthrax | http://purl.obolibrary.org/obo/MONDO_0005119 |
T2 | 89-96 | Disease | denotes | anthrax | http://purl.obolibrary.org/obo/MONDO_0005119 |
GlyCosmos600-FMA
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T1 | 171-178 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T2 | 515-519 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T3 | 520-527 | Body_part | denotes | cytosol | http://purl.org/sig/ont/fma/fma66836 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 39-46 | OrganismTaxon | denotes | anthrax | 117078 |
T2 | 89-96 | OrganismTaxon | denotes | anthrax | 117078 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 520-527 | Body_part | denotes | cytosol | http://purl.obolibrary.org/obo/GO_0005829 |