PubMed:12884381 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/12884381","sourcedb":"PubMed","sourceid":"12884381","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/12884381","text":"Stereoselective synthesis of 1-aminoalkanephosphonic acids with two chiral centers and their activity towards leucine aminopeptidase.\nThe stereoselective synthesis of 1-amino-2-alkylalkanephosphonic acids, namely, compounds bearing two chiral centers, was achieved by the condensation of hypophosphorous acid salts of (R)(+) or (S)(-)-N-alpha-methylbenzylamine with the appropriate aldehydes in isopropanol. Simultaneous deprotection and oxidation by the action of bromine water provided equimolar mixtures of the RS:RR and SR:SS diastereomers of desired acids. They appeared to act as moderate inhibitors of kidney leucine aminopeptidase with potency dependent on the absolute configuration of both centers of chirality.","tracks":[{"project":"AnEM_abstracts","denotations":[{"id":"T1","span":{"begin":609,"end":615},"obj":"Organ"}],"attributes":[{"subj":"T1","pred":"source","obj":"AnEM_abstracts"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"AnEM_abstracts","color":"#e793ec","default":true}]}]}}