PubMed:12875974
Annnotations
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 160-417 | DRI_Approach | denotes | To analyze differential gene expression of putative prostate tumor markers we compared the expression levels of more than 400 cancer-related genes using the cDNA array technique in a set of capsule-invasive prostate tumor and matched normal prostate tissue. |
| T2 | 418-579 | DRI_Background | denotes | The overexpression of Bax inhibitor-1 (BI-1) in prostate carcinoma and prostate cancer cell lines was confirmed by using Northern blot and Western blot analyses. |
| T3 | 580-689 | DRI_Background | denotes | Quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) on intact RNAs from 17 paired |
| T4 | 720-813 | DRI_Background | denotes | epithelial tissue samples confirmed up-regulated BI-1 expression in 11 of 17 prostate tumors. |
| T5 | 814-966 | DRI_Outcome | denotes | In addition, it was demonstrated that BI-1 expression is down-regulated in stromal cells as compared to matched normal epithelial cells of the prostate. |
| T6 | 967-1098 | DRI_Background | denotes | In situ hybridization experiments on prostate sections also revealed that BI-1 expression is mainly restricted to epithelial cells. |
| T7 | 1099-1301 | DRI_Background | denotes | Furthermore, quantitative RT-PCR on RNAs derived from five benign prostate hyperplasia (BPH) samples showed no significant difference in BI-1 expression as compared to normal epithelial prostate tissue. |
| T8 | 1302-1563 | DRI_Background | denotes | To determine the function of BI-1 in vitro, human PC-3, LNCaP, and DU-145 prostate carcinoma cells were transfected with small interfering double-strand RNA (siRNA) oligonucleotides against the BI-1 gene leading to a specific down-regulation of BI-1 expression. |
| T9 | 1564-1731 | DRI_Background | denotes | Furthermore, transfection of PC-3, LNCaP, and DU-145 cells with BI-1 sequence-specific siRNAs caused a significant increase in spontaneous apoptosis in all cell lines. |
| T10 | 1732-1949 | DRI_Outcome | denotes | Taken together, our results indicate that the human BI-1 gene contains the potential to serve as a prostate cancer expression marker and as a potential target for developing therapeutic strategies for prostate cancer. |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 12875974-0#0#15#gene7009 | 0-15 | gene7009 | denotes | Bax inhibitor-1 |
| 12875974-0#36#51#diseaseC0376358 | 36-51 | diseaseC0376358 | denotes | prostate cancer |
| 12875974-0#36#51#diseaseC0600139 | 36-51 | diseaseC0600139 | denotes | prostate cancer |
| 12875974-0#134#152#diseaseC0600139 | 134-152 | diseaseC0600139 | denotes | prostate carcinoma |
| 12875974-3#189#193#gene7009 | 769-773 | gene7009 | denotes | BI-1 |
| 12875974-3#217#232#diseaseC0033578 | 797-812 | diseaseC0033578 | denotes | prostate tumors |
| 12875974-6#137#141#gene7009 | 1236-1240 | gene7009 | denotes | BI-1 |
| 12875974-6#59#86#diseaseC1704272 | 1158-1185 | diseaseC1704272 | denotes | benign prostate hyperplasia |
| 12875974-6#88#91#diseaseC1704272 | 1187-1190 | diseaseC1704272 | denotes | BPH |
| 0#15#gene700936#51#diseaseC0376358 | 12875974-0#0#15#gene7009 | 12875974-0#36#51#diseaseC0376358 | associated_with | Bax inhibitor-1,prostate cancer |
| 0#15#gene700936#51#diseaseC0600139 | 12875974-0#0#15#gene7009 | 12875974-0#36#51#diseaseC0600139 | associated_with | Bax inhibitor-1,prostate cancer |
| 0#15#gene7009134#152#diseaseC0600139 | 12875974-0#0#15#gene7009 | 12875974-0#134#152#diseaseC0600139 | associated_with | Bax inhibitor-1,prostate carcinoma |
| 189#193#gene7009217#232#diseaseC0033578 | 12875974-3#189#193#gene7009 | 12875974-3#217#232#diseaseC0033578 | associated_with | BI-1,prostate tumors |
| 137#141#gene700959#86#diseaseC1704272 | 12875974-6#137#141#gene7009 | 12875974-6#59#86#diseaseC1704272 | associated_with | BI-1,benign prostate hyperplasia |
| 137#141#gene700988#91#diseaseC1704272 | 12875974-6#137#141#gene7009 | 12875974-6#88#91#diseaseC1704272 | associated_with | BI-1,BPH |
CoMAGC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 457-461 | Gene | denotes | BI-1 |
| E1 | 422-436 | Gene_expression | denotes | overexpression |
| E2 | 422-436 | Positive_regulation | denotes | overexpression |
| T2 | 489-504 | prostate cancer | denotes | prostate cancer |
| T3 | 466-484 | prostate cancer | denotes | prostate carcinoma |
| R1 | T1 | E1 | themeOf | BI-1,overexpression |
| R2 | E1 | E2 | themeOf | overexpression,overexpression |
| R3 | T1 | T2 | CGE-increased | BI-1,prostate cancer |
| R4 | T1 | T2 | CCS-normalTOcancer | BI-1,prostate cancer |
| R5 | T1 | T2 | PT-observation | BI-1,prostate cancer |
| R3 | T1 | T2 | IGE-unchanged | BI-1,prostate cancer |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2 | 1784-1788 | gene:7009 | denotes | BI-1 |
| T3 | 1831-1846 | disease:C0600139 | denotes | prostate cancer |
| T4 | 1784-1788 | gene:7009 | denotes | BI-1 |
| T5 | 1933-1948 | disease:C0376358 | denotes | prostate cancer |
| T6 | 1784-1788 | gene:7009 | denotes | BI-1 |
| T7 | 1933-1948 | disease:C0600139 | denotes | prostate cancer |
| T0 | 1784-1788 | gene:7009 | denotes | BI-1 |
| T1 | 1831-1846 | disease:C0376358 | denotes | prostate cancer |
| R1 | T0 | T1 | associated_with | BI-1,prostate cancer |
| R2 | T2 | T3 | associated_with | BI-1,prostate cancer |
| R3 | T4 | T5 | associated_with | BI-1,prostate cancer |
| R4 | T6 | T7 | associated_with | BI-1,prostate cancer |