PubMed:12851408 JSON TXT

Annnotations TAB JSON ListView MergeView

CL-cell

Id	Subject	Object	Predicate	Lexical cue	cl_id
T1	165-179	Cell	denotes	synovial cells	http://purl.obolibrary.org/obo/CL:0000214
T2	184-195	Cell	denotes	macrophages	http://purl.obolibrary.org/obo/CL:0000235\|http://purl.obolibrary.org/obo/CL:0000394

Inflammaging

Id	Subject	Object	Predicate	Lexical cue
T1	0-93	Sentence	denotes	Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39.
T2	94-216	Sentence	denotes	The human cartilage glycoprotein-39 (HCgp-39 or YKL40) is expressed by synovial cells and macrophages during inflammation.
T3	217-259	Sentence	denotes	Its precise physiological role is unknown.
T4	260-423	Sentence	denotes	However, it has been proposed that HCgp-39 acts as an autoantigen in rheumatoid arthritis, and high expression levels have been associated with cancer development.
T5	424-549	Sentence	denotes	HCgp-39 shares high sequence homology with family 18 chitinases, and although it binds to chitin it lacks enzymatic activity.
T6	550-687	Sentence	denotes	The crystal structure of HCgp-39 shows that the protein displays a (beta/alpha)8-barrel fold with an insertion of an alpha + beta domain.
T7	688-809	Sentence	denotes	A 43-A long carbohydrate-binding cleft is present at the C-terminal side of the beta-strands in the (beta/alpha)8 barrel.
T8	810-912	Sentence	denotes	Binding of chitin fragments of different lengths identified nine sugar-binding subsites in the groove.
T9	913-1026	Sentence	denotes	Protein-carbohydrate interactions are mainly mediated by stacking of side chains of aromatic amino acid residues.
T10	1027-1131	Sentence	denotes	Surprisingly, the specificity of chitin binding to HCgp-39 depends on the length of the oligosaccharide.
T11	1132-1266	Sentence	denotes	Although chitin disaccharides tend to occupy the distal subsites, longer chains bind preferably to the central subsites in the groove.
T12	1267-1462	Sentence	denotes	Despite the absence of enzymatic activity, long chitin fragments are distorted upon binding, with the GlcNAc at subsite -1 in a boat conformation, similar to what has been observed in chitinases.
T13	1463-1537	Sentence	denotes	The presence of chitin in the human body has never been documented so far.
T14	1538-1717	Sentence	denotes	However, the binding features observed in the complex structures suggest that either chitin or a closely related oligosaccharide could act as the physiological ligand for HCgp-39.
T1	0-93	Sentence	denotes	Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39.
T2	94-216	Sentence	denotes	The human cartilage glycoprotein-39 (HCgp-39 or YKL40) is expressed by synovial cells and macrophages during inflammation.
T3	217-259	Sentence	denotes	Its precise physiological role is unknown.
T4	260-423	Sentence	denotes	However, it has been proposed that HCgp-39 acts as an autoantigen in rheumatoid arthritis, and high expression levels have been associated with cancer development.
T5	424-549	Sentence	denotes	HCgp-39 shares high sequence homology with family 18 chitinases, and although it binds to chitin it lacks enzymatic activity.
T6	550-687	Sentence	denotes	The crystal structure of HCgp-39 shows that the protein displays a (beta/alpha)8-barrel fold with an insertion of an alpha + beta domain.
T7	688-809	Sentence	denotes	A 43-A long carbohydrate-binding cleft is present at the C-terminal side of the beta-strands in the (beta/alpha)8 barrel.
T8	810-912	Sentence	denotes	Binding of chitin fragments of different lengths identified nine sugar-binding subsites in the groove.
T9	913-1026	Sentence	denotes	Protein-carbohydrate interactions are mainly mediated by stacking of side chains of aromatic amino acid residues.
T10	1027-1131	Sentence	denotes	Surprisingly, the specificity of chitin binding to HCgp-39 depends on the length of the oligosaccharide.
T11	1132-1266	Sentence	denotes	Although chitin disaccharides tend to occupy the distal subsites, longer chains bind preferably to the central subsites in the groove.
T12	1267-1462	Sentence	denotes	Despite the absence of enzymatic activity, long chitin fragments are distorted upon binding, with the GlcNAc at subsite -1 in a boat conformation, similar to what has been observed in chitinases.
T13	1463-1537	Sentence	denotes	The presence of chitin in the human body has never been documented so far.
T14	1538-1717	Sentence	denotes	However, the binding features observed in the complex structures suggest that either chitin or a closely related oligosaccharide could act as the physiological ligand for HCgp-39.

sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-93	Sentence	denotes	Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39.
T2	94-216	Sentence	denotes	The human cartilage glycoprotein-39 (HCgp-39 or YKL40) is expressed by synovial cells and macrophages during inflammation.
T3	217-259	Sentence	denotes	Its precise physiological role is unknown.
T4	260-423	Sentence	denotes	However, it has been proposed that HCgp-39 acts as an autoantigen in rheumatoid arthritis, and high expression levels have been associated with cancer development.
T5	424-549	Sentence	denotes	HCgp-39 shares high sequence homology with family 18 chitinases, and although it binds to chitin it lacks enzymatic activity.
T6	550-687	Sentence	denotes	The crystal structure of HCgp-39 shows that the protein displays a (beta/alpha)8-barrel fold with an insertion of an alpha + beta domain.
T7	688-809	Sentence	denotes	A 43-A long carbohydrate-binding cleft is present at the C-terminal side of the beta-strands in the (beta/alpha)8 barrel.
T8	810-912	Sentence	denotes	Binding of chitin fragments of different lengths identified nine sugar-binding subsites in the groove.
T9	913-1026	Sentence	denotes	Protein-carbohydrate interactions are mainly mediated by stacking of side chains of aromatic amino acid residues.
T10	1027-1131	Sentence	denotes	Surprisingly, the specificity of chitin binding to HCgp-39 depends on the length of the oligosaccharide.
T11	1132-1266	Sentence	denotes	Although chitin disaccharides tend to occupy the distal subsites, longer chains bind preferably to the central subsites in the groove.
T12	1267-1462	Sentence	denotes	Despite the absence of enzymatic activity, long chitin fragments are distorted upon binding, with the GlcNAc at subsite -1 in a boat conformation, similar to what has been observed in chitinases.
T13	1463-1537	Sentence	denotes	The presence of chitin in the human body has never been documented so far.
T14	1538-1717	Sentence	denotes	However, the binding features observed in the complex structures suggest that either chitin or a closely related oligosaccharide could act as the physiological ligand for HCgp-39.

Glycosmos6-MAT

Id	Subject	Object	Predicate	Lexical cue
T1	67-76	http://purl.obolibrary.org/obo/MAT_0000189	denotes	cartilage
T2	104-113	http://purl.obolibrary.org/obo/MAT_0000189	denotes	cartilage

NGLY1-deficiency

Id	Subject	Object	Predicate	Lexical cue
PD-NGLY1-deficiency-B_T1	1369-1375	chem:24139	denotes	GlcNAc

mondo_disease

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	203-215	Disease	denotes	inflammation	http://purl.obolibrary.org/obo/MONDO_0021166
T2	329-349	Disease	denotes	rheumatoid arthritis	http://purl.obolibrary.org/obo/MONDO_0008383
T3	404-410	Disease	denotes	cancer	http://purl.obolibrary.org/obo/MONDO_0004992

Anatomy-MAT

Id	Subject	Object	Predicate	Lexical cue	mat_id
T1	67-76	Body_part	denotes	cartilage	http://purl.obolibrary.org/obo/MAT_0000189
T2	104-113	Body_part	denotes	cartilage	http://purl.obolibrary.org/obo/MAT_0000189

HP-phenotype

Id	Subject	Object	Predicate	Lexical cue	hp_id
T1	329-349	Phenotype	denotes	rheumatoid arthritis	HP:0001370
T2	404-410	Phenotype	denotes	cancer	HP:0002664

Glycan-GlyCosmos

Id	Subject	Object	Predicate	Lexical cue	image
T1	514-520	Glycan	denotes	chitin	https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T2	821-827	Glycan	denotes	chitin	https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T3	1060-1066	Glycan	denotes	chitin	https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T4	1141-1147	Glycan	denotes	chitin	https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T5	1315-1321	Glycan	denotes	chitin	https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T6	1479-1485	Glycan	denotes	chitin	https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T7	1623-1629	Glycan	denotes	chitin	https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY

GlyCosmos15-HP

Id	Subject	Object	Predicate	Lexical cue	hp_id
T1	329-349	Phenotype	denotes	rheumatoid arthritis	HP:0001370
T2	404-410	Phenotype	denotes	cancer	HP:0002664

GlyCosmos15-NCBITAXON

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	61-66	OrganismTaxon	denotes	human	9606
T2	98-103	OrganismTaxon	denotes	human	9606
T3	1493-1498	OrganismTaxon	denotes	human	9606

GlyCosmos15-CL

Id	Subject	Object	Predicate	Lexical cue	cl_id
T1	165-179	Cell	denotes	synovial cells	http://purl.obolibrary.org/obo/CL:0000214
T2	184-195	Cell	denotes	macrophages	http://purl.obolibrary.org/obo/CL:0000235\|http://purl.obolibrary.org/obo/CL:0000394

GlyCosmos15-UBERON

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T1	67-76	Body_part	denotes	cartilage	http://purl.obolibrary.org/obo/UBERON_0002418\|http://purl.obolibrary.org/obo/UBERON_0007844
T3	104-113	Body_part	denotes	cartilage	http://purl.obolibrary.org/obo/UBERON_0002418\|http://purl.obolibrary.org/obo/UBERON_0007844
T5	165-179	Body_part	denotes	synovial cells	http://purl.obolibrary.org/obo/CL_0000214
T6	184-195	Body_part	denotes	macrophages	http://purl.obolibrary.org/obo/CL_0000235
T7	905-911	Body_part	denotes	groove	http://purl.obolibrary.org/obo/UBERON_0004704\|http://purl.obolibrary.org/obo/UBERON_0006846\|http://purl.obolibrary.org/obo/UBERON_0014764
T10	1259-1265	Body_part	denotes	groove	http://purl.obolibrary.org/obo/UBERON_0004704\|http://purl.obolibrary.org/obo/UBERON_0006846\|http://purl.obolibrary.org/obo/UBERON_0014764

sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-93	Sentence	denotes	Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39.
T2	94-216	Sentence	denotes	The human cartilage glycoprotein-39 (HCgp-39 or YKL40) is expressed by synovial cells and macrophages during inflammation.
T3	217-259	Sentence	denotes	Its precise physiological role is unknown.
T4	260-423	Sentence	denotes	However, it has been proposed that HCgp-39 acts as an autoantigen in rheumatoid arthritis, and high expression levels have been associated with cancer development.
T5	424-549	Sentence	denotes	HCgp-39 shares high sequence homology with family 18 chitinases, and although it binds to chitin it lacks enzymatic activity.
T6	550-687	Sentence	denotes	The crystal structure of HCgp-39 shows that the protein displays a (beta/alpha)8-barrel fold with an insertion of an alpha + beta domain.
T7	688-809	Sentence	denotes	A 43-A long carbohydrate-binding cleft is present at the C-terminal side of the beta-strands in the (beta/alpha)8 barrel.
T8	810-912	Sentence	denotes	Binding of chitin fragments of different lengths identified nine sugar-binding subsites in the groove.
T9	913-1026	Sentence	denotes	Protein-carbohydrate interactions are mainly mediated by stacking of side chains of aromatic amino acid residues.
T10	1027-1131	Sentence	denotes	Surprisingly, the specificity of chitin binding to HCgp-39 depends on the length of the oligosaccharide.
T11	1132-1266	Sentence	denotes	Although chitin disaccharides tend to occupy the distal subsites, longer chains bind preferably to the central subsites in the groove.
T12	1267-1462	Sentence	denotes	Despite the absence of enzymatic activity, long chitin fragments are distorted upon binding, with the GlcNAc at subsite -1 in a boat conformation, similar to what has been observed in chitinases.
T13	1463-1537	Sentence	denotes	The presence of chitin in the human body has never been documented so far.
T14	1538-1717	Sentence	denotes	However, the binding features observed in the complex structures suggest that either chitin or a closely related oligosaccharide could act as the physiological ligand for HCgp-39.

GlyCosmos15-Sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-93	Sentence	denotes	Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39.
T2	94-216	Sentence	denotes	The human cartilage glycoprotein-39 (HCgp-39 or YKL40) is expressed by synovial cells and macrophages during inflammation.
T3	217-259	Sentence	denotes	Its precise physiological role is unknown.
T4	260-423	Sentence	denotes	However, it has been proposed that HCgp-39 acts as an autoantigen in rheumatoid arthritis, and high expression levels have been associated with cancer development.
T5	424-549	Sentence	denotes	HCgp-39 shares high sequence homology with family 18 chitinases, and although it binds to chitin it lacks enzymatic activity.
T6	550-687	Sentence	denotes	The crystal structure of HCgp-39 shows that the protein displays a (beta/alpha)8-barrel fold with an insertion of an alpha + beta domain.
T7	688-809	Sentence	denotes	A 43-A long carbohydrate-binding cleft is present at the C-terminal side of the beta-strands in the (beta/alpha)8 barrel.
T8	810-912	Sentence	denotes	Binding of chitin fragments of different lengths identified nine sugar-binding subsites in the groove.
T9	913-1026	Sentence	denotes	Protein-carbohydrate interactions are mainly mediated by stacking of side chains of aromatic amino acid residues.
T10	1027-1131	Sentence	denotes	Surprisingly, the specificity of chitin binding to HCgp-39 depends on the length of the oligosaccharide.
T11	1132-1266	Sentence	denotes	Although chitin disaccharides tend to occupy the distal subsites, longer chains bind preferably to the central subsites in the groove.
T12	1267-1462	Sentence	denotes	Despite the absence of enzymatic activity, long chitin fragments are distorted upon binding, with the GlcNAc at subsite -1 in a boat conformation, similar to what has been observed in chitinases.
T13	1463-1537	Sentence	denotes	The presence of chitin in the human body has never been documented so far.
T14	1538-1717	Sentence	denotes	However, the binding features observed in the complex structures suggest that either chitin or a closely related oligosaccharide could act as the physiological ligand for HCgp-39.

Lectin-Jamboree-Sentence

Id	Subject	Object	Predicate	Lexical cue
T1	0-93	Sentence	denotes	Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39.
T2	94-216	Sentence	denotes	The human cartilage glycoprotein-39 (HCgp-39 or YKL40) is expressed by synovial cells and macrophages during inflammation.
T3	217-259	Sentence	denotes	Its precise physiological role is unknown.
T4	260-423	Sentence	denotes	However, it has been proposed that HCgp-39 acts as an autoantigen in rheumatoid arthritis, and high expression levels have been associated with cancer development.
T5	424-549	Sentence	denotes	HCgp-39 shares high sequence homology with family 18 chitinases, and although it binds to chitin it lacks enzymatic activity.
T6	550-687	Sentence	denotes	The crystal structure of HCgp-39 shows that the protein displays a (beta/alpha)8-barrel fold with an insertion of an alpha + beta domain.
T7	688-809	Sentence	denotes	A 43-A long carbohydrate-binding cleft is present at the C-terminal side of the beta-strands in the (beta/alpha)8 barrel.
T8	810-912	Sentence	denotes	Binding of chitin fragments of different lengths identified nine sugar-binding subsites in the groove.
T9	913-1026	Sentence	denotes	Protein-carbohydrate interactions are mainly mediated by stacking of side chains of aromatic amino acid residues.
T10	1027-1131	Sentence	denotes	Surprisingly, the specificity of chitin binding to HCgp-39 depends on the length of the oligosaccharide.
T11	1132-1266	Sentence	denotes	Although chitin disaccharides tend to occupy the distal subsites, longer chains bind preferably to the central subsites in the groove.
T12	1267-1462	Sentence	denotes	Despite the absence of enzymatic activity, long chitin fragments are distorted upon binding, with the GlcNAc at subsite -1 in a boat conformation, similar to what has been observed in chitinases.
T13	1463-1537	Sentence	denotes	The presence of chitin in the human body has never been documented so far.
T14	1538-1717	Sentence	denotes	However, the binding features observed in the complex structures suggest that either chitin or a closely related oligosaccharide could act as the physiological ligand for HCgp-39.

GlyCosmos15-MONDO

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	329-349	Disease	denotes	rheumatoid arthritis	MONDO:0008383
T2	404-410	Disease	denotes	cancer	MONDO:0004992

GlyCosmos15-FMA

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	67-76	Body_part	denotes	cartilage	FMA:71500
T2	104-113	Body_part	denotes	cartilage	FMA:71500
T3	165-179	Body_part	denotes	synovial cells	FMA:66786
T4	184-195	Body_part	denotes	macrophages	FMA:63261
T5	905-911	Body_part	denotes	groove	FMA:75037
T6	1259-1265	Body_part	denotes	groove	FMA:75037
T7	1493-1503	Body_part	denotes	human body	FMA:305853

GlyCosmos15-MAT

Id	Subject	Object	Predicate	Lexical cue	mat_id
T1	67-76	Body_part	denotes	cartilage	http://purl.obolibrary.org/obo/MAT_0000189
T2	104-113	Body_part	denotes	cartilage	http://purl.obolibrary.org/obo/MAT_0000189

GlyCosmos15-Glycan

Id	Subject	Object	Predicate	Lexical cue	image
T1	514-520	Glycan	denotes	chitin	https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T2	821-827	Glycan	denotes	chitin	https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T3	1060-1066	Glycan	denotes	chitin	https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T4	1141-1147	Glycan	denotes	chitin	https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T5	1315-1321	Glycan	denotes	chitin	https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T6	1479-1485	Glycan	denotes	chitin	https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY
T7	1623-1629	Glycan	denotes	chitin	https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY

NCBITAXON

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	61-66	OrganismTaxon	denotes	human	9606
T2	98-103	OrganismTaxon	denotes	human	9606
T3	1493-1498	OrganismTaxon	denotes	human	9606

Anatomy-UBERON

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T1	67-76	Body_part	denotes	cartilage	http://purl.obolibrary.org/obo/UBERON_0002418\|http://purl.obolibrary.org/obo/UBERON_0007844
T3	104-113	Body_part	denotes	cartilage	http://purl.obolibrary.org/obo/UBERON_0002418\|http://purl.obolibrary.org/obo/UBERON_0007844
T5	165-179	Body_part	denotes	synovial cells	http://purl.obolibrary.org/obo/CL_0000214
T6	184-195	Body_part	denotes	macrophages	http://purl.obolibrary.org/obo/CL_0000235
T7	905-911	Body_part	denotes	groove	http://purl.obolibrary.org/obo/UBERON_0004704\|http://purl.obolibrary.org/obo/UBERON_0006846\|http://purl.obolibrary.org/obo/UBERON_0014764
T10	1259-1265	Body_part	denotes	groove	http://purl.obolibrary.org/obo/UBERON_0004704\|http://purl.obolibrary.org/obo/UBERON_0006846\|http://purl.obolibrary.org/obo/UBERON_0014764