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PubMed:12851290 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 423-430 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 493-500 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 423-430 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T2 493-500 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 423-430 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 493-500 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-126 Sentence denotes Computational analysis of multivalency in lectins: structures of garlic lectin-oligosaccharide complexes and their aggregates.
TextSentencer_T2 127-214 Sentence denotes Multivalency in lectins is a phenomenon that has been discussed at considerable length.
TextSentencer_T3 215-339 Sentence denotes The structural basis for the role of multivalency in garlic lectin has been investigated here through computational studies.
TextSentencer_T4 340-501 Sentence denotes Biochemical studies have shown that the binding affinity of garlic lectin for high mannose oligosaccharides is orders of magnitude greater than that for mannose.
TextSentencer_T5 502-693 Sentence denotes Modeling and energy calculations clearly indicate that such increase in affinity cannot be accounted for by binding of these oligosaccharides at any of the six sites of a garlic lectin dimer.
TextSentencer_T6 694-826 Sentence denotes These studies also indicate that a given oligosaccharide cannot bind simultaneously to more than one binding site on a lectin dimer.
TextSentencer_T7 827-966 Sentence denotes The possibility of a given oligosaccharide simultaneously binding to and hence linking two or more lectin molecules was therefore explored.
TextSentencer_T8 967-1183 Sentence denotes This study showed that trimannosides and higher oligomers can cross-link lectin dimers, amplifying the protein-oligosaccharide interactions severalfold, thus explaining the role of multivalency in enhancing affinity.
TextSentencer_T9 1184-1281 Sentence denotes A comprehensive exploration of all possible cross-links posed a formidable computational problem.
TextSentencer_T10 1282-1526 Sentence denotes Even a partial exploration involving a carefully chosen region of the conformational space clearly showed that a given dimer pair can be cross-linked not only by a single oligosaccharide molecule but also simultaneously by two oligosaccharides.
TextSentencer_T11 1527-1730 Sentence denotes The number of such possible double cross-links, including those forming interesting tetrameric structures, generally increases with the size of the oligosaccharide, correlating with the biochemical data.
TextSentencer_T12 1731-1879 Sentence denotes In addition to their immediate relevance to garlic lectin, these studies are of general interest in relation to lectin-oligosaccharide interactions.
T1 0-126 Sentence denotes Computational analysis of multivalency in lectins: structures of garlic lectin-oligosaccharide complexes and their aggregates.
T2 127-214 Sentence denotes Multivalency in lectins is a phenomenon that has been discussed at considerable length.
T3 215-339 Sentence denotes The structural basis for the role of multivalency in garlic lectin has been investigated here through computational studies.
T4 340-501 Sentence denotes Biochemical studies have shown that the binding affinity of garlic lectin for high mannose oligosaccharides is orders of magnitude greater than that for mannose.
T5 502-693 Sentence denotes Modeling and energy calculations clearly indicate that such increase in affinity cannot be accounted for by binding of these oligosaccharides at any of the six sites of a garlic lectin dimer.
T6 694-826 Sentence denotes These studies also indicate that a given oligosaccharide cannot bind simultaneously to more than one binding site on a lectin dimer.
T7 827-966 Sentence denotes The possibility of a given oligosaccharide simultaneously binding to and hence linking two or more lectin molecules was therefore explored.
T8 967-1183 Sentence denotes This study showed that trimannosides and higher oligomers can cross-link lectin dimers, amplifying the protein-oligosaccharide interactions severalfold, thus explaining the role of multivalency in enhancing affinity.
T9 1184-1281 Sentence denotes A comprehensive exploration of all possible cross-links posed a formidable computational problem.
T10 1282-1526 Sentence denotes Even a partial exploration involving a carefully chosen region of the conformational space clearly showed that a given dimer pair can be cross-linked not only by a single oligosaccharide molecule but also simultaneously by two oligosaccharides.
T11 1527-1730 Sentence denotes The number of such possible double cross-links, including those forming interesting tetrameric structures, generally increases with the size of the oligosaccharide, correlating with the biochemical data.
T12 1731-1879 Sentence denotes In addition to their immediate relevance to garlic lectin, these studies are of general interest in relation to lectin-oligosaccharide interactions.
T1 0-126 Sentence denotes Computational analysis of multivalency in lectins: structures of garlic lectin-oligosaccharide complexes and their aggregates.
T2 127-214 Sentence denotes Multivalency in lectins is a phenomenon that has been discussed at considerable length.
T3 215-339 Sentence denotes The structural basis for the role of multivalency in garlic lectin has been investigated here through computational studies.
T4 340-501 Sentence denotes Biochemical studies have shown that the binding affinity of garlic lectin for high mannose oligosaccharides is orders of magnitude greater than that for mannose.
T5 502-693 Sentence denotes Modeling and energy calculations clearly indicate that such increase in affinity cannot be accounted for by binding of these oligosaccharides at any of the six sites of a garlic lectin dimer.
T6 694-826 Sentence denotes These studies also indicate that a given oligosaccharide cannot bind simultaneously to more than one binding site on a lectin dimer.
T7 827-966 Sentence denotes The possibility of a given oligosaccharide simultaneously binding to and hence linking two or more lectin molecules was therefore explored.
T8 967-1183 Sentence denotes This study showed that trimannosides and higher oligomers can cross-link lectin dimers, amplifying the protein-oligosaccharide interactions severalfold, thus explaining the role of multivalency in enhancing affinity.
T9 1184-1281 Sentence denotes A comprehensive exploration of all possible cross-links posed a formidable computational problem.
T10 1282-1526 Sentence denotes Even a partial exploration involving a carefully chosen region of the conformational space clearly showed that a given dimer pair can be cross-linked not only by a single oligosaccharide molecule but also simultaneously by two oligosaccharides.
T11 1527-1730 Sentence denotes The number of such possible double cross-links, including those forming interesting tetrameric structures, generally increases with the size of the oligosaccharide, correlating with the biochemical data.
T12 1731-1879 Sentence denotes In addition to their immediate relevance to garlic lectin, these studies are of general interest in relation to lectin-oligosaccharide interactions.

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 79-94 FMAID:196731 denotes oligosaccharide
_T2 79-94 FMAID:82742 denotes oligosaccharide
_T3 423-430 FMAID:196796 denotes mannose
_T4 423-430 FMAID:82801 denotes mannose
_T5 431-447 FMAID:82742 denotes oligosaccharides
_T6 431-447 FMAID:196731 denotes oligosaccharides
_T7 493-500 FMAID:196796 denotes mannose
_T8 493-500 FMAID:82801 denotes mannose
_T9 627-643 FMAID:196731 denotes oligosaccharides
_T10 627-643 FMAID:82742 denotes oligosaccharides
_T11 735-750 FMAID:196731 denotes oligosaccharide
_T12 735-750 FMAID:82742 denotes oligosaccharide
_T13 854-869 FMAID:196731 denotes oligosaccharide
_T14 854-869 FMAID:82742 denotes oligosaccharide
_T15 1070-1077 FMAID:165447 denotes protein
_T16 1070-1077 FMAID:67257 denotes protein
_T17 1078-1093 FMAID:82742 denotes oligosaccharide
_T18 1078-1093 FMAID:196731 denotes oligosaccharide
_T23 1675-1690 FMAID:196731 denotes oligosaccharide
_T19 1453-1468 FMAID:196731 denotes oligosaccharide
_T20 1453-1468 FMAID:82742 denotes oligosaccharide
_T21 1509-1525 FMAID:196731 denotes oligosaccharides
_T22 1509-1525 FMAID:82742 denotes oligosaccharides
_T24 1675-1690 FMAID:82742 denotes oligosaccharide
_T25 1850-1865 FMAID:196731 denotes oligosaccharide
_T26 1850-1865 FMAID:82742 denotes oligosaccharide

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 1234-1239 http://www.uniprot.org/uniprot/Q8BI79 denotes links
T2 1568-1573 http://www.uniprot.org/uniprot/Q8BI79 denotes links

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 1611-1621 http://purl.bioontology.org/ontology/NCBITAXON/435742 denotes tetrameric
T2 1831-1839 http://purl.bioontology.org/ontology/NCBITAXON/353209 denotes relation

GO-MF

Id Subject Object Predicate Lexical cue
T1 380-387 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T2 610-617 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 795-802 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 758-762 http://purl.obolibrary.org/obo/GO_0070026 denotes bind
T5 380-387 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T6 610-617 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T7 795-802 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T8 758-762 http://purl.obolibrary.org/obo/GO_0003680 denotes bind
T9 380-387 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T10 610-617 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T11 795-802 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T12 758-762 http://purl.obolibrary.org/obo/GO_0017091 denotes bind
T13 380-387 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T14 610-617 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T15 795-802 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T16 758-762 http://purl.obolibrary.org/obo/GO_0005488 denotes bind

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 331-338 http://edamontology.org/topic_3678 denotes studies
T2 352-359 http://edamontology.org/topic_3678 denotes studies
T3 700-707 http://edamontology.org/topic_3678 denotes studies
T4 933-942 http://edamontology.org/topic_2839 denotes molecules
T5 972-977 http://edamontology.org/topic_3678 denotes study
T6 1070-1077 http://edamontology.org/topic_0078 denotes protein
T7 1094-1106 http://edamontology.org/topic_0602 denotes interactions
T8 1469-1477 http://edamontology.org/topic_2839 denotes molecule
T9 1796-1803 http://edamontology.org/topic_3678 denotes studies
T10 1866-1878 http://edamontology.org/topic_0602 denotes interactions

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 14-22 http://edamontology.org/operation_2945 denotes analysis
T2 51-61 http://edamontology.org/data_0883 denotes structures
T3 219-229 http://edamontology.org/data_0883 denotes structural
T4 522-534 http://edamontology.org/operation_3438 denotes calculations
T5 1070-1077 http://edamontology.org/data_1467 denotes protein
T6 1070-1077 http://edamontology.org/format_1208 denotes protein
T7 1407-1411 http://edamontology.org/format_1996 denotes pair
T8 1622-1632 http://edamontology.org/data_0883 denotes structures
T9 1634-1643 http://edamontology.org/operation_3429 denotes generally
T10 1692-1703 http://edamontology.org/operation_3465 denotes correlating
T11 1725-1729 http://edamontology.org/data_0006 denotes data
T12 1811-1818 http://edamontology.org/operation_3429 denotes general

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 418-430 http://rdf.glycoinfo.org/glycan/G00028MO denotes high mannose

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 1215-1218 "http://rdf.glycoinfo.org/glycan/G41652MJ" denotes all
GlycanIUPAC_T2 1215-1218 "http://rdf.glycoinfo.org/glycan/G20761YC" denotes all
GlycanIUPAC_T3 1215-1218 "http://rdf.glycoinfo.org/glycan/G19807HM" denotes all
GlycanIUPAC_T4 1215-1218 "http://rdf.glycoinfo.org/glycan/G20351TE" denotes all
GlycanIUPAC_T5 1215-1218 "http://rdf.glycoinfo.org/glycan/G71957MR" denotes all
GlycanIUPAC_T6 1215-1218 "http://rdf.glycoinfo.org/glycan/G59040AE" denotes all
GlycanIUPAC_T7 1215-1218 "http://rdf.glycoinfo.org/glycan/G14987PW" denotes all
GlycanIUPAC_T8 1215-1218 "http://rdf.glycoinfo.org/glycan/G95064PC" denotes all
GlycanIUPAC_T9 1215-1218 "http://rdf.glycoinfo.org/glycan/G39143AQ" denotes all
GlycanIUPAC_T10 1215-1218 "http://rdf.glycoinfo.org/glycan/G65149OO" denotes all
GlycanIUPAC_T11 1215-1218 "http://rdf.glycoinfo.org/glycan/G02766SY" denotes all
GlycanIUPAC_T12 1215-1218 "http://rdf.glycoinfo.org/glycan/G26019KJ" denotes all
GlycanIUPAC_T13 1215-1218 "http://rdf.glycoinfo.org/glycan/G36429CZ" denotes all
GlycanIUPAC_T14 1215-1218 "http://rdf.glycoinfo.org/glycan/G89633TP" denotes all
GlycanIUPAC_T15 1215-1218 "http://rdf.glycoinfo.org/glycan/G28494FO" denotes all
GlycanIUPAC_T16 1215-1218 "http://rdf.glycoinfo.org/glycan/G06219CP" denotes all
GlycanIUPAC_T17 1215-1218 "http://rdf.glycoinfo.org/glycan/G44237SM" denotes all
GlycanIUPAC_T18 1215-1218 "http://rdf.glycoinfo.org/glycan/G57948RL" denotes all
GlycanIUPAC_T19 1215-1218 "http://rdf.glycoinfo.org/glycan/G64016DN" denotes all
GlycanIUPAC_T20 1215-1218 "http://rdf.glycoinfo.org/glycan/G14536PC" denotes all
GlycanIUPAC_T21 1215-1218 "http://rdf.glycoinfo.org/glycan/G14356FW" denotes all
GlycanIUPAC_T22 1215-1218 "http://rdf.glycoinfo.org/glycan/G34565UO" denotes all
GlycanIUPAC_T23 1215-1218 "http://rdf.glycoinfo.org/glycan/G67124MW" denotes all
GlycanIUPAC_T24 1215-1218 "http://rdf.glycoinfo.org/glycan/G71457ZU" denotes all
GlycanIUPAC_T25 1215-1218 "http://rdf.glycoinfo.org/glycan/G55228VZ" denotes all
GlycanIUPAC_T26 1215-1218 "http://rdf.glycoinfo.org/glycan/G31034MJ" denotes all
GlycanIUPAC_T27 1215-1218 "http://rdf.glycoinfo.org/glycan/G25776IP" denotes all
GlycanIUPAC_T28 1215-1218 "http://rdf.glycoinfo.org/glycan/G64442BV" denotes all
GlycanIUPAC_T29 1215-1218 "http://rdf.glycoinfo.org/glycan/G57018LE" denotes all
GlycanIUPAC_T30 1215-1218 "http://rdf.glycoinfo.org/glycan/G61761GX" denotes all
GlycanIUPAC_T31 1215-1218 "http://rdf.glycoinfo.org/glycan/G76318UX" denotes all
GlycanIUPAC_T32 1215-1218 "http://rdf.glycoinfo.org/glycan/G61906ER" denotes all
GlycanIUPAC_T33 1215-1218 "http://rdf.glycoinfo.org/glycan/G68723GR" denotes all
GlycanIUPAC_T34 1215-1218 "http://rdf.glycoinfo.org/glycan/G19540LE" denotes all
GlycanIUPAC_T35 1215-1218 "http://rdf.glycoinfo.org/glycan/G74944PO" denotes all
GlycanIUPAC_T36 1215-1218 "http://rdf.glycoinfo.org/glycan/G89489ZJ" denotes all
GlycanIUPAC_T37 1215-1218 "http://rdf.glycoinfo.org/glycan/G04434YU" denotes all
GlycanIUPAC_T38 1215-1218 "http://rdf.glycoinfo.org/glycan/G21450PB" denotes all
GlycanIUPAC_T39 1215-1218 "http://rdf.glycoinfo.org/glycan/G93629QY" denotes all
GlycanIUPAC_T40 1215-1218 "http://rdf.glycoinfo.org/glycan/G02603TR" denotes all
GlycanIUPAC_T41 1215-1218 "http://rdf.glycoinfo.org/glycan/G40280JP" denotes all
GlycanIUPAC_T42 1215-1218 "http://rdf.glycoinfo.org/glycan/G95259IC" denotes all
GlycanIUPAC_T43 1215-1218 "http://rdf.glycoinfo.org/glycan/G26900FE" denotes all
GlycanIUPAC_T44 1215-1218 "http://rdf.glycoinfo.org/glycan/G21346KK" denotes all
GlycanIUPAC_T45 1215-1218 "http://rdf.glycoinfo.org/glycan/G62509FF" denotes all
GlycanIUPAC_T46 1215-1218 "http://rdf.glycoinfo.org/glycan/G83932AK" denotes all
GlycanIUPAC_T47 1215-1218 "http://rdf.glycoinfo.org/glycan/G96978IB" denotes all
GlycanIUPAC_T48 1215-1218 "http://rdf.glycoinfo.org/glycan/G34275DN" denotes all
GlycanIUPAC_T49 1215-1218 "http://rdf.glycoinfo.org/glycan/G07071JF" denotes all
GlycanIUPAC_T50 1215-1218 "http://rdf.glycoinfo.org/glycan/G80639QD" denotes all
GlycanIUPAC_T51 1215-1218 "http://rdf.glycoinfo.org/glycan/G99460PJ" denotes all
GlycanIUPAC_T52 1215-1218 "http://rdf.glycoinfo.org/glycan/G22024BZ" denotes all
GlycanIUPAC_T53 1215-1218 "http://rdf.glycoinfo.org/glycan/G74097ZY" denotes all
GlycanIUPAC_T54 1215-1218 "http://rdf.glycoinfo.org/glycan/G84439YP" denotes all
GlycanIUPAC_T55 1215-1218 "http://rdf.glycoinfo.org/glycan/G52207WQ" denotes all
GlycanIUPAC_T56 1215-1218 "http://rdf.glycoinfo.org/glycan/G90695MS" denotes all
GlycanIUPAC_T57 1215-1218 "http://rdf.glycoinfo.org/glycan/G50398QX" denotes all
GlycanIUPAC_T58 1215-1218 "http://rdf.glycoinfo.org/glycan/G12166ZT" denotes all
GlycanIUPAC_T59 1215-1218 "http://rdf.glycoinfo.org/glycan/G48368BR" denotes all
GlycanIUPAC_T60 1215-1218 "http://rdf.glycoinfo.org/glycan/G57407RW" denotes all
GlycanIUPAC_T61 1215-1218 "http://rdf.glycoinfo.org/glycan/G00386TY" denotes all
GlycanIUPAC_T62 1215-1218 "http://rdf.glycoinfo.org/glycan/G18723JK" denotes all
GlycanIUPAC_T63 1215-1218 "http://rdf.glycoinfo.org/glycan/G93757OR" denotes all
GlycanIUPAC_T64 1215-1218 "http://rdf.glycoinfo.org/glycan/G29006SI" denotes all
GlycanIUPAC_T65 1215-1218 "http://rdf.glycoinfo.org/glycan/G03099OQ" denotes all
GlycanIUPAC_T66 1215-1218 "http://rdf.glycoinfo.org/glycan/G53739OW" denotes all
GlycanIUPAC_T67 1215-1218 "http://rdf.glycoinfo.org/glycan/G70440ZO" denotes all
GlycanIUPAC_T68 1215-1218 "http://rdf.glycoinfo.org/glycan/G29951RR" denotes all
GlycanIUPAC_T69 1215-1218 "http://rdf.glycoinfo.org/glycan/G58402TI" denotes all
GlycanIUPAC_T70 1215-1218 "http://rdf.glycoinfo.org/glycan/G39875TP" denotes all
GlycanIUPAC_T71 1215-1218 "http://rdf.glycoinfo.org/glycan/G83439QV" denotes all
GlycanIUPAC_T72 1215-1218 "http://rdf.glycoinfo.org/glycan/G41762RC" denotes all
GlycanIUPAC_T73 1215-1218 "http://rdf.glycoinfo.org/glycan/G91604UI" denotes all
GlycanIUPAC_T74 1215-1218 "http://rdf.glycoinfo.org/glycan/G88447WE" denotes all
GlycanIUPAC_T75 1215-1218 "http://rdf.glycoinfo.org/glycan/G93634BS" denotes all
GlycanIUPAC_T76 1215-1218 "http://rdf.glycoinfo.org/glycan/G02587BH" denotes all
GlycanIUPAC_T77 1215-1218 "http://rdf.glycoinfo.org/glycan/G43511MX" denotes all
GlycanIUPAC_T78 1215-1218 "http://rdf.glycoinfo.org/glycan/G64958DH" denotes all
GlycanIUPAC_T79 1215-1218 "http://rdf.glycoinfo.org/glycan/G30384TR" denotes all
GlycanIUPAC_T80 1215-1218 "http://rdf.glycoinfo.org/glycan/G15624EX" denotes all
GlycanIUPAC_T81 1215-1218 "http://rdf.glycoinfo.org/glycan/G22706ST" denotes all
GlycanIUPAC_T82 1215-1218 "http://rdf.glycoinfo.org/glycan/G57408PI" denotes all
GlycanIUPAC_T83 1215-1218 "http://rdf.glycoinfo.org/glycan/G86403XX" denotes all
GlycanIUPAC_T84 1215-1218 "http://rdf.glycoinfo.org/glycan/G78043YB" denotes all
GlycanIUPAC_T85 1215-1218 "http://rdf.glycoinfo.org/glycan/G18952JK" denotes all
GlycanIUPAC_T86 1215-1218 "http://rdf.glycoinfo.org/glycan/G49020ND" denotes all
GlycanIUPAC_T87 1215-1218 "http://rdf.glycoinfo.org/glycan/G63590YW" denotes all
GlycanIUPAC_T88 1215-1218 "http://rdf.glycoinfo.org/glycan/G22793KS" denotes all
GlycanIUPAC_T89 1215-1218 "http://rdf.glycoinfo.org/glycan/G64134SS" denotes all
GlycanIUPAC_T90 1215-1218 "http://rdf.glycoinfo.org/glycan/G17338HY" denotes all
GlycanIUPAC_T91 1215-1218 "http://rdf.glycoinfo.org/glycan/G99745XF" denotes all
GlycanIUPAC_T92 1215-1218 "http://rdf.glycoinfo.org/glycan/G27782HN" denotes all
GlycanIUPAC_T93 1215-1218 "http://rdf.glycoinfo.org/glycan/G57496DC" denotes all
GlycanIUPAC_T94 1215-1218 "http://rdf.glycoinfo.org/glycan/G93169WB" denotes all
GlycanIUPAC_T95 1215-1218 "http://rdf.glycoinfo.org/glycan/G05518TD" denotes all
GlycanIUPAC_T96 1215-1218 "http://rdf.glycoinfo.org/glycan/G62603DN" denotes all
GlycanIUPAC_T97 1215-1218 "http://rdf.glycoinfo.org/glycan/G59574FS" denotes all
GlycanIUPAC_T98 1215-1218 "http://rdf.glycoinfo.org/glycan/G47567WC" denotes all

Lectin-Jamboree

Id Subject Object Predicate Lexical cue
T1 39-49 lectin denotes in lectins
T2 72-78 lectin denotes lectin
T3 140-150 lectin denotes in lectins
T4 275-281 lectin denotes lectin
T5 407-413 lectin denotes lectin
T6 680-686 lectin denotes lectin
T7 813-819 lectin denotes lectin
T8 926-932 lectin denotes lectin
T9 1040-1046 lectin denotes lectin
T10 1782-1788 lectin denotes lectin
T11 1843-1849 lectin denotes lectin

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-126 Sentence denotes Computational analysis of multivalency in lectins: structures of garlic lectin-oligosaccharide complexes and their aggregates.
T2 127-214 Sentence denotes Multivalency in lectins is a phenomenon that has been discussed at considerable length.
T3 215-339 Sentence denotes The structural basis for the role of multivalency in garlic lectin has been investigated here through computational studies.
T4 340-501 Sentence denotes Biochemical studies have shown that the binding affinity of garlic lectin for high mannose oligosaccharides is orders of magnitude greater than that for mannose.
T5 502-693 Sentence denotes Modeling and energy calculations clearly indicate that such increase in affinity cannot be accounted for by binding of these oligosaccharides at any of the six sites of a garlic lectin dimer.
T6 694-826 Sentence denotes These studies also indicate that a given oligosaccharide cannot bind simultaneously to more than one binding site on a lectin dimer.
T7 827-966 Sentence denotes The possibility of a given oligosaccharide simultaneously binding to and hence linking two or more lectin molecules was therefore explored.
T8 967-1183 Sentence denotes This study showed that trimannosides and higher oligomers can cross-link lectin dimers, amplifying the protein-oligosaccharide interactions severalfold, thus explaining the role of multivalency in enhancing affinity.
T9 1184-1281 Sentence denotes A comprehensive exploration of all possible cross-links posed a formidable computational problem.
T10 1282-1526 Sentence denotes Even a partial exploration involving a carefully chosen region of the conformational space clearly showed that a given dimer pair can be cross-linked not only by a single oligosaccharide molecule but also simultaneously by two oligosaccharides.
T11 1527-1730 Sentence denotes The number of such possible double cross-links, including those forming interesting tetrameric structures, generally increases with the size of the oligosaccharide, correlating with the biochemical data.
T12 1731-1879 Sentence denotes In addition to their immediate relevance to garlic lectin, these studies are of general interest in relation to lectin-oligosaccharide interactions.

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1367-1372 Body_part denotes space http://purl.obolibrary.org/obo/UBERON_0000464