PubMed:12840014
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 21-32 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T2 | 128-135 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T4 | 254-265 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T5 | 326-337 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T6 | 646-657 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T7 | 845-856 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T8 | 1575-1586 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T9 | 1717-1728 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T10 | 1820-1831 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 21-32 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T2 | 128-135 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T3 | 128-135 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T4 | 254-265 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T5 | 326-337 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T6 | 646-657 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T7 | 845-856 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T8 | 1575-1586 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T9 | 1717-1728 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T10 | 1820-1831 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-171 | Sentence | denotes | Heterogeneity of the chondroitin sulfate portion of phosphacan/6B4 proteoglycan regulates its binding affinity for pleiotrophin/heparin binding growth-associated molecule. |
| T2 | 172-321 | Sentence | denotes | PTP zeta is a receptor-type protein-tyrosine phosphatase that is synthesized as a chondroitin sulfate proteoglycan and uses pleiotrophin as a ligand. |
| T3 | 322-426 | Sentence | denotes | The chondroitin sulfate portion of this receptor is essential for high affinity binding to pleiotrophin. |
| T4 | 427-641 | Sentence | denotes | Here, we purified phosphacan, which corresponds to the extracellular domain of PTP zeta, from postnatal day 7 (P7) and P12 rat cerebral cortex (PG-P7 and PG-P12, respectively) and from P20 rat whole brain (PG-P20). |
| T5 | 642-755 | Sentence | denotes | The chondroitin sulfate of these preparations displayed immunologically and compositionally different structures. |
| T6 | 756-934 | Sentence | denotes | In particular, only PG-P20 reacted with the monoclonal antibody MO-225, which recognizes chondroitin sulfate containing the GlcA(2S)beta 1-3GalNAc(6S) disaccharide unit (D unit). |
| T7 | 935-1178 | Sentence | denotes | Analysis of the chondroitinase digestion products revealed that GlcA beta 1-3GalNAc(4S) disaccharide unit (A unit) was the major component in these preparations and that PG-P20 contained 1.3% D unit, which was not detected in PG-P7 and PG-P12. |
| T8 | 1179-1539 | Sentence | denotes | Interaction analysis using a surface plasmon resonance biosensor indicated that PG-P20 had approximately 5-fold stronger affinity for pleiotrophin (dissociation constant (KD) = 0.14 nM) than PG-P7 and PG-P12, although all these preparations showed similar low affinity binding to pleiotrophin after chondroitinase ABC digestion (KD = 1.4 approximately 1.6 nM). |
| T9 | 1540-1779 | Sentence | denotes | We also found that shark cartilage chondroitin sulfate D containing approximately 20% D unit bound to pleiotrophin with moderate affinity (KD = 2.7 nM), whereas whale cartilage chondroitin sulfate A showed no binding to this growth factor. |
| T10 | 1780-1916 | Sentence | denotes | These results suggest that variation of chondroitin sulfate plays important roles in the regulation of signal transduction in the brain. |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 21-32 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T2 | 254-265 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T3 | 326-337 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T4 | 646-657 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T5 | 820-826 | http://www.glycoepitope.jp/epitopes/AN0138 | denotes | MO-225 |
| T6 | 845-856 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T7 | 1575-1586 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T8 | 1717-1728 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T9 | 1820-1831 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 554-569 | http://purl.obolibrary.org/obo/MAT_0000108 | denotes | cerebral cortex |
| T2 | 626-631 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T3 | 1565-1574 | http://purl.obolibrary.org/obo/MAT_0000189 | denotes | cartilage |
| T4 | 1707-1716 | http://purl.obolibrary.org/obo/MAT_0000189 | denotes | cartilage |
| T5 | 1910-1915 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 21-32 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T2 | 254-265 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T3 | 326-337 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T4 | 646-657 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T5 | 845-856 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T6 | 1575-1586 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T7 | 1717-1728 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T8 | 1820-1831 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 21-32 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T2 | 254-265 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T3 | 326-337 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T4 | 646-657 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T5 | 820-826 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | MO-225 | http://www.glycoepitope.jp/epitopes/AN0138 |
| T6 | 845-856 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T7 | 1575-1586 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T8 | 1717-1728 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T9 | 1820-1831 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 550-553 | OrganismTaxon | denotes | rat | 10114|10116 |
| T3 | 616-619 | OrganismTaxon | denotes | rat | 10114|10116 |
| T5 | 1701-1706 | OrganismTaxon | denotes | whale | 9721 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 482-495 | Body_part | denotes | extracellular | http://purl.obolibrary.org/obo/GO_0005576 |
| T2 | 554-569 | Body_part | denotes | cerebral cortex | http://purl.obolibrary.org/obo/UBERON_0000956 |
| T3 | 626-631 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T5 | 1565-1574 | Body_part | denotes | cartilage | http://purl.obolibrary.org/obo/UBERON_0002418|http://purl.obolibrary.org/obo/UBERON_0007844 |
| T7 | 1707-1716 | Body_part | denotes | cartilage | http://purl.obolibrary.org/obo/UBERON_0002418|http://purl.obolibrary.org/obo/UBERON_0007844 |
| T9 | 1910-1915 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 554-569 | Body_part | denotes | cerebral cortex | http://purl.obolibrary.org/obo/MAT_0000108 |
| T2 | 626-631 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T3 | 1565-1574 | Body_part | denotes | cartilage | http://purl.obolibrary.org/obo/MAT_0000189 |
| T4 | 1707-1716 | Body_part | denotes | cartilage | http://purl.obolibrary.org/obo/MAT_0000189 |
| T5 | 1910-1915 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-171 | Sentence | denotes | Heterogeneity of the chondroitin sulfate portion of phosphacan/6B4 proteoglycan regulates its binding affinity for pleiotrophin/heparin binding growth-associated molecule. |
| T2 | 172-321 | Sentence | denotes | PTP zeta is a receptor-type protein-tyrosine phosphatase that is synthesized as a chondroitin sulfate proteoglycan and uses pleiotrophin as a ligand. |
| T3 | 322-426 | Sentence | denotes | The chondroitin sulfate portion of this receptor is essential for high affinity binding to pleiotrophin. |
| T4 | 427-641 | Sentence | denotes | Here, we purified phosphacan, which corresponds to the extracellular domain of PTP zeta, from postnatal day 7 (P7) and P12 rat cerebral cortex (PG-P7 and PG-P12, respectively) and from P20 rat whole brain (PG-P20). |
| T5 | 642-755 | Sentence | denotes | The chondroitin sulfate of these preparations displayed immunologically and compositionally different structures. |
| T6 | 756-934 | Sentence | denotes | In particular, only PG-P20 reacted with the monoclonal antibody MO-225, which recognizes chondroitin sulfate containing the GlcA(2S)beta 1-3GalNAc(6S) disaccharide unit (D unit). |
| T7 | 935-1178 | Sentence | denotes | Analysis of the chondroitinase digestion products revealed that GlcA beta 1-3GalNAc(4S) disaccharide unit (A unit) was the major component in these preparations and that PG-P20 contained 1.3% D unit, which was not detected in PG-P7 and PG-P12. |
| T8 | 1179-1539 | Sentence | denotes | Interaction analysis using a surface plasmon resonance biosensor indicated that PG-P20 had approximately 5-fold stronger affinity for pleiotrophin (dissociation constant (KD) = 0.14 nM) than PG-P7 and PG-P12, although all these preparations showed similar low affinity binding to pleiotrophin after chondroitinase ABC digestion (KD = 1.4 approximately 1.6 nM). |
| T9 | 1540-1779 | Sentence | denotes | We also found that shark cartilage chondroitin sulfate D containing approximately 20% D unit bound to pleiotrophin with moderate affinity (KD = 2.7 nM), whereas whale cartilage chondroitin sulfate A showed no binding to this growth factor. |
| T10 | 1780-1916 | Sentence | denotes | These results suggest that variation of chondroitin sulfate plays important roles in the regulation of signal transduction in the brain. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-171 | Sentence | denotes | Heterogeneity of the chondroitin sulfate portion of phosphacan/6B4 proteoglycan regulates its binding affinity for pleiotrophin/heparin binding growth-associated molecule. |
| T2 | 172-321 | Sentence | denotes | PTP zeta is a receptor-type protein-tyrosine phosphatase that is synthesized as a chondroitin sulfate proteoglycan and uses pleiotrophin as a ligand. |
| T3 | 322-426 | Sentence | denotes | The chondroitin sulfate portion of this receptor is essential for high affinity binding to pleiotrophin. |
| T4 | 427-641 | Sentence | denotes | Here, we purified phosphacan, which corresponds to the extracellular domain of PTP zeta, from postnatal day 7 (P7) and P12 rat cerebral cortex (PG-P7 and PG-P12, respectively) and from P20 rat whole brain (PG-P20). |
| T5 | 642-755 | Sentence | denotes | The chondroitin sulfate of these preparations displayed immunologically and compositionally different structures. |
| T6 | 756-934 | Sentence | denotes | In particular, only PG-P20 reacted with the monoclonal antibody MO-225, which recognizes chondroitin sulfate containing the GlcA(2S)beta 1-3GalNAc(6S) disaccharide unit (D unit). |
| T7 | 935-1178 | Sentence | denotes | Analysis of the chondroitinase digestion products revealed that GlcA beta 1-3GalNAc(4S) disaccharide unit (A unit) was the major component in these preparations and that PG-P20 contained 1.3% D unit, which was not detected in PG-P7 and PG-P12. |
| T8 | 1179-1539 | Sentence | denotes | Interaction analysis using a surface plasmon resonance biosensor indicated that PG-P20 had approximately 5-fold stronger affinity for pleiotrophin (dissociation constant (KD) = 0.14 nM) than PG-P7 and PG-P12, although all these preparations showed similar low affinity binding to pleiotrophin after chondroitinase ABC digestion (KD = 1.4 approximately 1.6 nM). |
| T9 | 1540-1779 | Sentence | denotes | We also found that shark cartilage chondroitin sulfate D containing approximately 20% D unit bound to pleiotrophin with moderate affinity (KD = 2.7 nM), whereas whale cartilage chondroitin sulfate A showed no binding to this growth factor. |
| T10 | 1780-1916 | Sentence | denotes | These results suggest that variation of chondroitin sulfate plays important roles in the regulation of signal transduction in the brain. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 21-32 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T2 | 254-265 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T3 | 326-337 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T4 | 646-657 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T5 | 845-856 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T6 | 1575-1586 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T7 | 1717-1728 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T8 | 1820-1831 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 21-32 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T2 | 254-265 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T3 | 326-337 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T4 | 646-657 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T5 | 820-826 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | MO-225 | http://www.glycoepitope.jp/epitopes/AN0138 |
| T6 | 845-856 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T7 | 1575-1586 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T8 | 1717-1728 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T9 | 1820-1831 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 550-553 | OrganismTaxon | denotes | rat | 10114|10116 |
| T3 | 616-619 | OrganismTaxon | denotes | rat | 10114|10116 |
| T5 | 1701-1706 | OrganismTaxon | denotes | whale | 9721 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 482-495 | Body_part | denotes | extracellular | http://purl.obolibrary.org/obo/GO_0005576 |
| T2 | 554-569 | Body_part | denotes | cerebral cortex | http://purl.obolibrary.org/obo/UBERON_0000956 |
| T3 | 626-631 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T5 | 1565-1574 | Body_part | denotes | cartilage | http://purl.obolibrary.org/obo/UBERON_0002418|http://purl.obolibrary.org/obo/UBERON_0007844 |
| T7 | 1707-1716 | Body_part | denotes | cartilage | http://purl.obolibrary.org/obo/UBERON_0002418|http://purl.obolibrary.org/obo/UBERON_0007844 |
| T9 | 1910-1915 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 554-569 | Body_part | denotes | cerebral cortex | http://purl.obolibrary.org/obo/MAT_0000108 |
| T2 | 626-631 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T3 | 1565-1574 | Body_part | denotes | cartilage | http://purl.obolibrary.org/obo/MAT_0000189 |
| T4 | 1707-1716 | Body_part | denotes | cartilage | http://purl.obolibrary.org/obo/MAT_0000189 |
| T5 | 1910-1915 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |