PubMed:12829702
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 23-26 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T3 | 58-61 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T5 | 257-260 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T7 | 662-665 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T9 | 673-676 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T11 | 709-732 | Glycan_Motif | denotes | N-acetylneuraminic acid | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G50850NI |
| T13 | 784-787 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T15 | 834-837 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T17 | 949-952 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T19 | 1026-1029 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T21 | 1121-1124 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
| T23 | 1289-1292 | Glycan_Motif | denotes | GM2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-82 | Sentence | denotes | Presence of an unusual GM2 derivative, taurine-conjugated GM2, in Tay-Sachs brain. |
| T2 | 83-162 | Sentence | denotes | Tay-Sachs disease (TSD) is a classical glycosphingolipid (GSL) storage disease. |
| T3 | 163-360 | Sentence | denotes | Although the genetic and biochemical bases for a massive cerebral accumulation of ganglioside GM2 in TSD have been well established, the mechanism for the neural dysfunction in TSD remains elusive. |
| T4 | 361-477 | Sentence | denotes | Upon analysis of GSLs from a variant B TS brain, we have detected a novel GSL that has not been previously revealed. |
| T5 | 478-517 | Sentence | denotes | We have isolated this GSL in pure form. |
| T6 | 518-757 | Sentence | denotes | Using NMR spectroscopy, mass spectrometry, and chemical synthesis, the structure of this unusual GSL was established to be a taurine-conjugated GM2 (tauro-GM2) in which the carboxyl group of N-acetylneuraminic acid was amidated by taurine. |
| T7 | 758-923 | Sentence | denotes | Using a rabbit anti-tauro-GM2 serum, we also detected the presence of tauro-GM2 in three other small brain samples from one variant B and two variant O TSD patients. |
| T8 | 924-1003 | Sentence | denotes | On the other hand, tauro-GM2 was not found in three normal human brain samples. |
| T9 | 1004-1165 | Sentence | denotes | The presence of tauro-GM2 in TS brains, but not in normal brains, indicates the possible association of this unusual GM2 derivative with the pathogenesis of TSD. |
| T10 | 1166-1293 | Sentence | denotes | Our findings point to taurine conjugation as a heretofore unelucidated mechanism for TS brain to cope with water-insoluble GM2. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 23-26 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T2 | 23-26 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T3 | 58-61 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T4 | 58-61 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T5 | 257-260 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T6 | 257-260 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T7 | 662-665 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T8 | 662-665 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T9 | 673-676 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T10 | 673-676 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T11 | 709-732 | https://glytoucan.org/Structures/Glycans/G50850NI | denotes | N-acetylneuraminic acid |
| T12 | 709-732 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | N-acetylneuraminic acid |
| T13 | 784-787 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T14 | 784-787 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T15 | 834-837 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T16 | 834-837 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T17 | 949-952 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T18 | 949-952 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T19 | 1026-1029 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T20 | 1026-1029 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T21 | 1121-1124 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T22 | 1121-1124 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
| T23 | 1289-1292 | https://glytoucan.org/Structures/Glycans/G61168WC | denotes | GM2 |
| T24 | 1289-1292 | https://glytoucan.org/Structures/Glycans/G79389NT | denotes | GM2 |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 76-81 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T2 | 403-408 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T3 | 859-864 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T4 | 937-941 | http://purl.obolibrary.org/obo/MAT_0000091 | denotes | hand |
| T5 | 989-994 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T6 | 1036-1042 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brains |
| T7 | 1062-1068 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brains |
| T8 | 1254-1259 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 229-260 | HP_0003495 | denotes | accumulation of ganglioside GM2 |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 23-26 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T2 | 58-61 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T3 | 257-260 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T4 | 662-665 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T5 | 673-676 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T6 | 784-787 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T7 | 834-837 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T8 | 949-952 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T9 | 1026-1029 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T10 | 1121-1124 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T11 | 1289-1292 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 83-100 | Disease | denotes | Tay-Sachs disease | http://purl.obolibrary.org/obo/MONDO_0010100 |
| T2 | 102-105 | Disease | denotes | TSD | http://purl.obolibrary.org/obo/MONDO_0010100 |
| T3 | 264-267 | Disease | denotes | TSD | http://purl.obolibrary.org/obo/MONDO_0010100 |
| T4 | 340-343 | Disease | denotes | TSD | http://purl.obolibrary.org/obo/MONDO_0010100 |
| T5 | 910-913 | Disease | denotes | TSD | http://purl.obolibrary.org/obo/MONDO_0010100 |
| T6 | 1161-1164 | Disease | denotes | TSD | http://purl.obolibrary.org/obo/MONDO_0010100 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 76-81 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T2 | 403-408 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T3 | 859-864 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T4 | 937-941 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/MAT_0000091 |
| T5 | 989-994 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T6 | 1036-1042 | Body_part | denotes | brains | http://purl.obolibrary.org/obo/MAT_0000098 |
| T7 | 1062-1068 | Body_part | denotes | brains | http://purl.obolibrary.org/obo/MAT_0000098 |
| T8 | 1254-1259 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 23-26 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T2 | 58-61 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T3 | 257-260 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T4 | 662-665 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T5 | 673-676 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T6 | 784-787 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T7 | 834-837 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T8 | 949-952 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T9 | 1026-1029 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T10 | 1121-1124 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
| T11 | 1289-1292 | Glycan | denotes | GM2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 76-81 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T2 | 403-408 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T3 | 859-864 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T4 | 937-941 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/UBERON_0002398 |
| T5 | 989-994 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
| T6 | 1254-1259 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 914-922 | Organism | denotes | patients | 9606 |
| T2 | 983-988 | Organism | denotes | human | 9606 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-82 | Sentence | denotes | Presence of an unusual GM2 derivative, taurine-conjugated GM2, in Tay-Sachs brain. |
| T2 | 83-162 | Sentence | denotes | Tay-Sachs disease (TSD) is a classical glycosphingolipid (GSL) storage disease. |
| T3 | 163-360 | Sentence | denotes | Although the genetic and biochemical bases for a massive cerebral accumulation of ganglioside GM2 in TSD have been well established, the mechanism for the neural dysfunction in TSD remains elusive. |
| T4 | 361-477 | Sentence | denotes | Upon analysis of GSLs from a variant B TS brain, we have detected a novel GSL that has not been previously revealed. |
| T5 | 478-517 | Sentence | denotes | We have isolated this GSL in pure form. |
| T6 | 518-757 | Sentence | denotes | Using NMR spectroscopy, mass spectrometry, and chemical synthesis, the structure of this unusual GSL was established to be a taurine-conjugated GM2 (tauro-GM2) in which the carboxyl group of N-acetylneuraminic acid was amidated by taurine. |
| T7 | 758-923 | Sentence | denotes | Using a rabbit anti-tauro-GM2 serum, we also detected the presence of tauro-GM2 in three other small brain samples from one variant B and two variant O TSD patients. |
| T8 | 924-1003 | Sentence | denotes | On the other hand, tauro-GM2 was not found in three normal human brain samples. |
| T9 | 1004-1165 | Sentence | denotes | The presence of tauro-GM2 in TS brains, but not in normal brains, indicates the possible association of this unusual GM2 derivative with the pathogenesis of TSD. |
| T10 | 1166-1293 | Sentence | denotes | Our findings point to taurine conjugation as a heretofore unelucidated mechanism for TS brain to cope with water-insoluble GM2. |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 83-100 | Disease | denotes | Tay-Sachs disease | MONDO:0010100 |
| T2 | 102-105 | Disease | denotes | TSD | MONDO:0010100 |
| T3 | 264-267 | Disease | denotes | TSD | MONDO:0010100 |
| T4 | 340-343 | Disease | denotes | TSD | MONDO:0010100 |
| T5 | 910-913 | Disease | denotes | TSD | MONDO:0010100 |
| T6 | 1161-1164 | Disease | denotes | TSD | MONDO:0010100 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 76-81 | Body_part | denotes | brain | FMA:50801 |
| T2 | 403-408 | Body_part | denotes | brain | FMA:50801 |
| T3 | 788-793 | Body_part | denotes | serum | FMA:63083 |
| T4 | 859-864 | Body_part | denotes | brain | FMA:50801 |
| T5 | 937-941 | Body_part | denotes | hand | FMA:9712 |
| T6 | 989-994 | Body_part | denotes | brain | FMA:50801 |
| T7 | 1254-1259 | Body_part | denotes | brain | FMA:50801 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 76-81 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T2 | 403-408 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T3 | 859-864 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T4 | 937-941 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/MAT_0000091 |
| T5 | 989-994 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T6 | 1036-1042 | Body_part | denotes | brains | http://purl.obolibrary.org/obo/MAT_0000098 |
| T7 | 1062-1068 | Body_part | denotes | brains | http://purl.obolibrary.org/obo/MAT_0000098 |
| T8 | 1254-1259 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 983-988 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 76-81 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T3 | 403-408 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T5 | 859-864 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T7 | 937-941 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/UBERON_0002398 |
| T8 | 989-994 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T10 | 1254-1259 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |