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PubMed:12813373 JSONTXT

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AnEM_abstracts

Id Subject Object Predicate Lexical cue
T1 47-52 Organ denotes organ
T2 69-82 Multi-tissue_structure denotes portal venous
T3 96-103 Organ denotes hepatic
T4 122-132 Tissue denotes sinusoidal
T5 145-162 Cell denotes inflammatory cell
T6 178-192 Cell denotes hepatocellular
T7 221-225 Cell denotes cell
T8 351-368 Pathological_formation denotes abdominal abscess
T9 555-572 Pathological_formation denotes abdominal abscess
T10 656-675 Organism_substance denotes Portal venous blood
T11 694-699 Organ denotes liver
T12 715-732 Pathological_formation denotes abdominal abscess
T13 921-959 Organism_substance denotes suprahepatic inferior vena caval blood
T14 997-1008 Multi-tissue_structure denotes portal vein
T15 1060-1071 Multi-tissue_structure denotes portal vein
T16 1110-1115 Organ denotes liver
T17 1117-1122 Organ denotes Liver
T18 1146-1156 Tissue denotes sinusoidal
T19 1185-1197 Multi-tissue_structure denotes central vein
T20 1340-1357 Cell denotes inflammatory cell
T21 1375-1389 Cell denotes hepatocellular
T22 1582-1587 Cell denotes cells
T23 1604-1616 Multi-tissue_structure denotes central vein
T24 1746-1758 Multi-tissue_structure denotes central vein
T25 1787-1799 Organ denotes septic liver
T26 1805-1827 Cell denotes pericentral vein cells
T27 1896-1901 Cell denotes cells
T28 1946-1959 Multi-tissue_structure denotes abscess walls
T29 4-23 Multi-tissue_structure denotes septic abscess wall
T30 1044-1056 Multi-tissue_structure denotes abscess wall
T31 2036-2053 Pathological_formation denotes abdominal abscess
T32 2162-2174 Multi-tissue_structure denotes abscess wall
T33 2205-2218 Multi-tissue_structure denotes portal venous
T34 2300-2305 Organ denotes liver
T35 2383-2388 Cell denotes cells
T36 2396-2408 Multi-tissue_structure denotes central vein
T37 2460-2477 Cell denotes inflammatory cell
T38 2739-2751 Multi-tissue_structure denotes abscess wall
T39 2503-2524 Multi-tissue_structure denotes liver lobular sinuses
T40 2797-2811 Organ denotes septic hepatic
T41 2655-2669 Cell denotes hepatocellular
T42 588-592 Tissue denotes wall

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-232 Sentence denotes The septic abscess wall: a cytokine-generating organ associated with portal venous cytokinemia, hepatic outflow fibrosis, sinusoidal congestion, inflammatory cell sequestration, hepatocellular lipid deposition, and focal cell death.
T2 233-503 Sentence denotes An acute septic inflammatory response with access to the portal circulation was created in a rat model using an intra-abdominal abscess composed of a sterile agar pellet, or one contaminated with 102 Escherichia coli (E. coli) and 109 Bacteriodes fragilis (B. fragilis).
T3 504-655 Sentence denotes After 3 days postimplantation, a well-formed intra-abdominal abscess occurred whose wall showed IL-6 DNA by PCR and IL-6 mRNA by in situ hybridization.
T4 656-865 Sentence denotes Portal venous blood draining into the liver from the intra-abdominal abscess had increased levels of TNF-alpha, IL-1beta, and IL-6 in both sterile and septic groups compared with a control normal animal group.
T5 866-1116 Sentence denotes Increased levels of these cytokines were also found in suprahepatic inferior vena caval blood, but were correlated with the higher portal vein levels, suggesting a gradient from abscess wall to portal vein into the systemic circulation via the liver.
T6 1117-1276 Sentence denotes Liver histology demonstrated sinusoidal congestion centering on the central vein, growing worse with progression from normal in control, to sterile, to septic.
T7 1277-1472 Sentence denotes Similarly, the degree of intrahepatic myeloperoxidase-positive inflammatory cell infiltration and hepatocellular lipid deposition and apoptosis also increased from control, to sterile, to septic.
T8 1473-1800 Sentence denotes Gene expression by in situ hybridization demonstrated a significant increase in IL-6 and fibrinogen mRNAs in cells surrounding the central vein in sterile and septic animals, being greatest in animals with sepsis, associated with an increased deposition of collagen in the central vein area, most prominent in the septic liver.
T9 1801-2004 Sentence denotes The pericentral vein cells with IL-6 and fibrinogen mRNA increases paralleled the increases in cells containing IL-6 and fibrinogen mRNAs in the abscess walls of sterile and septic animals, respectively.
T10 2005-2306 Sentence denotes The data suggest that an intra-abdominal abscess, especially when contaminated with gram-negative bacteria, induces mRNA-generated cytokine responses in the abscess wall that are related to increased portal venous levels of the inflammatory cytokines TNF-alpha, IL-1beta, and IL-6 perfusing the liver.
T11 2307-2525 Sentence denotes These, in turn, induce localized production of IL-6 and fibrinogen mRNAs in cells at the central vein area with resultant outflow fibrosis and increased inflammatory cell sequestration within the liver lobular sinuses.
T12 2526-2630 Sentence denotes This is associated with a generalized inflammatory response and intrahepatic portal sinusoid congestion.
T13 2631-2701 Sentence denotes There is also increased hepatocellular lipid deposition and apoptosis.
T14 2702-2821 Sentence denotes Thus, the cytokine production of the abscess wall itself appears to be a major mediator of the septic hepatic response.
T1 0-232 Sentence denotes The septic abscess wall: a cytokine-generating organ associated with portal venous cytokinemia, hepatic outflow fibrosis, sinusoidal congestion, inflammatory cell sequestration, hepatocellular lipid deposition, and focal cell death.
T2 233-503 Sentence denotes An acute septic inflammatory response with access to the portal circulation was created in a rat model using an intra-abdominal abscess composed of a sterile agar pellet, or one contaminated with 102 Escherichia coli (E. coli) and 109 Bacteriodes fragilis (B. fragilis).
T3 504-655 Sentence denotes After 3 days postimplantation, a well-formed intra-abdominal abscess occurred whose wall showed IL-6 DNA by PCR and IL-6 mRNA by in situ hybridization.
T4 656-865 Sentence denotes Portal venous blood draining into the liver from the intra-abdominal abscess had increased levels of TNF-alpha, IL-1beta, and IL-6 in both sterile and septic groups compared with a control normal animal group.
T5 866-1116 Sentence denotes Increased levels of these cytokines were also found in suprahepatic inferior vena caval blood, but were correlated with the higher portal vein levels, suggesting a gradient from abscess wall to portal vein into the systemic circulation via the liver.
T6 1117-1276 Sentence denotes Liver histology demonstrated sinusoidal congestion centering on the central vein, growing worse with progression from normal in control, to sterile, to septic.
T7 1277-1472 Sentence denotes Similarly, the degree of intrahepatic myeloperoxidase-positive inflammatory cell infiltration and hepatocellular lipid deposition and apoptosis also increased from control, to sterile, to septic.
T8 1473-1800 Sentence denotes Gene expression by in situ hybridization demonstrated a significant increase in IL-6 and fibrinogen mRNAs in cells surrounding the central vein in sterile and septic animals, being greatest in animals with sepsis, associated with an increased deposition of collagen in the central vein area, most prominent in the septic liver.
T9 1801-2004 Sentence denotes The pericentral vein cells with IL-6 and fibrinogen mRNA increases paralleled the increases in cells containing IL-6 and fibrinogen mRNAs in the abscess walls of sterile and septic animals, respectively.
T10 2005-2306 Sentence denotes The data suggest that an intra-abdominal abscess, especially when contaminated with gram-negative bacteria, induces mRNA-generated cytokine responses in the abscess wall that are related to increased portal venous levels of the inflammatory cytokines TNF-alpha, IL-1beta, and IL-6 perfusing the liver.
T11 2307-2525 Sentence denotes These, in turn, induce localized production of IL-6 and fibrinogen mRNAs in cells at the central vein area with resultant outflow fibrosis and increased inflammatory cell sequestration within the liver lobular sinuses.
T12 2526-2630 Sentence denotes This is associated with a generalized inflammatory response and intrahepatic portal sinusoid congestion.
T13 2631-2701 Sentence denotes There is also increased hepatocellular lipid deposition and apoptosis.
T14 2702-2821 Sentence denotes Thus, the cytokine production of the abscess wall itself appears to be a major mediator of the septic hepatic response.