
PubMed:12810672
Annnotations
c_corpus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-10 | Q92563 | denotes | Testican 2 |
T2 | 0-10 | PR:000015555 | denotes | Testican 2 |
T3 | 0-10 | Q9ER58 | denotes | Testican 2 |
T4 | 35-43 | UBERON:0000094 | denotes | membrane |
T6 | 35-43 | UBERON:0000158 | denotes | membrane |
T5 | 35-43 | GO:0016020 | denotes | membrane |
T7 | 35-74 | D053504 | denotes | membrane-type matrix metalloproteinases |
T8 | 49-55 | UBERON:0027368 | denotes | matrix |
T11 | 100-108 | CHEBI:36080 | denotes | proteins |
T12 | 126-134 | CHEBI:36080 | denotes | proteins |
T13 | 148-161 | GO:0005576 | denotes | extracellular |
T14 | 162-169 | CHEBI:24500 | denotes | heparan |
T21 | 170-203 | D011508 | denotes | chondroitin sulfate proteoglycans |
T22 | 170-203 | D011508 | denotes | chondroitin sulfate proteoglycans |
T27 | 207-214 | 32644 | denotes | unknown |
T30 | 250-253 | PR:Q8LNZ2 | denotes | Tes |
T31 | 250-253 | PR:Q9UGI8 | denotes | Tes |
T32 | 250-253 | PR:Q90YH9 | denotes | Tes |
T34 | 250-253 | PR:000016239 | denotes | Tes |
T35 | 250-253 | A0A144KPJ6 | denotes | Tes |
T36 | 250-253 | PR:P47226 | denotes | Tes |
T37 | 250-253 | PR:Q2LAP6 | denotes | Tes |
T28 | 250-253 | CHEBI:44356 | denotes | Tes |
T29 | 250-253 | C004551 | denotes | Tes |
T33 | 250-253 | CHEBI:39035 | denotes | Tes |
T38 | 250-253 | C004551 | denotes | Tes |
T39 | 277-287 | PR:000015556 | denotes | testican 3 |
T40 | 277-287 | Q9BQ16 | denotes | testican 3 |
T41 | 277-287 | Q8BKV0 | denotes | testican 3 |
T42 | 277-287 | Q5RD69 | denotes | testican 3 |
T43 | 288-296 | GO:0045292 | denotes | splicing |
T44 | 288-304 | SO:0001568 | denotes | splicing variant |
T46 | 305-309 | SO:0000704 | denotes | gene |
T47 | 317-326 | CHEBI:35222 | denotes | inhibitor |
T49 | 330-338 | GO:0016020 | denotes | membrane |
T48 | 330-338 | UBERON:0000094 | denotes | membrane |
T50 | 330-338 | UBERON:0000158 | denotes | membrane |
T51 | 330-369 | D053504 | denotes | membrane-type matrix metalloproteinases |
T52 | 344-350 | UBERON:0027368 | denotes | matrix |
T55 | 374-378 | D020782 | denotes | MMPs |
T56 | 456-466 | Q92563 | denotes | testican 2 |
T57 | 456-466 | PR:000015555 | denotes | testican 2 |
T58 | 456-466 | Q9ER58 | denotes | testican 2 |
T81 | 518-521 | CVCL_2501 | denotes | MT1 |
T66 | 518-521 | GO:0047152 | denotes | MT1 |
T75 | 518-521 | GO:0043791 | denotes | MT1 |
T84 | 518-521 | GO:0043834 | denotes | MT1 |
T100 | 518-525 | Q9XT90 | denotes | MT1-MMP |
T101 | 518-525 | P50281 | denotes | MT1-MMP |
T102 | 518-525 | Q9GLE4 | denotes | MT1-MMP |
T103 | 518-525 | PR:000010474 | denotes | MT1-MMP |
T104 | 518-525 | Q10739 | denotes | MT1-MMP |
T105 | 518-525 | Q95220 | denotes | MT1-MMP |
T107 | 518-525 | P53690 | denotes | MT1-MMP |
T106 | 518-525 | D053511 | denotes | MT1-MMP |
T110 | 522-525 | GO:0004235 | denotes | MMP |
T114 | 530-533 | CVCL_M516 | denotes | MT3 |
T119 | 530-533 | CVCL_M520 | denotes | MT3 |
T121 | 530-533 | CVCL_2129 | denotes | MT3 |
T138 | 530-537 | P51512 | denotes | MT3-MMP |
T139 | 530-537 | O35548 | denotes | MT3-MMP |
T141 | 530-537 | PR:000010476 | denotes | MT3-MMP |
T142 | 530-537 | Q9WTR0 | denotes | MT3-MMP |
T140 | 530-537 | D053513 | denotes | MT3-MMP |
T145 | 534-537 | GO:0004235 | denotes | MMP |
T148 | 547-550 | CVCL_N817 | denotes | pro |
T152 | 547-550 | SO:0001439 | denotes | pro |
T154 | 547-556 | C069860 | denotes | pro-MMP-2 |
T159 | 551-556 | PR:P08253 | denotes | MMP-2 |
T160 | 551-556 | Q9GLE5 | denotes | MMP-2 |
T161 | 551-556 | P08253 | denotes | MMP-2 |
T162 | 551-556 | Q90611 | denotes | MMP-2 |
T164 | 551-556 | PR:Q8MPP3 | denotes | MMP-2 |
T165 | 551-556 | P33436 | denotes | MMP-2 |
T166 | 551-556 | PR:Q90611 | denotes | MMP-2 |
T167 | 551-556 | PR:P33436 | denotes | MMP-2 |
T168 | 551-556 | PR:000010479 | denotes | MMP-2 |
T169 | 551-556 | PR:P33434 | denotes | MMP-2 |
T170 | 551-556 | P33434 | denotes | MMP-2 |
T171 | 551-556 | P50757 | denotes | MMP-2 |
T163 | 551-556 | GO:0004228 | denotes | MMP-2 |
T172 | 602-612 | Q92563 | denotes | Testican 2 |
T173 | 602-612 | PR:000015555 | denotes | Testican 2 |
T174 | 602-612 | Q9ER58 | denotes | Testican 2 |
T177 | 627-630 | PR:Q8LNZ2 | denotes | Tes |
T178 | 627-630 | PR:Q9UGI8 | denotes | Tes |
T179 | 627-630 | PR:Q90YH9 | denotes | Tes |
T181 | 627-630 | PR:000016239 | denotes | Tes |
T182 | 627-630 | A0A144KPJ6 | denotes | Tes |
T183 | 627-630 | PR:P47226 | denotes | Tes |
T184 | 627-630 | PR:Q2LAP6 | denotes | Tes |
T175 | 627-630 | CHEBI:44356 | denotes | Tes |
T176 | 627-630 | C004551 | denotes | Tes |
T180 | 627-630 | CHEBI:39035 | denotes | Tes |
T185 | 627-630 | C004551 | denotes | Tes |
T186 | 634-641 | SO:0100018 | denotes | binding |
T187 | 634-641 | SO:0001091 | denotes | binding |
T188 | 634-641 | GO:0005488 | denotes | binding |
T189 | 649-653 | CHEBI:46883 | denotes | COOH |
T190 | 663-676 | GO:0005576 | denotes | extracellular |
T191 | 677-684 | 1895 | denotes | calcium |
T192 | 677-684 | CHEBI:29320 | denotes | calcium |
T193 | 677-684 | CHEBI:22984 | denotes | calcium |
T194 | 685-692 | SO:0100018 | denotes | binding |
T195 | 685-692 | SO:0001091 | denotes | binding |
T196 | 685-692 | GO:0005488 | denotes | binding |
T197 | 693-699 | SO:0000417 | denotes | domain |
T200 | 705-708 | PR:Q8LNZ2 | denotes | Tes |
T201 | 705-708 | PR:Q9UGI8 | denotes | Tes |
T202 | 705-708 | PR:Q90YH9 | denotes | Tes |
T204 | 705-708 | PR:000016239 | denotes | Tes |
T205 | 705-708 | A0A144KPJ6 | denotes | Tes |
T206 | 705-708 | PR:P47226 | denotes | Tes |
T207 | 705-708 | PR:Q2LAP6 | denotes | Tes |
T198 | 705-708 | CHEBI:44356 | denotes | Tes |
T199 | 705-708 | C004551 | denotes | Tes |
T203 | 705-708 | CHEBI:39035 | denotes | Tes |
T208 | 705-708 | C004551 | denotes | Tes |
T209 | 721-725 | CHEBI:29337 | denotes | NH(2 |
T210 | 721-725 | CHEBI:29339 | denotes | NH(2 |
T211 | 721-725 | CHEBI:29338 | denotes | NH(2 |
T212 | 721-725 | CHEBI:29318 | denotes | NH(2 |
T213 | 721-725 | CHEBI:29345 | denotes | NH(2 |
T214 | 721-725 | CHEBI:29340 | denotes | NH(2 |
T215 | 721-725 | CHEBI:46882 | denotes | NH(2 |
T216 | 743-749 | SO:0000417 | denotes | domain |
T217 | 812-822 | Q92563 | denotes | testican 2 |
T218 | 812-822 | PR:000015555 | denotes | testican 2 |
T219 | 812-822 | Q9ER58 | denotes | testican 2 |
T222 | 852-855 | PR:Q8LNZ2 | denotes | Tes |
T223 | 852-855 | PR:Q9UGI8 | denotes | Tes |
T224 | 852-855 | PR:Q90YH9 | denotes | Tes |
T226 | 852-855 | PR:000016239 | denotes | Tes |
T227 | 852-855 | A0A144KPJ6 | denotes | Tes |
T228 | 852-855 | PR:P47226 | denotes | Tes |
T229 | 852-855 | PR:Q2LAP6 | denotes | Tes |
T220 | 852-855 | CHEBI:44356 | denotes | Tes |
T221 | 852-855 | C004551 | denotes | Tes |
T225 | 852-855 | CHEBI:39035 | denotes | Tes |
T230 | 852-855 | C004551 | denotes | Tes |
T231 | 856-864 | SO:0000159 | denotes | deletion |
T232 | 884-897 | GO:0005576 | denotes | extracellular |
T233 | 898-905 | 1895 | denotes | calcium |
T234 | 898-905 | CHEBI:29320 | denotes | calcium |
T235 | 898-905 | CHEBI:22984 | denotes | calcium |
T236 | 906-913 | SO:0100018 | denotes | binding |
T237 | 906-913 | SO:0001091 | denotes | binding |
T238 | 906-913 | GO:0005488 | denotes | binding |
T239 | 914-920 | SO:0000417 | denotes | domain |
T242 | 924-927 | PR:Q8LNZ2 | denotes | Tes |
T243 | 924-927 | PR:Q9UGI8 | denotes | Tes |
T244 | 924-927 | PR:Q90YH9 | denotes | Tes |
T246 | 924-927 | PR:000016239 | denotes | Tes |
T247 | 924-927 | A0A144KPJ6 | denotes | Tes |
T248 | 924-927 | PR:P47226 | denotes | Tes |
T249 | 924-927 | PR:Q2LAP6 | denotes | Tes |
T240 | 924-927 | CHEBI:44356 | denotes | Tes |
T241 | 924-927 | C004551 | denotes | Tes |
T245 | 924-927 | CHEBI:39035 | denotes | Tes |
T250 | 924-927 | C004551 | denotes | Tes |
T251 | 953-957 | CVCL_0021 | denotes | U251 |
T253 | 967-975 | 2714 | denotes | collagen |
T254 | 967-975 | D003094 | denotes | collagen |
T255 | 967-975 | CHEBI:3815 | denotes | collagen |
T252 | 967-975 | GO:0005202 | denotes | collagen |
T278 | 1000-1003 | CVCL_2501 | denotes | MT1 |
T263 | 1000-1003 | GO:0047152 | denotes | MT1 |
T272 | 1000-1003 | GO:0043791 | denotes | MT1 |
T281 | 1000-1003 | GO:0043834 | denotes | MT1 |
T297 | 1000-1007 | Q9XT90 | denotes | MT1-MMP |
T298 | 1000-1007 | P50281 | denotes | MT1-MMP |
T299 | 1000-1007 | Q9GLE4 | denotes | MT1-MMP |
T300 | 1000-1007 | PR:000010474 | denotes | MT1-MMP |
T301 | 1000-1007 | Q10739 | denotes | MT1-MMP |
T302 | 1000-1007 | Q95220 | denotes | MT1-MMP |
T304 | 1000-1007 | P53690 | denotes | MT1-MMP |
T303 | 1000-1007 | D053511 | denotes | MT1-MMP |
T307 | 1004-1007 | GO:0004235 | denotes | MMP |
T310 | 1023-1028 | UBERON:0001977 | denotes | serum |
T313 | 1064-1067 | PR:Q8LNZ2 | denotes | Tes |
T314 | 1064-1067 | PR:Q9UGI8 | denotes | Tes |
T315 | 1064-1067 | PR:Q90YH9 | denotes | Tes |
T317 | 1064-1067 | PR:000016239 | denotes | Tes |
T318 | 1064-1067 | A0A144KPJ6 | denotes | Tes |
T319 | 1064-1067 | PR:P47226 | denotes | Tes |
T320 | 1064-1067 | PR:Q2LAP6 | denotes | Tes |
T311 | 1064-1067 | CHEBI:44356 | denotes | Tes |
T312 | 1064-1067 | C004551 | denotes | Tes |
T316 | 1064-1067 | CHEBI:39035 | denotes | Tes |
T321 | 1064-1067 | C004551 | denotes | Tes |
T324 | 1073-1076 | PR:Q8LNZ2 | denotes | Tes |
T325 | 1073-1076 | PR:Q9UGI8 | denotes | Tes |
T326 | 1073-1076 | PR:Q90YH9 | denotes | Tes |
T328 | 1073-1076 | PR:000016239 | denotes | Tes |
T329 | 1073-1076 | A0A144KPJ6 | denotes | Tes |
T330 | 1073-1076 | PR:P47226 | denotes | Tes |
T331 | 1073-1076 | PR:Q2LAP6 | denotes | Tes |
T322 | 1073-1076 | CHEBI:44356 | denotes | Tes |
T323 | 1073-1076 | C004551 | denotes | Tes |
T327 | 1073-1076 | CHEBI:39035 | denotes | Tes |
T332 | 1073-1076 | C004551 | denotes | Tes |
T334 | 1100-1108 | 2714 | denotes | collagen |
T335 | 1100-1108 | D003094 | denotes | collagen |
T336 | 1100-1108 | CHEBI:3815 | denotes | collagen |
T333 | 1100-1108 | GO:0005202 | denotes | collagen |
T337 | 1110-1120 | Q92563 | denotes | Testican 2 |
T338 | 1110-1120 | PR:000015555 | denotes | Testican 2 |
T339 | 1110-1120 | Q9ER58 | denotes | Testican 2 |
T341 | 1147-1155 | 2714 | denotes | collagen |
T342 | 1147-1155 | D003094 | denotes | collagen |
T343 | 1147-1155 | CHEBI:3815 | denotes | collagen |
T340 | 1147-1155 | GO:0005202 | denotes | collagen |
T346 | 1211-1214 | PR:Q8LNZ2 | denotes | Tes |
T347 | 1211-1214 | PR:Q9UGI8 | denotes | Tes |
T348 | 1211-1214 | PR:Q90YH9 | denotes | Tes |
T350 | 1211-1214 | PR:000016239 | denotes | Tes |
T351 | 1211-1214 | A0A144KPJ6 | denotes | Tes |
T352 | 1211-1214 | PR:P47226 | denotes | Tes |
T353 | 1211-1214 | PR:Q2LAP6 | denotes | Tes |
T344 | 1211-1214 | CHEBI:44356 | denotes | Tes |
T345 | 1211-1214 | C004551 | denotes | Tes |
T349 | 1211-1214 | CHEBI:39035 | denotes | Tes |
T354 | 1211-1214 | C004551 | denotes | Tes |
T355 | 1232-1242 | Q92563 | denotes | testican 2 |
T356 | 1232-1242 | PR:000015555 | denotes | testican 2 |
T357 | 1232-1242 | Q9ER58 | denotes | testican 2 |
T360 | 1254-1257 | PR:Q8LNZ2 | denotes | Tes |
T361 | 1254-1257 | PR:Q9UGI8 | denotes | Tes |
T362 | 1254-1257 | PR:Q90YH9 | denotes | Tes |
T364 | 1254-1257 | PR:000016239 | denotes | Tes |
T365 | 1254-1257 | A0A144KPJ6 | denotes | Tes |
T366 | 1254-1257 | PR:P47226 | denotes | Tes |
T367 | 1254-1257 | PR:Q2LAP6 | denotes | Tes |
T358 | 1254-1257 | CHEBI:44356 | denotes | Tes |
T359 | 1254-1257 | C004551 | denotes | Tes |
T363 | 1254-1257 | CHEBI:39035 | denotes | Tes |
T368 | 1254-1257 | C004551 | denotes | Tes |
T370 | 1271-1279 | 2714 | denotes | collagen |
T371 | 1271-1279 | D003094 | denotes | collagen |
T372 | 1271-1279 | CHEBI:3815 | denotes | collagen |
T369 | 1271-1279 | GO:0005202 | denotes | collagen |
T373 | 1292-1302 | Q92563 | denotes | testican 2 |
T374 | 1292-1302 | PR:000015555 | denotes | testican 2 |
T375 | 1292-1302 | Q9ER58 | denotes | testican 2 |
T378 | 1308-1311 | PR:Q8LNZ2 | denotes | Tes |
T379 | 1308-1311 | PR:Q9UGI8 | denotes | Tes |
T380 | 1308-1311 | PR:Q90YH9 | denotes | Tes |
T382 | 1308-1311 | PR:000016239 | denotes | Tes |
T383 | 1308-1311 | A0A144KPJ6 | denotes | Tes |
T384 | 1308-1311 | PR:P47226 | denotes | Tes |
T385 | 1308-1311 | PR:Q2LAP6 | denotes | Tes |
T376 | 1308-1311 | CHEBI:44356 | denotes | Tes |
T377 | 1308-1311 | C004551 | denotes | Tes |
T381 | 1308-1311 | CHEBI:39035 | denotes | Tes |
T386 | 1308-1311 | C004551 | denotes | Tes |
T388 | 1325-1333 | 2714 | denotes | collagen |
T389 | 1325-1333 | D003094 | denotes | collagen |
T390 | 1325-1333 | CHEBI:3815 | denotes | collagen |
T387 | 1325-1333 | GO:0005202 | denotes | collagen |
T398 | 1372-1375 | GO:0047152 | denotes | MT1 |
T407 | 1372-1375 | GO:0043791 | denotes | MT1 |
T416 | 1372-1375 | GO:0043834 | denotes | MT1 |
T413 | 1372-1375 | CVCL_2501 | denotes | MT1 |
T432 | 1372-1379 | Q9XT90 | denotes | MT1-MMP |
T433 | 1372-1379 | P50281 | denotes | MT1-MMP |
T434 | 1372-1379 | Q9GLE4 | denotes | MT1-MMP |
T435 | 1372-1379 | PR:000010474 | denotes | MT1-MMP |
T436 | 1372-1379 | Q10739 | denotes | MT1-MMP |
T437 | 1372-1379 | Q95220 | denotes | MT1-MMP |
T439 | 1372-1379 | P53690 | denotes | MT1-MMP |
T438 | 1372-1379 | D053511 | denotes | MT1-MMP |
T442 | 1376-1379 | GO:0004235 | denotes | MMP |
T445 | 1388-1397 | SO:0000817 | denotes | wild-type |
T448 | 1400-1403 | PR:Q8LNZ2 | denotes | Tes |
T449 | 1400-1403 | PR:Q9UGI8 | denotes | Tes |
T450 | 1400-1403 | PR:Q90YH9 | denotes | Tes |
T452 | 1400-1403 | PR:000016239 | denotes | Tes |
T453 | 1400-1403 | A0A144KPJ6 | denotes | Tes |
T454 | 1400-1403 | PR:P47226 | denotes | Tes |
T455 | 1400-1403 | PR:Q2LAP6 | denotes | Tes |
T446 | 1400-1403 | CHEBI:44356 | denotes | Tes |
T447 | 1400-1403 | C004551 | denotes | Tes |
T451 | 1400-1403 | CHEBI:39035 | denotes | Tes |
T456 | 1400-1403 | C004551 | denotes | Tes |
T459 | 1407-1410 | PR:Q8LNZ2 | denotes | Tes |
T460 | 1407-1410 | PR:Q9UGI8 | denotes | Tes |
T461 | 1407-1410 | PR:Q90YH9 | denotes | Tes |
T463 | 1407-1410 | PR:000016239 | denotes | Tes |
T464 | 1407-1410 | A0A144KPJ6 | denotes | Tes |
T465 | 1407-1410 | PR:P47226 | denotes | Tes |
T466 | 1407-1410 | PR:Q2LAP6 | denotes | Tes |
T457 | 1407-1410 | CHEBI:44356 | denotes | Tes |
T458 | 1407-1410 | C004551 | denotes | Tes |
T462 | 1407-1410 | CHEBI:39035 | denotes | Tes |
T467 | 1407-1410 | C004551 | denotes | Tes |
T468 | 1437-1447 | Q92563 | denotes | testican 2 |
T469 | 1437-1447 | PR:000015555 | denotes | testican 2 |
T470 | 1437-1447 | Q9ER58 | denotes | testican 2 |
T471 | 1474-1484 | Q92563 | denotes | testican 2 |
T472 | 1474-1484 | PR:000015555 | denotes | testican 2 |
T473 | 1474-1484 | Q9ER58 | denotes | testican 2 |
T474 | 1501-1515 | GO:0016477 | denotes | cell migration |
T477 | 1529-1532 | PR:Q8LNZ2 | denotes | Tes |
T478 | 1529-1532 | PR:Q9UGI8 | denotes | Tes |
T479 | 1529-1532 | PR:Q90YH9 | denotes | Tes |
T481 | 1529-1532 | PR:000016239 | denotes | Tes |
T482 | 1529-1532 | A0A144KPJ6 | denotes | Tes |
T483 | 1529-1532 | PR:P47226 | denotes | Tes |
T484 | 1529-1532 | PR:Q2LAP6 | denotes | Tes |
T475 | 1529-1532 | CHEBI:44356 | denotes | Tes |
T476 | 1529-1532 | C004551 | denotes | Tes |
T480 | 1529-1532 | CHEBI:39035 | denotes | Tes |
T485 | 1529-1532 | C004551 | denotes | Tes |
T486 | 1657-1662 | UBERON:6110636 | denotes | brain |
T487 | 1657-1662 | UBERON:0000955 | denotes | brain |
T488 | 1681-1688 | SO:0001031 | denotes | reverse |
T489 | 1681-1702 | GO:0001171 | denotes | reverse transcription |
T491 | 1703-1706 | Q41249 | denotes | PCR |
T492 | 1703-1706 | O66148 | denotes | PCR |
T493 | 1703-1706 | Q59987 | denotes | PCR |
T494 | 1703-1706 | Q01289 | denotes | PCR |
T495 | 1703-1706 | O80333 | denotes | PCR |
T496 | 1703-1706 | P15904 | denotes | PCR |
T497 | 1703-1706 | Q9SDT1 | denotes | PCR |
T498 | 1703-1706 | Q39617 | denotes | PCR |
T499 | 1805-1810 | UBERON:6110636 | denotes | brain |
T500 | 1805-1810 | UBERON:0000955 | denotes | brain |
T501 | 1852-1857 | D009369 | denotes | tumor |
T502 | 1852-1857 | D009369 | denotes | tumor |
T503 | 1899-1909 | Q92563 | denotes | testican 2 |
T504 | 1899-1909 | PR:000015555 | denotes | testican 2 |
T505 | 1899-1909 | Q9ER58 | denotes | testican 2 |
T506 | 2003-2009 | D009369 | denotes | tumors |
T507 | 2003-2009 | D009369 | denotes | tumors |
T508 | 2063-2073 | Q92563 | denotes | testican 2 |
T509 | 2063-2073 | PR:000015555 | denotes | testican 2 |
T510 | 2063-2073 | Q9ER58 | denotes | testican 2 |
T511 | 2092-2098 | D005910 | denotes | glioma |
T512 | 2092-2098 | D005910 | denotes | glioma |
T515 | 2166-2169 | PR:Q8LNZ2 | denotes | Tes |
T516 | 2166-2169 | PR:Q9UGI8 | denotes | Tes |
T517 | 2166-2169 | PR:Q90YH9 | denotes | Tes |
T519 | 2166-2169 | PR:000016239 | denotes | Tes |
T520 | 2166-2169 | A0A144KPJ6 | denotes | Tes |
T521 | 2166-2169 | PR:P47226 | denotes | Tes |
T522 | 2166-2169 | PR:Q2LAP6 | denotes | Tes |
T513 | 2166-2169 | CHEBI:44356 | denotes | Tes |
T514 | 2166-2169 | C004551 | denotes | Tes |
T518 | 2166-2169 | CHEBI:39035 | denotes | Tes |
T523 | 2166-2169 | C004551 | denotes | Tes |
T524 | 2192-2196 | D020782 | denotes | MMPs |
T527 | 2216-2219 | PR:Q8LNZ2 | denotes | Tes |
T528 | 2216-2219 | PR:Q9UGI8 | denotes | Tes |
T529 | 2216-2219 | PR:Q90YH9 | denotes | Tes |
T531 | 2216-2219 | PR:000016239 | denotes | Tes |
T532 | 2216-2219 | A0A144KPJ6 | denotes | Tes |
T533 | 2216-2219 | PR:P47226 | denotes | Tes |
T534 | 2216-2219 | PR:Q2LAP6 | denotes | Tes |
T525 | 2216-2219 | CHEBI:44356 | denotes | Tes |
T526 | 2216-2219 | C004551 | denotes | Tes |
T530 | 2216-2219 | CHEBI:39035 | denotes | Tes |
T535 | 2216-2219 | C004551 | denotes | Tes |
T536 | 2253-2263 | Q92563 | denotes | testican 2 |
T537 | 2253-2263 | PR:000015555 | denotes | testican 2 |
T538 | 2253-2263 | Q9ER58 | denotes | testican 2 |
T539 | 2317-2323 | D005910 | denotes | glioma |
T540 | 2317-2323 | D005910 | denotes | glioma |
UseCases_ArguminSci_Discourse
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-109 | DRI_Background | denotes | Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins. |
T2 | 110-224 | DRI_Background | denotes | Testican family proteins are putative extracellular heparan/chondroitin sulfate proteoglycans of unknown function. |
T3 | 225-380 | DRI_Approach | denotes | We identified recently N-Tes, which is a product of testican 3 splicing variant gene, as an inhibitor of membrane-type matrix metalloproteinases (MT-MMPs). |
T4 | 381-529 | DRI_Background | denotes | The inhibitory function is common among testican family members except for testican 2, which was shown to uniquely abolish inhibition of MT1-MMP- or |
T5 | 530-556 | Token_Label.OUTSIDE | denotes | MT3-MMP-mediated pro-MMP-2 |
T6 | 557-601 | DRI_Background | denotes | activation by other testican family members. |
T7 | 602-939 | DRI_Background | denotes | Testican 2 inactivates N-Tes by binding to the COOH-terminal extracellular calcium-binding domain of N-Tes through its NH(2)-terminal unique domain as demonstrated by coimmunoprecipitation analysis, and, thus, testican 2 was unable to inactivate a N-Tes deletion mutant lacking the extracellular calcium-binding domain (N-Tes-Delta 122). |
T8 | 940-1109 | DRI_Background | denotes | Migration of U251 cells on collagen, which was dependent on MT1-MMP activity under serum-free condition, was inhibited by N-Tes or N-Tes-Delta 122 deposited on collagen. |
T9 | 1110-1280 | DRI_Background | denotes | Testican 2 was not incorporated into collagen by itself, and was deposited only in the presence of N-Tes, suggesting that testican 2 binds to N-Tes deposited on collagen. |
T10 | 1281-1380 | DRI_Background | denotes | Binding of testican 2 to N-Tes deposited on collagen allowed migration of cells expressing MT1-MMP. |
T11 | 1381-1543 | DRI_Outcome | denotes | Unlike wild-type N-Tes, N-Tes-Delta 122 did not bind to testican 2, and, thus, expression of testican 2 did not recover cell migration blocked by N-Tes-Delta 122. |
T12 | 1544-1663 | DRI_Background | denotes | In situ hybridization showed that neurons are a major source of all of the testican family members in the normal brain. |
T13 | 1664-1874 | DRI_Outcome | denotes | The quantitative reverse transcription-PCR analysis demonstrated that all of the testican family members are expressed prominently in normal brain, and their expression levels decrease as tumor grade increases. |
T14 | 1875-2010 | DRI_Background | denotes | The expression level of testican 2 was the highest among testican family members regardless of histological grade of astrocytic tumors. |
T15 | 2011-2197 | DRI_Background | denotes | These results suggest that abundant distribution of testican 2 may contribute to glioma invasion by inactivating other testican family members including N-Tes, which all inhibit MT-MMPs. |
T16 | 2198-2333 | DRI_Approach | denotes | We propose that N-Tes-Delta 122, which is resistant to testican 2, may have therapeutic potential as a barrier against glioma invasion. |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 2063-2073 | gene:9806 | denotes | testican 2 |
T1 | 2092-2098 | disease:C0017638 | denotes | glioma |
T2 | 2253-2263 | gene:9806 | denotes | testican 2 |
T3 | 2317-2323 | disease:C0017638 | denotes | glioma |
R1 | T0 | T1 | associated_with | testican 2,glioma |
R2 | T2 | T3 | associated_with | testican 2,glioma |