> top > docs > PubMed:12810672 > annotations

PubMed:12810672 JSONTXT

Annnotations TAB JSON ListView MergeView

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-10 Q92563 denotes Testican 2
T2 0-10 PR:000015555 denotes Testican 2
T3 0-10 Q9ER58 denotes Testican 2
T4 35-43 UBERON:0000094 denotes membrane
T6 35-43 UBERON:0000158 denotes membrane
T5 35-43 GO:0016020 denotes membrane
T7 35-74 D053504 denotes membrane-type matrix metalloproteinases
T8 49-55 UBERON:0027368 denotes matrix
T11 100-108 CHEBI:36080 denotes proteins
T12 126-134 CHEBI:36080 denotes proteins
T13 148-161 GO:0005576 denotes extracellular
T14 162-169 CHEBI:24500 denotes heparan
T21 170-203 D011508 denotes chondroitin sulfate proteoglycans
T22 170-203 D011508 denotes chondroitin sulfate proteoglycans
T27 207-214 32644 denotes unknown
T30 250-253 PR:Q8LNZ2 denotes Tes
T31 250-253 PR:Q9UGI8 denotes Tes
T32 250-253 PR:Q90YH9 denotes Tes
T34 250-253 PR:000016239 denotes Tes
T35 250-253 A0A144KPJ6 denotes Tes
T36 250-253 PR:P47226 denotes Tes
T37 250-253 PR:Q2LAP6 denotes Tes
T28 250-253 CHEBI:44356 denotes Tes
T29 250-253 C004551 denotes Tes
T33 250-253 CHEBI:39035 denotes Tes
T38 250-253 C004551 denotes Tes
T39 277-287 PR:000015556 denotes testican 3
T40 277-287 Q9BQ16 denotes testican 3
T41 277-287 Q8BKV0 denotes testican 3
T42 277-287 Q5RD69 denotes testican 3
T43 288-296 GO:0045292 denotes splicing
T44 288-304 SO:0001568 denotes splicing variant
T46 305-309 SO:0000704 denotes gene
T47 317-326 CHEBI:35222 denotes inhibitor
T49 330-338 GO:0016020 denotes membrane
T48 330-338 UBERON:0000094 denotes membrane
T50 330-338 UBERON:0000158 denotes membrane
T51 330-369 D053504 denotes membrane-type matrix metalloproteinases
T52 344-350 UBERON:0027368 denotes matrix
T55 374-378 D020782 denotes MMPs
T56 456-466 Q92563 denotes testican 2
T57 456-466 PR:000015555 denotes testican 2
T58 456-466 Q9ER58 denotes testican 2
T81 518-521 CVCL_2501 denotes MT1
T66 518-521 GO:0047152 denotes MT1
T75 518-521 GO:0043791 denotes MT1
T84 518-521 GO:0043834 denotes MT1
T100 518-525 Q9XT90 denotes MT1-MMP
T101 518-525 P50281 denotes MT1-MMP
T102 518-525 Q9GLE4 denotes MT1-MMP
T103 518-525 PR:000010474 denotes MT1-MMP
T104 518-525 Q10739 denotes MT1-MMP
T105 518-525 Q95220 denotes MT1-MMP
T107 518-525 P53690 denotes MT1-MMP
T106 518-525 D053511 denotes MT1-MMP
T110 522-525 GO:0004235 denotes MMP
T114 530-533 CVCL_M516 denotes MT3
T119 530-533 CVCL_M520 denotes MT3
T121 530-533 CVCL_2129 denotes MT3
T138 530-537 P51512 denotes MT3-MMP
T139 530-537 O35548 denotes MT3-MMP
T141 530-537 PR:000010476 denotes MT3-MMP
T142 530-537 Q9WTR0 denotes MT3-MMP
T140 530-537 D053513 denotes MT3-MMP
T145 534-537 GO:0004235 denotes MMP
T148 547-550 CVCL_N817 denotes pro
T152 547-550 SO:0001439 denotes pro
T154 547-556 C069860 denotes pro-MMP-2
T159 551-556 PR:P08253 denotes MMP-2
T160 551-556 Q9GLE5 denotes MMP-2
T161 551-556 P08253 denotes MMP-2
T162 551-556 Q90611 denotes MMP-2
T164 551-556 PR:Q8MPP3 denotes MMP-2
T165 551-556 P33436 denotes MMP-2
T166 551-556 PR:Q90611 denotes MMP-2
T167 551-556 PR:P33436 denotes MMP-2
T168 551-556 PR:000010479 denotes MMP-2
T169 551-556 PR:P33434 denotes MMP-2
T170 551-556 P33434 denotes MMP-2
T171 551-556 P50757 denotes MMP-2
T163 551-556 GO:0004228 denotes MMP-2
T172 602-612 Q92563 denotes Testican 2
T173 602-612 PR:000015555 denotes Testican 2
T174 602-612 Q9ER58 denotes Testican 2
T177 627-630 PR:Q8LNZ2 denotes Tes
T178 627-630 PR:Q9UGI8 denotes Tes
T179 627-630 PR:Q90YH9 denotes Tes
T181 627-630 PR:000016239 denotes Tes
T182 627-630 A0A144KPJ6 denotes Tes
T183 627-630 PR:P47226 denotes Tes
T184 627-630 PR:Q2LAP6 denotes Tes
T175 627-630 CHEBI:44356 denotes Tes
T176 627-630 C004551 denotes Tes
T180 627-630 CHEBI:39035 denotes Tes
T185 627-630 C004551 denotes Tes
T186 634-641 SO:0100018 denotes binding
T187 634-641 SO:0001091 denotes binding
T188 634-641 GO:0005488 denotes binding
T189 649-653 CHEBI:46883 denotes COOH
T190 663-676 GO:0005576 denotes extracellular
T191 677-684 1895 denotes calcium
T192 677-684 CHEBI:29320 denotes calcium
T193 677-684 CHEBI:22984 denotes calcium
T194 685-692 SO:0100018 denotes binding
T195 685-692 SO:0001091 denotes binding
T196 685-692 GO:0005488 denotes binding
T197 693-699 SO:0000417 denotes domain
T200 705-708 PR:Q8LNZ2 denotes Tes
T201 705-708 PR:Q9UGI8 denotes Tes
T202 705-708 PR:Q90YH9 denotes Tes
T204 705-708 PR:000016239 denotes Tes
T205 705-708 A0A144KPJ6 denotes Tes
T206 705-708 PR:P47226 denotes Tes
T207 705-708 PR:Q2LAP6 denotes Tes
T198 705-708 CHEBI:44356 denotes Tes
T199 705-708 C004551 denotes Tes
T203 705-708 CHEBI:39035 denotes Tes
T208 705-708 C004551 denotes Tes
T209 721-725 CHEBI:29337 denotes NH(2
T210 721-725 CHEBI:29339 denotes NH(2
T211 721-725 CHEBI:29338 denotes NH(2
T212 721-725 CHEBI:29318 denotes NH(2
T213 721-725 CHEBI:29345 denotes NH(2
T214 721-725 CHEBI:29340 denotes NH(2
T215 721-725 CHEBI:46882 denotes NH(2
T216 743-749 SO:0000417 denotes domain
T217 812-822 Q92563 denotes testican 2
T218 812-822 PR:000015555 denotes testican 2
T219 812-822 Q9ER58 denotes testican 2
T222 852-855 PR:Q8LNZ2 denotes Tes
T223 852-855 PR:Q9UGI8 denotes Tes
T224 852-855 PR:Q90YH9 denotes Tes
T226 852-855 PR:000016239 denotes Tes
T227 852-855 A0A144KPJ6 denotes Tes
T228 852-855 PR:P47226 denotes Tes
T229 852-855 PR:Q2LAP6 denotes Tes
T220 852-855 CHEBI:44356 denotes Tes
T221 852-855 C004551 denotes Tes
T225 852-855 CHEBI:39035 denotes Tes
T230 852-855 C004551 denotes Tes
T231 856-864 SO:0000159 denotes deletion
T232 884-897 GO:0005576 denotes extracellular
T233 898-905 1895 denotes calcium
T234 898-905 CHEBI:29320 denotes calcium
T235 898-905 CHEBI:22984 denotes calcium
T236 906-913 SO:0100018 denotes binding
T237 906-913 SO:0001091 denotes binding
T238 906-913 GO:0005488 denotes binding
T239 914-920 SO:0000417 denotes domain
T242 924-927 PR:Q8LNZ2 denotes Tes
T243 924-927 PR:Q9UGI8 denotes Tes
T244 924-927 PR:Q90YH9 denotes Tes
T246 924-927 PR:000016239 denotes Tes
T247 924-927 A0A144KPJ6 denotes Tes
T248 924-927 PR:P47226 denotes Tes
T249 924-927 PR:Q2LAP6 denotes Tes
T240 924-927 CHEBI:44356 denotes Tes
T241 924-927 C004551 denotes Tes
T245 924-927 CHEBI:39035 denotes Tes
T250 924-927 C004551 denotes Tes
T251 953-957 CVCL_0021 denotes U251
T253 967-975 2714 denotes collagen
T254 967-975 D003094 denotes collagen
T255 967-975 CHEBI:3815 denotes collagen
T252 967-975 GO:0005202 denotes collagen
T278 1000-1003 CVCL_2501 denotes MT1
T263 1000-1003 GO:0047152 denotes MT1
T272 1000-1003 GO:0043791 denotes MT1
T281 1000-1003 GO:0043834 denotes MT1
T297 1000-1007 Q9XT90 denotes MT1-MMP
T298 1000-1007 P50281 denotes MT1-MMP
T299 1000-1007 Q9GLE4 denotes MT1-MMP
T300 1000-1007 PR:000010474 denotes MT1-MMP
T301 1000-1007 Q10739 denotes MT1-MMP
T302 1000-1007 Q95220 denotes MT1-MMP
T304 1000-1007 P53690 denotes MT1-MMP
T303 1000-1007 D053511 denotes MT1-MMP
T307 1004-1007 GO:0004235 denotes MMP
T310 1023-1028 UBERON:0001977 denotes serum
T313 1064-1067 PR:Q8LNZ2 denotes Tes
T314 1064-1067 PR:Q9UGI8 denotes Tes
T315 1064-1067 PR:Q90YH9 denotes Tes
T317 1064-1067 PR:000016239 denotes Tes
T318 1064-1067 A0A144KPJ6 denotes Tes
T319 1064-1067 PR:P47226 denotes Tes
T320 1064-1067 PR:Q2LAP6 denotes Tes
T311 1064-1067 CHEBI:44356 denotes Tes
T312 1064-1067 C004551 denotes Tes
T316 1064-1067 CHEBI:39035 denotes Tes
T321 1064-1067 C004551 denotes Tes
T324 1073-1076 PR:Q8LNZ2 denotes Tes
T325 1073-1076 PR:Q9UGI8 denotes Tes
T326 1073-1076 PR:Q90YH9 denotes Tes
T328 1073-1076 PR:000016239 denotes Tes
T329 1073-1076 A0A144KPJ6 denotes Tes
T330 1073-1076 PR:P47226 denotes Tes
T331 1073-1076 PR:Q2LAP6 denotes Tes
T322 1073-1076 CHEBI:44356 denotes Tes
T323 1073-1076 C004551 denotes Tes
T327 1073-1076 CHEBI:39035 denotes Tes
T332 1073-1076 C004551 denotes Tes
T334 1100-1108 2714 denotes collagen
T335 1100-1108 D003094 denotes collagen
T336 1100-1108 CHEBI:3815 denotes collagen
T333 1100-1108 GO:0005202 denotes collagen
T337 1110-1120 Q92563 denotes Testican 2
T338 1110-1120 PR:000015555 denotes Testican 2
T339 1110-1120 Q9ER58 denotes Testican 2
T341 1147-1155 2714 denotes collagen
T342 1147-1155 D003094 denotes collagen
T343 1147-1155 CHEBI:3815 denotes collagen
T340 1147-1155 GO:0005202 denotes collagen
T346 1211-1214 PR:Q8LNZ2 denotes Tes
T347 1211-1214 PR:Q9UGI8 denotes Tes
T348 1211-1214 PR:Q90YH9 denotes Tes
T350 1211-1214 PR:000016239 denotes Tes
T351 1211-1214 A0A144KPJ6 denotes Tes
T352 1211-1214 PR:P47226 denotes Tes
T353 1211-1214 PR:Q2LAP6 denotes Tes
T344 1211-1214 CHEBI:44356 denotes Tes
T345 1211-1214 C004551 denotes Tes
T349 1211-1214 CHEBI:39035 denotes Tes
T354 1211-1214 C004551 denotes Tes
T355 1232-1242 Q92563 denotes testican 2
T356 1232-1242 PR:000015555 denotes testican 2
T357 1232-1242 Q9ER58 denotes testican 2
T360 1254-1257 PR:Q8LNZ2 denotes Tes
T361 1254-1257 PR:Q9UGI8 denotes Tes
T362 1254-1257 PR:Q90YH9 denotes Tes
T364 1254-1257 PR:000016239 denotes Tes
T365 1254-1257 A0A144KPJ6 denotes Tes
T366 1254-1257 PR:P47226 denotes Tes
T367 1254-1257 PR:Q2LAP6 denotes Tes
T358 1254-1257 CHEBI:44356 denotes Tes
T359 1254-1257 C004551 denotes Tes
T363 1254-1257 CHEBI:39035 denotes Tes
T368 1254-1257 C004551 denotes Tes
T370 1271-1279 2714 denotes collagen
T371 1271-1279 D003094 denotes collagen
T372 1271-1279 CHEBI:3815 denotes collagen
T369 1271-1279 GO:0005202 denotes collagen
T373 1292-1302 Q92563 denotes testican 2
T374 1292-1302 PR:000015555 denotes testican 2
T375 1292-1302 Q9ER58 denotes testican 2
T378 1308-1311 PR:Q8LNZ2 denotes Tes
T379 1308-1311 PR:Q9UGI8 denotes Tes
T380 1308-1311 PR:Q90YH9 denotes Tes
T382 1308-1311 PR:000016239 denotes Tes
T383 1308-1311 A0A144KPJ6 denotes Tes
T384 1308-1311 PR:P47226 denotes Tes
T385 1308-1311 PR:Q2LAP6 denotes Tes
T376 1308-1311 CHEBI:44356 denotes Tes
T377 1308-1311 C004551 denotes Tes
T381 1308-1311 CHEBI:39035 denotes Tes
T386 1308-1311 C004551 denotes Tes
T388 1325-1333 2714 denotes collagen
T389 1325-1333 D003094 denotes collagen
T390 1325-1333 CHEBI:3815 denotes collagen
T387 1325-1333 GO:0005202 denotes collagen
T398 1372-1375 GO:0047152 denotes MT1
T407 1372-1375 GO:0043791 denotes MT1
T416 1372-1375 GO:0043834 denotes MT1
T413 1372-1375 CVCL_2501 denotes MT1
T432 1372-1379 Q9XT90 denotes MT1-MMP
T433 1372-1379 P50281 denotes MT1-MMP
T434 1372-1379 Q9GLE4 denotes MT1-MMP
T435 1372-1379 PR:000010474 denotes MT1-MMP
T436 1372-1379 Q10739 denotes MT1-MMP
T437 1372-1379 Q95220 denotes MT1-MMP
T439 1372-1379 P53690 denotes MT1-MMP
T438 1372-1379 D053511 denotes MT1-MMP
T442 1376-1379 GO:0004235 denotes MMP
T445 1388-1397 SO:0000817 denotes wild-type
T448 1400-1403 PR:Q8LNZ2 denotes Tes
T449 1400-1403 PR:Q9UGI8 denotes Tes
T450 1400-1403 PR:Q90YH9 denotes Tes
T452 1400-1403 PR:000016239 denotes Tes
T453 1400-1403 A0A144KPJ6 denotes Tes
T454 1400-1403 PR:P47226 denotes Tes
T455 1400-1403 PR:Q2LAP6 denotes Tes
T446 1400-1403 CHEBI:44356 denotes Tes
T447 1400-1403 C004551 denotes Tes
T451 1400-1403 CHEBI:39035 denotes Tes
T456 1400-1403 C004551 denotes Tes
T459 1407-1410 PR:Q8LNZ2 denotes Tes
T460 1407-1410 PR:Q9UGI8 denotes Tes
T461 1407-1410 PR:Q90YH9 denotes Tes
T463 1407-1410 PR:000016239 denotes Tes
T464 1407-1410 A0A144KPJ6 denotes Tes
T465 1407-1410 PR:P47226 denotes Tes
T466 1407-1410 PR:Q2LAP6 denotes Tes
T457 1407-1410 CHEBI:44356 denotes Tes
T458 1407-1410 C004551 denotes Tes
T462 1407-1410 CHEBI:39035 denotes Tes
T467 1407-1410 C004551 denotes Tes
T468 1437-1447 Q92563 denotes testican 2
T469 1437-1447 PR:000015555 denotes testican 2
T470 1437-1447 Q9ER58 denotes testican 2
T471 1474-1484 Q92563 denotes testican 2
T472 1474-1484 PR:000015555 denotes testican 2
T473 1474-1484 Q9ER58 denotes testican 2
T474 1501-1515 GO:0016477 denotes cell migration
T477 1529-1532 PR:Q8LNZ2 denotes Tes
T478 1529-1532 PR:Q9UGI8 denotes Tes
T479 1529-1532 PR:Q90YH9 denotes Tes
T481 1529-1532 PR:000016239 denotes Tes
T482 1529-1532 A0A144KPJ6 denotes Tes
T483 1529-1532 PR:P47226 denotes Tes
T484 1529-1532 PR:Q2LAP6 denotes Tes
T475 1529-1532 CHEBI:44356 denotes Tes
T476 1529-1532 C004551 denotes Tes
T480 1529-1532 CHEBI:39035 denotes Tes
T485 1529-1532 C004551 denotes Tes
T486 1657-1662 UBERON:6110636 denotes brain
T487 1657-1662 UBERON:0000955 denotes brain
T488 1681-1688 SO:0001031 denotes reverse
T489 1681-1702 GO:0001171 denotes reverse transcription
T491 1703-1706 Q41249 denotes PCR
T492 1703-1706 O66148 denotes PCR
T493 1703-1706 Q59987 denotes PCR
T494 1703-1706 Q01289 denotes PCR
T495 1703-1706 O80333 denotes PCR
T496 1703-1706 P15904 denotes PCR
T497 1703-1706 Q9SDT1 denotes PCR
T498 1703-1706 Q39617 denotes PCR
T499 1805-1810 UBERON:6110636 denotes brain
T500 1805-1810 UBERON:0000955 denotes brain
T501 1852-1857 D009369 denotes tumor
T502 1852-1857 D009369 denotes tumor
T503 1899-1909 Q92563 denotes testican 2
T504 1899-1909 PR:000015555 denotes testican 2
T505 1899-1909 Q9ER58 denotes testican 2
T506 2003-2009 D009369 denotes tumors
T507 2003-2009 D009369 denotes tumors
T508 2063-2073 Q92563 denotes testican 2
T509 2063-2073 PR:000015555 denotes testican 2
T510 2063-2073 Q9ER58 denotes testican 2
T511 2092-2098 D005910 denotes glioma
T512 2092-2098 D005910 denotes glioma
T515 2166-2169 PR:Q8LNZ2 denotes Tes
T516 2166-2169 PR:Q9UGI8 denotes Tes
T517 2166-2169 PR:Q90YH9 denotes Tes
T519 2166-2169 PR:000016239 denotes Tes
T520 2166-2169 A0A144KPJ6 denotes Tes
T521 2166-2169 PR:P47226 denotes Tes
T522 2166-2169 PR:Q2LAP6 denotes Tes
T513 2166-2169 CHEBI:44356 denotes Tes
T514 2166-2169 C004551 denotes Tes
T518 2166-2169 CHEBI:39035 denotes Tes
T523 2166-2169 C004551 denotes Tes
T524 2192-2196 D020782 denotes MMPs
T527 2216-2219 PR:Q8LNZ2 denotes Tes
T528 2216-2219 PR:Q9UGI8 denotes Tes
T529 2216-2219 PR:Q90YH9 denotes Tes
T531 2216-2219 PR:000016239 denotes Tes
T532 2216-2219 A0A144KPJ6 denotes Tes
T533 2216-2219 PR:P47226 denotes Tes
T534 2216-2219 PR:Q2LAP6 denotes Tes
T525 2216-2219 CHEBI:44356 denotes Tes
T526 2216-2219 C004551 denotes Tes
T530 2216-2219 CHEBI:39035 denotes Tes
T535 2216-2219 C004551 denotes Tes
T536 2253-2263 Q92563 denotes testican 2
T537 2253-2263 PR:000015555 denotes testican 2
T538 2253-2263 Q9ER58 denotes testican 2
T539 2317-2323 D005910 denotes glioma
T540 2317-2323 D005910 denotes glioma

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-109 DRI_Background denotes Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins.
T2 110-224 DRI_Background denotes Testican family proteins are putative extracellular heparan/chondroitin sulfate proteoglycans of unknown function.
T3 225-380 DRI_Approach denotes We identified recently N-Tes, which is a product of testican 3 splicing variant gene, as an inhibitor of membrane-type matrix metalloproteinases (MT-MMPs).
T4 381-529 DRI_Background denotes The inhibitory function is common among testican family members except for testican 2, which was shown to uniquely abolish inhibition of MT1-MMP- or
T5 530-556 Token_Label.OUTSIDE denotes MT3-MMP-mediated pro-MMP-2
T6 557-601 DRI_Background denotes activation by other testican family members.
T7 602-939 DRI_Background denotes Testican 2 inactivates N-Tes by binding to the COOH-terminal extracellular calcium-binding domain of N-Tes through its NH(2)-terminal unique domain as demonstrated by coimmunoprecipitation analysis, and, thus, testican 2 was unable to inactivate a N-Tes deletion mutant lacking the extracellular calcium-binding domain (N-Tes-Delta 122).
T8 940-1109 DRI_Background denotes Migration of U251 cells on collagen, which was dependent on MT1-MMP activity under serum-free condition, was inhibited by N-Tes or N-Tes-Delta 122 deposited on collagen.
T9 1110-1280 DRI_Background denotes Testican 2 was not incorporated into collagen by itself, and was deposited only in the presence of N-Tes, suggesting that testican 2 binds to N-Tes deposited on collagen.
T10 1281-1380 DRI_Background denotes Binding of testican 2 to N-Tes deposited on collagen allowed migration of cells expressing MT1-MMP.
T11 1381-1543 DRI_Outcome denotes Unlike wild-type N-Tes, N-Tes-Delta 122 did not bind to testican 2, and, thus, expression of testican 2 did not recover cell migration blocked by N-Tes-Delta 122.
T12 1544-1663 DRI_Background denotes In situ hybridization showed that neurons are a major source of all of the testican family members in the normal brain.
T13 1664-1874 DRI_Outcome denotes The quantitative reverse transcription-PCR analysis demonstrated that all of the testican family members are expressed prominently in normal brain, and their expression levels decrease as tumor grade increases.
T14 1875-2010 DRI_Background denotes The expression level of testican 2 was the highest among testican family members regardless of histological grade of astrocytic tumors.
T15 2011-2197 DRI_Background denotes These results suggest that abundant distribution of testican 2 may contribute to glioma invasion by inactivating other testican family members including N-Tes, which all inhibit MT-MMPs.
T16 2198-2333 DRI_Approach denotes We propose that N-Tes-Delta 122, which is resistant to testican 2, may have therapeutic potential as a barrier against glioma invasion.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 2063-2073 gene:9806 denotes testican 2
T1 2092-2098 disease:C0017638 denotes glioma
T2 2253-2263 gene:9806 denotes testican 2
T3 2317-2323 disease:C0017638 denotes glioma
R1 T0 T1 associated_with testican 2,glioma
R2 T2 T3 associated_with testican 2,glioma