PubMed:1280226 JSONTXT

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":547,"end":552},"obj":"HP_0002664"}],"text":"Cloning of TRAP, a ligand for CD40 on human T cells.\nA cDNA clone, designated TRAP (TNF-related activation protein) was isolated from a collection of T cell activation genes. The polypeptide encoded by a mRNA of approx. 2.3 kb is 261 amino acids long with a calculated M(r) of 29.3 kDa. The structural features predict a type II transmembrane protein, but are also compatible with a secreted form. TRAP is highly similar to an identified murine CD40 ligand both at the cDNA (82.8% identity) and the protein (77.4% identity) levels, and related to tumor necrosis factor/lymphotoxin. Expressed in a murine myeloma, TRAP was identified as a ligand for CD40 by binding to a soluble CD40 construct. TRAP mRNA is expressed in a T cell-specific fashion with a maximum at 8 h after stimulation. The TRAP gene is located in the q26.3-q27.1 region of the X chromosome."}

{"project":"FSU-PRGE","denotations":[{"id":"T1","span":{"begin":11,"end":15},"obj":"protein"},{"id":"T2","span":{"begin":30,"end":34},"obj":"protein"},{"id":"T3","span":{"begin":78,"end":82},"obj":"protein"},{"id":"T4","span":{"begin":84,"end":114},"obj":"protein"},{"id":"T5","span":{"begin":398,"end":402},"obj":"protein"},{"id":"T6","span":{"begin":445,"end":456},"obj":"protein"},{"id":"T7","span":{"begin":547,"end":568},"obj":"protein"},{"id":"T8","span":{"begin":569,"end":580},"obj":"protein"},{"id":"T9","span":{"begin":613,"end":617},"obj":"protein"},{"id":"T10","span":{"begin":649,"end":653},"obj":"protein"},{"id":"T11","span":{"begin":678,"end":682},"obj":"protein"},{"id":"T12","span":{"begin":694,"end":698},"obj":"protein"},{"id":"T13","span":{"begin":791,"end":795},"obj":"protein"}],"text":"Cloning of TRAP, a ligand for CD40 on human T cells.\nA cDNA clone, designated TRAP (TNF-related activation protein) was isolated from a collection of T cell activation genes. The polypeptide encoded by a mRNA of approx. 2.3 kb is 261 amino acids long with a calculated M(r) of 29.3 kDa. The structural features predict a type II transmembrane protein, but are also compatible with a secreted form. TRAP is highly similar to an identified murine CD40 ligand both at the cDNA (82.8% identity) and the protein (77.4% identity) levels, and related to tumor necrosis factor/lymphotoxin. Expressed in a murine myeloma, TRAP was identified as a ligand for CD40 by binding to a soluble CD40 construct. TRAP mRNA is expressed in a T cell-specific fashion with a maximum at 8 h after stimulation. The TRAP gene is located in the q26.3-q27.1 region of the X chromosome."}

{"project":"AIMed","denotations":[{"id":"T1","span":{"begin":11,"end":15},"obj":"protein"},{"id":"T2","span":{"begin":30,"end":34},"obj":"protein"},{"id":"T3","span":{"begin":78,"end":82},"obj":"protein"},{"id":"T4","span":{"begin":84,"end":114},"obj":"protein"},{"id":"T5","span":{"begin":398,"end":402},"obj":"protein"},{"id":"T6","span":{"begin":445,"end":456},"obj":"protein"},{"id":"T7","span":{"begin":569,"end":580},"obj":"protein"},{"id":"T8","span":{"begin":613,"end":617},"obj":"protein"},{"id":"T9","span":{"begin":649,"end":653},"obj":"protein"},{"id":"T10","span":{"begin":678,"end":682},"obj":"protein"},{"id":"T11","span":{"begin":694,"end":698},"obj":"protein"},{"id":"T12","span":{"begin":791,"end":795},"obj":"protein"}],"text":"Cloning of TRAP, a ligand for CD40 on human T cells.\nA cDNA clone, designated TRAP (TNF-related activation protein) was isolated from a collection of T cell activation genes. The polypeptide encoded by a mRNA of approx. 2.3 kb is 261 amino acids long with a calculated M(r) of 29.3 kDa. The structural features predict a type II transmembrane protein, but are also compatible with a secreted form. TRAP is highly similar to an identified murine CD40 ligand both at the cDNA (82.8% identity) and the protein (77.4% identity) levels, and related to tumor necrosis factor/lymphotoxin. Expressed in a murine myeloma, TRAP was identified as a ligand for CD40 by binding to a soluble CD40 construct. TRAP mRNA is expressed in a T cell-specific fashion with a maximum at 8 h after stimulation. The TRAP gene is located in the q26.3-q27.1 region of the X chromosome."}