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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-241 Sentence denotes A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.
T2 242-384 Sentence denotes Corticosteroids are the preeminent antiinflammatory agents although the molecular mechanisms that impart their efficacy have not been defined.
T3 385-656 Sentence denotes The endothelium plays a critical role in inflammation by directing circulating leukocytes into extravascular tissues by expressing adhesive molecules for leukocytes [e.g., endothelial-leukocyte adhesion molecule 1 (ELAM-1) and intercellular adhesion molecule 1 (ICAM-1)].
T4 657-833 Sentence denotes We therefore determined whether corticosteroids suppress inflammation by inhibiting endothelial expression of adhesion molecules for neutrophils (polymorphonuclear leukocytes).
T5 834-1215 Sentence denotes Preincubation of endothelial cells with endotoxin [lipopolysaccharide (LPS), 1 microgram/ml] led to a 4-fold increase in subsequent adherence of polymorphonuclear leukocytes (P < 0.0001, n = 10) to endothelial cells, an increase that was markedly attenuated when endothelial cells were treated with dexamethasone (IC50 < 1 nM, P < 0.0001, n = 6 or 7) during preincubation with LPS.
T6 1216-1394 Sentence denotes Moreover, the steroid receptor agonist cortisol (10 microM), but not its inactive metabolite tetrahydrocortisol (10 microM), diminished LPS-induced endothelial cell adhesiveness.
T7 1395-1611 Sentence denotes Further evidence that the action of dexamethasone was mediated through ligation of corticosteroid receptors [human glucocorticoid receptors (hGRs)] was provided by experiments utilizing the steroid antagonist RU-486.
T8 1612-1857 Sentence denotes RU-486 (10 microM), which prevents translocation of ligated hGR to the nucleus by inhibiting dissociation of hGR from heat shock protein 90, completely aborted the effect of dexamethasone on adhesiveness of endothelial cells (P < 0.0005, n = 3).
T9 1858-2112 Sentence denotes Treatment of endothelial cells with LPS (1 microgram/ml) stimulated transcription of ELAM-1, as shown by Northern blot analysis, and expression of membrane-associated ELAM-1 and ICAM-1, as shown by quantitative immunofluorescence (both P < 0.001, n = 9).
T10 2113-2361 Sentence denotes Dexamethasone markedly inhibited LPS-stimulated accumulation of mRNA for ELAM-1 and expression of ELAM-1 and ICAM-1 (IC50 < 10 nM, both P < 0.001, n = 4-9); inhibition of expression by dexamethasone was reversed by RU-486 (both P < 0.005, n = 4-6).
T11 2362-2497 Sentence denotes As in the adhesion studies, cortisol but not tetrahydrocortisol inhibited expression of ELAM-1 and ICAM-1 (both P < 0.005, n = 3 or 4).
T12 2498-2606 Sentence denotes In contrast, sodium salicylate (1 mM) inhibited neither adhesion nor expression of these adhesion molecules.
T13 2607-2838 Sentence denotes These studies suggest that antagonism by dexamethasone of endotoxin-induced inflammation is a specific instance of the general biological principle that the glucocorticoid receptor is a hormone-dependent regulator of transcription.
T1 0-241 Sentence denotes A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.
T2 242-384 Sentence denotes Corticosteroids are the preeminent antiinflammatory agents although the molecular mechanisms that impart their efficacy have not been defined.
T3 385-656 Sentence denotes The endothelium plays a critical role in inflammation by directing circulating leukocytes into extravascular tissues by expressing adhesive molecules for leukocytes [e.g., endothelial-leukocyte adhesion molecule 1 (ELAM-1) and intercellular adhesion molecule 1 (ICAM-1)].
T4 657-833 Sentence denotes We therefore determined whether corticosteroids suppress inflammation by inhibiting endothelial expression of adhesion molecules for neutrophils (polymorphonuclear leukocytes).
T5 834-1215 Sentence denotes Preincubation of endothelial cells with endotoxin [lipopolysaccharide (LPS), 1 microgram/ml] led to a 4-fold increase in subsequent adherence of polymorphonuclear leukocytes (P < 0.0001, n = 10) to endothelial cells, an increase that was markedly attenuated when endothelial cells were treated with dexamethasone (IC50 < 1 nM, P < 0.0001, n = 6 or 7) during preincubation with LPS.
T6 1216-1394 Sentence denotes Moreover, the steroid receptor agonist cortisol (10 microM), but not its inactive metabolite tetrahydrocortisol (10 microM), diminished LPS-induced endothelial cell adhesiveness.
T7 1395-1611 Sentence denotes Further evidence that the action of dexamethasone was mediated through ligation of corticosteroid receptors [human glucocorticoid receptors (hGRs)] was provided by experiments utilizing the steroid antagonist RU-486.
T8 1612-1857 Sentence denotes RU-486 (10 microM), which prevents translocation of ligated hGR to the nucleus by inhibiting dissociation of hGR from heat shock protein 90, completely aborted the effect of dexamethasone on adhesiveness of endothelial cells (P < 0.0005, n = 3).
T9 1858-2112 Sentence denotes Treatment of endothelial cells with LPS (1 microgram/ml) stimulated transcription of ELAM-1, as shown by Northern blot analysis, and expression of membrane-associated ELAM-1 and ICAM-1, as shown by quantitative immunofluorescence (both P < 0.001, n = 9).
T10 2113-2361 Sentence denotes Dexamethasone markedly inhibited LPS-stimulated accumulation of mRNA for ELAM-1 and expression of ELAM-1 and ICAM-1 (IC50 < 10 nM, both P < 0.001, n = 4-9); inhibition of expression by dexamethasone was reversed by RU-486 (both P < 0.005, n = 4-6).
T11 2362-2497 Sentence denotes As in the adhesion studies, cortisol but not tetrahydrocortisol inhibited expression of ELAM-1 and ICAM-1 (both P < 0.005, n = 3 or 4).
T12 2498-2606 Sentence denotes In contrast, sodium salicylate (1 mM) inhibited neither adhesion nor expression of these adhesion molecules.
T13 2607-2838 Sentence denotes These studies suggest that antagonism by dexamethasone of endotoxin-induced inflammation is a specific instance of the general biological principle that the glucocorticoid receptor is a hormone-dependent regulator of transcription.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 69-92 protein denotes glucocorticoid receptor
T2 125-142 cell_type denotes endothelial cells
T3 161-202 protein denotes endothelial-leukocyte adhesion molecule 1
T4 207-240 protein denotes intercellular adhesion molecule 1
T5 452-474 cell_type denotes circulating leukocytes
T6 516-534 protein denotes adhesive molecules
T7 539-549 cell_type denotes leukocytes
T8 557-598 protein denotes endothelial-leukocyte adhesion molecule 1
T9 600-606 protein denotes ELAM-1
T10 612-645 protein denotes intercellular adhesion molecule 1
T11 647-653 protein denotes ICAM-1
T12 767-785 protein denotes adhesion molecules
T13 790-801 cell_type denotes neutrophils
T14 803-831 cell_type denotes polymorphonuclear leukocytes
T15 851-868 cell_type denotes endothelial cells
T16 979-1007 cell_type denotes polymorphonuclear leukocytes
T17 1032-1049 cell_type denotes endothelial cells
T18 1097-1114 cell_type denotes endothelial cells
T19 1230-1246 protein denotes steroid receptor
T20 1478-1502 protein denotes corticosteroid receptors
T21 1504-1534 protein denotes human glucocorticoid receptors
T22 1536-1540 protein denotes hGRs
T23 1672-1675 protein denotes hGR
T24 1721-1724 protein denotes hGR
T25 1819-1836 cell_type denotes endothelial cells
T26 1871-1888 cell_type denotes endothelial cells
T27 1943-1949 protein denotes ELAM-1
T28 2005-2031 protein denotes membrane-associated ELAM-1
T29 2036-2042 protein denotes ICAM-1
T30 2186-2192 protein denotes ELAM-1
T31 2211-2217 protein denotes ELAM-1
T32 2222-2228 protein denotes ICAM-1
T33 2450-2456 protein denotes ELAM-1
T34 2461-2467 protein denotes ICAM-1
T35 2587-2605 protein denotes adhesion molecules
T36 2665-2674 protein denotes endotoxin
T37 2764-2787 protein denotes glucocorticoid receptor

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-241 Sentence denotes A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.
S2 242-384 Sentence denotes Corticosteroids are the preeminent antiinflammatory agents although the molecular mechanisms that impart their efficacy have not been defined.
S3 385-656 Sentence denotes The endothelium plays a critical role in inflammation by directing circulating leukocytes into extravascular tissues by expressing adhesive molecules for leukocytes [e.g., endothelial-leukocyte adhesion molecule 1 (ELAM-1) and intercellular adhesion molecule 1 (ICAM-1)].
S4 657-833 Sentence denotes We therefore determined whether corticosteroids suppress inflammation by inhibiting endothelial expression of adhesion molecules for neutrophils (polymorphonuclear leukocytes).
S5 834-1215 Sentence denotes Preincubation of endothelial cells with endotoxin [lipopolysaccharide (LPS), 1 microgram/ml] led to a 4-fold increase in subsequent adherence of polymorphonuclear leukocytes (P < 0.0001, n = 10) to endothelial cells, an increase that was markedly attenuated when endothelial cells were treated with dexamethasone (IC50 < 1 nM, P < 0.0001, n = 6 or 7) during preincubation with LPS.
S6 1216-1394 Sentence denotes Moreover, the steroid receptor agonist cortisol (10 microM), but not its inactive metabolite tetrahydrocortisol (10 microM), diminished LPS-induced endothelial cell adhesiveness.
S7 1395-1611 Sentence denotes Further evidence that the action of dexamethasone was mediated through ligation of corticosteroid receptors [human glucocorticoid receptors (hGRs)] was provided by experiments utilizing the steroid antagonist RU-486.
S8 1612-1857 Sentence denotes RU-486 (10 microM), which prevents translocation of ligated hGR to the nucleus by inhibiting dissociation of hGR from heat shock protein 90, completely aborted the effect of dexamethasone on adhesiveness of endothelial cells (P < 0.0005, n = 3).
S9 1858-2112 Sentence denotes Treatment of endothelial cells with LPS (1 microgram/ml) stimulated transcription of ELAM-1, as shown by Northern blot analysis, and expression of membrane-associated ELAM-1 and ICAM-1, as shown by quantitative immunofluorescence (both P < 0.001, n = 9).
S10 2113-2361 Sentence denotes Dexamethasone markedly inhibited LPS-stimulated accumulation of mRNA for ELAM-1 and expression of ELAM-1 and ICAM-1 (IC50 < 10 nM, both P < 0.001, n = 4-9); inhibition of expression by dexamethasone was reversed by RU-486 (both P < 0.005, n = 4-6).
S11 2362-2497 Sentence denotes As in the adhesion studies, cortisol but not tetrahydrocortisol inhibited expression of ELAM-1 and ICAM-1 (both P < 0.005, n = 3 or 4).
S12 2498-2606 Sentence denotes In contrast, sodium salicylate (1 mM) inhibited neither adhesion nor expression of these adhesion molecules.
S13 2607-2838 Sentence denotes These studies suggest that antagonism by dexamethasone of endotoxin-induced inflammation is a specific instance of the general biological principle that the glucocorticoid receptor is a hormone-dependent regulator of transcription.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 48-63 NP denotes corticosteroids
C2 65-92 NP denotes the glucocorticoid receptor
C3 125-142 NP denotes endothelial cells
C5 161-202 NP denotes endothelial-leukocyte adhesion molecule 1
C6 207-240 NP denotes intercellular adhesion molecule 1
C4 147-240 NP denotes expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1
C7 242-257 NP denotes Corticosteroids
C8 310-334 NP denotes the molecular mechanisms
C9 335-339 NP denotes that
C10 347-352 NP denotes their
C11 426-438 NP denotes inflammation
C12 516-534 NP denotes adhesive molecules
C13 557-607 NP denotes endothelial-leukocyte adhesion molecule 1 (ELAM-1)
C14 612-654 NP denotes intercellular adhesion molecule 1 (ICAM-1)
C15 689-704 NP denotes corticosteroids
C16 714-726 NP denotes inflammation
C18 767-785 NP denotes adhesion molecules
C17 741-785 NP denotes endothelial expression of adhesion molecules
C19 790-832 NP denotes neutrophils (polymorphonuclear leukocytes)
C20 851-868 NP denotes endothelial cells
C21 885-909 NP denotes lipopolysaccharide (LPS)
C23 979-1007 NP denotes polymorphonuclear leukocytes
C24 1032-1049 NP denotes endothelial cells
C22 934-1049 NP denotes a 4-fold increase in subsequent adherence of polymorphonuclear leukocytes (P < 0.0001, n = 10) to endothelial cells
C26 1051-1062 NP denotes an increase
C27 1063-1067 NP denotes that
C28 1097-1114 NP denotes endothelial cells
C29 1133-1146 NP denotes dexamethasone
C30 1211-1214 NP denotes LPS
C25 1051-1214 NP denotes an increase that was markedly attenuated when endothelial cells were treated with dexamethasone (IC50 < 1 nM, P < 0.0001, n = 6 or 7) during preincubation with LPS
C31 1226-1275 NP denotes the steroid receptor agonist cortisol (10 microM)
C32 1285-1288 NP denotes its
C34 1364-1380 NP denotes endothelial cell
C33 1364-1393 NP denotes endothelial cell adhesiveness
C35 1395-1411 NP denotes Further evidence
C36 1412-1416 NP denotes that
C37 1431-1444 NP denotes dexamethasone
C38 1478-1542 NP denotes corticosteroid receptors [human glucocorticoid receptors (hGRs)]
C39 1585-1610 NP denotes steroid antagonist RU-486
C40 1612-1630 NP denotes RU-486 (10 microM)
C41 1632-1637 NP denotes which
C42 1664-1675 NP denotes ligated hGR
C43 1721-1724 NP denotes hGR
C44 1786-1799 NP denotes dexamethasone
C46 1819-1836 NP denotes endothelial cells
C45 1803-1836 NP denotes adhesiveness of endothelial cells
C47 1871-1888 NP denotes endothelial cells
C48 1894-1897 NP denotes LPS
C49 1943-1949 NP denotes ELAM-1
C51 2005-2031 NP denotes membrane-associated ELAM-1
C52 2036-2042 NP denotes ICAM-1
C50 1991-2042 NP denotes expression of membrane-associated ELAM-1 and ICAM-1
C53 2113-2126 NP denotes Dexamethasone
C54 2186-2192 NP denotes ELAM-1
C56 2211-2217 NP denotes ELAM-1
C57 2222-2228 NP denotes ICAM-1
C55 2197-2228 NP denotes expression of ELAM-1 and ICAM-1
C58 2298-2311 NP denotes dexamethasone
C59 2328-2334 NP denotes RU-486
C62 2450-2456 NP denotes ELAM-1
C63 2461-2467 NP denotes ICAM-1
C61 2450-2467 NP denotes ELAM-1 and ICAM-1
C60 2436-2467 NP denotes expression of ELAM-1 and ICAM-1
C65 2581-2605 NP denotes these adhesion molecules
C64 2567-2605 NP denotes expression of these adhesion molecules
C66 2648-2661 NP denotes dexamethasone
C67 2722-2754 NP denotes the general biological principle
C68 2755-2759 NP denotes that
C69 2760-2787 NP denotes the glucocorticoid receptor
R1 C7 C1 coref-ident Corticosteroids,corticosteroids
R2 C9 C8 coref-relat that,the molecular mechanisms
R3 C10 C7 coref-pron their,Corticosteroids
R4 C13 C5 coref-ident endothelial-leukocyte adhesion molecule 1 (ELAM-1),endothelial-leukocyte adhesion molecule 1
R5 C14 C6 coref-ident intercellular adhesion molecule 1 (ICAM-1),intercellular adhesion molecule 1
R6 C15 C7 coref-ident corticosteroids,Corticosteroids
R7 C16 C11 coref-ident inflammation,inflammation
R8 C18 C12 coref-other adhesion molecules,adhesive molecules
R9 C17 C4 coref-other endothelial expression of adhesion molecules,expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1
R10 C20 C3 coref-ident endothelial cells,endothelial cells
R11 C23 C19 coref-ident polymorphonuclear leukocytes,neutrophils (polymorphonuclear leukocytes)
R12 C24 C20 coref-ident endothelial cells,endothelial cells
R13 C27 C26 coref-relat that,an increase
R14 C28 C24 coref-ident endothelial cells,endothelial cells
R15 C30 C21 coref-ident LPS,lipopolysaccharide (LPS)
R16 C25 C62 coref-appos "an increase that was markedly attenuated when endothelial cells were treated with dexamethasone (IC50 < 1 nM, P < 0.0001, n = 6 or 7) during preincubation with LPS",ELAM-1
R17 C32 C31 coref-pron its,the steroid receptor agonist cortisol (10 microM)
R18 C34 C28 coref-other endothelial cell,endothelial cells
R19 C36 C35 coref-relat that,Further evidence
R20 C37 C29 coref-ident dexamethasone,dexamethasone
R21 C38 C2 coref-other corticosteroid receptors [human glucocorticoid receptors (hGRs)],the glucocorticoid receptor
R22 C40 C39 coref-ident RU-486 (10 microM),steroid antagonist RU-486
R23 C41 C40 coref-relat which,RU-486 (10 microM)
R24 C42 C38 coref-other ligated hGR,corticosteroid receptors [human glucocorticoid receptors (hGRs)]
R25 C43 C38 coref-ident hGR,corticosteroid receptors [human glucocorticoid receptors (hGRs)]
R26 C44 C37 coref-ident dexamethasone,dexamethasone
R27 C46 C34 coref-ident endothelial cells,endothelial cell
R28 C45 C33 coref-ident adhesiveness of endothelial cells,endothelial cell adhesiveness
R29 C47 C46 coref-ident endothelial cells,endothelial cells
R30 C48 C30 coref-ident LPS,LPS
R31 C49 C13 coref-ident ELAM-1,endothelial-leukocyte adhesion molecule 1 (ELAM-1)
R32 C51 C49 coref-other membrane-associated ELAM-1,ELAM-1
R33 C52 C14 coref-ident ICAM-1,intercellular adhesion molecule 1 (ICAM-1)
R34 C50 C17 coref-other expression of membrane-associated ELAM-1 and ICAM-1,endothelial expression of adhesion molecules
R35 C53 C44 coref-ident Dexamethasone,dexamethasone
R36 C54 C49 coref-ident ELAM-1,ELAM-1
R37 C56 C54 coref-ident ELAM-1,ELAM-1
R38 C57 C52 coref-ident ICAM-1,ICAM-1
R39 C55 C50 coref-other expression of ELAM-1 and ICAM-1,expression of membrane-associated ELAM-1 and ICAM-1
R40 C58 C53 coref-ident dexamethasone,Dexamethasone
R41 C59 C40 coref-ident RU-486,RU-486 (10 microM)
R42 C62 C56 coref-ident ELAM-1,ELAM-1
R43 C63 C57 coref-ident ICAM-1,ICAM-1
R44 C60 C55 coref-ident expression of ELAM-1 and ICAM-1,expression of ELAM-1 and ICAM-1
R45 C65 C61 coref-ident these adhesion molecules,ELAM-1 and ICAM-1
R46 C64 C60 coref-other expression of these adhesion molecules,expression of ELAM-1 and ICAM-1
R47 C66 C58 coref-ident dexamethasone,dexamethasone
R48 C68 C67 coref-relat that,the general biological principle
R49 C69 C38 coref-other the glucocorticoid receptor,corticosteroid receptors [human glucocorticoid receptors (hGRs)]

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 20-44 other_name denotes antiinflammatory effects
T2 48-63 lipid denotes corticosteroids
T3 69-92 protein_family_or_group denotes glucocorticoid receptor
T4 103-121 other_name denotes leukocyte adhesion
T5 125-142 cell_type denotes endothelial cells
T6 161-202 protein_molecule denotes endothelial-leukocyte adhesion molecule 1
T7 207-240 protein_molecule denotes intercellular adhesion molecule 1
T8 242-257 lipid denotes Corticosteroids
T9 266-300 other_name denotes preeminent antiinflammatory agents
T10 314-334 other_name denotes molecular mechanisms
T11 452-474 cell_type denotes circulating leukocytes
T12 480-501 tissue denotes extravascular tissues
T13 516-534 protein_molecule denotes adhesive molecules
T14 539-549 cell_type denotes leukocytes
T15 557-598 protein_molecule denotes endothelial-leukocyte adhesion molecule 1
T16 600-606 protein_molecule denotes ELAM-1
T17 612-645 protein_molecule denotes intercellular adhesion molecule 1
T18 647-653 protein_molecule denotes ICAM-1
T19 689-704 lipid denotes corticosteroids
T20 714-726 other_name denotes inflammation
T21 767-785 protein_molecule denotes adhesion molecules
T22 790-801 cell_type denotes neutrophils
T23 803-820 cell_type denotes polymorphonuclear
T24 821-831 cell_type denotes leukocytes
T25 851-868 cell_type denotes endothelial cells
T26 885-903 lipid denotes lipopolysaccharide
T27 905-908 lipid denotes LPS
T28 979-1007 cell_type denotes polymorphonuclear leukocytes
T29 1032-1049 cell_type denotes endothelial cells
T30 1097-1114 cell_type denotes endothelial cells
T31 1133-1146 lipid denotes dexamethasone
T32 1211-1214 lipid denotes LPS
T33 1230-1246 protein_family_or_group denotes steroid receptor
T34 1255-1263 lipid denotes cortisol
T35 1289-1308 other_organic_compound denotes inactive metabolite
T36 1309-1327 lipid denotes tetrahydrocortisol
T37 1352-1355 lipid denotes LPS
T38 1431-1444 lipid denotes dexamethasone
T39 1478-1502 protein_family_or_group denotes corticosteroid receptors
T40 1504-1534 protein_family_or_group denotes human glucocorticoid receptors
T41 1536-1540 protein_family_or_group denotes hGRs
T42 1585-1603 other_name denotes steroid antagonist
T43 1604-1610 other_organic_compound denotes RU-486
T44 1672-1675 protein_family_or_group denotes hGR
T45 1683-1690 cell_component denotes nucleus
T46 1721-1724 protein_family_or_group denotes hGR
T47 1786-1799 lipid denotes dexamethasone
T48 1819-1836 cell_type denotes endothelial cells
T49 1871-1888 cell_type denotes endothelial cells
T50 1894-1897 lipid denotes LPS
T51 1943-1949 protein_molecule denotes ELAM-1
T52 1963-1985 other_name denotes Northern blot analysis
T53 2005-2024 protein_molecule denotes membrane-associated
T54 2025-2031 protein_molecule denotes ELAM-1
T55 2036-2042 protein_molecule denotes ICAM-1
T56 2056-2087 other_name denotes quantitative immunofluorescence
T57 2146-2149 lipid denotes LPS
T58 2186-2192 protein_molecule denotes ELAM-1
T59 2211-2217 protein_molecule denotes ELAM-1
T60 2222-2228 protein_molecule denotes ICAM-1
T61 2298-2311 lipid denotes dexamethasone
T62 2328-2334 other_organic_compound denotes RU-486
T63 2390-2398 lipid denotes cortisol
T64 2407-2425 lipid denotes tetrahydrocortisol
T65 2450-2456 protein_molecule denotes ELAM-1
T66 2461-2467 protein_molecule denotes ICAM-1
T67 2587-2605 protein_molecule denotes adhesion molecules
T68 2648-2661 lipid denotes dexamethasone
T69 2665-2674 protein_family_or_group denotes endotoxin
T70 2764-2787 protein_family_or_group denotes glucocorticoid receptor
T71 2793-2837 other_name denotes hormone-dependent regulator of transcription