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PubMed:12782800 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 67-70 gene:8626 denotes p63
T1 99-117 disease:C0007137 denotes squamous carcinoma
T2 67-70 gene:7405 denotes p63
T3 99-117 disease:C0007137 denotes squamous carcinoma
T4 67-70 gene:10970 denotes p63
T5 99-117 disease:C0007137 denotes squamous carcinoma
T6 14-46 gene:1956 denotes epidermal growth factor receptor
T7 99-117 disease:C0007137 denotes squamous carcinoma
T8 67-70 gene:6121 denotes p63
T9 99-117 disease:C0007137 denotes squamous carcinoma
T10 219-222 gene:8626 denotes p63
T11 277-314 disease:C1168401 denotes head and neck squamous cell carcinoma
T12 205-208 gene:7157 denotes p53
T13 316-321 disease:C1168401 denotes HNSCC
T14 219-222 gene:10970 denotes p63
T15 277-314 disease:C1168401 denotes head and neck squamous cell carcinoma
T16 219-222 gene:7405 denotes p63
T17 277-314 disease:C1168401 denotes head and neck squamous cell carcinoma
T18 205-208 gene:7157 denotes p53
T19 277-314 disease:C1168401 denotes head and neck squamous cell carcinoma
T20 219-222 gene:6121 denotes p63
T21 277-314 disease:C1168401 denotes head and neck squamous cell carcinoma
T22 219-222 gene:10970 denotes p63
T23 316-321 disease:C1168401 denotes HNSCC
T24 191-195 gene:1956 denotes EGFR
T25 316-321 disease:C1168401 denotes HNSCC
T26 219-222 gene:8626 denotes p63
T27 316-321 disease:C1168401 denotes HNSCC
T28 219-222 gene:6121 denotes p63
T29 316-321 disease:C1168401 denotes HNSCC
T30 191-195 gene:1956 denotes EGFR
T31 277-314 disease:C1168401 denotes head and neck squamous cell carcinoma
T32 157-189 gene:1956 denotes epidermal growth factor receptor
T33 316-321 disease:C1168401 denotes HNSCC
T34 157-189 gene:1956 denotes epidermal growth factor receptor
T35 277-314 disease:C1168401 denotes head and neck squamous cell carcinoma
T36 219-222 gene:7405 denotes p63
T37 316-321 disease:C1168401 denotes HNSCC
T38 566-570 gene:1956 denotes EGFR
T39 645-650 disease:C1168401 denotes HNSCC
T40 693-696 gene:10970 denotes p63
T41 740-745 disease:C1168401 denotes HNSCC
T42 693-696 gene:7405 denotes p63
T43 740-745 disease:C1168401 denotes HNSCC
T44 693-696 gene:8626 denotes p63
T45 740-745 disease:C1168401 denotes HNSCC
T46 693-696 gene:6121 denotes p63
T47 740-745 disease:C1168401 denotes HNSCC
R1 T0 T1 associated_with p63,squamous carcinoma
R2 T2 T3 associated_with p63,squamous carcinoma
R3 T4 T5 associated_with p63,squamous carcinoma
R4 T6 T7 associated_with epidermal growth factor receptor,squamous carcinoma
R5 T8 T9 associated_with p63,squamous carcinoma
R6 T10 T11 associated_with p63,head and neck squamous cell carcinoma
R7 T12 T13 associated_with p53,HNSCC
R8 T14 T15 associated_with p63,head and neck squamous cell carcinoma
R9 T16 T17 associated_with p63,head and neck squamous cell carcinoma
R10 T18 T19 associated_with p53,head and neck squamous cell carcinoma
R11 T20 T21 associated_with p63,head and neck squamous cell carcinoma
R12 T22 T23 associated_with p63,HNSCC
R13 T24 T25 associated_with EGFR,HNSCC
R14 T26 T27 associated_with p63,HNSCC
R15 T28 T29 associated_with p63,HNSCC
R16 T30 T31 associated_with EGFR,head and neck squamous cell carcinoma
R17 T32 T33 associated_with epidermal growth factor receptor,HNSCC
R18 T34 T35 associated_with epidermal growth factor receptor,head and neck squamous cell carcinoma
R19 T36 T37 associated_with p63,HNSCC
R20 T38 T39 associated_with EGFR,HNSCC
R21 T40 T41 associated_with p63,HNSCC
R22 T42 T43 associated_with p63,HNSCC
R23 T44 T45 associated_with p63,HNSCC
R24 T46 T47 associated_with p63,HNSCC

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
12782800-0#67#70#gene8626 67-70 gene8626 denotes p63
12782800-0#14#46#gene1956 14-46 gene1956 denotes epidermal growth factor receptor
12782800-0#99#117#diseaseC0007137 99-117 diseaseC0007137 denotes squamous carcinoma
12782800-0#99#117#diseaseC0007137 99-117 diseaseC0007137 denotes squamous carcinoma
12782800-1#57#60#gene7157 205-208 gene7157 denotes p53
12782800-1#129#166#diseaseC1168401 277-314 diseaseC1168401 denotes head and neck squamous cell carcinoma
12782800-1#168#173#diseaseC1168401 316-321 diseaseC1168401 denotes HNSCC
67#70#gene862699#117#diseaseC0007137 12782800-0#67#70#gene8626 12782800-0#99#117#diseaseC0007137 associated_with p63,squamous carcinoma
67#70#gene862699#117#diseaseC0007137 12782800-0#67#70#gene8626 12782800-0#99#117#diseaseC0007137 associated_with p63,squamous carcinoma
14#46#gene195699#117#diseaseC0007137 12782800-0#14#46#gene1956 12782800-0#99#117#diseaseC0007137 associated_with epidermal growth factor receptor,squamous carcinoma
14#46#gene195699#117#diseaseC0007137 12782800-0#14#46#gene1956 12782800-0#99#117#diseaseC0007137 associated_with epidermal growth factor receptor,squamous carcinoma
57#60#gene7157129#166#diseaseC1168401 12782800-1#57#60#gene7157 12782800-1#129#166#diseaseC1168401 associated_with p53,head and neck squamous cell carcinoma
57#60#gene7157168#173#diseaseC1168401 12782800-1#57#60#gene7157 12782800-1#168#173#diseaseC1168401 associated_with p53,HNSCC

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 148-943 OBJECTIVE denotes Both the epidermal growth factor receptor (EGFR) and the p53 homologue p63 are overexpressed in a significant number of cases of head and neck squamous cell carcinoma (HNSCC). Epidermal growth factor receptor and p63 both possess oncogenic properties, including the potential to increase cell proliferation and antagonize apoptosis. ZD1839 ("Iressa") is an adenosine triphosphate-competitive inhibitor specific to the EGFR tyrosine kinase currently under evaluation as a chemotherapeutic agent in HNSCC. The objective was to investigate whether p63 expression is decreased after treatment of HNSCC cells with ZD1839. Downregulation of p63 by ZD1839 would identify a potential molecular relationship between EGFR signaling and p63 and could provide insight into the mechanism of action of ZD1839.
T2 958-1020 METHODS denotes In vitro examination of p63 expression after ZD1839 treatment.
T3 1030-1280 METHODS denotes A human HNSCC cell line, SCC-012, was treated with varying doses of ZD1839. p63 protein and messenger RNA levels were analyzed by Western and Northern blot analyses. The effect of ZD1839 on SCC-012 cell cycle was analyzed by flow cytometric analysis.
T4 1290-1647 RESULTS denotes In SCC-012 cells there was a dose-dependent decrease in p63 protein and messenger RNA levels over the course of ZD1839 treatment. Levels of phosphorylated MAPK decreased and p27KIP-1 levels increased after ZD1839 treatment. ZD1839 treatment induced a twofold increase in G1-phase cells and a 3.5-fold decrease in S-phase cells consistent with growth arrest.
T5 1660-1785 CONCLUSIONS denotes ZD1839 downregulates p63 expression at the messenger RNA level, suggesting that p63 is a downstream target of EGFR signaling.