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PubMed:12773479 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-88 Sentence denotes Binding of the CC-chemokine RANTES to syndecan-1 and syndecan-4 expressed on HeLa cells.
TextSentencer_T2 89-169 Sentence denotes It is believed that proteoglycans influence biological properties of chemokines.
TextSentencer_T3 170-391 Sentence denotes We show that the CC chemokine RANTES binds not only to high-affinity binding sites on CCR5-positive HeLa cells but also to low-affinity binding sites on HeLa cells expressing or lacking RANTES G protein-coupled receptors.
TextSentencer_T4 392-554 Sentence denotes Coimmunoprecipitation studies demonstrate that RANTES forms complexes with glycanated syndecan (SD)-1 and -4, in addition to CCR5 on the CCR5-positive HeLa cells.
TextSentencer_T5 555-646 Sentence denotes Moreover, confocal microscopy analysis shows the colocalization of RANTES with SD-1 and -4.
TextSentencer_T6 647-828 Sentence denotes Glycosaminoglycans removal from the cells by glycosaminidases treatment prevented RANTES binding to SD-1 and -4 and decreased RANTES binding to CCR5 on the CCR5-positive HeLa cells.
TextSentencer_T7 829-985 Sentence denotes Removal of glycosaminoglycans by glycosaminidases treatment of the complexes, RANTES/SD-1/SD-4/+/-CCR5, immobilized on beads, reversed SD-1 and -4 bindings.
TextSentencer_T8 986-1101 Sentence denotes Therefore, RANTES bindings to SD-1 and -4 depend on glycosaminoglycans and facilitate RANTES interaction with CCR5.
TextSentencer_T9 1102-1263 Sentence denotes Extracting plasma membrane cholesterol abolished the coimmunoprecipitation of SD-1 with RANTES, suggesting that rafts are involved in RANTES association to SD-1.
TextSentencer_T10 1264-1438 Sentence denotes Confocal microscopy analysis as well as coimmunoprecipitation experiments show a RANTES-independent heteromeric complex on the CCR5-positive HeLa cells, SD-1, SD-4, and CCR5.
TextSentencer_T11 1439-1539 Sentence denotes This complex is likely a functional unit in which proteoglycans may modulate RANTES binding to CCR5.
T1 0-88 Sentence denotes Binding of the CC-chemokine RANTES to syndecan-1 and syndecan-4 expressed on HeLa cells.
T2 89-169 Sentence denotes It is believed that proteoglycans influence biological properties of chemokines.
T3 170-391 Sentence denotes We show that the CC chemokine RANTES binds not only to high-affinity binding sites on CCR5-positive HeLa cells but also to low-affinity binding sites on HeLa cells expressing or lacking RANTES G protein-coupled receptors.
T4 392-554 Sentence denotes Coimmunoprecipitation studies demonstrate that RANTES forms complexes with glycanated syndecan (SD)-1 and -4, in addition to CCR5 on the CCR5-positive HeLa cells.
T5 555-646 Sentence denotes Moreover, confocal microscopy analysis shows the colocalization of RANTES with SD-1 and -4.
T6 647-828 Sentence denotes Glycosaminoglycans removal from the cells by glycosaminidases treatment prevented RANTES binding to SD-1 and -4 and decreased RANTES binding to CCR5 on the CCR5-positive HeLa cells.
T7 829-985 Sentence denotes Removal of glycosaminoglycans by glycosaminidases treatment of the complexes, RANTES/SD-1/SD-4/+/-CCR5, immobilized on beads, reversed SD-1 and -4 bindings.
T8 986-1101 Sentence denotes Therefore, RANTES bindings to SD-1 and -4 depend on glycosaminoglycans and facilitate RANTES interaction with CCR5.
T9 1102-1263 Sentence denotes Extracting plasma membrane cholesterol abolished the coimmunoprecipitation of SD-1 with RANTES, suggesting that rafts are involved in RANTES association to SD-1.
T10 1264-1438 Sentence denotes Confocal microscopy analysis as well as coimmunoprecipitation experiments show a RANTES-independent heteromeric complex on the CCR5-positive HeLa cells, SD-1, SD-4, and CCR5.
T11 1439-1539 Sentence denotes This complex is likely a functional unit in which proteoglycans may modulate RANTES binding to CCR5.
T1 0-88 Sentence denotes Binding of the CC-chemokine RANTES to syndecan-1 and syndecan-4 expressed on HeLa cells.
T2 89-169 Sentence denotes It is believed that proteoglycans influence biological properties of chemokines.
T3 170-391 Sentence denotes We show that the CC chemokine RANTES binds not only to high-affinity binding sites on CCR5-positive HeLa cells but also to low-affinity binding sites on HeLa cells expressing or lacking RANTES G protein-coupled receptors.
T4 392-554 Sentence denotes Coimmunoprecipitation studies demonstrate that RANTES forms complexes with glycanated syndecan (SD)-1 and -4, in addition to CCR5 on the CCR5-positive HeLa cells.
T5 555-646 Sentence denotes Moreover, confocal microscopy analysis shows the colocalization of RANTES with SD-1 and -4.
T6 647-828 Sentence denotes Glycosaminoglycans removal from the cells by glycosaminidases treatment prevented RANTES binding to SD-1 and -4 and decreased RANTES binding to CCR5 on the CCR5-positive HeLa cells.
T7 829-985 Sentence denotes Removal of glycosaminoglycans by glycosaminidases treatment of the complexes, RANTES/SD-1/SD-4/+/-CCR5, immobilized on beads, reversed SD-1 and -4 bindings.
T8 986-1101 Sentence denotes Therefore, RANTES bindings to SD-1 and -4 depend on glycosaminoglycans and facilitate RANTES interaction with CCR5.
T9 1102-1263 Sentence denotes Extracting plasma membrane cholesterol abolished the coimmunoprecipitation of SD-1 with RANTES, suggesting that rafts are involved in RANTES association to SD-1.
T10 1264-1438 Sentence denotes Confocal microscopy analysis as well as coimmunoprecipitation experiments show a RANTES-independent heteromeric complex on the CCR5-positive HeLa cells, SD-1, SD-4, and CCR5.
T11 1439-1539 Sentence denotes This complex is likely a functional unit in which proteoglycans may modulate RANTES binding to CCR5.

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 15-27 FMAID:241983 denotes CC-chemokine
_T2 15-27 FMAID:241982 denotes CC-chemokine
_T3 15-27 FMAID:241985 denotes CC-chemokine
_T4 15-27 FMAID:241984 denotes CC-chemokine
_T5 18-27 FMAID:241981 denotes chemokine
_T6 18-27 FMAID:241980 denotes chemokine
_T7 38-46 FMAID:63021 denotes syndecan
_T8 38-46 FMAID:167402 denotes syndecan
_T9 53-61 FMAID:63021 denotes syndecan
_T10 53-61 FMAID:167402 denotes syndecan
_T11 82-87 FMAID:169002 denotes cells
_T12 82-87 FMAID:68646 denotes cells
_T13 109-122 FMAID:63015 denotes proteoglycans
_T14 109-122 FMAID:167397 denotes proteoglycans
_T15 158-168 FMAID:241985 denotes chemokines
_T16 158-168 FMAID:241982 denotes chemokines
_T17 158-168 FMAID:241980 denotes chemokines
_T18 158-168 FMAID:241981 denotes chemokines
_T19 158-168 FMAID:241983 denotes chemokines
_T20 158-168 FMAID:241984 denotes chemokines
_T21 187-199 FMAID:241985 denotes CC chemokine
_T22 187-199 FMAID:241984 denotes CC chemokine
_T23 187-199 FMAID:241983 denotes CC chemokine
_T24 187-199 FMAID:241982 denotes CC chemokine
_T25 190-199 FMAID:241980 denotes chemokine
_T26 190-199 FMAID:241981 denotes chemokine
_T27 275-280 FMAID:169002 denotes cells
_T28 275-280 FMAID:68646 denotes cells
_T29 328-333 FMAID:68646 denotes cells
_T30 328-333 FMAID:169002 denotes cells
_T31 363-372 FMAID:166112 denotes G protein
_T32 365-372 FMAID:165447 denotes protein
_T33 365-372 FMAID:67257 denotes protein
_T34 478-486 FMAID:167402 denotes syndecan
_T35 478-486 FMAID:63021 denotes syndecan
_T36 548-553 FMAID:169002 denotes cells
_T37 548-553 FMAID:68646 denotes cells
_T38 647-665 FMAID:63011 denotes Glycosaminoglycans
_T39 647-665 FMAID:167395 denotes Glycosaminoglycans
_T40 683-688 FMAID:68646 denotes cells
_T41 683-688 FMAID:169002 denotes cells
_T42 822-827 FMAID:68646 denotes cells
_T43 822-827 FMAID:169002 denotes cells
_T44 840-858 FMAID:63011 denotes glycosaminoglycans
_T45 840-858 FMAID:167395 denotes glycosaminoglycans
_T46 1038-1056 FMAID:167395 denotes glycosaminoglycans
_T47 1038-1056 FMAID:63011 denotes glycosaminoglycans
_T48 1113-1119 FMAID:162307 denotes plasma
_T49 1113-1128 FMAID:63841 denotes plasma membrane
_T50 1113-1128 FMAID:166047 denotes plasma membrane
_T51 1113-1128 FMAID:66843 denotes plasma membrane
_T52 1113-1128 FMAID:164993 denotes plasma membrane
_T53 1113-1128 FMAID:210691 denotes plasma membrane
_T54 1113-1128 FMAID:162306 denotes plasma membrane
_T55 1410-1415 FMAID:169002 denotes cells
_T56 1410-1415 FMAID:68646 denotes cells
_T57 1489-1502 FMAID:167397 denotes proteoglycans
_T58 1489-1502 FMAID:63015 denotes proteoglycans

uniprot-human

Id Subject Object Predicate Lexical cue
T1 38-48 http://www.uniprot.org/uniprot/P18827 denotes syndecan-1
T2 53-63 http://www.uniprot.org/uniprot/P31431 denotes syndecan-4
T3 256-260 http://www.uniprot.org/uniprot/O14708 denotes CCR5
T4 517-521 http://www.uniprot.org/uniprot/O14708 denotes CCR5
T5 529-533 http://www.uniprot.org/uniprot/O14708 denotes CCR5
T6 791-795 http://www.uniprot.org/uniprot/O14708 denotes CCR5
T7 803-807 http://www.uniprot.org/uniprot/O14708 denotes CCR5
T8 927-931 http://www.uniprot.org/uniprot/O14708 denotes CCR5
T9 1096-1100 http://www.uniprot.org/uniprot/O14708 denotes CCR5
T10 1391-1395 http://www.uniprot.org/uniprot/O14708 denotes CCR5
T11 1433-1437 http://www.uniprot.org/uniprot/O14708 denotes CCR5
T12 1534-1538 http://www.uniprot.org/uniprot/O14708 denotes CCR5
T13 488-490 http://www.uniprot.org/uniprot/P46060 denotes SD
T14 634-636 http://www.uniprot.org/uniprot/P46060 denotes SD
T15 747-749 http://www.uniprot.org/uniprot/P46060 denotes SD
T16 914-916 http://www.uniprot.org/uniprot/P46060 denotes SD
T17 919-921 http://www.uniprot.org/uniprot/P46060 denotes SD
T18 964-966 http://www.uniprot.org/uniprot/P46060 denotes SD
T19 1016-1018 http://www.uniprot.org/uniprot/P46060 denotes SD
T20 1180-1182 http://www.uniprot.org/uniprot/P46060 denotes SD
T21 1258-1260 http://www.uniprot.org/uniprot/P46060 denotes SD
T22 1417-1419 http://www.uniprot.org/uniprot/P46060 denotes SD
T23 1423-1425 http://www.uniprot.org/uniprot/P46060 denotes SD

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 38-48 http://www.uniprot.org/uniprot/P18828 denotes syndecan-1
T2 53-63 http://www.uniprot.org/uniprot/O35988 denotes syndecan-4

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 82-87 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T2 275-280 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T3 328-333 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T4 381-390 http://purl.bioontology.org/ontology/STY/T192 denotes receptors
T5 548-553 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T6 683-688 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T7 822-827 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T8 1364-1375 http://purl.bioontology.org/ontology/NCBITAXON/133265 denotes heteromeric
T9 1410-1415 http://purl.bioontology.org/ontology/STY/T025 denotes cells

GO-MF

Id Subject Object Predicate Lexical cue
T1 0-7 http://purl.obolibrary.org/obo/GO_0070026 denotes Binding
T2 207-212 http://purl.obolibrary.org/obo/GO_0070026 denotes binds
T3 239-246 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 306-313 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T5 736-743 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T6 780-787 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T7 976-984 http://purl.obolibrary.org/obo/GO_0070026 denotes bindings
T8 1004-1012 http://purl.obolibrary.org/obo/GO_0070026 denotes bindings
T9 0-7 http://purl.obolibrary.org/obo/GO_0003680 denotes Binding
T10 207-212 http://purl.obolibrary.org/obo/GO_0003680 denotes binds
T11 239-246 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T12 306-313 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T13 736-743 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T14 780-787 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T15 976-984 http://purl.obolibrary.org/obo/GO_0003680 denotes bindings
T16 1004-1012 http://purl.obolibrary.org/obo/GO_0003680 denotes bindings
T17 0-7 http://purl.obolibrary.org/obo/GO_0017091 denotes Binding
T18 207-212 http://purl.obolibrary.org/obo/GO_0017091 denotes binds
T19 239-246 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T20 306-313 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T21 736-743 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T22 780-787 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T23 976-984 http://purl.obolibrary.org/obo/GO_0017091 denotes bindings
T24 1004-1012 http://purl.obolibrary.org/obo/GO_0017091 denotes bindings
T25 0-7 http://purl.obolibrary.org/obo/GO_0005488 denotes Binding
T26 207-212 http://purl.obolibrary.org/obo/GO_0005488 denotes binds
T27 239-246 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T28 306-313 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T29 736-743 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T30 780-787 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T31 976-984 http://purl.obolibrary.org/obo/GO_0005488 denotes bindings
T32 1004-1012 http://purl.obolibrary.org/obo/GO_0005488 denotes bindings
T33 200-212 http://purl.obolibrary.org/obo/GO_0071791 denotes RANTES binds
T34 729-743 http://purl.obolibrary.org/obo/GO_0071791 denotes RANTES binding
T35 773-787 http://purl.obolibrary.org/obo/GO_0071791 denotes RANTES binding
T36 997-1012 http://purl.obolibrary.org/obo/GO_0071791 denotes RANTES bindings

GO-CC

Id Subject Object Predicate Lexical cue
T1 82-87 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 275-280 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 328-333 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4 548-553 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 683-688 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6 822-827 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7 1410-1415 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8 1113-1128 http://purl.obolibrary.org/obo/GO_0005886 denotes plasma membrane
T9 1120-1128 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 363-390 http://edamontology.org/topic_0151 denotes G protein-coupled receptors
T2 365-372 http://edamontology.org/topic_0078 denotes protein
T3 392-413 http://edamontology.org/topic_3557 denotes Coimmunoprecipitation
T4 414-421 http://edamontology.org/topic_3678 denotes studies
T5 574-584 http://edamontology.org/topic_3382 denotes microscopy
T6 1079-1090 http://edamontology.org/topic_0602 denotes interaction
T7 1155-1176 http://edamontology.org/topic_3557 denotes coimmunoprecipitation
T8 1273-1283 http://edamontology.org/topic_3382 denotes microscopy
T9 1304-1325 http://edamontology.org/topic_3557 denotes coimmunoprecipitation
T10 1304-1337 http://edamontology.org/topic_3656 denotes coimmunoprecipitation experiments

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 365-372 http://edamontology.org/data_1467 denotes protein
T2 365-372 http://edamontology.org/format_1208 denotes protein
T3 422-433 http://edamontology.org/operation_2246 denotes demonstrate
T4 585-593 http://edamontology.org/operation_2945 denotes analysis
T5 1284-1292 http://edamontology.org/operation_2945 denotes analysis

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1113-1128 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886