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PubMed:12773477 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-65 Sentence denotes Modulation of prion protein structural integrity by geldanamycin.
TextSentencer_T2 66-222 Sentence denotes The cellular prion protein PrPc is of crucial importance for the development of neurodegenerative diseases called transmissible spongiform encephalopathies.
TextSentencer_T3 223-371 Sentence denotes We investigated if the function of members of the HSP90 family is required for the integrity of the normal, nonpathogenic prion protein called PrPc.
TextSentencer_T4 372-487 Sentence denotes Eukaryotic cells were treated with the structurally unrelated HSP90-inhibitors geldanamycin (GA) or radicicol (RC).
TextSentencer_T5 488-689 Sentence denotes In either case the cellular prion protein was induced and exhibited faster migrating bands on western blot analysis, whereas geldampicin (GE), an analog of GA known not to bind to HSP90, had no effect.
TextSentencer_T6 690-812 Sentence denotes Ongoing protein and messenger RNA synthesis during treatment were found to be necessary for the appearance of these bands.
TextSentencer_T7 813-913 Sentence denotes Cotreatment with tunicamycin abrogated any effect of HSP90 inhibitors on the cellular prion protein.
TextSentencer_T8 914-1103 Sentence denotes Finally, enzymatic deglycosylation with peptide:N-glycosidase F of the normal prion protein as well as the variant induced by benzoquinone ansamycins resulted in very similar band patterns.
TextSentencer_T9 1104-1279 Sentence denotes These experiments indicate that either altered glycosylation, or a change in conformation, or both are involved in the induction of faster migrating bands by HSP90 inhibitors.
TextSentencer_T10 1280-1441 Sentence denotes Thus the inhibition of the function of members of the HSP90 family of molecular chaperones results in profound changes in the physicochemical properties of PrPc.
T1 0-65 Sentence denotes Modulation of prion protein structural integrity by geldanamycin.
T2 66-222 Sentence denotes The cellular prion protein PrPc is of crucial importance for the development of neurodegenerative diseases called transmissible spongiform encephalopathies.
T3 223-371 Sentence denotes We investigated if the function of members of the HSP90 family is required for the integrity of the normal, nonpathogenic prion protein called PrPc.
T4 372-487 Sentence denotes Eukaryotic cells were treated with the structurally unrelated HSP90-inhibitors geldanamycin (GA) or radicicol (RC).
T5 488-689 Sentence denotes In either case the cellular prion protein was induced and exhibited faster migrating bands on western blot analysis, whereas geldampicin (GE), an analog of GA known not to bind to HSP90, had no effect.
T6 690-812 Sentence denotes Ongoing protein and messenger RNA synthesis during treatment were found to be necessary for the appearance of these bands.
T7 813-913 Sentence denotes Cotreatment with tunicamycin abrogated any effect of HSP90 inhibitors on the cellular prion protein.
T8 914-1103 Sentence denotes Finally, enzymatic deglycosylation with peptide:N-glycosidase F of the normal prion protein as well as the variant induced by benzoquinone ansamycins resulted in very similar band patterns.
T9 1104-1279 Sentence denotes These experiments indicate that either altered glycosylation, or a change in conformation, or both are involved in the induction of faster migrating bands by HSP90 inhibitors.
T10 1280-1441 Sentence denotes Thus the inhibition of the function of members of the HSP90 family of molecular chaperones results in profound changes in the physicochemical properties of PrPc.
T1 0-65 Sentence denotes Modulation of prion protein structural integrity by geldanamycin.
T2 66-222 Sentence denotes The cellular prion protein PrPc is of crucial importance for the development of neurodegenerative diseases called transmissible spongiform encephalopathies.
T3 223-371 Sentence denotes We investigated if the function of members of the HSP90 family is required for the integrity of the normal, nonpathogenic prion protein called PrPc.
T4 372-487 Sentence denotes Eukaryotic cells were treated with the structurally unrelated HSP90-inhibitors geldanamycin (GA) or radicicol (RC).
T5 488-689 Sentence denotes In either case the cellular prion protein was induced and exhibited faster migrating bands on western blot analysis, whereas geldampicin (GE), an analog of GA known not to bind to HSP90, had no effect.
T6 690-812 Sentence denotes Ongoing protein and messenger RNA synthesis during treatment were found to be necessary for the appearance of these bands.
T7 813-913 Sentence denotes Cotreatment with tunicamycin abrogated any effect of HSP90 inhibitors on the cellular prion protein.
T8 914-1103 Sentence denotes Finally, enzymatic deglycosylation with peptide:N-glycosidase F of the normal prion protein as well as the variant induced by benzoquinone ansamycins resulted in very similar band patterns.
T9 1104-1279 Sentence denotes These experiments indicate that either altered glycosylation, or a change in conformation, or both are involved in the induction of faster migrating bands by HSP90 inhibitors.
T10 1280-1441 Sentence denotes Thus the inhibition of the function of members of the HSP90 family of molecular chaperones results in profound changes in the physicochemical properties of PrPc.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 205-221 HP_0001298 denotes encephalopathies

ICD10

Id Subject Object Predicate Lexical cue
T1 205-221 http://purl.bioontology.org/ontology/ICD10/G93.4 denotes encephalopathies

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 20-27 FMAID:165447 denotes protein
_T2 20-27 FMAID:67257 denotes protein
_T3 85-92 FMAID:165447 denotes protein
_T4 85-92 FMAID:67257 denotes protein
_T5 351-358 FMAID:165447 denotes protein
_T6 351-358 FMAID:67257 denotes protein
_T7 383-388 FMAID:169002 denotes cells
_T8 383-388 FMAID:68646 denotes cells
_T9 465-467 FMAID:85816 denotes GA
_T10 522-529 FMAID:67257 denotes protein
_T11 522-529 FMAID:165447 denotes protein
_T12 644-646 FMAID:85816 denotes GA
_T13 698-705 FMAID:67257 denotes protein
_T14 698-705 FMAID:165447 denotes protein
_T15 710-723 FMAID:165202 denotes messenger RNA
_T16 905-912 FMAID:67257 denotes protein
_T17 905-912 FMAID:165447 denotes protein
_T18 998-1005 FMAID:67257 denotes protein
_T19 998-1005 FMAID:165447 denotes protein

uniprot-human

Id Subject Object Predicate Lexical cue
T1 465-467 http://www.uniprot.org/uniprot/Q9UI32 denotes GA
T2 644-646 http://www.uniprot.org/uniprot/Q9UI32 denotes GA
T3 483-485 http://www.uniprot.org/uniprot/Q15493 denotes RC

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 483-485 http://www.uniprot.org/uniprot/Q64374 denotes RC

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 14-19 http://purl.bioontology.org/ontology/NCBITAXON/94464 denotes prion
T2 14-19 http://purl.bioontology.org/ontology/NCBITAXON/94193 denotes prion
T3 79-84 http://purl.bioontology.org/ontology/NCBITAXON/94193 denotes prion
T4 79-84 http://purl.bioontology.org/ontology/NCBITAXON/94464 denotes prion
T5 194-204 http://purl.bioontology.org/ontology/NCBITAXON/942146 denotes spongiform
T6 345-350 http://purl.bioontology.org/ontology/NCBITAXON/94193 denotes prion
T7 345-350 http://purl.bioontology.org/ontology/NCBITAXON/94464 denotes prion
T8 372-382 http://purl.bioontology.org/ontology/NCBITAXON/2759 denotes Eukaryotic
T9 383-388 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T10 516-521 http://purl.bioontology.org/ontology/NCBITAXON/94464 denotes prion
T11 516-521 http://purl.bioontology.org/ontology/NCBITAXON/94193 denotes prion
T12 899-904 http://purl.bioontology.org/ontology/NCBITAXON/94193 denotes prion
T13 899-904 http://purl.bioontology.org/ontology/NCBITAXON/94464 denotes prion
T14 992-997 http://purl.bioontology.org/ontology/NCBITAXON/94464 denotes prion
T15 992-997 http://purl.bioontology.org/ontology/NCBITAXON/94193 denotes prion

GO-BP

Id Subject Object Predicate Lexical cue
T1 70-78 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T2 507-515 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T3 890-898 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T4 131-142 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T5 465-467 http://purl.obolibrary.org/obo/GO_0033968 denotes GA
T6 644-646 http://purl.obolibrary.org/obo/GO_0033968 denotes GA
T7 720-733 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T8 724-733 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T9 1151-1164 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation

GO-MF

Id Subject Object Predicate Lexical cue
T1 660-664 http://purl.obolibrary.org/obo/GO_0070026 denotes bind
T2 660-664 http://purl.obolibrary.org/obo/GO_0003680 denotes bind
T3 660-664 http://purl.obolibrary.org/obo/GO_0017091 denotes bind
T4 660-664 http://purl.obolibrary.org/obo/GO_0005488 denotes bind
T5 660-673 http://purl.obolibrary.org/obo/GO_0051879 denotes bind to HSP90

GO-CC

Id Subject Object Predicate Lexical cue
T1 383-388 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 483-485 http://purl.obolibrary.org/obo/GO_0046809 denotes RC

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 20-27 http://edamontology.org/topic_0078 denotes protein
T2 20-38 http://edamontology.org/topic_0698 denotes protein structural
T3 20-38 http://edamontology.org/topic_0166 denotes protein structural
T4 20-38 http://edamontology.org/topic_2826 denotes protein structural
T5 20-38 http://edamontology.org/topic_0694 denotes protein structural
T6 20-38 http://edamontology.org/topic_2814 denotes protein structural
T7 20-38 http://edamontology.org/topic_3542 denotes protein structural
T8 20-38 http://edamontology.org/topic_3538 denotes protein structural
T9 85-92 http://edamontology.org/topic_0078 denotes protein
T10 164-172 http://edamontology.org/topic_0634 denotes diseases
T11 351-358 http://edamontology.org/topic_0078 denotes protein
T12 372-382 http://edamontology.org/topic_2818 denotes Eukaryotic
T13 522-529 http://edamontology.org/topic_0078 denotes protein
T14 698-705 http://edamontology.org/topic_0078 denotes protein
T15 905-912 http://edamontology.org/topic_0078 denotes protein
T16 954-961 http://edamontology.org/topic_0154 denotes peptide
T17 998-1005 http://edamontology.org/topic_0078 denotes protein

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 20-27 http://edamontology.org/data_1467 denotes protein
T2 20-27 http://edamontology.org/format_1208 denotes protein
T3 20-38 http://edamontology.org/data_2878 denotes protein structural
T4 20-38 http://edamontology.org/operation_0321 denotes protein structural
T5 20-38 http://edamontology.org/data_1460 denotes protein structural
T6 20-38 http://edamontology.org/data_2992 denotes protein structural
T7 20-38 http://edamontology.org/data_1481 denotes protein structural
T8 20-38 http://edamontology.org/operation_2488 denotes protein structural
T9 28-38 http://edamontology.org/data_0883 denotes structural
T10 85-92 http://edamontology.org/data_1467 denotes protein
T11 85-92 http://edamontology.org/format_1208 denotes protein
T12 323-329 http://edamontology.org/operation_3435 denotes normal
T13 351-358 http://edamontology.org/format_1208 denotes protein
T14 351-358 http://edamontology.org/data_1467 denotes protein
T15 411-423 http://edamontology.org/data_0883 denotes structurally
T16 522-529 http://edamontology.org/data_1467 denotes protein
T17 522-529 http://edamontology.org/format_1208 denotes protein
T18 595-603 http://edamontology.org/operation_2945 denotes analysis
T19 698-705 http://edamontology.org/format_1208 denotes protein
T20 698-705 http://edamontology.org/data_1467 denotes protein
T21 905-912 http://edamontology.org/format_1208 denotes protein
T22 905-912 http://edamontology.org/data_1467 denotes protein
T23 954-961 http://edamontology.org/data_2906 denotes peptide
T24 985-991 http://edamontology.org/operation_3435 denotes normal
T25 998-1005 http://edamontology.org/data_1467 denotes protein
T26 998-1005 http://edamontology.org/format_1208 denotes protein
T27 1406-1432 http://edamontology.org/data_0897 denotes physicochemical properties
T28 1406-1432 http://edamontology.org/data_2087 denotes physicochemical properties

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 146-172 Disease denotes neurodegenerative diseases http://purl.obolibrary.org/obo/MONDO_0005559
T2 180-221 Disease denotes transmissible spongiform encephalopathies http://purl.obolibrary.org/obo/MONDO_0005429|http://purl.obolibrary.org/obo/MONDO_0018926

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 146-172 Phenotype denotes neurodegenerative diseases HP:0002180
T2 205-221 Phenotype denotes encephalopathies HP:0001298

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 372-388 Body_part denotes Eukaryotic cells http://purl.obolibrary.org/obo/CL_0000255

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 372-388 Cell denotes Eukaryotic cells http://purl.obolibrary.org/obo/CL:0000255
T2 1089-1093 Cell denotes band http://purl.obolibrary.org/obo/CL:0000560