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PubMed:12753091 JSONTXT

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Id Subject Object Predicate Lexical cue
T1 0-126 DRI_Background denotes In vivo neuroprotective role of NMDA receptors against kainate-induced excitotoxicity in murine hippocampal pyramidal neurons.
T2 127-298 DRI_Outcome denotes Activation of NMDA receptors has been shown to induce either neuronal cell death or neuroprotection against excitotoxicity in cultured cerebellar granule neurons in vitro.
T3 299-426 DRI_Outcome denotes We have investigated the effects of pretreatment with NMDA on kainate-induced neuronal cell death in mouse hippocampus in vivo.
T4 427-659 DRI_Outcome denotes The systemic administration of kainate (30 mg/kg), but not NMDA (100 mg/kg), induced severe damage in pyramidal neurons of the hippocampal CA1 and CA3 subfields 3-7 days later, without affecting granule neurons in the dentate gyrus.
T5 660-735 DRI_Background denotes An immunohistochemical study using an anti-single-stranded DNA antibody and
T6 736-753 Token_Label.OUTSIDE denotes TdT-mediated dUTP
T7 754-916 DRI_Background denotes nick end labeling analysis both revealed that kainate, but not NMDA, induced DNA fragmentation in the CA1 and CA3 pyramidal neurons 1-3 days after administration.
T8 917-1047 DRI_Background denotes Kainate-induced neuronal loss was completely prevented by the systemic administration of NMDA (100 mg/kg) 1 h to 1 day previously.
T9 1048-1176 DRI_Outcome denotes No pyramidal neuron was seen with fragmented DNA in the hippocampus of animals injected with kainate 1 day after NMDA treatment.
T10 1177-1283 DRI_Background denotes The neuroprotection mediated by NMDA was prevented by the non-competitive NMDA receptor antagonist MK-801.
T11 1284-1489 DRI_Outcome denotes Taken together these results indicate that in vivo activation of NMDA receptors is capable of protecting against kainate-induced neuronal damage through blockade of DNA fragmentation in murine hippocampus.