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PubMed:12740908 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-103 Sentence denotes Interspecies contamination of the KM3 cell line: implications for CD63 function in melanoma metastasis.
TextSentencer_T2 104-312 Sentence denotes CD63 is a member of the tetraspanin superfamily of membrane glycoproteins that has been hypothesised to provide a structural network in the organisation of large multimolecular microdomains at cell membranes.
TextSentencer_T3 313-491 Sentence denotes Detailed analyses of the role of CD63 in these complexes through mutagenic studies have been limited, however, by the ubiquitous cellular expression of CD63 in vivo and in vitro.
TextSentencer_T4 492-639 Sentence denotes In an attempt to define CD63-null cell lines, we have analysed the expression of CD63 and other tetraspanins on a panel of human cancer cell lines.
TextSentencer_T5 640-749 Sentence denotes Similar expression patterns were seen between cell lines from melanomas, breast cancers and prostate cancers.
TextSentencer_T6 750-901 Sentence denotes The melanoma cell line KM3, however, described previously as a CD63-null human cell line, was found to express none of the 7 human tetraspanins tested.
TextSentencer_T7 902-1001 Sentence denotes KM3 was identified definitively as a rat cell line by analysis of karyotype and antigen expression.
TextSentencer_T8 1002-1062 Sentence denotes Notably, KM3 was found to express the rat homologue of CD63.
TextSentencer_T9 1063-1275 Sentence denotes Conclusions concerning the function of human CD63 drawn from studies using KM3 cells therefore require re-evaluation as does the frequently cited hypothesis that CD63 expression is linked to melanoma progression.
TextSentencer_T10 1276-1422 Sentence denotes As KM3 is the only cell line thus far identified as CD63 negative, these results highlight the necessity for the production of a CD63 null system.
T1 0-103 Sentence denotes Interspecies contamination of the KM3 cell line: implications for CD63 function in melanoma metastasis.
T2 104-312 Sentence denotes CD63 is a member of the tetraspanin superfamily of membrane glycoproteins that has been hypothesised to provide a structural network in the organisation of large multimolecular microdomains at cell membranes.
T3 313-491 Sentence denotes Detailed analyses of the role of CD63 in these complexes through mutagenic studies have been limited, however, by the ubiquitous cellular expression of CD63 in vivo and in vitro.
T4 492-639 Sentence denotes In an attempt to define CD63-null cell lines, we have analysed the expression of CD63 and other tetraspanins on a panel of human cancer cell lines.
T5 640-749 Sentence denotes Similar expression patterns were seen between cell lines from melanomas, breast cancers and prostate cancers.
T6 750-901 Sentence denotes The melanoma cell line KM3, however, described previously as a CD63-null human cell line, was found to express none of the 7 human tetraspanins tested.
T7 902-1001 Sentence denotes KM3 was identified definitively as a rat cell line by analysis of karyotype and antigen expression.
T8 1002-1062 Sentence denotes Notably, KM3 was found to express the rat homologue of CD63.
T9 1063-1275 Sentence denotes Conclusions concerning the function of human CD63 drawn from studies using KM3 cells therefore require re-evaluation as does the frequently cited hypothesis that CD63 expression is linked to melanoma progression.
T10 1276-1422 Sentence denotes As KM3 is the only cell line thus far identified as CD63 negative, these results highlight the necessity for the production of a CD63 null system.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
12740908-0#66#70#gene967 66-70 gene967 denotes CD63
12740908-0#92#102#diseaseC0027627 92-102 diseaseC0027627 denotes metastasis
12740908-0#83#91#diseaseC0025202 83-91 diseaseC0025202 denotes melanoma
66#70#gene96792#102#diseaseC0027627 12740908-0#66#70#gene967 12740908-0#92#102#diseaseC0027627 associated_with CD63,metastasis
66#70#gene96783#91#diseaseC0025202 12740908-0#66#70#gene967 12740908-0#83#91#diseaseC0025202 associated_with CD63,melanoma

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1517 66-70 gene:967 denotes CD63
T1518 92-102 disease:C0027627 denotes metastasis
R1 T1517 T1518 associated_with CD63,metastasis

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 713-719 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 713-719 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

DisGeNET

Id Subject Object Predicate Lexical cue
T0 66-70 gene:967 denotes CD63
T1 83-91 disease:C0025202 denotes melanoma
T2 66-70 gene:967 denotes CD63
T3 92-102 disease:C0027627 denotes metastasis
T4 66-70 gene:967 denotes CD63
T5 92-102 disease:C2939420 denotes metastasis
T6 573-577 gene:967 denotes CD63
T7 621-627 disease:C0006826 denotes cancer
T8 573-577 gene:967 denotes CD63
T9 621-627 disease:C1306459 denotes cancer
R1 T0 T1 associated_with CD63,melanoma
R2 T2 T3 associated_with CD63,metastasis
R3 T4 T5 associated_with CD63,metastasis
R4 T6 T7 associated_with CD63,cancer
R5 T8 T9 associated_with CD63,cancer