PubMed:12739036 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/12739036","sourcedb":"PubMed","sourceid":"12739036","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/12739036","text":"Differential diagnosis of high serum creatine kinase levels in systemic lupus erythematosus.\nWe report the clinical and bioptic findings for a 57-year-old woman with severe chloroquine-induced myopathy. Since 1989, she had been suffering from systemic lupus erythematosus (SLE) with renal involvement and undergone periods of treatment with azathioprine and cyclophosphamide. Additional therapy with chloroquine (CQ) was started because of arthralgia. At the same time, slightly increased creatine kinase (CK) levels were noted. Myositis was suspected, and the patient was treated with steroids. The CK increase persisted, however, and she developed progressive muscular weakness and muscular atrophy. Routine controls revealed markedly elevated CK levels of 1,700 U/l. The neurological and electrophysiological findings were not typical of myositis. Thus, muscle biopsy of the deltoid muscle was performed in order to exclude polymyositis or toxic myopathy. As it revealed chloroquine-induced myopathy, medication was stopped. Discriminating between primary SLE-induced affection of the musculoskeletal system and drug-induced side effects is important for appropriate treatment of SLE patients.","tracks":[{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":31,"end":36},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":878,"end":885},"obj":"http://purl.obolibrary.org/obo/UBERON_0001476"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":1088,"end":1110},"obj":"http://purl.obolibrary.org/obo/UBERON_0002204"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T3","pred":"source","obj":"performance-test"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":193,"end":201},"obj":"HP_0003198"},{"id":"T2","span":{"begin":243,"end":271},"obj":"HP_0002725"},{"id":"T3","span":{"begin":283,"end":300},"obj":"HP_0012210"},{"id":"T4","span":{"begin":440,"end":450},"obj":"HP_0002829"},{"id":"T5","span":{"begin":479,"end":504},"obj":"HP_0003236"},{"id":"T6","span":{"begin":529,"end":537},"obj":"HP_0100614"},{"id":"T7","span":{"begin":650,"end":679},"obj":"HP_0003323"},{"id":"T8","span":{"begin":662,"end":679},"obj":"HP_0001324"},{"id":"T9","span":{"begin":684,"end":700},"obj":"HP_0003202"},{"id":"T10","span":{"begin":774,"end":820},"obj":"HP_0000707"},{"id":"T11","span":{"begin":774,"end":820},"obj":"HP_0012759"},{"id":"T12","span":{"begin":841,"end":849},"obj":"HP_0100614"},{"id":"T13","span":{"begin":949,"end":957},"obj":"HP_0003198"},{"id":"T14","span":{"begin":994,"end":1002},"obj":"HP_0003198"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"},{"subj":"T6","pred":"source","obj":"PubmedHPO"},{"subj":"T7","pred":"source","obj":"PubmedHPO"},{"subj":"T8","pred":"source","obj":"PubmedHPO"},{"subj":"T9","pred":"source","obj":"PubmedHPO"},{"subj":"T10","pred":"source","obj":"PubmedHPO"},{"subj":"T11","pred":"source","obj":"PubmedHPO"},{"subj":"T12","pred":"source","obj":"PubmedHPO"},{"subj":"T13","pred":"source","obj":"PubmedHPO"},{"subj":"T14","pred":"source","obj":"PubmedHPO"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":92},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":93,"end":202},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":203,"end":375},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":376,"end":451},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":452,"end":528},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":529,"end":595},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":596,"end":701},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":702,"end":769},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":770,"end":850},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":851,"end":958},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":959,"end":1027},"obj":"Sentence"},{"id":"TextSentencer_T12","span":{"begin":1028,"end":1196},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":92},"obj":"Sentence"},{"id":"T2","span":{"begin":93,"end":202},"obj":"Sentence"},{"id":"T3","span":{"begin":203,"end":375},"obj":"Sentence"},{"id":"T4","span":{"begin":376,"end":451},"obj":"Sentence"},{"id":"T5","span":{"begin":452,"end":528},"obj":"Sentence"},{"id":"T6","span":{"begin":529,"end":595},"obj":"Sentence"},{"id":"T7","span":{"begin":596,"end":701},"obj":"Sentence"},{"id":"T8","span":{"begin":702,"end":769},"obj":"Sentence"},{"id":"T9","span":{"begin":770,"end":850},"obj":"Sentence"},{"id":"T10","span":{"begin":851,"end":958},"obj":"Sentence"},{"id":"T11","span":{"begin":959,"end":1027},"obj":"Sentence"},{"id":"T12","span":{"begin":1028,"end":1196},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T9","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T10","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T11","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T12","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"}]},{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":31,"end":36},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":878,"end":885},"obj":"http://purl.obolibrary.org/obo/UBERON_0001476"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":1088,"end":1110},"obj":"http://purl.obolibrary.org/obo/UBERON_0002204"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T3","pred":"source","obj":"UBERON-AE"}]},{"project":"PubCasesHPO","denotations":[{"id":"TI1","span":{"begin":63,"end":91},"obj":"HP:0002725"},{"id":"AB1","span":{"begin":193,"end":201},"obj":"HP:0003198"},{"id":"AB2","span":{"begin":243,"end":271},"obj":"HP:0002725"},{"id":"AB3","span":{"begin":440,"end":450},"obj":"HP:0002829"},{"id":"AB4","span":{"begin":529,"end":537},"obj":"HP:0100614"},{"id":"AB5","span":{"begin":841,"end":849},"obj":"HP:0100614"},{"id":"AB6","span":{"begin":949,"end":957},"obj":"HP:0003198"},{"id":"AB7","span":{"begin":994,"end":1002},"obj":"HP:0003198"}],"attributes":[{"subj":"TI1","pred":"source","obj":"PubCasesHPO"},{"subj":"AB1","pred":"source","obj":"PubCasesHPO"},{"subj":"AB2","pred":"source","obj":"PubCasesHPO"},{"subj":"AB3","pred":"source","obj":"PubCasesHPO"},{"subj":"AB4","pred":"source","obj":"PubCasesHPO"},{"subj":"AB5","pred":"source","obj":"PubCasesHPO"},{"subj":"AB6","pred":"source","obj":"PubCasesHPO"},{"subj":"AB7","pred":"source","obj":"PubCasesHPO"}]},{"project":"PubCasesORDO","denotations":[{"id":"AB1","span":{"begin":927,"end":939},"obj":"ORDO:732"}],"namespaces":[{"prefix":"ORDO","uri":"http://www.orpha.net/ORDO/Orphanet_"}],"attributes":[{"subj":"AB1","pred":"source","obj":"PubCasesORDO"}]},{"project":"bc5cdr-valid-experiment","denotations":[{"id":"T1","span":{"begin":37,"end":45},"obj":"Chemical"},{"id":"T2","span":{"begin":63,"end":91},"obj":"Disease"},{"id":"T3","span":{"begin":173,"end":184},"obj":"Chemical"},{"id":"T4","span":{"begin":193,"end":201},"obj":"Disease"},{"id":"T5","span":{"begin":243,"end":271},"obj":"Disease"},{"id":"T6","span":{"begin":273,"end":276},"obj":"Disease"},{"id":"T7","span":{"begin":283,"end":300},"obj":"Disease"},{"id":"T8","span":{"begin":341,"end":353},"obj":"Chemical"},{"id":"T9","span":{"begin":358,"end":374},"obj":"Chemical"},{"id":"T10","span":{"begin":400,"end":411},"obj":"Chemical"},{"id":"T11","span":{"begin":413,"end":415},"obj":"Chemical"},{"id":"T12","span":{"begin":440,"end":450},"obj":"Disease"},{"id":"T13","span":{"begin":489,"end":497},"obj":"Chemical"},{"id":"T14","span":{"begin":529,"end":537},"obj":"Disease"},{"id":"T15","span":{"begin":586,"end":594},"obj":"Chemical"},{"id":"T16","span":{"begin":662,"end":679},"obj":"Disease"},{"id":"T17","span":{"begin":684,"end":700},"obj":"Disease"},{"id":"T18","span":{"begin":841,"end":849},"obj":"Disease"},{"id":"T19","span":{"begin":927,"end":939},"obj":"Disease"},{"id":"T20","span":{"begin":949,"end":957},"obj":"Disease"},{"id":"T21","span":{"begin":974,"end":985},"obj":"Chemical"},{"id":"T22","span":{"begin":994,"end":1002},"obj":"Disease"},{"id":"T23","span":{"begin":1059,"end":1062},"obj":"Disease"},{"id":"T24","span":{"begin":1071,"end":1110},"obj":"Disease"},{"id":"T25","span":{"begin":1183,"end":1186},"obj":"Disease"}],"attributes":[{"subj":"T1","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T2","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T3","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T4","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T5","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T6","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T7","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T8","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T9","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T10","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T11","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T12","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T13","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T14","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T15","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T16","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T17","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T18","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T19","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T20","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T21","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T22","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T23","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T24","pred":"source","obj":"bc5cdr-valid-experiment"},{"subj":"T25","pred":"source","obj":"bc5cdr-valid-experiment"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"performance-test","color":"#ecc093","default":true},{"id":"PubmedHPO","color":"#a693ec"},{"id":"sentences","color":"#99ec93"},{"id":"UBERON-AE","color":"#ec93b3"},{"id":"PubCasesHPO","color":"#93cdec"},{"id":"PubCasesORDO","color":"#e7ec93"},{"id":"bc5cdr-valid-experiment","color":"#d693ec"}]}]}}