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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 183-440 DRI_Challenge denotes Amyloid-beta (Abeta) is a major constituent of the neuritic plaque found in the brain of Alzheimer's disease patients, and a great deal of evidence suggests that the neuronal loss that is associated with the disease is a consequence of the actions of Abeta.
T2 441-686 DRI_Outcome denotes In the past few years, it has become apparent that activation of c-Jun N-terminal kinase (JNK) mediates some of the effects of Abeta on cultured cells; in particular, the evidence suggests that Abeta-triggered JNK activation leads to cell death.
T3 687-909 DRI_Approach denotes In this study, we investigated the effect of intracerebroventricular injection of Abeta(1-40) on signaling events in the hippocampus and on long term potentiation in Schaffer collateral CA1 pyramidal cell synapses in vivo.
T4 910-1154 DRI_Outcome denotes We report that Abeta(1-40) induced activation of JNK in CA1 and that this was coupled with expression of the proapoptotic protein, Bax, cytosolic cytochrome c, poly-(ADP-ribose) polymerase cleavage, and Fas ligand expression in the hippocampus.
T5 1155-1326 DRI_Approach denotes These data indicate that Abeta(1-40) inhibited expression of long term potentiation, and this effect was abrogated by administration of the JNK inhibitor peptide, D-JNKI1.
T6 1327-1426 DRI_Outcome denotes In parallel with these findings, we observed that Abeta-induced changes in caspase-3 activation and
T7 1454-1525 DRI_Outcome denotes labeling staining in neuronal cultured cells were inhibited by D-JNKI1.
T8 1526-1798 DRI_Challenge denotes We present evidence suggesting that interleukin (IL)-1beta plays a significant role in mediating the effects of Abeta(1-40) because Abeta(1-40) increased hippocampal IL-1beta and because several effects of Abeta(1-40) were inhibited by the caspase-1 inhibitor Ac-YVAD-CMK.
T9 1799-1962 DRI_Outcome denotes On the basis of our findings, we propose that Abeta-induced changes in hippocampal plasticity are likely to be dependent upon IL-1beta-triggered activation of JNK.

sentences

Id Subject Object Predicate Lexical cue
T1 0-182 Sentence denotes Activation of the c-Jun N-terminal kinase signaling cascade mediates the effect of amyloid-beta on long term potentiation and cell death in hippocampus: a role for interleukin-1beta?
T2 183-440 Sentence denotes Amyloid-beta (Abeta) is a major constituent of the neuritic plaque found in the brain of Alzheimer's disease patients, and a great deal of evidence suggests that the neuronal loss that is associated with the disease is a consequence of the actions of Abeta.
T3 441-686 Sentence denotes In the past few years, it has become apparent that activation of c-Jun N-terminal kinase (JNK) mediates some of the effects of Abeta on cultured cells; in particular, the evidence suggests that Abeta-triggered JNK activation leads to cell death.
T4 687-909 Sentence denotes In this study, we investigated the effect of intracerebroventricular injection of Abeta(1-40) on signaling events in the hippocampus and on long term potentiation in Schaffer collateral CA1 pyramidal cell synapses in vivo.
T5 910-1154 Sentence denotes We report that Abeta(1-40) induced activation of JNK in CA1 and that this was coupled with expression of the proapoptotic protein, Bax, cytosolic cytochrome c, poly-(ADP-ribose) polymerase cleavage, and Fas ligand expression in the hippocampus.
T6 1155-1326 Sentence denotes These data indicate that Abeta(1-40) inhibited expression of long term potentiation, and this effect was abrogated by administration of the JNK inhibitor peptide, D-JNKI1.
T7 1327-1525 Sentence denotes In parallel with these findings, we observed that Abeta-induced changes in caspase-3 activation and TdT-mediated dUTP nick-end labeling staining in neuronal cultured cells were inhibited by D-JNKI1.
T8 1526-1798 Sentence denotes We present evidence suggesting that interleukin (IL)-1beta plays a significant role in mediating the effects of Abeta(1-40) because Abeta(1-40) increased hippocampal IL-1beta and because several effects of Abeta(1-40) were inhibited by the caspase-1 inhibitor Ac-YVAD-CMK.
T9 1799-1962 Sentence denotes On the basis of our findings, we propose that Abeta-induced changes in hippocampal plasticity are likely to be dependent upon IL-1beta-triggered activation of JNK.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 140-151 http://purl.obolibrary.org/obo/MAT_0000114 denotes hippocampus
T2 263-268 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T3 808-819 http://purl.obolibrary.org/obo/MAT_0000114 denotes hippocampus
T4 1142-1153 http://purl.obolibrary.org/obo/MAT_0000114 denotes hippocampus

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 183-190 HP_0011034 denotes Amyloid
T2 234-249 HP_0100256 denotes neuritic plaque
T3 272-291 HP_0002511 denotes Alzheimer's disease
T4 314-318 HP_0000365 denotes deal
T5 349-362 HP_0002529 denotes neuronal loss

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-182 DRI_Approach denotes Activation of the c-Jun N-terminal kinase signaling cascade mediates the effect of amyloid-beta on long term potentiation and cell death in hippocampus: a role for interleukin-1beta?
T2 183-440 DRI_Challenge denotes Amyloid-beta (Abeta) is a major constituent of the neuritic plaque found in the brain of Alzheimer's disease patients, and a great deal of evidence suggests that the neuronal loss that is associated with the disease is a consequence of the actions of Abeta.
T3 441-686 DRI_Outcome denotes In the past few years, it has become apparent that activation of c-Jun N-terminal kinase (JNK) mediates some of the effects of Abeta on cultured cells; in particular, the evidence suggests that Abeta-triggered JNK activation leads to cell death.
T4 687-909 DRI_Approach denotes In this study, we investigated the effect of intracerebroventricular injection of Abeta(1-40) on signaling events in the hippocampus and on long term potentiation in Schaffer collateral CA1 pyramidal cell synapses in vivo.
T5 910-1154 DRI_Outcome denotes We report that Abeta(1-40) induced activation of JNK in CA1 and that this was coupled with expression of the proapoptotic protein, Bax, cytosolic cytochrome c, poly-(ADP-ribose) polymerase cleavage, and Fas ligand expression in the hippocampus.
T6 1155-1326 DRI_Approach denotes These data indicate that Abeta(1-40) inhibited expression of long term potentiation, and this effect was abrogated by administration of the JNK inhibitor peptide, D-JNKI1.
T7 1327-1426 DRI_Outcome denotes In parallel with these findings, we observed that Abeta-induced changes in caspase-3 activation and
T8 1427-1453 Token_Label.OUTSIDE denotes TdT-mediated dUTP nick-end
T9 1454-1525 DRI_Outcome denotes labeling staining in neuronal cultured cells were inhibited by D-JNKI1.
T10 1526-1798 DRI_Challenge denotes We present evidence suggesting that interleukin (IL)-1beta plays a significant role in mediating the effects of Abeta(1-40) because Abeta(1-40) increased hippocampal IL-1beta and because several effects of Abeta(1-40) were inhibited by the caspase-1 inhibitor Ac-YVAD-CMK.
T11 1799-1962 DRI_Outcome denotes On the basis of our findings, we propose that Abeta-induced changes in hippocampal plasticity are likely to be dependent upon IL-1beta-triggered activation of JNK.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 83-90 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T2 183-190 Disease denotes Amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T3 272-291 Disease denotes Alzheimer's disease http://purl.obolibrary.org/obo/MONDO_0004975

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 140-151 OrganismTaxon denotes hippocampus 72046
T2 808-819 OrganismTaxon denotes hippocampus 72046
T3 1142-1153 OrganismTaxon denotes hippocampus 72046

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 140-151 Body_part denotes hippocampus http://purl.obolibrary.org/obo/MAT_0000114
T2 263-268 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T3 808-819 Body_part denotes hippocampus http://purl.obolibrary.org/obo/MAT_0000114
T4 1142-1153 Body_part denotes hippocampus http://purl.obolibrary.org/obo/MAT_0000114

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 140-151 Body_part denotes hippocampus http://purl.obolibrary.org/obo/UBERON_0001954|http://purl.obolibrary.org/obo/UBERON_0002421|http://purl.obolibrary.org/obo/UBERON_0002961
T4 243-249 Body_part denotes plaque http://purl.obolibrary.org/obo/UBERON_0016482
T5 263-268 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T7 808-819 Body_part denotes hippocampus http://purl.obolibrary.org/obo/UBERON_0001954|http://purl.obolibrary.org/obo/UBERON_0002421|http://purl.obolibrary.org/obo/UBERON_0002961
T10 877-891 Body_part denotes pyramidal cell http://purl.obolibrary.org/obo/CL_0000598
T11 892-900 Body_part denotes synapses http://purl.obolibrary.org/obo/GO_0045202
T12 1142-1153 Body_part denotes hippocampus http://purl.obolibrary.org/obo/UBERON_0001954|http://purl.obolibrary.org/obo/UBERON_0002421|http://purl.obolibrary.org/obo/UBERON_0002961

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 234-249 Phenotype denotes neuritic plaque HP:0100256
T2 272-291 Phenotype denotes Alzheimer's disease HP:0002511
T3 349-362 Phenotype denotes neuronal loss HP:0002529

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 349-357 Cell denotes neuronal http://purl.obolibrary.org/obo/CL:0000540
T2 577-591 Cell denotes cultured cells http://purl.obolibrary.org/obo/CL:0000010
T3 877-891 Cell denotes pyramidal cell http://purl.obolibrary.org/obo/CL:0000598
T4 1070-1074 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T6 1475-1483 Cell denotes neuronal http://purl.obolibrary.org/obo/CL:0000540
T7 1484-1498 Cell denotes cultured cells http://purl.obolibrary.org/obo/CL:0000010