> top > docs > PubMed:12730195 > annotations

PubMed:12730195 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-125 Sentence denotes Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination.
T2 126-317 Sentence denotes A putative oncogene bcl-3 was originally identified and cloned at the breakpoint in the recurring chromosome translocation t(14;19) found in some cases of B cell chronic lymphocytic leukemia.
T3 318-503 Sentence denotes Studies of bcl-3-deficient mice demonstrated a critical role for bcl-3 in the development of a normal immune response and the formation of germinal centers in secondary lymphoid organs.
T4 504-623 Sentence denotes However, the molecular mechanism that underlies B cell leukemogenesis and the knockout mouse phenotype remains unclear.
T5 624-798 Sentence denotes Here we have identified and characterized BCL-3-binding protein (B3BP) as a protein interacting specifically with the bcl-3 gene product (BCL-3) by a yeast two-hybrid screen.
T6 799-894 Sentence denotes We found that B3BP associates with not only BCL-3 but also p300/CBP histone acetyltransferases.
T7 895-1017 Sentence denotes The N-terminal region of B3BP that contains the ATP-binding site is important for the interaction with BCL-3 and p300/CBP.
T8 1018-1264 Sentence denotes Homology searches indicate that the ATP-binding region of B3BP, which contains a typical Walker-type ATP-binding P-loop, most resembles that of 2',3'-cyclic nucleotide 3'-phosphodiesterase of mammals and polynucleotide kinase of T4 bacteriophage.
T9 1265-1331 Sentence denotes In fact B3BP shows intrinsic ATP binding and hydrolyzing activity.
T10 1332-1401 Sentence denotes Furthermore, we demonstrated that B3BP is a 5'-polynucleotide kinase.
T11 1402-1599 Sentence denotes We also found a small MutS-related domain, which is thought to be involved in the DNA repair or recombination reaction, in the C-terminal region of B3BP, and it shows nicking endonuclease activity.
T12 1600-1762 Sentence denotes These observations might help to gain new insights into the function of BCL-3 and p300/CBP, especially the coupling of transcription with repair or recombination.

relna

Id Subject Object Predicate Lexical cue
T16 1013-1016 Protein denotes CBP
T17 1076-1080 Protein denotes B3BP
T18 1273-1277 Protein denotes B3BP
T19 1366-1370 Protein denotes B3BP
T1 39-60 Protein denotes BCL-3-binding protein
T2 146-151 DNA denotes bcl-3
T3 329-334 DNA denotes bcl-3
T4 383-388 DNA denotes bcl-3
T5 666-687 Protein denotes BCL-3-binding protein
T6 689-693 Protein denotes B3BP
T7 742-747 DNA denotes bcl-3
T8 762-767 DNA denotes BCL-3
T9 813-817 Protein denotes B3BP
T10 843-848 DNA denotes BCL-3
T11 858-862 DNA denotes p300
T12 863-866 Protein denotes CBP
T13 920-924 Protein denotes B3BP
T14 998-1003 DNA denotes BCL-3
T15 1008-1012 DNA denotes p300
T20 1550-1554 Protein denotes B3BP
T21 1672-1677 DNA denotes BCL-3
T22 1682-1686 DNA denotes p300
T23 1687-1690 Protein denotes CBP
R0 T5 T7 linked BCL-3-binding protein,bcl-3
R1 T5 T8 linked BCL-3-binding protein,BCL-3
R2 T6 T7 linked B3BP,bcl-3
R3 T6 T8 linked B3BP,BCL-3
R4 T9 T10 linked B3BP,BCL-3
R5 T9 T11 linked B3BP,p300

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 281-316 Disease denotes B cell chronic lymphocytic leukemia http://purl.obolibrary.org/obo/MONDO_0004948
T2 863-866 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T3 1013-1016 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T4 1687-1690 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 288-316 Phenotype denotes chronic lymphocytic leukemia HP:0005550

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 345-349 OrganismTaxon denotes mice 10088
T2 591-596 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 224-234 Body_part denotes chromosome http://purl.obolibrary.org/obo/GO_0005694
T2 281-287 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236
T3 457-473 Body_part denotes germinal centers http://purl.obolibrary.org/obo/UBERON_0009039|http://purl.obolibrary.org/obo/UBERON_0010754
T5 487-502 Body_part denotes lymphoid organs http://purl.obolibrary.org/obo/UBERON_0004177
T6 552-558 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 281-287 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236
T2 296-307 Cell denotes lymphocytic http://purl.obolibrary.org/obo/CL:0000542
T3 552-558 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236