PubMed:12730195
Annnotations
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-125 | Sentence | denotes | Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination. |
T2 | 126-317 | Sentence | denotes | A putative oncogene bcl-3 was originally identified and cloned at the breakpoint in the recurring chromosome translocation t(14;19) found in some cases of B cell chronic lymphocytic leukemia. |
T3 | 318-503 | Sentence | denotes | Studies of bcl-3-deficient mice demonstrated a critical role for bcl-3 in the development of a normal immune response and the formation of germinal centers in secondary lymphoid organs. |
T4 | 504-623 | Sentence | denotes | However, the molecular mechanism that underlies B cell leukemogenesis and the knockout mouse phenotype remains unclear. |
T5 | 624-798 | Sentence | denotes | Here we have identified and characterized BCL-3-binding protein (B3BP) as a protein interacting specifically with the bcl-3 gene product (BCL-3) by a yeast two-hybrid screen. |
T6 | 799-894 | Sentence | denotes | We found that B3BP associates with not only BCL-3 but also p300/CBP histone acetyltransferases. |
T7 | 895-1017 | Sentence | denotes | The N-terminal region of B3BP that contains the ATP-binding site is important for the interaction with BCL-3 and p300/CBP. |
T8 | 1018-1264 | Sentence | denotes | Homology searches indicate that the ATP-binding region of B3BP, which contains a typical Walker-type ATP-binding P-loop, most resembles that of 2',3'-cyclic nucleotide 3'-phosphodiesterase of mammals and polynucleotide kinase of T4 bacteriophage. |
T9 | 1265-1331 | Sentence | denotes | In fact B3BP shows intrinsic ATP binding and hydrolyzing activity. |
T10 | 1332-1401 | Sentence | denotes | Furthermore, we demonstrated that B3BP is a 5'-polynucleotide kinase. |
T11 | 1402-1599 | Sentence | denotes | We also found a small MutS-related domain, which is thought to be involved in the DNA repair or recombination reaction, in the C-terminal region of B3BP, and it shows nicking endonuclease activity. |
T12 | 1600-1762 | Sentence | denotes | These observations might help to gain new insights into the function of BCL-3 and p300/CBP, especially the coupling of transcription with repair or recombination. |
relna
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T16 | 1013-1016 | Protein | denotes | CBP |
T17 | 1076-1080 | Protein | denotes | B3BP |
T18 | 1273-1277 | Protein | denotes | B3BP |
T19 | 1366-1370 | Protein | denotes | B3BP |
T1 | 39-60 | Protein | denotes | BCL-3-binding protein |
T2 | 146-151 | DNA | denotes | bcl-3 |
T3 | 329-334 | DNA | denotes | bcl-3 |
T4 | 383-388 | DNA | denotes | bcl-3 |
T5 | 666-687 | Protein | denotes | BCL-3-binding protein |
T6 | 689-693 | Protein | denotes | B3BP |
T7 | 742-747 | DNA | denotes | bcl-3 |
T8 | 762-767 | DNA | denotes | BCL-3 |
T9 | 813-817 | Protein | denotes | B3BP |
T10 | 843-848 | DNA | denotes | BCL-3 |
T11 | 858-862 | DNA | denotes | p300 |
T12 | 863-866 | Protein | denotes | CBP |
T13 | 920-924 | Protein | denotes | B3BP |
T14 | 998-1003 | DNA | denotes | BCL-3 |
T15 | 1008-1012 | DNA | denotes | p300 |
T20 | 1550-1554 | Protein | denotes | B3BP |
T21 | 1672-1677 | DNA | denotes | BCL-3 |
T22 | 1682-1686 | DNA | denotes | p300 |
T23 | 1687-1690 | Protein | denotes | CBP |
R0 | T5 | T7 | linked | BCL-3-binding protein,bcl-3 |
R1 | T5 | T8 | linked | BCL-3-binding protein,BCL-3 |
R2 | T6 | T7 | linked | B3BP,bcl-3 |
R3 | T6 | T8 | linked | B3BP,BCL-3 |
R4 | T9 | T10 | linked | B3BP,BCL-3 |
R5 | T9 | T11 | linked | B3BP,p300 |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 281-316 | Disease | denotes | B cell chronic lymphocytic leukemia | http://purl.obolibrary.org/obo/MONDO_0004948 |
T2 | 863-866 | Disease | denotes | CBP | http://purl.obolibrary.org/obo/MONDO_0010565 |
T3 | 1013-1016 | Disease | denotes | CBP | http://purl.obolibrary.org/obo/MONDO_0010565 |
T4 | 1687-1690 | Disease | denotes | CBP | http://purl.obolibrary.org/obo/MONDO_0010565 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 345-349 | OrganismTaxon | denotes | mice | 10088 |
T2 | 591-596 | OrganismTaxon | denotes | mouse | 10088|10090 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 224-234 | Body_part | denotes | chromosome | http://purl.obolibrary.org/obo/GO_0005694 |
T2 | 281-287 | Body_part | denotes | B cell | http://purl.obolibrary.org/obo/CL_0000236 |
T3 | 457-473 | Body_part | denotes | germinal centers | http://purl.obolibrary.org/obo/UBERON_0009039|http://purl.obolibrary.org/obo/UBERON_0010754 |
T5 | 487-502 | Body_part | denotes | lymphoid organs | http://purl.obolibrary.org/obo/UBERON_0004177 |
T6 | 552-558 | Body_part | denotes | B cell | http://purl.obolibrary.org/obo/CL_0000236 |