PubMed:12716890
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 23-34 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T2 | 76-87 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T3 | 101-112 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T4 | 154-165 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T5 | 364-375 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T6 | 389-400 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T7 | 498-509 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T8 | 594-605 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T9 | 1178-1199 | Glycan_Motif | denotes | N-acetylgalactosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G27025MB |
| T10 | 1226-1237 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T11 | 1465-1476 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T12 | 1794-1805 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-128 | Sentence | denotes | Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization. |
| T2 | 129-473 | Sentence | denotes | We recently cloned human chondroitin synthase (ChSy) exhibiting the glucuronyltransferase-II (GlcATII) and N-acetylgalactosaminyltransferase-II (GalNAcTII) activities responsible for the biosynthesis of repeating disaccharide units of chondroitin sulfate, but chondroitin polymerization was not demonstrated in vitro using the recombinant ChSy. |
| T3 | 474-643 | Sentence | denotes | We report here that the chondroitin polymerizing activity requires concomitant expression of a novel protein designated chondroitin polymerizing factor (ChPF) with ChSy. |
| T4 | 644-733 | Sentence | denotes | The human ChPF consists of 775 amino acids with a type II transmembrane protein topology. |
| T5 | 734-803 | Sentence | denotes | The amino acid sequence displayed 23% identity to that of human ChSy. |
| T6 | 804-942 | Sentence | denotes | The expression of a soluble recombinant form of the protein in COS-1 cells produced a protein with little GlcAT-II or GalNAcT-II activity. |
| T7 | 943-1120 | Sentence | denotes | In contrast, coexpression of the ChPF and ChSy yielded markedly augmented glycosyltransferase activities, whereas simple mixing of the two separately expressed proteins did not. |
| T8 | 1121-1377 | Sentence | denotes | Moreover, using both UDP-glucuronic acid (GlcUA) and UDP-N-acetylgalactosamine (GalNAc) as sugar donors, chondroitin polymerization was demonstrated on the so-called glycosaminoglycan-protein linkage region tetrasaccharide sequence of alpha-thrombomodulin. |
| T9 | 1378-1492 | Sentence | denotes | These results suggested that the ChPF acts as a specific activating factor for ChSy in chondroitin polymerization. |
| T10 | 1493-1597 | Sentence | denotes | The coding region of the ChPF was divided into four discrete exons and localized to chromosome 2q35-q36. |
| T11 | 1598-1762 | Sentence | denotes | Northern blot analysis revealed that the ChPF gene exhibited a markedly different expression pattern among various human tissues, which was similar to that of ChSy. |
| T12 | 1763-1846 | Sentence | denotes | Thus, the ChPF is required for chondroitin polymerizing activity of mammalian ChSy. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 23-34 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T2 | 76-87 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T3 | 101-112 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T4 | 154-165 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T5 | 364-375 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T6 | 389-400 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T7 | 498-509 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T8 | 594-605 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T9 | 1178-1199 | https://glytoucan.org/Structures/Glycans/G27025MB | denotes | N-acetylgalactosamine |
| T10 | 1226-1237 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T11 | 1465-1476 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T12 | 1794-1805 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 23-34 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T2 | 76-87 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T3 | 101-112 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T4 | 154-165 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T5 | 364-375 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T6 | 389-400 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T7 | 498-509 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T8 | 594-605 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T9 | 1226-1237 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T10 | 1465-1476 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T11 | 1794-1805 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 23-34 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T2 | 76-87 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T3 | 101-112 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T4 | 154-165 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T5 | 364-375 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T6 | 389-400 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T7 | 498-509 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T8 | 594-605 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T9 | 1201-1207 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T10 | 1226-1237 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T11 | 1465-1476 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T12 | 1794-1805 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 23-34 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T2 | 76-87 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T3 | 101-112 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T4 | 154-165 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T5 | 364-375 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T6 | 389-400 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T7 | 498-509 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T8 | 594-605 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T9 | 1226-1237 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T10 | 1465-1476 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T11 | 1794-1805 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 148-153 | OrganismTaxon | denotes | human | 9606 |
| T2 | 648-653 | OrganismTaxon | denotes | human | 9606 |
| T3 | 792-797 | OrganismTaxon | denotes | human | 9606 |
| T4 | 1713-1718 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 702-715 | Body_part | denotes | transmembrane | http://purl.obolibrary.org/obo/GO_0016020 |
| T2 | 1577-1587 | Body_part | denotes | chromosome | http://purl.obolibrary.org/obo/GO_0005694 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-128 | Sentence | denotes | Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization. |
| T2 | 129-473 | Sentence | denotes | We recently cloned human chondroitin synthase (ChSy) exhibiting the glucuronyltransferase-II (GlcATII) and N-acetylgalactosaminyltransferase-II (GalNAcTII) activities responsible for the biosynthesis of repeating disaccharide units of chondroitin sulfate, but chondroitin polymerization was not demonstrated in vitro using the recombinant ChSy. |
| T3 | 474-643 | Sentence | denotes | We report here that the chondroitin polymerizing activity requires concomitant expression of a novel protein designated chondroitin polymerizing factor (ChPF) with ChSy. |
| T4 | 644-733 | Sentence | denotes | The human ChPF consists of 775 amino acids with a type II transmembrane protein topology. |
| T5 | 734-803 | Sentence | denotes | The amino acid sequence displayed 23% identity to that of human ChSy. |
| T6 | 804-942 | Sentence | denotes | The expression of a soluble recombinant form of the protein in COS-1 cells produced a protein with little GlcAT-II or GalNAcT-II activity. |
| T7 | 943-1120 | Sentence | denotes | In contrast, coexpression of the ChPF and ChSy yielded markedly augmented glycosyltransferase activities, whereas simple mixing of the two separately expressed proteins did not. |
| T8 | 1121-1377 | Sentence | denotes | Moreover, using both UDP-glucuronic acid (GlcUA) and UDP-N-acetylgalactosamine (GalNAc) as sugar donors, chondroitin polymerization was demonstrated on the so-called glycosaminoglycan-protein linkage region tetrasaccharide sequence of alpha-thrombomodulin. |
| T9 | 1378-1492 | Sentence | denotes | These results suggested that the ChPF acts as a specific activating factor for ChSy in chondroitin polymerization. |
| T10 | 1493-1597 | Sentence | denotes | The coding region of the ChPF was divided into four discrete exons and localized to chromosome 2q35-q36. |
| T11 | 1598-1762 | Sentence | denotes | Northern blot analysis revealed that the ChPF gene exhibited a markedly different expression pattern among various human tissues, which was similar to that of ChSy. |
| T12 | 1763-1846 | Sentence | denotes | Thus, the ChPF is required for chondroitin polymerizing activity of mammalian ChSy. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-128 | Sentence | denotes | Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization. |
| T2 | 129-473 | Sentence | denotes | We recently cloned human chondroitin synthase (ChSy) exhibiting the glucuronyltransferase-II (GlcATII) and N-acetylgalactosaminyltransferase-II (GalNAcTII) activities responsible for the biosynthesis of repeating disaccharide units of chondroitin sulfate, but chondroitin polymerization was not demonstrated in vitro using the recombinant ChSy. |
| T3 | 474-643 | Sentence | denotes | We report here that the chondroitin polymerizing activity requires concomitant expression of a novel protein designated chondroitin polymerizing factor (ChPF) with ChSy. |
| T4 | 644-733 | Sentence | denotes | The human ChPF consists of 775 amino acids with a type II transmembrane protein topology. |
| T5 | 734-803 | Sentence | denotes | The amino acid sequence displayed 23% identity to that of human ChSy. |
| T6 | 804-942 | Sentence | denotes | The expression of a soluble recombinant form of the protein in COS-1 cells produced a protein with little GlcAT-II or GalNAcT-II activity. |
| T7 | 943-1120 | Sentence | denotes | In contrast, coexpression of the ChPF and ChSy yielded markedly augmented glycosyltransferase activities, whereas simple mixing of the two separately expressed proteins did not. |
| T8 | 1121-1377 | Sentence | denotes | Moreover, using both UDP-glucuronic acid (GlcUA) and UDP-N-acetylgalactosamine (GalNAc) as sugar donors, chondroitin polymerization was demonstrated on the so-called glycosaminoglycan-protein linkage region tetrasaccharide sequence of alpha-thrombomodulin. |
| T9 | 1378-1492 | Sentence | denotes | These results suggested that the ChPF acts as a specific activating factor for ChSy in chondroitin polymerization. |
| T10 | 1493-1597 | Sentence | denotes | The coding region of the ChPF was divided into four discrete exons and localized to chromosome 2q35-q36. |
| T11 | 1598-1762 | Sentence | denotes | Northern blot analysis revealed that the ChPF gene exhibited a markedly different expression pattern among various human tissues, which was similar to that of ChSy. |
| T12 | 1763-1846 | Sentence | denotes | Thus, the ChPF is required for chondroitin polymerizing activity of mammalian ChSy. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 23-34 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T2 | 76-87 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T3 | 101-112 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T4 | 154-165 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T5 | 364-375 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T6 | 389-400 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T7 | 498-509 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T8 | 594-605 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T9 | 1201-1207 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T10 | 1226-1237 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T11 | 1465-1476 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T12 | 1794-1805 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 23-34 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T2 | 76-87 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T3 | 101-112 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T4 | 154-165 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T5 | 364-375 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T6 | 389-400 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T7 | 498-509 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T8 | 594-605 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T9 | 1226-1237 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T10 | 1465-1476 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T11 | 1794-1805 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 148-153 | OrganismTaxon | denotes | human | 9606 |
| T2 | 648-653 | OrganismTaxon | denotes | human | 9606 |
| T3 | 792-797 | OrganismTaxon | denotes | human | 9606 |
| T4 | 1713-1718 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 702-715 | Body_part | denotes | transmembrane | http://purl.obolibrary.org/obo/GO_0016020 |
| T2 | 1577-1587 | Body_part | denotes | chromosome | http://purl.obolibrary.org/obo/GO_0005694 |