PubMed:12702523 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/12702523","sourcedb":"PubMed","sourceid":"12702523","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/12702523","text":"Prognostic value of p53 molecular status in high-risk primary breast cancer.\nBACKGROUND: Mutations in the p53 gene are the most common genetic alterations in human primary breast carcinoma and these mutations are often associated with worse prognosis and chemo/radioresistance.\nPATIENTS AND METHODS: The analysis of the p53 gene was performed by fluorescence-assisted mismatch analysis in 13 consecutive high-risk primary breast cancer (HR-BC) patients with 10 or more involved axillary nodes to evaluate its prognostic value.\nRESULTS: Three p53 mutations (23%) and four allelic variants were detected. After a median follow-up of 52 months the HR-BC disease-free survival (DFS) was 51% and overall survival 79%. All patients harboring a p53 mutation (p53(mut)) relapsed within 10 months of the median DFS while 67% of those showing a wild-type p53 status (p53(wt)) survive disease-free at a median follow-up of 43 months. One p53(mut) patient is still alive while all the p53(wt) patients survive at 56 months median follow-up. Two out of the four p53(wt) relapsing breast cancer patients showed the Arg72Pro allelic variant; one of these died at 75 months.\nCONCLUSIONS: p53 mutations may help identify a subset of very high risk breast cancer patients (vHR-BC) with worse prognosis.","tracks":[{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":20,"end":23},"obj":"gene:7157"},{"id":"T1","span":{"begin":62,"end":75},"obj":"disease:C0678222"},{"id":"T2","span":{"begin":20,"end":23},"obj":"gene:7157"},{"id":"T3","span":{"begin":62,"end":75},"obj":"disease:C0006142"},{"id":"T4","span":{"begin":106,"end":109},"obj":"gene:7157"},{"id":"T5","span":{"begin":172,"end":188},"obj":"disease:C0678222"},{"id":"T6","span":{"begin":106,"end":109},"obj":"gene:7157"},{"id":"T7","span":{"begin":172,"end":188},"obj":"disease:C0006142"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"},{"subj":"T6","pred":"source","obj":"DisGeNET"},{"subj":"T7","pred":"source","obj":"DisGeNET"}]},{"project":"DisGeNET5_variant_disease","denotations":[{"id":"12702523-7#72#80#geners11540654","span":{"begin":1101,"end":1109},"obj":"geners11540654"},{"id":"12702523-7#38#51#diseaseC0006142","span":{"begin":1067,"end":1080},"obj":"diseaseC0006142"},{"id":"12702523-7#38#51#diseaseC0678222","span":{"begin":1067,"end":1080},"obj":"diseaseC0678222"}],"relations":[{"id":"72#80#geners1154065438#51#diseaseC0006142","pred":"associated_with","subj":"12702523-7#72#80#geners11540654","obj":"12702523-7#38#51#diseaseC0006142"},{"id":"72#80#geners1154065438#51#diseaseC0678222","pred":"associated_with","subj":"12702523-7#72#80#geners11540654","obj":"12702523-7#38#51#diseaseC0678222"}],"attributes":[{"subj":"12702523-7#72#80#geners11540654","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"12702523-7#38#51#diseaseC0006142","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"12702523-7#38#51#diseaseC0678222","pred":"source","obj":"DisGeNET5_variant_disease"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"12702523-0#20#23#gene7157","span":{"begin":20,"end":23},"obj":"gene7157"},{"id":"12702523-0#62#75#diseaseC0006142","span":{"begin":62,"end":75},"obj":"diseaseC0006142"},{"id":"12702523-0#62#75#diseaseC0678222","span":{"begin":62,"end":75},"obj":"diseaseC0678222"}],"relations":[{"id":"20#23#gene715762#75#diseaseC0006142","pred":"associated_with","subj":"12702523-0#20#23#gene7157","obj":"12702523-0#62#75#diseaseC0006142"},{"id":"20#23#gene715762#75#diseaseC0678222","pred":"associated_with","subj":"12702523-0#20#23#gene7157","obj":"12702523-0#62#75#diseaseC0678222"}],"attributes":[{"subj":"12702523-0#20#23#gene7157","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"12702523-0#62#75#diseaseC0006142","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"12702523-0#62#75#diseaseC0678222","pred":"source","obj":"DisGeNET5_gene_disease"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"DisGeNET","color":"#a8ec93","default":true},{"id":"DisGeNET5_variant_disease","color":"#ec93c2"},{"id":"DisGeNET5_gene_disease","color":"#93dcec"}]}]}}