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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 147-333 DRI_Background denotes Apart from the extensive loss of motor neurons, degeneration of midbrain dopaminergic cells has been described in both familial and sporadic forms of amyotrophic lateral sclerosis (ALS).
T2 334-537 DRI_Background denotes Mice overexpressing the mutant human Cu/Zn superoxide dismutase (SOD1) show an ALS-like phenotype in that they show a progressive death of motor neurons accompanied by degeneration of dopaminergic cells.
T3 538-808 DRI_Background denotes To describe the functional alterations specifically associated with this dopaminergic dysfunction, we have investigated the corticostriatal synaptic plasticity in mice overexpressing the human SOD1 (SOD1+) and the mutated (Gly(93)-->Ala) form (G93A+) of the same enzyme.
T4 809-1088 DRI_Outcome denotes We show that repetitive stimulation of the corticostriatal pathway generates long-term depression (LTD) in SOD1+ mice and in control (G93A-/SOD1-) animals, whereas in G93A+ mice the same stimulation generates an N-methyl-D-aspartic acid receptor-dependent long-term potentiation.
T5 1089-1259 DRI_Background denotes No significant alterations were found in the intrinsic membrane properties of striatal medium spiny neurons and basal corticostriatal synaptic transmission of G93A+ mice.
T6 1260-1363 DRI_Background denotes Bath perfusion of dopamine or the D(2) dopamine receptor agonist quinpirole restored LTD in G93A+ mice.
T7 1364-1515 DRI_Outcome denotes Consistent with these in vitro results, habituation of locomotor activity and striatal-dependent active avoidance learning were impaired in G93A+ mice.
T8 1516-1807 DRI_Background denotes Thus, degeneration of dopaminergic neurons in the substantia nigra of G93A+ mice causes substantial modifications in striatal synaptic plasticity and related behaviors, and may be a cellular substrate of the extrapyramidal motor and cognitive disorders observed in familial and sporadic ALS.

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
12699776-3#223#236#geners121912438 761-774 geners121912438 denotes Gly(93)-->Ala
12699776-3#86#97#diseaseC3887505 624-635 diseaseC3887505 denotes dysfunction
223#236#geners12191243886#97#diseaseC3887505 12699776-3#223#236#geners121912438 12699776-3#86#97#diseaseC3887505 associated_with Gly(93)-->Ala,dysfunction

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
12699776-2#37#63#gene6647 371-397 gene6647 denotes Cu/Zn superoxide dismutase
12699776-2#65#69#gene6647 399-403 gene6647 denotes SOD1
12699776-2#79#82#diseaseC0002736 413-416 diseaseC0002736 denotes ALS
37#63#gene664779#82#diseaseC0002736 12699776-2#37#63#gene6647 12699776-2#79#82#diseaseC0002736 associated_with Cu/Zn superoxide dismutase,ALS
65#69#gene664779#82#diseaseC0002736 12699776-2#65#69#gene6647 12699776-2#79#82#diseaseC0002736 associated_with SOD1,ALS

DisGeNET

Id Subject Object Predicate Lexical cue
T0 371-397 gene:6647 denotes Cu/Zn superoxide dismutase
T1 413-416 disease:C0002736 denotes ALS
T2 399-403 gene:6647 denotes SOD1
T3 413-416 disease:C0002736 denotes ALS
R1 T0 T1 associated_with Cu/Zn superoxide dismutase,ALS
R2 T2 T3 associated_with SOD1,ALS