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c_corpus

Id Subject Object Predicate Lexical cue
T3 28-31 SO:0000352 denotes DNA
T1 28-31 GO:0005574 denotes DNA
T2 28-31 CHEBI:16991 denotes DNA
T4 28-31 D004247 denotes DNA
T5 32-47 GO:0006298 denotes mismatch repair
T6 48-52 SO:0000704 denotes gene
T10 53-57 CVCL_G669 denotes Mlh1
T7 53-57 PR:Q9ZRV4 denotes Mlh1
T8 53-57 PR:P38920 denotes Mlh1
T9 53-57 PR:Q54KD8 denotes Mlh1
T11 53-57 PR:Q9JK91 denotes Mlh1
T12 53-57 PR:P97679 denotes Mlh1
T13 53-57 PR:Q9P7W6 denotes Mlh1
T14 53-57 PR:000010442 denotes Mlh1
T15 53-57 PR:P40692 denotes Mlh1
T16 111-116 D009369 denotes tumor
T17 111-116 D009369 denotes tumor
T20 263-266 SO:0000352 denotes DNA
T18 263-266 GO:0005574 denotes DNA
T19 263-266 CHEBI:16991 denotes DNA
T21 263-266 D004247 denotes DNA
T22 267-282 GO:0006298 denotes mismatch repair
T23 284-287 GO:0006298 denotes MMR
T24 284-287 CVCL_E779 denotes MMR
T25 284-287 P22897 denotes MMR
T26 284-287 PR:000002972 denotes MMR
T27 284-287 Q61830 denotes MMR
T28 289-293 SO:0000704 denotes gene
T32 294-298 CVCL_G669 denotes Mlh1
T29 294-298 PR:Q9ZRV4 denotes Mlh1
T30 294-298 PR:P38920 denotes Mlh1
T31 294-298 PR:Q54KD8 denotes Mlh1
T33 294-298 PR:Q9JK91 denotes Mlh1
T34 294-298 PR:P97679 denotes Mlh1
T35 294-298 PR:Q9P7W6 denotes Mlh1
T36 294-298 PR:000010442 denotes Mlh1
T37 294-298 PR:P40692 denotes Mlh1
T38 348-355 D000860 denotes hypoxia
T39 348-355 D000860 denotes hypoxia
T40 385-388 GO:0006298 denotes MMR
T41 385-388 CVCL_E779 denotes MMR
T42 385-388 P22897 denotes MMR
T43 385-388 PR:000002972 denotes MMR
T44 385-388 Q61830 denotes MMR
T46 406-409 CHEBI:16768 denotes Msh
T50 406-409 D009074 denotes Msh
T51 406-409 D009074 denotes Msh
T52 406-410 PR:000010666 denotes Msh2
T53 406-410 PR:P25847 denotes Msh2
T54 406-410 PR:P43246 denotes Msh2
T55 406-410 P22711 denotes Msh2
T56 406-410 PR:P22711 denotes Msh2
T57 406-410 PR:P54275 denotes Msh2
T58 406-410 PR:O74773 denotes Msh2
T59 406-410 PR:P43247 denotes Msh2
T60 406-410 PR:Q553L4 denotes Msh2
T61 406-410 PR:O24617 denotes Msh2
T63 412-415 CHEBI:16768 denotes Msh
T67 412-415 D009074 denotes Msh
T68 412-415 D009074 denotes Msh
T69 412-416 PR:P52701 denotes Msh6
T70 412-416 PR:P54276 denotes Msh6
T71 412-416 PR:Q9VUM0 denotes Msh6
T72 412-416 PR:Q55GU9 denotes Msh6
T73 412-416 PR:O04716 denotes Msh6
T74 412-416 PR:Q03834 denotes Msh6
T75 412-416 PR:O74502 denotes Msh6
T76 412-416 PR:000010670 denotes Msh6
T77 422-425 CHEBI:53396 denotes Pms
T80 422-425 CHEBI:53430 denotes Pms
T82 422-425 CHEBI:8055 denotes Pms
T83 422-426 PR:P54279 denotes Pms2
T84 422-426 PR:F1NQJ3 denotes Pms2
T85 422-426 PR:P38920 denotes Pms2
T86 422-426 PR:000012914 denotes Pms2
T87 422-426 PR:P54278 denotes Pms2
T90 450-454 SO:0000234 denotes mRNA
T88 450-454 D012333 denotes mRNA
T89 450-454 CHEBI:33699 denotes mRNA
T97 485-489 PR:P54279 denotes PMS2
T98 485-489 PR:F1NQJ3 denotes PMS2
T99 485-489 PR:P38920 denotes PMS2
T100 485-489 PR:000012914 denotes PMS2
T101 485-489 PR:P54278 denotes PMS2
T102 485-497 D000070976 denotes PMS2 protein
T106 490-497 PR:000000001 denotes protein
T103 490-497 GO:0003675 denotes protein
T107 490-497 SO:0000104 denotes protein
T108 546-549 CHEBI:53396 denotes PMS
T111 546-549 CHEBI:53430 denotes PMS
T113 546-549 CHEBI:8055 denotes PMS
T114 546-550 PR:P54279 denotes PMS2
T115 546-550 PR:F1NQJ3 denotes PMS2
T116 546-550 PR:P38920 denotes PMS2
T117 546-550 PR:000012914 denotes PMS2
T118 546-550 PR:P54278 denotes PMS2
T119 594-598 PR:Q9ZRV4 denotes MLH1
T120 594-598 PR:P38920 denotes MLH1
T121 594-598 PR:Q54KD8 denotes MLH1
T123 594-598 PR:Q9JK91 denotes MLH1
T124 594-598 PR:P97679 denotes MLH1
T125 594-598 PR:Q9P7W6 denotes MLH1
T126 594-598 PR:000010442 denotes MLH1
T127 594-598 PR:P40692 denotes MLH1
T122 594-598 CVCL_G669 denotes MLH1
T128 604-611 D000860 denotes hypoxia
T129 604-611 D000860 denotes hypoxia
T130 620-629 MOP:0000569 denotes reduction
T131 633-637 PR:Q9ZRV4 denotes Mlh1
T132 633-637 PR:P38920 denotes Mlh1
T133 633-637 PR:Q54KD8 denotes Mlh1
T135 633-637 PR:Q9JK91 denotes Mlh1
T136 633-637 PR:P97679 denotes Mlh1
T137 633-637 PR:Q9P7W6 denotes Mlh1
T138 633-637 PR:000010442 denotes Mlh1
T139 633-637 PR:P40692 denotes Mlh1
T134 633-637 CVCL_G669 denotes Mlh1
T142 638-642 SO:0000234 denotes mRNA
T140 638-642 D012333 denotes mRNA
T141 638-642 CHEBI:33699 denotes mRNA
T144 664-671 PR:000041244 denotes histone
T147 664-693 D056572 denotes histone deacetylase inhibitor
T148 664-693 CHEBI:61115 denotes histone deacetylase inhibitor
T149 664-693 D056572 denotes histone deacetylase inhibitor
T152 694-708 CHEBI:46024 denotes trichostatin A
T153 694-708 C012589 denotes trichostatin A
T154 694-708 C012589 denotes trichostatin A
T155 726-733 D000860 denotes hypoxia
T156 726-733 D000860 denotes hypoxia
T157 751-755 PR:Q9ZRV4 denotes Mlh1
T158 751-755 PR:P38920 denotes Mlh1
T159 751-755 PR:Q54KD8 denotes Mlh1
T161 751-755 PR:Q9JK91 denotes Mlh1
T162 751-755 PR:P97679 denotes Mlh1
T163 751-755 PR:Q9P7W6 denotes Mlh1
T164 751-755 PR:000010442 denotes Mlh1
T165 751-755 PR:P40692 denotes Mlh1
T160 751-755 CVCL_G669 denotes Mlh1
T166 756-769 GO:0006351 denotes transcription
T168 774-781 PR:000041244 denotes histone
T167 774-781 D006657 denotes histone
T169 774-781 CHEBI:15358 denotes histone
T170 774-795 GO:0016575 denotes histone deacetylation
T171 782-795 MOP:0001030 denotes deacetylation
T173 838-842 90176 denotes iron
T174 838-851 CHEBI:38157 denotes iron chelator
T176 852-867 CHEBI:4356 denotes desferrioxamine
T177 852-867 CHEBI:50453 denotes desferrioxamine
T178 852-867 D003676 denotes desferrioxamine
T179 852-867 D003676 denotes desferrioxamine
T180 881-885 PR:Q9ZRV4 denotes MLH1
T181 881-885 PR:P38920 denotes MLH1
T182 881-885 PR:Q54KD8 denotes MLH1
T184 881-885 PR:Q9JK91 denotes MLH1
T185 881-885 PR:P97679 denotes MLH1
T186 881-885 PR:Q9P7W6 denotes MLH1
T187 881-885 PR:000010442 denotes MLH1
T188 881-885 PR:P40692 denotes MLH1
T183 881-885 CVCL_G669 denotes MLH1
T189 890-893 CHEBI:53396 denotes PMS
T192 890-893 CHEBI:53430 denotes PMS
T194 890-893 CHEBI:8055 denotes PMS
T195 890-894 PR:P54279 denotes PMS2
T196 890-894 PR:F1NQJ3 denotes PMS2
T197 890-894 PR:P38920 denotes PMS2
T198 890-894 PR:000012914 denotes PMS2
T199 890-894 PR:P54278 denotes PMS2
T201 923-929 7806 denotes oxygen
T200 923-929 CHEBI:25805 denotes oxygen
T202 955-961 SO:0000725 denotes signal
T203 955-961 SO:0000418 denotes signal
T204 988-991 GO:0006298 denotes MMR
T206 988-991 P22897 denotes MMR
T207 988-991 PR:000002972 denotes MMR
T208 988-991 Q61830 denotes MMR
T205 988-991 CVCL_E779 denotes MMR
T209 992-996 SO:0000704 denotes gene
T210 992-1007 GO:0010467 denotes gene expression
T211 1020-1023 GO:0006298 denotes MMR
T213 1020-1023 P22897 denotes MMR
T214 1020-1023 PR:000002972 denotes MMR
T215 1020-1023 Q61830 denotes MMR
T212 1020-1023 CVCL_E779 denotes MMR
T216 1020-1034 C536928 denotes MMR deficiency
T217 1020-1034 C536928 denotes MMR deficiency
T218 1024-1034 SO:1000029 denotes deficiency
T219 1041-1048 D000860 denotes hypoxia
T220 1041-1048 D000860 denotes hypoxia
T221 1099-1111 CHEBI:47885 denotes dinucleotide
T222 1112-1118 SO:0001068 denotes repeat
T224 1136-1147 SO:0001148 denotes mutagenesis
T223 1136-1147 GO:0006280 denotes mutagenesis
T225 1174-1178 SO:0000704 denotes gene
T226 1219-1226 CHEBI:34922 denotes pathway
T227 1261-1268 D000860 denotes hypoxia
T228 1261-1268 D000860 denotes hypoxia
T229 1277-1286 MOP:0000569 denotes reduction
T230 1312-1315 GO:0006298 denotes MMR
T232 1312-1315 P22897 denotes MMR
T233 1312-1315 PR:000002972 denotes MMR
T234 1312-1315 Q61830 denotes MMR
T231 1312-1315 CVCL_E779 denotes MMR
T235 1316-1324 CHEBI:36080 denotes proteins
T236 1422-1429 CHEBI:34922 denotes pathway
T237 1433-1449 GO:0070314 denotes stationary-phase
T238 1433-1449 GO:0072690 denotes stationary-phase
T240 1450-1461 SO:0001148 denotes mutagenesis
T239 1450-1461 GO:0006280 denotes mutagenesis

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-98 DRI_Background denotes Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells.
T2 99-186 DRI_Background denotes The hypoxic tumor microenvironment has been shown to contribute to genetic instability.
T3 187-461 DRI_Outcome denotes As one possible mechanism for this effect, we report that expression of the DNA mismatch repair (MMR) gene Mlh1 is specifically reduced in mammalian cells under hypoxia, whereas expression of other MMR genes, including Msh2, Msh6, and Pms2, is not altered at the mRNA level.
T4 462-599 DRI_Approach denotes However, levels of the PMS2 protein are reduced, consistent with destabilization of PMS2 in the absence of its heterodimer partner, MLH1.
T5 600-796 DRI_Outcome denotes The hypoxia-induced reduction in Mlh1 mRNA was prevented by the histone deacetylase inhibitor trichostatin A, suggesting that hypoxia causes decreased Mlh1 transcription via histone deacetylation.
T6 797-842 DRI_Background denotes In addition, treatment of cells with the iron
T7 843-867 Token_Label.OUTSIDE denotes chelator desferrioxamine
T8 868-1008 DRI_Background denotes also reduced MLH1 and PMS2 levels, in keeping with low oxygen tension being the stress signal that provokes the altered MMR gene expression.
T9 1009-1179 DRI_Background denotes Functional MMR deficiency under hypoxia was detected as induced instability of a (CA)(29) dinucleotide repeat and by increased mutagenesis in a chromosomal reporter gene.
T10 1180-1325 DRI_Challenge denotes These results identify a potential new pathway of genetic instability in cancer: hypoxia-induced reduction in the expression of key MMR proteins.
T11 1326-1479 DRI_Challenge denotes In addition, this stress-induced genetic instability may represent a conceptual parallel to the pathway of stationary-phase mutagenesis seen in bacteria.