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PubMed:12663670 JSONTXT

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GlyCosmos6-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 265-272 Body_part denotes element http://purl.obolibrary.org/obo/UBERON_0000062
T2 757-770 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T3 1154-1160 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T4 1577-1581 Body_part denotes cell http://purl.obolibrary.org/obo/CL_0000000

sentences

Id Subject Object Predicate Lexical cue
T1 0-182 Sentence denotes The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair.
T2 183-366 Sentence denotes The activating transcription factor 2 (ATF2) is a member of the ATF/cAMP-response element-binding protein family of basic-leucine zipper proteins involved in cellular stress response.
T3 367-551 Sentence denotes The transcription potential of ATF2 is enhanced markedly by NH2-terminal phosphorylation by c-Jun NH2-terminal kinase (JNK) and mediates stress responses including DNA-damaging events.
T4 552-884 Sentence denotes We have observed that four DNA-damaging agents (cisplatin, actinomycin D, MMS, and etoposide), but not the cisplatin isomer, transplatin, which does not readily damage DNA, strongly activate JNK, p38, and extracellular signal-regulated kinase (ERK), and strongly increase phosphorylation and ATF2-dependent transcriptional activity.
T5 885-1118 Sentence denotes Selective inhibition studies with PD98059, SB202190, SP600125, and the dominant negative JNK indicate that activation of JNK but not p38 kinase or ERK kinase is required for the phosphorylation and transcriptional activation of ATF2.
T6 1119-1297 Sentence denotes Stable expression of ATF2 in human breast carcinoma BT474 cells increases transcriptional activity and confers resistance to the four DNA-damaging agents, but not to transplatin.
T7 1298-1592 Sentence denotes Conversely, stable expression of a dominant negative ATF2 (dnATF2) quantitatively blocks phosphorylation of endogenous ATF2 leading to a marked decrease in transcriptional activity by endogenous ATF2 and a markedly increased sensitivity to the four agents as judged by decreased cell viability.
T8 1593-1764 Sentence denotes Similarly, application of SB202190 at 50 micro m or SP600125 inhibited JNK activity, blocked transactivation, and sensitized parental cells to the four DNA-damaging drugs.
T9 1765-1909 Sentence denotes Moreover, the wild type ATF2-expressing clones exhibited rapid DNA repair after treatment with the four DNA-damaging agents but not transplatin.
T10 1910-1976 Sentence denotes Conversely, expression of dnATF2 quantitatively blocks DNA repair.
T11 1977-2171 Sentence denotes These results indicate that JNK-dependent phosphorylation of ATF2 plays an important role in the drug resistance phenotype likely by mediating enhanced DNA repair by a p53-independent mechanism.
T12 2172-2265 Sentence denotes JNK may be a rational target for sensitizing tumor cells to DNA-damaging chemotherapy agents.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 1148-1153 OrganismTaxon denotes human NCBItxid:9606

GlyCosmos6-CLO

Id Subject Object Predicate Lexical cue
T1 4-14 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T2 111-121 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T3 187-197 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T4 251-255 http://purl.obolibrary.org/obo/CLO_0053428 denotes cAMP
T5 734-742 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T6 875-883 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T7 992-1002 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T8 1099-1109 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T9 1171-1176 http://purl.obolibrary.org/obo/CLO_0002042 denotes BT474
T10 1171-1176 http://purl.obolibrary.org/obo/CLO_0052119 denotes BT474
T11 1177-1182 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12 1209-1217 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T13 1470-1478 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T14 1577-1581 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T15 1668-1676 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T16 1727-1732 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17 2223-2228 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1154-1170 Disease denotes breast carcinoma http://purl.obolibrary.org/obo/MONDO_0004989
T2 2217-2222 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

bionlp-st-pc-2013-training

Id Subject Object Predicate Lexical cue
T1 18-43 Gene_or_gene_product denotes c-Jun NH2-terminal kinase
T2 45-48 Gene_or_gene_product denotes JNK
T3 111-144 Gene_or_gene_product denotes activating transcription factor 2
T4 146-150 Gene_or_gene_product denotes ATF2
T5 187-220 Gene_or_gene_product denotes activating transcription factor 2
T6 222-226 Gene_or_gene_product denotes ATF2
T7 247-288 Gene_or_gene_product denotes ATF/cAMP-response element-binding protein
T8 305-312 Simple_chemical denotes leucine
T9 398-402 Gene_or_gene_product denotes ATF2
T10 459-484 Gene_or_gene_product denotes c-Jun NH2-terminal kinase
T11 486-489 Gene_or_gene_product denotes JNK
T12 600-609 Simple_chemical denotes cisplatin
T13 611-624 Simple_chemical denotes actinomycin D
T14 626-629 Simple_chemical denotes MMS
T15 635-644 Simple_chemical denotes etoposide
T16 659-668 Simple_chemical denotes cisplatin
T17 677-688 Simple_chemical denotes transplatin
T18 743-746 Gene_or_gene_product denotes JNK
T19 748-751 Gene_or_gene_product denotes p38
T20 757-794 Gene_or_gene_product denotes extracellular signal-regulated kinase
T21 796-799 Gene_or_gene_product denotes ERK
T22 844-848 Gene_or_gene_product denotes ATF2
T23 919-926 Simple_chemical denotes PD98059
T24 928-936 Simple_chemical denotes SB202190
T25 938-946 Simple_chemical denotes SP600125
T26 974-977 Gene_or_gene_product denotes JNK
T27 1006-1009 Gene_or_gene_product denotes JNK
T28 1018-1021 Gene_or_gene_product denotes p38
T29 1032-1035 Gene_or_gene_product denotes ERK
T30 1113-1117 Gene_or_gene_product denotes ATF2
T31 1140-1144 Gene_or_gene_product denotes ATF2
T32 1285-1296 Simple_chemical denotes transplatin
T33 1351-1355 Gene_or_gene_product denotes ATF2
T34 1357-1363 Gene_or_gene_product denotes dnATF2
T35 1417-1421 Gene_or_gene_product denotes ATF2
T36 1493-1497 Gene_or_gene_product denotes ATF2
T37 1619-1627 Simple_chemical denotes SB202190
T38 1645-1653 Simple_chemical denotes SP600125
T39 1664-1667 Gene_or_gene_product denotes JNK
T40 1789-1793 Gene_or_gene_product denotes ATF2
T41 1897-1908 Simple_chemical denotes transplatin
T42 1936-1942 Gene_or_gene_product denotes dnATF2
T43 2005-2008 Gene_or_gene_product denotes JNK
T44 2038-2042 Gene_or_gene_product denotes ATF2
T45 2145-2148 Gene_or_gene_product denotes p53
T46 2172-2175 Gene_or_gene_product denotes JNK

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
12663670-5#21#25#gene1386 1140-1144 gene1386 denotes ATF2
12663670-5#35#51#diseaseC0678222 1154-1170 diseaseC0678222 denotes breast carcinoma
21#25#gene138635#51#diseaseC0678222 12663670-5#21#25#gene1386 12663670-5#35#51#diseaseC0678222 associated_with ATF2,breast carcinoma

DisGeNET

Id Subject Object Predicate Lexical cue
T0 222-226 gene:1386 denotes ATF2
T1 350-356 disease:C3825627 denotes stress
T2 187-220 gene:1386 denotes activating transcription factor 2
T3 350-356 disease:C3825627 denotes stress
T4 398-402 gene:1386 denotes ATF2
T5 504-510 disease:C3825627 denotes stress
R1 T0 T1 associated_with ATF2,stress
R2 T2 T3 associated_with activating transcription factor 2,stress
R3 T4 T5 associated_with ATF2,stress