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PubMed:12657185 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 20-27 gene:2520 denotes gastrin
T1 92-109 disease:C0555198 denotes malignant gliomas
T2 229-236 gene:2520 denotes gastrin
T3 327-344 disease:C0555198 denotes malignant gliomas
T4 372-379 gene:2520 denotes Gastrin
T5 574-585 disease:C0206726 denotes gliosarcoma
R1 T0 T1 associated_with gastrin,malignant gliomas
R2 T2 T3 associated_with gastrin,malignant gliomas
R3 T4 T5 associated_with Gastrin,gliosarcoma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
12657185-0#20#27#gene2520 20-27 gene2520 denotes gastrin
12657185-0#92#109#diseaseC0555198 92-109 diseaseC0555198 denotes malignant gliomas
12657185-11#0#7#gene2520 2160-2167 gene2520 denotes Gastrin
12657185-11#86#93#diseaseC0017638 2246-2253 diseaseC0017638 denotes gliomas
12657185-3#202#213#diseaseC0206726 574-585 diseaseC0206726 denotes gliosarcoma
12657185-7#136#141#gene887 1558-1563 gene887 denotes CCK(B
12657185-7#146#149#gene885 1568-1571 gene885 denotes CCK
12657185-7#153#169#gene887 1575-1591 gene887 denotes gastrin receptor
12657185-7#293#296#gene885 1715-1718 gene885 denotes CCK
12657185-7#89#116#diseaseC3640999 1511-1538 diseaseC3640999 denotes high-grade astrocytic tumor
12657185-7#192#203#diseaseC0206726 1614-1625 diseaseC0206726 denotes gliosarcoma
12657185-7#89#116#diseaseC3640999 1511-1538 diseaseC3640999 denotes high-grade astrocytic tumor
12657185-7#192#203#diseaseC0206726 1614-1625 diseaseC0206726 denotes gliosarcoma
12657185-7#89#116#diseaseC3640999 1511-1538 diseaseC3640999 denotes high-grade astrocytic tumor
12657185-7#192#203#diseaseC0206726 1614-1625 diseaseC0206726 denotes gliosarcoma
12657185-9#97#101#gene1019 1963-1967 gene1019 denotes CDK4
12657185-9#130#136#diseaseC0017638 1996-2002 diseaseC0017638 denotes glioma
20#27#gene252092#109#diseaseC0555198 12657185-0#20#27#gene2520 12657185-0#92#109#diseaseC0555198 associated_with gastrin,malignant gliomas
0#7#gene252086#93#diseaseC0017638 12657185-11#0#7#gene2520 12657185-11#86#93#diseaseC0017638 associated_with Gastrin,gliomas
136#141#gene88789#116#diseaseC3640999 12657185-7#136#141#gene887 12657185-7#89#116#diseaseC3640999 associated_with CCK(B,high-grade astrocytic tumor
136#141#gene887192#203#diseaseC0206726 12657185-7#136#141#gene887 12657185-7#192#203#diseaseC0206726 associated_with CCK(B,gliosarcoma
136#141#gene88789#116#diseaseC3640999 12657185-7#136#141#gene887 12657185-7#89#116#diseaseC3640999 associated_with CCK(B,high-grade astrocytic tumor
136#141#gene887192#203#diseaseC0206726 12657185-7#136#141#gene887 12657185-7#192#203#diseaseC0206726 associated_with CCK(B,gliosarcoma
136#141#gene88789#116#diseaseC3640999 12657185-7#136#141#gene887 12657185-7#89#116#diseaseC3640999 associated_with CCK(B,high-grade astrocytic tumor
136#141#gene887192#203#diseaseC0206726 12657185-7#136#141#gene887 12657185-7#192#203#diseaseC0206726 associated_with CCK(B,gliosarcoma
146#149#gene88589#116#diseaseC3640999 12657185-7#146#149#gene885 12657185-7#89#116#diseaseC3640999 associated_with CCK,high-grade astrocytic tumor
146#149#gene885192#203#diseaseC0206726 12657185-7#146#149#gene885 12657185-7#192#203#diseaseC0206726 associated_with CCK,gliosarcoma
146#149#gene88589#116#diseaseC3640999 12657185-7#146#149#gene885 12657185-7#89#116#diseaseC3640999 associated_with CCK,high-grade astrocytic tumor
146#149#gene885192#203#diseaseC0206726 12657185-7#146#149#gene885 12657185-7#192#203#diseaseC0206726 associated_with CCK,gliosarcoma
146#149#gene88589#116#diseaseC3640999 12657185-7#146#149#gene885 12657185-7#89#116#diseaseC3640999 associated_with CCK,high-grade astrocytic tumor
146#149#gene885192#203#diseaseC0206726 12657185-7#146#149#gene885 12657185-7#192#203#diseaseC0206726 associated_with CCK,gliosarcoma
153#169#gene88789#116#diseaseC3640999 12657185-7#153#169#gene887 12657185-7#89#116#diseaseC3640999 associated_with gastrin receptor,high-grade astrocytic tumor
153#169#gene887192#203#diseaseC0206726 12657185-7#153#169#gene887 12657185-7#192#203#diseaseC0206726 associated_with gastrin receptor,gliosarcoma
153#169#gene88789#116#diseaseC3640999 12657185-7#153#169#gene887 12657185-7#89#116#diseaseC3640999 associated_with gastrin receptor,high-grade astrocytic tumor
153#169#gene887192#203#diseaseC0206726 12657185-7#153#169#gene887 12657185-7#192#203#diseaseC0206726 associated_with gastrin receptor,gliosarcoma
153#169#gene88789#116#diseaseC3640999 12657185-7#153#169#gene887 12657185-7#89#116#diseaseC3640999 associated_with gastrin receptor,high-grade astrocytic tumor
153#169#gene887192#203#diseaseC0206726 12657185-7#153#169#gene887 12657185-7#192#203#diseaseC0206726 associated_with gastrin receptor,gliosarcoma
293#296#gene88589#116#diseaseC3640999 12657185-7#293#296#gene885 12657185-7#89#116#diseaseC3640999 associated_with CCK,high-grade astrocytic tumor
293#296#gene885192#203#diseaseC0206726 12657185-7#293#296#gene885 12657185-7#192#203#diseaseC0206726 associated_with CCK,gliosarcoma
293#296#gene88589#116#diseaseC3640999 12657185-7#293#296#gene885 12657185-7#89#116#diseaseC3640999 associated_with CCK,high-grade astrocytic tumor
293#296#gene885192#203#diseaseC0206726 12657185-7#293#296#gene885 12657185-7#192#203#diseaseC0206726 associated_with CCK,gliosarcoma
293#296#gene88589#116#diseaseC3640999 12657185-7#293#296#gene885 12657185-7#89#116#diseaseC3640999 associated_with CCK,high-grade astrocytic tumor
293#296#gene885192#203#diseaseC0206726 12657185-7#293#296#gene885 12657185-7#192#203#diseaseC0206726 associated_with CCK,gliosarcoma
97#101#gene1019130#136#diseaseC0017638 12657185-9#97#101#gene1019 12657185-9#130#136#diseaseC0017638 associated_with CDK4,glioma

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 122-362 OBJECTIVE denotes Growth patterns of astrocytic tumors can be modulated in vitro by gastrin. In this study, the influence of gastrin on the in vitro cell cycle kinetics and the in vivo growth features of three experimental malignant gliomas was investigated.
T2 372-1412 METHODS denotes Gastrin-induced influence on overall growth was assayed in vitro by means of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium colorimetric assay for human U373 and rat C6 gliomas and for rat 9L gliosarcoma. Although cell cycle analyses were performed by means of computer-assisted microscope analyses of Feulgen-stained nuclei, the gastrin-induced effects of the levels of expression of cyclins D3 and E, CDK2, CDK4, CDK5, CDK7, p15, p16, E2F1, and E2F2 were assayed by means of quantitative Western blot test. The presence of ribonucleic acids for the CCK(B) and CCK(C) gastrin receptors in the U373, C6, and 9L models was assayed by means of quantitative reverse transcriptase-polymerase chain reaction, and the presence or absence of ribonucleic acids for CCK(A) receptor was checked by means of conventional polymerase chain reaction. The influence of gastrin was also characterized in vivo in terms of the survival periods of conventional rats orthotopically grafted with the C6 and 9L models and nude rats with the U373 model.
T3 1422-2147 RESULTS denotes Gastrin significantly decreased the overall growth rate in the rat C6 and the human U373 high-grade astrocytic tumor models with either CCK(B) or CCK(C) gastrin receptor but not in the 9L rat gliosarcoma, which had no CCK(B) gastrin receptor (but had CCK(A) receptor) and only weak amounts of CCK(C) receptor. This effect seems to occur via a cytostatic effect; that is, an accumulation of tumor astrocytes occurs in the G(1) cell cycle phase. The cytostatic effect could relate to a gastrin-induced decrease in the amounts of the cyclin D3-CDK4 complex in both C6 and U373 glioma cells. In vivo, gastrin significantly increased the survival periods of C6 and U373 glioma-bearing rats, but not of 9L gliosarcoma-bearing rats.
T4 2160-2254 CONCLUSIONS denotes Gastrin is able to significantly modify the growth levels of a number of experimental gliomas.