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PubMed:12652078 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 945-956 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T2 1502-1513 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T3 1518-1524 Glycan_Motif denotes fucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82576YO

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 945-956 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 1502-1513 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T3 1518-1524 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-85 Sentence denotes Glycosylation and over-expression of endometriosis-associated peritoneal haptoglobin.
TextSentencer_T2 86-248 Sentence denotes Peritoneal endometriotic tissues synthesize and secrete haptoglobin (pHp), which has an analogous nucleotide sequence to hepatic haptoglobin found in serum (sHp).
TextSentencer_T3 249-538 Sentence denotes This study performed enzymatic digestions and lectin binding assays to determine if differences in protein glycosylation exist between sHp and pHp, which may provide insight into pHp function and/or identify epitopes for development of novel methods of medical management of endometriosis.
TextSentencer_T4 539-728 Sentence denotes To reduce the dependence on surgical collection of peritoneal tissues from women, recombinant peritoneal Hp (rpHp) was produced and its glycosylation analyzed for future functional studies.
TextSentencer_T5 729-814 Sentence denotes These results showed the apparent molecular weight of pHp was 3 kDa smaller than sHp.
TextSentencer_T6 815-1070 Sentence denotes Desialylation and complete N-deglycosylation elicited similar shifts in sHp and pHp electrophoretic migration, suggesting similar sialic acid content and indicating the 3 kDa variance was due to carbohydrate content, not protein degradation, respectively.
TextSentencer_T7 1071-1250 Sentence denotes Sequential deglycosylation of the four sHp N-glycan chains caused a 3 kDa shift per N-glycan removed suggesting the 3 kDa difference between sHp and pHp may be one N-glycan chain.
TextSentencer_T8 1251-1534 Sentence denotes Lectin ELISA and lectin-blotting analyses demonstrated increased pHp and rpHp interactions with MAL and LTL but no difference in binding to SNL compared to sHp from healthy individuals, identifying variations in the ratios of alpha(2-3) to alpha(2-6) sialic acid and fucose residues.
TextSentencer_T9 1535-1680 Sentence denotes Recombinant pHp was 100-fold over-expressed with a similar glycosylation pattern to pHp, albeit in an unprocessed alpha-beta Hp polypeptide form.
TextSentencer_T10 1681-2052 Sentence denotes These results are the first to identify differences between pHp and sHp glycosylation and lay groundwork further studies to characterize anomalies in glycan composition and structure, which likely impart pHp with known immunomodulatory functions and may be used as epitopes for development of immune based therapeutics for novel, non-surgical management of endometriosis.
T1 0-85 Sentence denotes Glycosylation and over-expression of endometriosis-associated peritoneal haptoglobin.
T2 86-248 Sentence denotes Peritoneal endometriotic tissues synthesize and secrete haptoglobin (pHp), which has an analogous nucleotide sequence to hepatic haptoglobin found in serum (sHp).
T3 249-538 Sentence denotes This study performed enzymatic digestions and lectin binding assays to determine if differences in protein glycosylation exist between sHp and pHp, which may provide insight into pHp function and/or identify epitopes for development of novel methods of medical management of endometriosis.
T4 539-728 Sentence denotes To reduce the dependence on surgical collection of peritoneal tissues from women, recombinant peritoneal Hp (rpHp) was produced and its glycosylation analyzed for future functional studies.
T5 729-814 Sentence denotes These results showed the apparent molecular weight of pHp was 3 kDa smaller than sHp.
T6 815-1070 Sentence denotes Desialylation and complete N-deglycosylation elicited similar shifts in sHp and pHp electrophoretic migration, suggesting similar sialic acid content and indicating the 3 kDa variance was due to carbohydrate content, not protein degradation, respectively.
T7 1071-1250 Sentence denotes Sequential deglycosylation of the four sHp N-glycan chains caused a 3 kDa shift per N-glycan removed suggesting the 3 kDa difference between sHp and pHp may be one N-glycan chain.
T8 1251-1534 Sentence denotes Lectin ELISA and lectin-blotting analyses demonstrated increased pHp and rpHp interactions with MAL and LTL but no difference in binding to SNL compared to sHp from healthy individuals, identifying variations in the ratios of alpha(2-3) to alpha(2-6) sialic acid and fucose residues.
T9 1535-1680 Sentence denotes Recombinant pHp was 100-fold over-expressed with a similar glycosylation pattern to pHp, albeit in an unprocessed alpha-beta Hp polypeptide form.
T10 1681-2052 Sentence denotes These results are the first to identify differences between pHp and sHp glycosylation and lay groundwork further studies to characterize anomalies in glycan composition and structure, which likely impart pHp with known immunomodulatory functions and may be used as epitopes for development of immune based therapeutics for novel, non-surgical management of endometriosis.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 73-84 gene:3240 denotes haptoglobin
T1 37-50 disease:C0014175 denotes endometriosis
R1 T0 T1 associated_with haptoglobin,endometriosis

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 37-50 Disease denotes endometriosis http://purl.obolibrary.org/obo/MONDO_0005133
T2 524-537 Disease denotes endometriosis http://purl.obolibrary.org/obo/MONDO_0005133
T3 2038-2051 Disease denotes endometriosis http://purl.obolibrary.org/obo/MONDO_0005133

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 155-158 Body_part denotes pHp http://purl.obolibrary.org/obo/UBERON_0002657
T2 392-395 Body_part denotes pHp http://purl.obolibrary.org/obo/UBERON_0002657
T3 428-431 Body_part denotes pHp http://purl.obolibrary.org/obo/UBERON_0002657
T4 783-786 Body_part denotes pHp http://purl.obolibrary.org/obo/UBERON_0002657
T5 895-898 Body_part denotes pHp http://purl.obolibrary.org/obo/UBERON_0002657
T6 1220-1223 Body_part denotes pHp http://purl.obolibrary.org/obo/UBERON_0002657
T7 1316-1319 Body_part denotes pHp http://purl.obolibrary.org/obo/UBERON_0002657
T8 1547-1550 Body_part denotes pHp http://purl.obolibrary.org/obo/UBERON_0002657
T9 1619-1622 Body_part denotes pHp http://purl.obolibrary.org/obo/UBERON_0002657
T10 1741-1744 Body_part denotes pHp http://purl.obolibrary.org/obo/UBERON_0002657
T11 1885-1888 Body_part denotes pHp http://purl.obolibrary.org/obo/UBERON_0002657

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 37-50 Phenotype denotes endometriosis HP:0030127
T2 524-537 Phenotype denotes endometriosis HP:0030127
T3 2038-2051 Phenotype denotes endometriosis HP:0030127