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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 1146-1167 Glycan_Motif denotes globotriaosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO
T2 1169-1172 Glycan_Motif denotes Gb3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO
T3 1178-1200 Glycan_Motif denotes globotetraosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G04616ST|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO
T5 1202-1205 Glycan_Motif denotes Gb4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO
T6 1235-1238 Glycan_Motif denotes Gb3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO
T7 1243-1246 Glycan_Motif denotes Gb4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO
T8 1414-1417 Glycan_Motif denotes Gb3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO
T9 1422-1425 Glycan_Motif denotes Gb4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO
T10 1480-1483 Glycan_Motif denotes Gb3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO
T11 1487-1490 Glycan_Motif denotes Gb4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO
T12 1539-1542 Glycan_Motif denotes Gb3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO
T13 1547-1550 Glycan_Motif denotes Gb4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO
T14 1918-1921 Glycan_Motif denotes Gb3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO
T15 1926-1929 Glycan_Motif denotes Gb4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Identification of glycosphingolipid receptors for pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly.
T2 132-243 Sentence denotes Pierisin-1, a cytotoxic protein found naturally in the cabbage butterfly, induces apoptosis of mammalian cells.
T3 244-464 Sentence denotes Our recent studies suggest that pierisin-1 consists of an N-terminal ADP-ribosyltransferase domain, and a C-terminal region that binds to receptors on the surfaces of target cells and incorporates the protein into cells.
T4 465-535 Sentence denotes The present study was undertaken to identify receptors for pierisin-1.
T5 536-660 Sentence denotes The cross-linking and cloning experiments suggested that the proteins on cell membrane had no binding ability to pierisin-1.
T6 661-869 Sentence denotes Inhibitory assays of fractionated lipids from human cervical carcinoma HeLa cells, which are highly sensitive to pierisin-1, indicated neutral glycosphingolipids on the cell surface to show receptor activity.
T7 870-1009 Sentence denotes Inhibitory assays and TLC immunostaining using anti-pierisin-1 antibodies demonstrated two neutral glycosphingolipids as active components.
T8 1010-1207 Sentence denotes Analysis of their structures with glycosphingolipid-specific antibodies and negative secondary ion mass spectrometry identified them as globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4).
T9 1208-1313 Sentence denotes The receptor activities of Gb3 and Gb4 for pierisin-1 were also confirmed with these authentic compounds.
T10 1314-1532 Sentence denotes Pierisin-1-insensitive mouse melanoma MEB4 cells were found to lack pierisin-1 receptors, including Gb3 and Gb4, but pretreatment of the cells with glycosphingolipid Gb3 or Gb4 enhanced their sensitivity to pierisin-1.
T11 1533-1596 Sentence denotes Thus, Gb3 and Gb4 were proven to serve as pierisin-1 receptors.
T12 1597-1767 Sentence denotes The C-terminal region of pierisin-1 consists of possible lectin domains of a ricin B-chain, containing QXW sequences, which are essential for its structural organization.
T13 1768-1866 Sentence denotes Alteration of QXW by site-directed mutagenesis caused marked reduction of pierisin-1 cytotoxicity.
T14 1867-2061 Sentence denotes Thus, our results suggest that pierisin-1 binds to Gb3 and Gb4 receptors at the C-terminal region, in a manner similar to ricin, and then exhibits cytotoxicity after incorporation into the cell.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 1146-1167 https://glytoucan.org/Structures/Glycans/G00059MO denotes globotriaosylceramide
T2 1169-1172 https://glytoucan.org/Structures/Glycans/G00059MO denotes Gb3
T3 1178-1200 https://glytoucan.org/Structures/Glycans/G00061MO denotes globotetraosylceramide
T4 1178-1200 https://glytoucan.org/Structures/Glycans/G04616ST denotes globotetraosylceramide
T5 1202-1205 https://glytoucan.org/Structures/Glycans/G00061MO denotes Gb4
T6 1235-1238 https://glytoucan.org/Structures/Glycans/G00059MO denotes Gb3
T7 1243-1246 https://glytoucan.org/Structures/Glycans/G00061MO denotes Gb4
T8 1414-1417 https://glytoucan.org/Structures/Glycans/G00059MO denotes Gb3
T9 1422-1425 https://glytoucan.org/Structures/Glycans/G00061MO denotes Gb4
T10 1480-1483 https://glytoucan.org/Structures/Glycans/G00059MO denotes Gb3
T11 1487-1490 https://glytoucan.org/Structures/Glycans/G00061MO denotes Gb4
T12 1539-1542 https://glytoucan.org/Structures/Glycans/G00059MO denotes Gb3
T13 1547-1550 https://glytoucan.org/Structures/Glycans/G00061MO denotes Gb4
T14 1918-1921 https://glytoucan.org/Structures/Glycans/G00059MO denotes Gb3
T15 1926-1929 https://glytoucan.org/Structures/Glycans/G00061MO denotes Gb4

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 1169-1172 http://www.glycoepitope.jp/epitopes/EP0071 denotes Gb3
T2 1235-1238 http://www.glycoepitope.jp/epitopes/EP0071 denotes Gb3
T3 1414-1417 http://www.glycoepitope.jp/epitopes/EP0071 denotes Gb3
T4 1480-1483 http://www.glycoepitope.jp/epitopes/EP0071 denotes Gb3
T5 1539-1542 http://www.glycoepitope.jp/epitopes/EP0071 denotes Gb3
T6 1918-1921 http://www.glycoepitope.jp/epitopes/EP0071 denotes Gb3

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1169-1172 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T2 1202-1205 Glycan denotes Gb4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO
T3 1235-1238 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T4 1243-1246 Glycan denotes Gb4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO
T5 1414-1417 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T6 1422-1425 Glycan denotes Gb4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO
T7 1480-1483 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T8 1487-1490 Glycan denotes Gb4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO
T9 1539-1542 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T10 1547-1550 Glycan denotes Gb4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO
T11 1918-1921 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T12 1926-1929 Glycan denotes Gb4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 713-731 Disease denotes cervical carcinoma http://purl.obolibrary.org/obo/MONDO_0005131
T2 1343-1351 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 411-423 Phenotype denotes target cells HP:0034280
T2 722-731 Phenotype denotes carcinoma HP:0030731
T3 754-770 Phenotype denotes highly sensitive HP:0041092
T4 1343-1351 Phenotype denotes melanoma HP:0002861

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 1169-1172 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T2 1202-1205 Glycan denotes Gb4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO
T3 1235-1238 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T4 1243-1246 Glycan denotes Gb4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO
T5 1414-1417 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T6 1422-1425 Glycan denotes Gb4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO
T7 1480-1483 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T8 1487-1490 Glycan denotes Gb4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO
T9 1539-1542 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T10 1547-1550 Glycan denotes Gb4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO
T11 1918-1921 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T12 1926-1929 Glycan denotes Gb4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1169-1172 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T2 1235-1238 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T3 1414-1417 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T4 1480-1483 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T5 1539-1542 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T6 1918-1921 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 722-731 Phenotype denotes carcinoma HP:0030731
T2 754-770 Phenotype denotes highly sensitive HP:0041092
T3 1343-1351 Phenotype denotes melanoma HP:0002861

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 713-731 Disease denotes cervical carcinoma MONDO:0005131|MONDO:0008614
T3 1343-1351 Disease denotes melanoma MONDO:0005105

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 113-130 Organism denotes cabbage butterfly 7116
T2 187-204 Organism denotes cabbage butterfly 7116
T3 227-236 Organism denotes mammalian 40674
T4 707-712 Organism denotes human 9606
T5 1337-1342 Organism denotes mouse 10088|10090

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1169-1172 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T2 1235-1238 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T3 1414-1417 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T4 1480-1483 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T5 1539-1542 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T6 1918-1921 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Identification of glycosphingolipid receptors for pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly.
T2 132-243 Sentence denotes Pierisin-1, a cytotoxic protein found naturally in the cabbage butterfly, induces apoptosis of mammalian cells.
T3 244-464 Sentence denotes Our recent studies suggest that pierisin-1 consists of an N-terminal ADP-ribosyltransferase domain, and a C-terminal region that binds to receptors on the surfaces of target cells and incorporates the protein into cells.
T4 465-535 Sentence denotes The present study was undertaken to identify receptors for pierisin-1.
T5 536-660 Sentence denotes The cross-linking and cloning experiments suggested that the proteins on cell membrane had no binding ability to pierisin-1.
T6 661-869 Sentence denotes Inhibitory assays of fractionated lipids from human cervical carcinoma HeLa cells, which are highly sensitive to pierisin-1, indicated neutral glycosphingolipids on the cell surface to show receptor activity.
T7 870-1009 Sentence denotes Inhibitory assays and TLC immunostaining using anti-pierisin-1 antibodies demonstrated two neutral glycosphingolipids as active components.
T8 1010-1207 Sentence denotes Analysis of their structures with glycosphingolipid-specific antibodies and negative secondary ion mass spectrometry identified them as globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4).
T9 1208-1313 Sentence denotes The receptor activities of Gb3 and Gb4 for pierisin-1 were also confirmed with these authentic compounds.
T10 1314-1532 Sentence denotes Pierisin-1-insensitive mouse melanoma MEB4 cells were found to lack pierisin-1 receptors, including Gb3 and Gb4, but pretreatment of the cells with glycosphingolipid Gb3 or Gb4 enhanced their sensitivity to pierisin-1.
T11 1533-1596 Sentence denotes Thus, Gb3 and Gb4 were proven to serve as pierisin-1 receptors.
T12 1597-1767 Sentence denotes The C-terminal region of pierisin-1 consists of possible lectin domains of a ricin B-chain, containing QXW sequences, which are essential for its structural organization.
T13 1768-1866 Sentence denotes Alteration of QXW by site-directed mutagenesis caused marked reduction of pierisin-1 cytotoxicity.
T14 1867-2061 Sentence denotes Thus, our results suggest that pierisin-1 binds to Gb3 and Gb4 receptors at the C-terminal region, in a manner similar to ricin, and then exhibits cytotoxicity after incorporation into the cell.

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Identification of glycosphingolipid receptors for pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly.
T2 132-243 Sentence denotes Pierisin-1, a cytotoxic protein found naturally in the cabbage butterfly, induces apoptosis of mammalian cells.
T3 244-464 Sentence denotes Our recent studies suggest that pierisin-1 consists of an N-terminal ADP-ribosyltransferase domain, and a C-terminal region that binds to receptors on the surfaces of target cells and incorporates the protein into cells.
T4 465-535 Sentence denotes The present study was undertaken to identify receptors for pierisin-1.
T5 536-660 Sentence denotes The cross-linking and cloning experiments suggested that the proteins on cell membrane had no binding ability to pierisin-1.
T6 661-869 Sentence denotes Inhibitory assays of fractionated lipids from human cervical carcinoma HeLa cells, which are highly sensitive to pierisin-1, indicated neutral glycosphingolipids on the cell surface to show receptor activity.
T7 870-1009 Sentence denotes Inhibitory assays and TLC immunostaining using anti-pierisin-1 antibodies demonstrated two neutral glycosphingolipids as active components.
T8 1010-1207 Sentence denotes Analysis of their structures with glycosphingolipid-specific antibodies and negative secondary ion mass spectrometry identified them as globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4).
T9 1208-1313 Sentence denotes The receptor activities of Gb3 and Gb4 for pierisin-1 were also confirmed with these authentic compounds.
T10 1314-1532 Sentence denotes Pierisin-1-insensitive mouse melanoma MEB4 cells were found to lack pierisin-1 receptors, including Gb3 and Gb4, but pretreatment of the cells with glycosphingolipid Gb3 or Gb4 enhanced their sensitivity to pierisin-1.
T11 1533-1596 Sentence denotes Thus, Gb3 and Gb4 were proven to serve as pierisin-1 receptors.
T12 1597-1767 Sentence denotes The C-terminal region of pierisin-1 consists of possible lectin domains of a ricin B-chain, containing QXW sequences, which are essential for its structural organization.
T13 1768-1866 Sentence denotes Alteration of QXW by site-directed mutagenesis caused marked reduction of pierisin-1 cytotoxicity.
T14 1867-2061 Sentence denotes Thus, our results suggest that pierisin-1 binds to Gb3 and Gb4 receptors at the C-terminal region, in a manner similar to ricin, and then exhibits cytotoxicity after incorporation into the cell.

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 609-622 Body_part denotes cell membrane http://purl.obolibrary.org/obo/GO_0005886

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 609-622 Body_part denotes cell membrane FMA:63841
T2 830-842 Body_part denotes cell surface FMA:67653

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 113-130 OrganismTaxon denotes cabbage butterfly 7116
T2 187-204 OrganismTaxon denotes cabbage butterfly 7116
T3 707-712 OrganismTaxon denotes human 9606
T4 1337-1342 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 609-622 Body_part denotes cell membrane http://purl.obolibrary.org/obo/GO_0005886