> top > docs > PubMed:12590135 > annotations

PubMed:12590135 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-65 Sentence denotes The histone deacetylase 9 gene encodes multiple protein isoforms.
T2 66-204 Sentence denotes Histone deacetylases (HDACs) perform an important function in transcriptional regulation by modifying the core histones of the nucleosome.
T3 205-285 Sentence denotes We have now fully characterized a new member of the Class II HDAC family, HDAC9.
T4 286-463 Sentence denotes The enzyme contains a conserved deacetylase domain, represses reporter activity when recruited to a promoter, and utilizes histones H3 and H4 as substrates in vitro and in vivo.
T5 464-550 Sentence denotes HDAC9 is expressed in a tissue-specific pattern that partially overlaps that of HDAC4.
T6 551-668 Sentence denotes Within the human hematopoietic system, expression of HDAC9 is biased toward cells of monocytic and lymphoid lineages.
T7 669-781 Sentence denotes The HDAC9 gene encodes multiple protein isoforms, some of which display distinct cellular localization patterns.
T8 782-915 Sentence denotes For example, full-length HDAC9 is localized in the nucleus, but the isoform lacking the region encoded by exon 7 is in the cytoplasm.
T9 916-1132 Sentence denotes HDAC9 interacts and co-localizes in vivo with a number of transcriptional repressors and co-repressors, including TEL and N-CoR, whose functions have been implicated in the pathogenesis of hematological malignancies.
T10 1133-1266 Sentence denotes These results suggest that HDAC9 plays a role in hematopoiesis; its deregulated expression may be associated with some human cancers.

relna

Id Subject Object Predicate Lexical cue
T1 4-25 Protein denotes histone deacetylase 9
T2 279-284 Protein denotes HDAC9
T3 464-469 Protein denotes HDAC9
T4 544-549 Protein denotes HDAC4
T5 604-609 Protein denotes HDAC9
T6 673-678 Protein denotes HDAC9
T7 807-812 Protein denotes HDAC9
T8 916-921 Protein denotes HDAC9
T9 1030-1033 DNA denotes TEL
T10 1038-1043 DNA denotes N-CoR
T11 1160-1165 Protein denotes HDAC9
R0 T8 T9 linked HDAC9,TEL
R1 T8 T10 linked HDAC9,N-CoR

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1258-1265 HP_0002664 denotes cancers

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
12590135-8#0#5#gene9734 916-921 gene9734 denotes HDAC9
12590135-8#114#117#gene2120 1030-1033 gene2120 denotes TEL
12590135-8#122#127#gene9611 1038-1043 gene9611 denotes N-CoR
12590135-8#189#215#diseaseC0376545 1105-1131 diseaseC0376545 denotes hematological malignancies
0#5#gene9734189#215#diseaseC0376545 12590135-8#0#5#gene9734 12590135-8#189#215#diseaseC0376545 associated_with HDAC9,hematological malignancies
114#117#gene2120189#215#diseaseC0376545 12590135-8#114#117#gene2120 12590135-8#189#215#diseaseC0376545 associated_with TEL,hematological malignancies
122#127#gene9611189#215#diseaseC0376545 12590135-8#122#127#gene9611 12590135-8#189#215#diseaseC0376545 associated_with N-CoR,hematological malignancies

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1038-1043 gene:9611 denotes N-CoR
T1 1105-1131 disease:C0376545 denotes hematological malignancies
T2 916-921 gene:9734 denotes HDAC9
T3 1105-1131 disease:C0376545 denotes hematological malignancies
T4 1030-1033 gene:2120 denotes TEL
T5 1105-1131 disease:C0376545 denotes hematological malignancies
T6 1160-1165 gene:9734 denotes HDAC9
T7 1258-1265 disease:C0006826 denotes cancers
R1 T0 T1 associated_with N-CoR,hematological malignancies
R2 T2 T3 associated_with HDAC9,hematological malignancies
R3 T4 T5 associated_with TEL,hematological malignancies
R4 T6 T7 associated_with HDAC9,cancers

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1105-1131 Disease denotes hematological malignancies http://purl.obolibrary.org/obo/MONDO_0002334|http://purl.obolibrary.org/obo/MONDO_0044881

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 562-567 OrganismTaxon denotes human 9606
T2 1252-1257 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 488-494 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T2 568-588 Body_part denotes hematopoietic system http://purl.obolibrary.org/obo/UBERON_0002390
T3 833-840 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T5 905-914 Body_part denotes cytoplasm http://purl.obolibrary.org/obo/GO_0005737

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 636-645 Cell denotes monocytic http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054