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PubMed:12588862 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-130 Sentence denotes The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6).
T2 131-343 Sentence denotes H-L(3)MBT, the human homolog of the Drosophila lethal(3)malignant brain tumor protein, is a member of the polycomb group (PcG) of proteins, which function as transcriptional regulators in large protein complexes.
T3 344-466 Sentence denotes Homozygous mutations in the l(3)mbt gene cause brain tumors in Drosophila, identifying l(3)mbt as a tumor suppressor gene.
T4 467-594 Sentence denotes The h-l(3)mbt gene maps to chromosome 20q12, within a common deleted region associated with myeloid hematopoietic malignancies.
T5 595-949 Sentence denotes H-L(3)MBT contains three repeats of 100 residues called MBT repeats, whose function is unknown, and a C-terminal alpha-helical structure, the SPM (SCM, PH, MBT domain, which is structurally similar to the SAM (sterile alpha motif) protein-protein interaction domain, found in several ETS transcription factors, including TEL (translocation Ets leukemia).
T6 950-1110 Sentence denotes We report that H-L(3)MBT is a transcriptional repressor and that its activity is largely dependent on the presence of a region containing the three MBT repeats.
T7 1111-1241 Sentence denotes H-L(3)MBT acts as a histone deacetylase-independent transcriptional repressor, based on its lack of sensitivity to trichostatin A.
T8 1242-1369 Sentence denotes We found that H-L(3)MBT binds in vivo to TEL, and we have mapped the region of interaction to their respective SPM/SAM domains.
T9 1370-1549 Sentence denotes We show that the ability of TEL to repress TEL-responsive promoters is enhanced by the presence of H-L(3)MBT, an effect dependent on the H-L(3)MBT and the TEL interacting domains.
T10 1550-1690 Sentence denotes These experiments suggest that histone deacetylase-independent transcriptional repression by TEL depends on the recruitment of PcG proteins.
T11 1691-1833 Sentence denotes We speculate that the interaction of TEL with H-L(3)MBT can direct a PcG complex to genes repressed by TEL, stabilizing their repressed state.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 197-202 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T2 391-396 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain

relna

Id Subject Object Predicate Lexical cue
T1 14-17 Protein denotes MBT
T2 119-122 DNA denotes TEL
T3 124-128 DNA denotes ETV6
T4 131-140 DNA denotes H-L(3)MBT
T5 178-208 Protein denotes lethal(3)malignant brain tumor
T6 376-379 Protein denotes mbt
T7 435-438 Protein denotes mbt
T8 471-480 DNA denotes h-l(3)mbt
T9 595-604 DNA denotes H-L(3)MBT
T10 651-654 Protein denotes MBT
T11 916-919 DNA denotes TEL
T12 921-947 DNA denotes translocation Ets leukemia
T13 965-974 DNA denotes H-L(3)MBT
T14 1098-1101 Protein denotes MBT
T15 1111-1120 DNA denotes H-L(3)MBT
T16 1256-1265 DNA denotes H-L(3)MBT
T17 1283-1286 DNA denotes TEL
T18 1398-1401 DNA denotes TEL
T19 1413-1416 DNA denotes TEL
T20 1469-1478 DNA denotes H-L(3)MBT
T21 1507-1516 DNA denotes H-L(3)MBT
T22 1643-1646 DNA denotes TEL
T23 1728-1731 DNA denotes TEL
T24 1737-1746 DNA denotes H-L(3)MBT
T25 1794-1797 DNA denotes TEL
R0 T1 T2 linked MBT,TEL
R1 T1 T3 linked MBT,ETV6

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
12588862-1#0#9#gene26013 131-140 gene26013 denotes H-L(3)MBT
12588862-1#56#77#diseaseC0153633 187-208 diseaseC0153633 denotes malignant brain tumor
12588862-2#28#35#gene26013 372-379 gene26013 denotes l(3)mbt
12588862-2#28#35#gene83746 372-379 gene83746 denotes l(3)mbt
12588862-2#87#94#gene26013 431-438 gene26013 denotes l(3)mbt
12588862-2#87#94#gene83746 431-438 gene83746 denotes l(3)mbt
12588862-2#47#59#diseaseC0006118 391-403 diseaseC0006118 denotes brain tumors
12588862-3#4#13#gene26013 471-480 gene26013 denotes h-l(3)mbt
12588862-3#100#126#diseaseC0376544 567-593 diseaseC0376544 denotes hematopoietic malignancies
12588862-4#56#59#gene5657 651-654 gene5657 denotes MBT
12588862-4#156#159#gene5657 751-754 gene5657 denotes MBT
12588862-4#321#324#gene2120 916-919 gene2120 denotes TEL
12588862-4#344#352#diseaseC0023418 939-947 diseaseC0023418 denotes leukemia
0#9#gene2601356#77#diseaseC0153633 12588862-1#0#9#gene26013 12588862-1#56#77#diseaseC0153633 associated_with H-L(3)MBT,malignant brain tumor
28#35#gene2601347#59#diseaseC0006118 12588862-2#28#35#gene26013 12588862-2#47#59#diseaseC0006118 associated_with l(3)mbt,brain tumors
28#35#gene8374647#59#diseaseC0006118 12588862-2#28#35#gene83746 12588862-2#47#59#diseaseC0006118 associated_with l(3)mbt,brain tumors
87#94#gene2601347#59#diseaseC0006118 12588862-2#87#94#gene26013 12588862-2#47#59#diseaseC0006118 associated_with l(3)mbt,brain tumors
87#94#gene8374647#59#diseaseC0006118 12588862-2#87#94#gene83746 12588862-2#47#59#diseaseC0006118 associated_with l(3)mbt,brain tumors
4#13#gene26013100#126#diseaseC0376544 12588862-3#4#13#gene26013 12588862-3#100#126#diseaseC0376544 associated_with h-l(3)mbt,hematopoietic malignancies
56#59#gene5657344#352#diseaseC0023418 12588862-4#56#59#gene5657 12588862-4#344#352#diseaseC0023418 associated_with MBT,leukemia
156#159#gene5657344#352#diseaseC0023418 12588862-4#156#159#gene5657 12588862-4#344#352#diseaseC0023418 associated_with MBT,leukemia
321#324#gene2120344#352#diseaseC0023418 12588862-4#321#324#gene2120 12588862-4#344#352#diseaseC0023418 associated_with TEL,leukemia

DisGeNET

Id Subject Object Predicate Lexical cue
T0 131-140 gene:26013 denotes H-L(3)MBT
T1 187-208 disease:C0750979 denotes malignant brain tumor
T2 131-140 gene:26013 denotes H-L(3)MBT
T3 187-208 disease:C0153633 denotes malignant brain tumor
T4 372-379 gene:83746 denotes l(3)mbt
T5 391-403 disease:C0006118 denotes brain tumors
T6 372-379 gene:26013 denotes l(3)mbt
T7 391-403 disease:C0006118 denotes brain tumors
T8 471-480 gene:26013 denotes h-l(3)mbt
T9 567-593 disease:C0376544 denotes hematopoietic malignancies
T10 595-604 gene:26013 denotes H-L(3)MBT
T11 939-947 disease:C0023418 denotes leukemia
T12 651-654 gene:5657 denotes MBT
T13 939-947 disease:C0023418 denotes leukemia
T14 751-754 gene:5657 denotes MBT
T15 939-947 disease:C0023418 denotes leukemia
T16 916-919 gene:2120 denotes TEL
T17 939-947 disease:C0023418 denotes leukemia
R1 T0 T1 associated_with H-L(3)MBT,malignant brain tumor
R2 T2 T3 associated_with H-L(3)MBT,malignant brain tumor
R3 T4 T5 associated_with l(3)mbt,brain tumors
R4 T6 T7 associated_with l(3)mbt,brain tumors
R5 T8 T9 associated_with h-l(3)mbt,hematopoietic malignancies
R6 T10 T11 associated_with H-L(3)MBT,leukemia
R7 T12 T13 associated_with MBT,leukemia
R8 T14 T15 associated_with MBT,leukemia
R9 T16 T17 associated_with TEL,leukemia

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 187-208 Disease denotes malignant brain tumor http://purl.obolibrary.org/obo/MONDO_0001657
T2 391-403 Disease denotes brain tumors http://purl.obolibrary.org/obo/MONDO_0021211
T3 444-449 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T4 737-740 Disease denotes SPM http://purl.obolibrary.org/obo/MONDO_0010400
T5 805-812 Disease denotes sterile http://purl.obolibrary.org/obo/MONDO_0005047
T6 939-947 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T7 1353-1356 Disease denotes SPM http://purl.obolibrary.org/obo/MONDO_0010400

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 197-202 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T2 391-396 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 4-9 OrganismTaxon denotes human 9606
T2 146-151 OrganismTaxon denotes human 9606
T3 167-177 OrganismTaxon denotes Drosophila 2081351|32281|7215
T6 407-417 OrganismTaxon denotes Drosophila 2081351|32281|7215

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 197-202 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T3 391-396 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T5 494-504 Body_part denotes chromosome http://purl.obolibrary.org/obo/GO_0005694

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 197-208 Phenotype denotes brain tumor HP:0030692
T2 391-403 Phenotype denotes brain tumors HP:0030692
T3 444-449 Phenotype denotes tumor HP:0002664
T4 939-947 Phenotype denotes leukemia HP:0001909