> top > docs > PubMed:12586840 > annotations

PubMed:12586840 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-109 Sentence denotes Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2.
T2 110-369 Sentence denotes The transcriptional co-activators and histone acetyltransferases p300/CREB-binding protein (CBP) interact with CITED2, a transcription factor AP-2 (TFAP2) co-activator. p300/CBP, CITED2, and TFAP2A are essential for normal neural tube and cardiac development.
T3 370-446 Sentence denotes Here we show that p300 and CBP co-activate TFAP2A in the presence of CITED2.
T4 447-757 Sentence denotes TFAP2A transcriptional activity was modestly impaired in p300(+/-) and CBP(+/-) mouse embryonic fibroblasts; this was rescued by ectopic expression of p300/CBP. p300, TFAP2A, and endogenous CITED2 could be co-immunoprecipitated from transfected U2-OS cells indicating that they can interact physically in vivo.
T5 758-854 Sentence denotes CITED2 interacted with the dimerization domain of TFAP2C, which is highly conserved in TFAP2A/B.
T6 855-967 Sentence denotes In mammalian two-hybrid experiments, full-length p300 and TFAP2A interacted only when CITED2 was co-transfected.
T7 968-1146 Sentence denotes N-terminal residues of TFAP2A, containing the transactivation domain, are both necessary and sufficient for interaction with p300, and this interaction was independent of CITED2.
T8 1147-1258 Sentence denotes Consistent with this, N-terminal residues of TFAP2A were required for p300- and CITED2-dependent co-activation.
T9 1259-1424 Sentence denotes A histone acetyltransferase-deficient p300 mutant (D1399Y) did not co-activate TFAP2A and did not affect the expression or cellular localization of TFAP2A or CITED2.
T10 1425-1576 Sentence denotes In mammalian two-hybrid experiments p300D1399Y failed to interact with TFAP2A, explaining, at least in part, its failure to function as a co-activator.
T11 1577-1773 Sentence denotes Our results suggest a model wherein interactions among TFAP2A, CITED2, and p300/CBP are necessary for TFAP2A-mediated transcriptional activation and for normal neural tube and cardiac development.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 333-344 http://purl.obolibrary.org/obo/MAT_0000069 denotes neural tube
T2 1737-1748 http://purl.obolibrary.org/obo/MAT_0000069 denotes neural tube

relna

Id Subject Object Predicate Lexical cue
T1 71-96 DNA denotes p300/CREB-binding protein
T2 102-108 DNA denotes CITED2
T3 175-200 DNA denotes p300/CREB-binding protein
T4 202-205 DNA denotes CBP
T5 221-227 DNA denotes CITED2
T6 279-283 DNA denotes p300
T7 284-287 DNA denotes CBP
T8 289-295 DNA denotes CITED2
T9 301-307 DNA denotes TFAP2A
T10 388-392 DNA denotes p300
T11 397-400 DNA denotes CBP
T12 413-419 DNA denotes TFAP2A
T13 439-445 DNA denotes CITED2
T14 447-453 DNA denotes TFAP2A
T15 504-508 DNA denotes p300
T16 518-521 DNA denotes CBP
T17 598-602 DNA denotes p300
T18 603-606 DNA denotes CBP
T19 608-612 DNA denotes p300
T20 614-620 DNA denotes TFAP2A
T21 637-643 DNA denotes CITED2
T22 758-764 DNA denotes CITED2
T23 808-814 DNA denotes TFAP2C
T24 845-853 DNA denotes TFAP2A/B
T25 904-908 DNA denotes p300
T26 913-919 DNA denotes TFAP2A
T27 941-947 DNA denotes CITED2
T28 991-997 DNA denotes TFAP2A
T29 1093-1097 DNA denotes p300
T30 1139-1145 DNA denotes CITED2
T31 1192-1198 DNA denotes TFAP2A
T32 1217-1221 DNA denotes p300
T33 1227-1233 DNA denotes CITED2
T34 1297-1301 DNA denotes p300
T35 1338-1344 DNA denotes TFAP2A
T36 1407-1413 DNA denotes TFAP2A
T37 1417-1423 DNA denotes CITED2
T38 1496-1502 DNA denotes TFAP2A
T39 1632-1638 DNA denotes TFAP2A
T40 1640-1646 DNA denotes CITED2
T41 1652-1656 DNA denotes p300
T42 1657-1660 DNA denotes CBP
T43 1679-1685 DNA denotes TFAP2A

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 202-205 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T2 284-287 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T3 397-400 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T4 518-521 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T5 603-606 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565
T6 1657-1660 Disease denotes CBP http://purl.obolibrary.org/obo/MONDO_0010565

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 527-532 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 333-344 Body_part denotes neural tube http://purl.obolibrary.org/obo/UBERON_0001049
T2 533-554 Body_part denotes embryonic fibroblasts http://purl.obolibrary.org/obo/CL_2000042
T3 1737-1748 Body_part denotes neural tube http://purl.obolibrary.org/obo/UBERON_0001049

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 333-344 Body_part denotes neural tube http://purl.obolibrary.org/obo/MAT_0000069
T2 1737-1748 Body_part denotes neural tube http://purl.obolibrary.org/obo/MAT_0000069

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 533-554 Cell denotes embryonic fibroblasts http://purl.obolibrary.org/obo/CL:2000042