PubMed:12529363
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 884-895 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T2 | 900-911 | Cell | denotes | lymphocytes | http://purl.obolibrary.org/obo/CL:0000542 |
| T3 | 1047-1058 | Cell | denotes | Neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T4 | 1157-1168 | Cell | denotes | lymphocytes | http://purl.obolibrary.org/obo/CL:0000542 |
| T5 | 1776-1787 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T6 | 1792-1803 | Cell | denotes | lymphocytes | http://purl.obolibrary.org/obo/CL:0000542 |
| T7 | 2030-2040 | Cell | denotes | neutrophil | http://purl.obolibrary.org/obo/CL:0000775 |
| T8 | 2053-2064 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T9 | 2084-2101 | Cell | denotes | endothelial cells | http://purl.obolibrary.org/obo/CL:0000115 |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 9-15 | Glycan_Motif | denotes | core 1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T2 | 20-26 | Glycan_Motif | denotes | core 2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO |
| T3 | 70-84 | Glycan_Motif | denotes | sialyl Lewis X | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO |
| T4 | 147-161 | Glycan_Motif | denotes | sialyl Lewis x | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO |
| T5 | 154-161 | Glycan_Motif | denotes | Lewis x | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO |
| T7 | 165-171 | Glycan_Motif | denotes | core 2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO |
| T8 | 263-284 | Glycan_Motif | denotes | 6-sulfosialyl Lewis x | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G80722US|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G53231FE|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G23322RK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00672PE |
| T12 | 277-284 | Glycan_Motif | denotes | Lewis x | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO |
| T14 | 297-303 | Glycan_Motif | denotes | core 1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T15 | 493-499 | Glycan_Motif | denotes | core 1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T16 | 536-542 | Glycan_Motif | denotes | core 1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T17 | 703-709 | Glycan_Motif | denotes | core 1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T18 | 773-779 | Glycan_Motif | denotes | core 1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T19 | 980-986 | Glycan_Motif | denotes | core 2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO |
| T20 | 1258-1272 | Glycan_Motif | denotes | sialyl Lewis x | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO |
| T21 | 1265-1272 | Glycan_Motif | denotes | Lewis x | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO |
| T23 | 1285-1291 | Glycan_Motif | denotes | core 1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T24 | 1551-1565 | Glycan_Motif | denotes | sialyl Lewis x | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO |
| T25 | 1558-1565 | Glycan_Motif | denotes | Lewis x | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO |
| T27 | 1578-1584 | Glycan_Motif | denotes | core 1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T28 | 1589-1595 | Glycan_Motif | denotes | core 2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO |
| T29 | 1657-1671 | Glycan_Motif | denotes | sialyl Lewis x | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO |
| T30 | 1664-1671 | Glycan_Motif | denotes | Lewis x | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO |
| T32 | 1684-1690 | Glycan_Motif | denotes | core 1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T33 | 1845-1859 | Glycan_Motif | denotes | sialyl Lewis x | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO |
| T34 | 1852-1859 | Glycan_Motif | denotes | Lewis x | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO |
| T36 | 1863-1869 | Glycan_Motif | denotes | core 2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO |
| T37 | 1918-1932 | Glycan_Motif | denotes | sialyl Lewis x | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO |
| T38 | 1925-1932 | Glycan_Motif | denotes | Lewis x | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO |
| T40 | 1945-1951 | Glycan_Motif | denotes | core 1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-117 | Sentence | denotes | Extended core 1 and core 2 branched O-glycans differentially modulate sialyl Lewis X-type L-selectin ligand activity. |
| T2 | 118-229 | Sentence | denotes | It has been established that sialyl Lewis x in core 2 branched O-glycans serves as an E- and P-selectin ligand. |
| T3 | 230-483 | Sentence | denotes | Recently, it was discovered that 6-sulfosialyl Lewis x in extended core 1 O-glycans, NeuNAcalpha2-->3Galbeta1-->4(Fucalpha1-->3(sulfo-->6))GlcNAcbeta1--> 3Galbeta1-->3GalNAcalpha1-->Ser/Thr, functions as an L-selectin ligand in high endothelial venules. |
| T4 | 484-571 | Sentence | denotes | Extended core 1 O-glycans can be synthesized when a core 1 extension enzyme is present. |
| T5 | 572-809 | Sentence | denotes | In this study, we first show that beta1,3-N-acetylglucosaminyltransferase-3 (beta3GlcNAcT-3) is almost exclusively responsible for core 1 extension among seven different beta3GlcNAcTs and thus acts on core 1 O-glycans attached to PSGL-1. |
| T6 | 810-1046 | Sentence | denotes | We found that transcripts encoding beta3GlcNAcT-3 were expressed in human neutrophils and lymphocytes but that their levels were lower than those of transcripts encoding core 2 beta1,6-N-acetylglucosaminyltransferase I (Core2GlcNAcT-I). |
| T7 | 1047-1231 | Sentence | denotes | Neutrophils also expressed transcripts encoding fucosyltransferase VII (FucT-VII) and Core2GlcNAcT-I, whereas lymphocytes expressed only small amounts of transcripts encoding FucT-VII. |
| T8 | 1232-1434 | Sentence | denotes | To determine the roles of sialyl Lewis x in extended core 1 O-glycans, Chinese hamster ovary (CHO) cells were stably transfected to express PSGL-1, FucT-VII, and either beta3GlcNAcT-3 or Core2GlcNAcT-I. |
| T9 | 1435-1615 | Sentence | denotes | Glycan structural analyses disclosed that PSGL-1 expressed in these transfected cells carried comparable amounts of sialyl Lewis x in extended core 1 and core 2 branched O-glycans. |
| T10 | 1616-1889 | Sentence | denotes | In a rolling assay, CHO cells expressing sialyl Lewis x in extended core 1 O-glycans supported a significant degree of shear-dependent tethering and rolling of neutrophils and lymphocytes, although less than CHO cells expressing sialyl Lewis x in core 2 branched O-glycans. |
| T11 | 1890-2102 | Sentence | denotes | These results indicate that sialyl Lewis x in extended core 1 O-glycans can function as an L-selectin ligand and is potentially involved in neutrophil adhesion on neutrophils bound to activated endothelial cells. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 9-15 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T2 | 70-84 | https://glytoucan.org/Structures/Glycans/G00054MO | denotes | sialyl Lewis X |
| T3 | 77-84 | https://glytoucan.org/Structures/Glycans/G00051MO | denotes | Lewis X |
| T4 | 147-161 | https://glytoucan.org/Structures/Glycans/G00054MO | denotes | sialyl Lewis x |
| T5 | 154-161 | https://glytoucan.org/Structures/Glycans/G00051MO | denotes | Lewis x |
| T6 | 154-161 | https://glytoucan.org/Structures/Glycans/G01187XC | denotes | Lewis x |
| T7 | 263-284 | https://glytoucan.org/Structures/Glycans/G23322RK | denotes | 6-sulfosialyl Lewis x |
| T8 | 263-284 | https://glytoucan.org/Structures/Glycans/G80722US | denotes | 6-sulfosialyl Lewis x |
| T9 | 277-284 | https://glytoucan.org/Structures/Glycans/G00051MO | denotes | Lewis x |
| T10 | 277-284 | https://glytoucan.org/Structures/Glycans/G01187XC | denotes | Lewis x |
| T11 | 297-303 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T12 | 493-499 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T13 | 536-542 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T14 | 703-709 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T15 | 773-779 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T16 | 1258-1272 | https://glytoucan.org/Structures/Glycans/G00054MO | denotes | sialyl Lewis x |
| T17 | 1265-1272 | https://glytoucan.org/Structures/Glycans/G00051MO | denotes | Lewis x |
| T18 | 1265-1272 | https://glytoucan.org/Structures/Glycans/G01187XC | denotes | Lewis x |
| T19 | 1285-1291 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T20 | 1551-1565 | https://glytoucan.org/Structures/Glycans/G00054MO | denotes | sialyl Lewis x |
| T21 | 1558-1565 | https://glytoucan.org/Structures/Glycans/G00051MO | denotes | Lewis x |
| T22 | 1558-1565 | https://glytoucan.org/Structures/Glycans/G01187XC | denotes | Lewis x |
| T23 | 1578-1584 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T24 | 1657-1671 | https://glytoucan.org/Structures/Glycans/G00054MO | denotes | sialyl Lewis x |
| T25 | 1664-1671 | https://glytoucan.org/Structures/Glycans/G00051MO | denotes | Lewis x |
| T26 | 1664-1671 | https://glytoucan.org/Structures/Glycans/G01187XC | denotes | Lewis x |
| T27 | 1684-1690 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T28 | 1845-1859 | https://glytoucan.org/Structures/Glycans/G00054MO | denotes | sialyl Lewis x |
| T29 | 1852-1859 | https://glytoucan.org/Structures/Glycans/G00051MO | denotes | Lewis x |
| T30 | 1852-1859 | https://glytoucan.org/Structures/Glycans/G01187XC | denotes | Lewis x |
| T31 | 1918-1932 | https://glytoucan.org/Structures/Glycans/G00054MO | denotes | sialyl Lewis x |
| T32 | 1925-1932 | https://glytoucan.org/Structures/Glycans/G00051MO | denotes | Lewis x |
| T33 | 1925-1932 | https://glytoucan.org/Structures/Glycans/G01187XC | denotes | Lewis x |
| T34 | 1945-1951 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 70-84 | http://www.glycoepitope.jp/epitopes/EP0012 | denotes | sialyl Lewis X |
| T2 | 147-161 | http://www.glycoepitope.jp/epitopes/EP0012 | denotes | sialyl Lewis x |
| T3 | 154-161 | http://www.glycoepitope.jp/epitopes/EP0011 | denotes | Lewis x |
| T4 | 263-284 | http://www.glycoepitope.jp/epitopes/EP0014 | denotes | 6-sulfosialyl Lewis x |
| T5 | 277-284 | http://www.glycoepitope.jp/epitopes/EP0011 | denotes | Lewis x |
| T6 | 1258-1272 | http://www.glycoepitope.jp/epitopes/EP0012 | denotes | sialyl Lewis x |
| T7 | 1265-1272 | http://www.glycoepitope.jp/epitopes/EP0011 | denotes | Lewis x |
| T8 | 1551-1565 | http://www.glycoepitope.jp/epitopes/EP0012 | denotes | sialyl Lewis x |
| T9 | 1558-1565 | http://www.glycoepitope.jp/epitopes/EP0011 | denotes | Lewis x |
| T10 | 1657-1671 | http://www.glycoepitope.jp/epitopes/EP0012 | denotes | sialyl Lewis x |
| T11 | 1664-1671 | http://www.glycoepitope.jp/epitopes/EP0011 | denotes | Lewis x |
| T12 | 1845-1859 | http://www.glycoepitope.jp/epitopes/EP0012 | denotes | sialyl Lewis x |
| T13 | 1852-1859 | http://www.glycoepitope.jp/epitopes/EP0011 | denotes | Lewis x |
| T14 | 1918-1932 | http://www.glycoepitope.jp/epitopes/EP0012 | denotes | sialyl Lewis x |
| T15 | 1925-1932 | http://www.glycoepitope.jp/epitopes/EP0011 | denotes | Lewis x |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 9-15 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T2 | 20-26 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T3 | 70-84 | Glycan | denotes | sialyl Lewis X | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T4 | 147-161 | Glycan | denotes | sialyl Lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T5 | 165-171 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T6 | 263-284 | Glycan | denotes | 6-sulfosialyl Lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00672PE |
| T7 | 297-303 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T8 | 493-499 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T9 | 536-542 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T10 | 703-709 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T11 | 773-779 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T12 | 980-986 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T13 | 1258-1272 | Glycan | denotes | sialyl Lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T14 | 1285-1291 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T15 | 1551-1565 | Glycan | denotes | sialyl Lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T16 | 1578-1584 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T17 | 1589-1595 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T18 | 1657-1671 | Glycan | denotes | sialyl Lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T19 | 1684-1690 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T20 | 1845-1859 | Glycan | denotes | sialyl Lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T21 | 1863-1869 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T22 | 1918-1932 | Glycan | denotes | sialyl Lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T23 | 1945-1951 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 9-15 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T2 | 20-26 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T3 | 70-84 | Glycan | denotes | sialyl Lewis X | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T4 | 147-161 | Glycan | denotes | sialyl Lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T5 | 165-171 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T6 | 263-284 | Glycan | denotes | 6-sulfosialyl Lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00672PE |
| T7 | 297-303 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T8 | 493-499 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T9 | 536-542 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T10 | 703-709 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T11 | 773-779 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T12 | 980-986 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T13 | 1258-1272 | Glycan | denotes | sialyl Lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T14 | 1285-1291 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T15 | 1551-1565 | Glycan | denotes | sialyl Lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T16 | 1578-1584 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T17 | 1589-1595 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T18 | 1657-1671 | Glycan | denotes | sialyl Lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T19 | 1684-1690 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T20 | 1845-1859 | Glycan | denotes | sialyl Lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T21 | 1863-1869 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T22 | 1918-1932 | Glycan | denotes | sialyl Lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T23 | 1945-1951 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 70-84 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis X | http://www.glycoepitope.jp/epitopes/EP0012 |
| T2 | 147-161 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis x | http://www.glycoepitope.jp/epitopes/EP0012 |
| T3 | 263-284 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 6-sulfosialyl Lewis x | http://www.glycoepitope.jp/epitopes/EP0014 |
| T4 | 1258-1272 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis x | http://www.glycoepitope.jp/epitopes/EP0012 |
| T5 | 1551-1565 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis x | http://www.glycoepitope.jp/epitopes/EP0012 |
| T6 | 1657-1671 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis x | http://www.glycoepitope.jp/epitopes/EP0012 |
| T7 | 1845-1859 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis x | http://www.glycoepitope.jp/epitopes/EP0012 |
| T8 | 1918-1932 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis x | http://www.glycoepitope.jp/epitopes/EP0012 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 884-895 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T2 | 900-911 | Cell | denotes | lymphocytes | http://purl.obolibrary.org/obo/CL:0000542 |
| T3 | 1047-1058 | Cell | denotes | Neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T4 | 1157-1168 | Cell | denotes | lymphocytes | http://purl.obolibrary.org/obo/CL:0000542 |
| T5 | 1776-1787 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T6 | 1792-1803 | Cell | denotes | lymphocytes | http://purl.obolibrary.org/obo/CL:0000542 |
| T7 | 2030-2040 | Cell | denotes | neutrophil | http://purl.obolibrary.org/obo/CL:0000775 |
| T8 | 2053-2064 | Cell | denotes | neutrophils | http://purl.obolibrary.org/obo/CL:0000775 |
| T9 | 2084-2101 | Cell | denotes | endothelial cells | http://purl.obolibrary.org/obo/CL:0000115 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 458-482 | Body_part | denotes | high endothelial venules | http://purl.obolibrary.org/obo/UBERON_8410037 |
| T2 | 543-552 | Body_part | denotes | extension | http://purl.obolibrary.org/obo/UBERON_2000106 |
| T3 | 710-719 | Body_part | denotes | extension | http://purl.obolibrary.org/obo/UBERON_2000106 |
| T4 | 884-895 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T5 | 900-911 | Body_part | denotes | lymphocytes | http://purl.obolibrary.org/obo/CL_0000542 |
| T6 | 1047-1058 | Body_part | denotes | Neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T7 | 1157-1168 | Body_part | denotes | lymphocytes | http://purl.obolibrary.org/obo/CL_0000542 |
| T8 | 1319-1324 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |
| T9 | 1776-1787 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T10 | 1792-1803 | Body_part | denotes | lymphocytes | http://purl.obolibrary.org/obo/CL_0000542 |
| T11 | 2030-2040 | Body_part | denotes | neutrophil | http://purl.obolibrary.org/obo/CL_0000775 |
| T12 | 2053-2064 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T13 | 2084-2101 | Body_part | denotes | endothelial cells | http://purl.obolibrary.org/obo/CL_0000115 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 878-883 | Organism | denotes | human | 9606 |
| T2 | 1303-1318 | Organism | denotes | Chinese hamster | 10029 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-117 | Sentence | denotes | Extended core 1 and core 2 branched O-glycans differentially modulate sialyl Lewis X-type L-selectin ligand activity. |
| T2 | 118-229 | Sentence | denotes | It has been established that sialyl Lewis x in core 2 branched O-glycans serves as an E- and P-selectin ligand. |
| T3 | 230-483 | Sentence | denotes | Recently, it was discovered that 6-sulfosialyl Lewis x in extended core 1 O-glycans, NeuNAcalpha2-->3Galbeta1-->4(Fucalpha1-->3(sulfo-->6))GlcNAcbeta1--> 3Galbeta1-->3GalNAcalpha1-->Ser/Thr, functions as an L-selectin ligand in high endothelial venules. |
| T4 | 484-571 | Sentence | denotes | Extended core 1 O-glycans can be synthesized when a core 1 extension enzyme is present. |
| T5 | 572-809 | Sentence | denotes | In this study, we first show that beta1,3-N-acetylglucosaminyltransferase-3 (beta3GlcNAcT-3) is almost exclusively responsible for core 1 extension among seven different beta3GlcNAcTs and thus acts on core 1 O-glycans attached to PSGL-1. |
| T6 | 810-1046 | Sentence | denotes | We found that transcripts encoding beta3GlcNAcT-3 were expressed in human neutrophils and lymphocytes but that their levels were lower than those of transcripts encoding core 2 beta1,6-N-acetylglucosaminyltransferase I (Core2GlcNAcT-I). |
| T7 | 1047-1231 | Sentence | denotes | Neutrophils also expressed transcripts encoding fucosyltransferase VII (FucT-VII) and Core2GlcNAcT-I, whereas lymphocytes expressed only small amounts of transcripts encoding FucT-VII. |
| T8 | 1232-1615 | Sentence | denotes | To determine the roles of sialyl Lewis x in extended core 1 O-glycans, Chinese hamster ovary (CHO) cells were stably transfected to express PSGL-1, FucT-VII, and either beta3GlcNAcT-3 or Core2GlcNAcT-I. Glycan structural analyses disclosed that PSGL-1 expressed in these transfected cells carried comparable amounts of sialyl Lewis x in extended core 1 and core 2 branched O-glycans. |
| T9 | 1616-1889 | Sentence | denotes | In a rolling assay, CHO cells expressing sialyl Lewis x in extended core 1 O-glycans supported a significant degree of shear-dependent tethering and rolling of neutrophils and lymphocytes, although less than CHO cells expressing sialyl Lewis x in core 2 branched O-glycans. |
| T10 | 1890-2102 | Sentence | denotes | These results indicate that sialyl Lewis x in extended core 1 O-glycans can function as an L-selectin ligand and is potentially involved in neutrophil adhesion on neutrophils bound to activated endothelial cells. |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 70-84 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis X | http://www.glycoepitope.jp/epitopes/EP0012 |
| T2 | 147-161 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis x | http://www.glycoepitope.jp/epitopes/EP0012 |
| T3 | 263-284 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 6-sulfosialyl Lewis x | http://www.glycoepitope.jp/epitopes/EP0014 |
| T4 | 1258-1272 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis x | http://www.glycoepitope.jp/epitopes/EP0012 |
| T5 | 1551-1565 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis x | http://www.glycoepitope.jp/epitopes/EP0012 |
| T6 | 1657-1671 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis x | http://www.glycoepitope.jp/epitopes/EP0012 |
| T7 | 1845-1859 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis x | http://www.glycoepitope.jp/epitopes/EP0012 |
| T8 | 1918-1932 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl Lewis x | http://www.glycoepitope.jp/epitopes/EP0012 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 475-482 | Body_part | denotes | venules | FMA:63130 |
| T2 | 884-895 | Body_part | denotes | neutrophils | FMA:62860 |
| T3 | 900-911 | Body_part | denotes | lymphocytes | FMA:62863 |
| T4 | 1047-1058 | Body_part | denotes | Neutrophils | FMA:62860 |
| T5 | 1157-1168 | Body_part | denotes | lymphocytes | FMA:62863 |
| T6 | 1319-1324 | Body_part | denotes | ovary | FMA:7209 |
| T7 | 1776-1787 | Body_part | denotes | neutrophils | FMA:62860 |
| T8 | 1792-1803 | Body_part | denotes | lymphocytes | FMA:62863 |
| T9 | 2030-2040 | Body_part | denotes | neutrophil | FMA:62860 |
| T10 | 2053-2064 | Body_part | denotes | neutrophils | FMA:62860 |
| T11 | 2084-2101 | Body_part | denotes | endothelial cells | FMA:66772 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 878-883 | OrganismTaxon | denotes | human | 9606 |
| T2 | 1303-1318 | OrganismTaxon | denotes | Chinese hamster | 10029 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 458-482 | Body_part | denotes | high endothelial venules | http://purl.obolibrary.org/obo/UBERON_8410037 |
| T2 | 543-552 | Body_part | denotes | extension | http://purl.obolibrary.org/obo/UBERON_2000106 |
| T3 | 710-719 | Body_part | denotes | extension | http://purl.obolibrary.org/obo/UBERON_2000106 |
| T4 | 884-895 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T5 | 900-911 | Body_part | denotes | lymphocytes | http://purl.obolibrary.org/obo/CL_0000542 |
| T6 | 1047-1058 | Body_part | denotes | Neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T7 | 1157-1168 | Body_part | denotes | lymphocytes | http://purl.obolibrary.org/obo/CL_0000542 |
| T8 | 1319-1324 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |
| T9 | 1776-1787 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T10 | 1792-1803 | Body_part | denotes | lymphocytes | http://purl.obolibrary.org/obo/CL_0000542 |
| T11 | 2030-2040 | Body_part | denotes | neutrophil | http://purl.obolibrary.org/obo/CL_0000775 |
| T12 | 2053-2064 | Body_part | denotes | neutrophils | http://purl.obolibrary.org/obo/CL_0000775 |
| T13 | 2084-2101 | Body_part | denotes | endothelial cells | http://purl.obolibrary.org/obo/CL_0000115 |