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PubMed:12507076 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 1060-1065 gene:4193 denotes mdm-2
T1 1131-1134 disease:C0003857 denotes AVM
R1 T0 T1 associated_with mdm-2,AVM

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
12507076-10#34#37#gene6606 1698-1701 gene6606 denotes SMA
12507076-10#34#37#gene6607 1698-1701 gene6607 denotes SMA
12507076-10#34#37#gene6606 1698-1701 gene6606 denotes SMA
12507076-10#34#37#gene6607 1698-1701 gene6607 denotes SMA
12507076-10#65#68#diseaseC0003857 1729-1732 diseaseC0003857 denotes AVM
12507076-10#264#267#diseaseC0003857 1928-1931 diseaseC0003857 denotes AVM
12507076-3#194#198#gene6271 654-658 gene6271 denotes S100
12507076-3#194#198#gene6285 654-658 gene6285 denotes S100
12507076-3#110#141#gene2670 570-601 gene2670 denotes glial fibrillary acidic protein
12507076-3#273#276#diseaseC0003857 733-736 diseaseC0003857 denotes AVM
12507076-3#273#276#diseaseC0003857 733-736 diseaseC0003857 denotes AVM
12507076-6#23#28#gene4193 1060-1065 gene4193 denotes mdm-2
12507076-6#94#97#diseaseC0003857 1131-1134 diseaseC0003857 denotes AVM
34#37#gene660665#68#diseaseC0003857 12507076-10#34#37#gene6606 12507076-10#65#68#diseaseC0003857 associated_with SMA,AVM
34#37#gene6606264#267#diseaseC0003857 12507076-10#34#37#gene6606 12507076-10#264#267#diseaseC0003857 associated_with SMA,AVM
34#37#gene660765#68#diseaseC0003857 12507076-10#34#37#gene6607 12507076-10#65#68#diseaseC0003857 associated_with SMA,AVM
34#37#gene6607264#267#diseaseC0003857 12507076-10#34#37#gene6607 12507076-10#264#267#diseaseC0003857 associated_with SMA,AVM
34#37#gene660665#68#diseaseC0003857 12507076-10#34#37#gene6606 12507076-10#65#68#diseaseC0003857 associated_with SMA,AVM
34#37#gene6606264#267#diseaseC0003857 12507076-10#34#37#gene6606 12507076-10#264#267#diseaseC0003857 associated_with SMA,AVM
34#37#gene660765#68#diseaseC0003857 12507076-10#34#37#gene6607 12507076-10#65#68#diseaseC0003857 associated_with SMA,AVM
34#37#gene6607264#267#diseaseC0003857 12507076-10#34#37#gene6607 12507076-10#264#267#diseaseC0003857 associated_with SMA,AVM
194#198#gene6271273#276#diseaseC0003857 12507076-3#194#198#gene6271 12507076-3#273#276#diseaseC0003857 associated_with S100,AVM
194#198#gene6271273#276#diseaseC0003857 12507076-3#194#198#gene6271 12507076-3#273#276#diseaseC0003857 associated_with S100,AVM
194#198#gene6285273#276#diseaseC0003857 12507076-3#194#198#gene6285 12507076-3#273#276#diseaseC0003857 associated_with S100,AVM
194#198#gene6285273#276#diseaseC0003857 12507076-3#194#198#gene6285 12507076-3#273#276#diseaseC0003857 associated_with S100,AVM
110#141#gene2670273#276#diseaseC0003857 12507076-3#110#141#gene2670 12507076-3#273#276#diseaseC0003857 associated_with glial fibrillary acidic protein,AVM
110#141#gene2670273#276#diseaseC0003857 12507076-3#110#141#gene2670 12507076-3#273#276#diseaseC0003857 associated_with glial fibrillary acidic protein,AVM
23#28#gene419394#97#diseaseC0003857 12507076-6#23#28#gene4193 12507076-6#94#97#diseaseC0003857 associated_with mdm-2,AVM

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 119-348 OBJECTIVE denotes The purpose of this study was to analyze the effect of single high-dose gamma irradiation at a cellular biological level on tissue cultures obtained in patients who underwent surgery for cerebral arteriovenous malformation (AVM).
T2 358-1650 METHODS denotes The cell proliferation indices and changes in activation of p53, p21Waf-1, and mdm-2 were determined. Additionally, immunohistochemical investigations for vimentin, desmin, alpha-smooth muscle actin (alpha-SMA), glial fibrillary acidic protein, Factor VIII-related antigen (F-VIII), cytokeratin, S100, and transforming growth factor-beta (TGFbeta) were performed on cultured AVM cells after a single high-dose irradiation. Normal human brain microvessel endothelial (HBE) cells and aortic smooth muscle cells served as controls. The proliferation index decreased on the 5th day after irradiation and remained depressed over the observation period in the irradiated AVM cultures. The p53, p21Waf-1, and mdm-2 messenger RNA measurements showed considerable elevation both in AVM cultures and HBE cells after 15-Gy irradiation, which indicated apoptosis. Immunohistochemistry revealed strong vimentin positivity in the nonirradiated cultures, which gradually decreased in the irradiated cultures. Transforming growth factor-beta positivity was demonstrated in the irradiated specimens, indicating transformation of fibroblastic cells into activated myofibroblastic elements. This transformation was confirmed by demonstrating elevated SMA expression as well in the radiation-treated fibroblasts.
T3 1664-1974 CONCLUSIONS denotes The presence of TGFbeta and alpha-SMA activity in the irradiated AVM cells suggests that along with the genetically confirmed apoptotic activity, fibroblast transformation into myofibroblasts might be one of the mechanisms leading to shrinkage and obliteration of AVMs after single high-dose gamma irradiation.